Experts and Doctors on rats in Montréal, Quebec, Canada

Summary

Locale: Montréal, Quebec, Canada
Topic: rats

Top Publications

  1. Chow L, Fournel M, Davidson D, Veillette A. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk. Nature. 1993;365:156-60 pubmed
    ..We report here that p50csk negatively regulates TCR-induced tyrosine protein phosphorylation and lymphokine production. This provides evidence for the involvement of Csk in the regulation of T-cell activation. ..
  2. Morales C, El Alfy M, Zhao Q, Igdoura S. Molecular role of sulfated glycoprotein-1 (SGP-1/prosaposin) in Sertoli cells. Histol Histopathol. 1995;10:1023-34 pubmed
    ..Due to its capacity to bind certain types of gangliosides, SGP-1 appears to act as glycolipid transfer between Sertoli cells and the developing spermatids. ..
  3. Hussain N, Yamabhai M, Ramjaun A, Guy A, Baranes D, O Bryan J, et al. Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. J Biol Chem. 1999;274:15671-7 pubmed
    ..These data suggest that the long and short forms of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. ..
  4. Desjardins P, Todd K, Hazell A, Butterworth R. Increased "peripheral-type" benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats. Neurochem Int. 1999;35:363-9 pubmed
    ..Positron Emission Tomography using 11C-PK11195 could provide a novel approach to the diagnosis and assessment of the extent of thalamic damage due to thiamine deficiency in humans with Wernicke's Encephalopathy. ..
  5. Meloche S, Landry J, Huot J, Houle F, Marceau F, Giasson E. p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2000;279:H741-51 pubmed
    ..These results suggest that the p38 MAP kinase pathway selectively modulates the vasoconstrictor action of ANG II in vascular smooth muscle...
  6. Cloutier F, de Sousa Buck H, Ongali B, Couture R. Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats. Br J Pharmacol. 2002;135:1641-54 pubmed
  7. Ruocco I, Cuello A, Parent A, Ribeiro Da Silva A. Skin blood vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers. J Comp Neurol. 2002;448:323-36 pubmed
    ..Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers. ..
  8. Szaszi K, Paulsen A, Szabo E, Numata M, Grinstein S, Orlowski J. Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton. J Biol Chem. 2002;277:42623-32 pubmed
    ..These observations demonstrate that NHE5 is localized to the recycling endosomal pathway and is dynamically regulated by phosphatidylinositol 3'-kinase and by the state of F-actin assembly. ..
  9. Lam Yuk Tseung S, Govoni G, Forbes J, Gros P. Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Blood. 2003;101:3699-707 pubmed
    ..This indicates that His267/His272 are not directly involved in metal binding but, rather, play an important role in pH regulation of metal transport by Nramp proteins. ..

More Information

Publications465 found, 100 shown here

  1. Stewart L, Stifani S. Dendritic localization of the transcriptional co-repressor Groucho/TLE1 in cortical and cerebellar neurons. Brain Res Mol Brain Res. 2005;140:106-10 pubmed
    ..These results demonstrate that TLE1 expression occurs in the mature nervous system and suggest that this protein may perform new functions outside of the nucleus in selected cortical and cerebellar neurons. ..
  2. Tahvildari B, Fransen E, Alonso A, Hasselmo M. Switching between "On" and "Off" states of persistent activity in lateral entorhinal layer III neurons. Hippocampus. 2007;17:257-63 pubmed
    ..The neuronal ability to switch "On" and "Off" persistent activity may facilitate the concurrent representation of temporally segregated information arriving in the EC and being directed toward the hippocampus. ..
  3. Wild G, Searles L, Koski K, Drozdowski L, Begum Hasan J, Thomson A. Oral polyamine administration modifies the ontogeny of hexose transporter gene expression in the postnatal rat intestine. Am J Physiol Gastrointest Liver Physiol. 2007;293:G453-60 pubmed
    ..Thus, 3 days of oral polyamine administration induces the precocious maturation of glucose transporters in the postnatal rat small intestine, which may be mediated by alterations in ODC expression. ..
  4. Ligorio M, Descarries L, Warren R. Cholinergic innervation and thalamic input in rat nucleus accumbens. J Chem Neuroanat. 2009;37:33-45 pubmed publisher
  5. Almarestani L, Longo G, Ribeiro Da Silva A. Autonomic fiber sprouting in the skin in chronic inflammation. Mol Pain. 2008;4:56 pubmed publisher
    ..The increased peptidergic fiber innervation and the ectopic autonomic fibers found in the upper dermis may have a role in the pain-related behavior displayed by these animals. ..
  6. Walker C, Naef L, D Asti E, Long H, Xu Z, Moreau A, et al. Perinatal maternal fat intake affects metabolism and hippocampal function in the offspring: a potential role for leptin. Ann N Y Acad Sci. 2008;1144:189-202 pubmed publisher
  7. Jain M, Choi A, Neibert K, Maysinger D. Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system. Nanomedicine (Lond). 2009;4:277-90 pubmed publisher
    ..Complex multicellular model systems, along with homogenous cell models, should be utilized in standard screening and monitoring procedures for evaluating nanomaterial safety. ..
  8. Archbold G, Bouton M, Nader K. Evidence for the persistence of contextual fear memories following immediate extinction. Eur J Neurosci. 2010;31:1303-11 pubmed publisher
    ..Overall, the results provide little evidence that extinction conducted immediately after conditioning destroys or erases the original memory trace. ..
  9. Taylor A, Ribeiro Da Silva A. GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting. Pain. 2011;152:1502-10 pubmed publisher
  10. Laferriere A, Pitcher M, Haldane A, Huang Y, Cornea V, Kumar N, et al. PKM? is essential for spinal plasticity underlying the maintenance of persistent pain. Mol Pain. 2011;7:99 pubmed publisher
    ..These results suggest spinal PKM? is essential for the maintenance of persistent pain by sustaining spinal nociceptive plasticity. ..
  11. Oligny Longpré G, Corbani M, Zhou J, Hogue M, Guillon G, Bouvier M. Engagement of ?-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation. Proc Natl Acad Sci U S A. 2012;109:E1028-37 pubmed publisher
  12. Taylor A, Osikowicz M, Ribeiro Da Silva A. Consequences of the ablation of nonpeptidergic afferents in an animal model of trigeminal neuropathic pain. Pain. 2012;153:1311-9 pubmed publisher
    ..This was an unexpected finding, as it has been suggested that nonpeptidergic fibers play a major role in mechanical pain, and suggests that these fibers play a complex role in the development of neuropathic pain. ..
  13. Wright J, Dobosiewicz M, Clarke P. The role of dopaminergic transmission through D1-like and D2-like receptors in amphetamine-induced rat ultrasonic vocalizations. Psychopharmacology (Berl). 2013;225:853-68 pubmed publisher
  14. Gouspillou G, Hepple R. Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion. Exp Gerontol. 2013;48:1075-84 pubmed publisher
  15. An J, Beauchemin N, Albanese J, Abney T, Sullivan A. Use of a rat cDNA probe specific for the Y chromosome to detect male-derived cells. J Androl. 1997;18:289-93 pubmed
    ..In addition, a cDNA probe that is specific for the rat Sry gene might be valuable in studies of fetal male sexual development or the study of spermiogenesis. ..
  16. Jia J, Han Q, Borregaard N, Lollike K, Cygler M. Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. J Mol Biol. 2000;300:1271-81 pubmed
    ..Electrostatic potential distribution shows significant differences between grancalcin and calpain domain VI demonstrating their distinct character. ..
  17. Szabo S, Blier P. Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. Eur J Neurosci. 2001;13:2077-87 pubmed
    ..In conclusion, sustained NA reuptake blockade by reboxetine lead to profound alterations in the function of NA neurons and of 5-HT receptors modulating their firing activity. ..
  18. Beauchemin N, Draber P, Dveksler G, Gold P, Gray Owen S, Grunert F, et al. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res. 1999;252:243-9 pubmed
  19. Boivin B, Chevalier D, Villeneuve L, Rousseau E, Allen B. Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. J Biol Chem. 2003;278:29153-63 pubmed
    ..Hence, cardiac nuclei possess both ETAR and ETBR subtypes, which are functional with respect to ligand binding and are coupled to signaling mechanisms within the nuclear membrane. ..
  20. Bouchard J, Moore S, Tritsch N, Roux P, Shekarabi M, Barker P, et al. Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. J Neurosci. 2004;24:3040-50 pubmed
  21. Pladys P, Lahaie I, Cambonie G, Thibault G, Lê N, Abran D, et al. Role of brain and peripheral angiotensin II in hypertension and altered arterial baroreflex programmed during fetal life in rat. Pediatr Res. 2004;55:1042-9 pubmed
    ..These data demonstrate a major tonic role of brain and peripheral RAS on hypertension associated with antenatal nutrient deprivation. ..
  22. Benkirane K, Amiri F, Diep Q, El Mabrouk M, Schiffrin E. PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. Am J Physiol Heart Circ Physiol. 2006;290:H390-7 pubmed
    ..Modulation of these pathways by PPAR-gamma activators may contribute to regression of vascular remodeling in hypertension. ..
  23. Saragovi H. Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex. J Neurochem. 2005;95:1472-80 pubmed
    ..We speculate that neurotrophic deficits may be a shared mechanism for cognitive decline in aging and Alzheimer's disease. ..
  24. Hao W, Takano T, Guillemette J, Papillon J, Ren G, Cybulsky A. Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J Biol Chem. 2006;281:3075-84 pubmed
    ..Attenuation of the protective aspects of the endoplasmic reticulum stress response by SLK may contribute to its proapoptotic effect. ..
  25. Hamam B, Sinai M, Poirier G, Chapman C. Cholinergic suppression of excitatory synaptic responses in layer II of the medial entorhinal cortex. Hippocampus. 2007;17:103-13 pubmed
  26. Ferdinandi E, Brazeau P, High K, Procter B, Fennell S, Dubreuil P. Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue. Basic Clin Pharmacol Toxicol. 2007;100:49-58 pubmed
    ..The adverse treatment-related effects in dogs appear to be associated with sustained exposure to supraphysiological levels of growth hormone and IGF-1 induced by prolonged TH9507 treatment. ..
  27. Dias J, Ismael M, Pilon M, de Champlain J, Ferrari B, Carayon P, et al. The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Br J Pharmacol. 2007;152:280-7 pubmed
    ..Thus, orally active non-peptide B(1) receptor antagonists should have clinical therapeutic potential in the treatment of sensory polyneuropathy. ..
  28. Cameron N, Shahrokh D, Del Corpo A, Dhir S, Szyf M, Champagne F, et al. Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care. J Neuroendocrinol. 2008;20:795-801 pubmed publisher
    ..The tissue-specific nature of such effects may underlie the co-ordinated variation in multiple forms of reproductive function, resulting in distinct reproductive strategies. ..
  29. Marcangione C, Rompre P. Topographical Fos induction within the ventral midbrain and projection sites following self-stimulation of the posterior mesencephalon. Neuroscience. 2008;154:1227-41 pubmed publisher
    ..They provide additional support for the functional link between neurons that support PM and VTA self-stimulation, and offer topographical guidance to future attempts at their identification. ..
  30. Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay P, Meloche S. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. J Cell Physiol. 2008;217:778-88 pubmed publisher
    ..Our results demonstrate the importance of activation loop phosphorylation in the regulation of ERK3/ERK4 function and highlight differences in the regulation of atypical MAP kinases as compared to classical family members. ..
  31. Khatchadourian A, Maysinger D. Lipid droplets: their role in nanoparticle-induced oxidative stress. Mol Pharm. 2009;6:1125-37 pubmed publisher
    ..Results from these studies suggest that oleic acid-induced LD in PC12 cells are dynamic and adaptive organelles, which provide energy to starving cells and facilitate their rescue under starvation and exposure to metallic nanoparticles...
  32. Boncoeur E, Tardif V, Tessier M, Morneau F, Lavoie J, Gendreau Berthiaume E, et al. Modulation of epithelial sodium channel activity by lipopolysaccharide in alveolar type II cells: involvement of purinergic signaling. Am J Physiol Lung Cell Mol Physiol. 2010;298:L417-26 pubmed publisher
    ..Together, these findings demonstrate an important role of extracellular ATP signaling in the response of epithelial cells to LPS. ..
  33. Pellicelli M, Taheri M, St Louis M, Bériault V, DesGroseillers L, Boileau G, et al. PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4. J Cell Physiol. 2012;227:2378-87 pubmed publisher
    ..These results underline the important role of E4BP4 in osteoblastic cells and further define the repression mechanism of PHEX gene by PTHrP(1-34). ..
  34. Farah C, Sossin W. A new mechanism of action of a C2 domain-derived novel PKC inhibitor peptide. Neurosci Lett. 2011;504:306-10 pubmed publisher
    ..This inhibition was removed by R273H mutation in the C1b domain and by phosphatidic acid, which can both remove C2-domain mediated inhibition suggesting that the peptide can regulate C1-C2 domain interactions. ..
  35. Vaniotis G, Glazkova I, Merlen C, Smith C, Villeneuve L, Chatenet D, et al. Regulation of cardiac nitric oxide signaling by nuclear ?-adrenergic and endothelin receptors. J Mol Cell Cardiol. 2013;62:58-68 pubmed publisher
    ..Furthermore, we have demonstrated the potential utility of caged receptor ligands in selectively modulating signaling via endogenous intracellular G protein-coupled receptors. ..
  36. Rosenzweig D, Chicatun F, Nazhat S, Quinn T. Cartilaginous constructs using primary chondrocytes from continuous expansion culture seeded in dense collagen gels. Acta Biomater. 2013;9:9360-9 pubmed publisher
    ..Chondrocytes grown in CE culture and seeded in dense collagen gels produce more cartilaginous matrix with superior mechanical properties, making them more suitable than SS cultured cells for tissue engineering applications. ..
  37. Dawe G, Musgaard M, Andrews E, Daniels B, Aurousseau M, Biggin P, et al. Defining the structural relationship between kainate-receptor deactivation and desensitization. Nat Struct Mol Biol. 2013;20:1054-61 pubmed publisher
    ..This sequence of events is absent from AMPA-type iGluRs; thus, cations are identified as gatekeepers of KAR gating, a role unique among even closely related LGICs. ..
  38. Zhang D, Qi Y, Klyubin I, Ondrejcak T, Sarell C, Cuello A, et al. Targeting glutamatergic and cellular prion protein mechanisms of amyloid β-mediated persistent synaptic plasticity disruption: Longitudinal studies. Neuropharmacology. 2017;121:231-246 pubmed publisher
    ..Overall, the present findings support the ongoing development of therapeutics for early Alzheimer's disease based on these complementary approaches. ..
  39. Wang Y, Brulé E, Silander T, Bak B, Joustra S, Bernard D. The short mRNA isoform of the immunoglobulin superfamily, member 1 gene encodes an intracellular glycoprotein. PLoS ONE. 2017;12:e0180731 pubmed publisher
    ..Whether the protein plays intracellular functions or is trafficked through the secretory pathway under certain physiologic or pathophysiologic conditions has yet to be determined. ..
  40. Jankowski M, Rachelska G, Donghao W, McCann S, Gutkowska J. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Proc Natl Acad Sci U S A. 2001;98:11765-70 pubmed
    ..Changes in plasma ANP correlated with changes in ANP content in the right atrium, as demonstrated by RIA. Increased ANP expression and secretion in response to ERalpha activation may be a protective mechanism in the heart. ..
  41. Elvira G, Massie B, DesGroseillers L. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons. J Neurochem. 2006;96:105-17 pubmed
    ..They also suggest that one of these roles may be linked to Staufen2(62)-containing RNA granule formation in the nucleus and/or to their nucleo-cytoplasmic shuttling. ..
  42. Fortin M, Ferrari N, Higgins M, Séguin S, Allam M, Allakhverdi Z, et al. Effects of antisense oligodeoxynucleotides targeting CCR3 on the airway response to antigen in rats. Oligonucleotides. 2006;16:203-12 pubmed
    ..Topical inhibition of CCR3 expression, using an AS-ODN, could represent a novel approach for the treatment of asthma. ..
  43. Ahboucha S, Jiang W, Chatauret N, Mamer O, Baker G, Butterworth R. Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis. Neurogastroenterol Motil. 2008;20:949-57 pubmed publisher
    ..Pharmacological approaches using agents that either reduce neurosteroid synthesis or modulate the neurosteroid site on GABA-A receptor could offer new therapeutic tools for the management and treatment of HE. ..
  44. Panuccio G, Curia G, Colosimo A, Cruccu G, Avoli M. Epileptiform synchronization in the cingulate cortex. Epilepsia. 2009;50:521-36 pubmed publisher
    ..In addition, mu-opioid receptors appear to modulate both excitatory and inhibitory mechanisms, thus influencing epileptiform synchronization in the ACC. ..
  45. Alain T, Lun X, Martineau Y, Sean P, Pulendran B, Petroulakis E, et al. Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proc Natl Acad Sci U S A. 2010;107:1576-81 pubmed publisher
    ..These results demonstrate that reducing type I IFNs through inhibition of mTORC1 is an effective strategy to augment the therapeutic activity of VSV(DeltaM51). ..
  46. Mogil J. The surprising empathic abilities of rodents. Trends Cogn Sci. 2012;16:143-4 pubmed publisher
    ..By demonstrating empathy-based helping behavior in rats, a recently published study has provided clear-cut evidence that pro-social behaviors are not limited to humans. ..
  47. Pouliot M, Talbot S, Sénécal J, Dotigny F, Vaucher E, Couture R. Ocular application of the kinin B1 receptor antagonist LF22-0542 inhibits retinal inflammation and oxidative stress in streptozotocin-diabetic rats. PLoS ONE. 2012;7:e33864 pubmed publisher
    ..Hence, topical application of kinin B(1)R antagonist appears a highly promising novel approach for the treatment of diabetic retinopathy. ..
  48. Bernier L, Blais D, Boué Grabot E, Séguéla P. A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family. PLoS ONE. 2012;7:e40595 pubmed publisher
  49. Singh K, Mukherjee A, De Vouge M, Mukherjee B. Differential processing of osteopontin transcripts in rat kidney- and osteoblast-derived cell lines. J Biol Chem. 1992;267:23847-51 pubmed
    ..In addition, we demonstrate that, in contrast to most transformed cells, levels of OP expression are significantly reduced in KNRK cells as compared to NRK cells...
  50. Wada I, Rindress D, Cameron P, Ou W, Doherty J, Louvard D, et al. SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Biol Chem. 1991;266:19599-610 pubmed
    ..We propose that the function of the complex is to regulate Ca(2+)-dependent retention mechanisms for luminal proteins of the endoplasmic reticulum. ..
  51. Moukhles H, Carbonetto S. Dystroglycan contributes to the formation of multiple dystrophin-like complexes in brain. J Neurochem. 2001;78:824-34 pubmed
    ..Thus in the brain, unlike in muscle, the association of syntrophin with dystrophin is not crucial for the DAP complex which suggests that it may be associated with other proteins. ..
  52. Gianoulakis C. Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism. J Psychiatry Neurosci. 2001;26:304-18 pubmed
  53. Ahboucha S, Pomier Layrargues G, Butterworth R. Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy. Metab Brain Dis. 2004;19:241-51 pubmed
    ..These findings suggest the presence of nonbenzodiazepine substances (possibly neurosteroids) with positive allosteric modulatory properties at the GABA-A receptor complex in brain in hepatic encephalopathy. ..
  54. Mounier C, Dumas V, Posner B. Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins. Endocrinology. 2006;147:2383-91 pubmed
    ..In conclusion, we have found that in rat liver, insulin inhibition of IGFBP-1 mRNA levels can occur in the absence of the phosphorylation of Foxo1/Foxo3, whereas activation of the mTOR pathway is both necessary and sufficient. ..
  55. Duong C, Charron S, Xiao C, Hamet P, Ménard A, Roy J, et al. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Mamm Genome. 2006;17:1147-61 pubmed
    ..The discovery of individual Km and Cakm QTLs will likely facilitate the identification of mechanisms underlying renal, cardiac, and/or aortic hypertrophy independent of hypertension. ..
  56. Ramos A, Ho W, Forte S, Dickson K, Boutilier J, Favell K, et al. Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription. J Neurosci. 2007;27:1498-506 pubmed
    ..We propose that stress-induced Sp1 accumulation that results from reductions in Sp1 turnover rate contributes to injury-induced gene expression. ..
  57. Millecamps M, Coderre T. Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome--type I. Eur J Pharmacol. 2008;583:97-102 pubmed publisher
    ..These results are consistent with findings that complex region pain syndrome-I pain is refractory to most standard analgesic treatments. ..
  58. Lesage F, Brieu N, Dubeau S, Beaumont E. Optical imaging of vascular and metabolic responses in the lumbar spinal cord after T10 transection in rats. Neurosci Lett. 2009;454:105-9 pubmed publisher
    ..In conclusion, our results indicate that new avenues quantifying the influence of vascular plumbing will have to be developed to explore the efficacy of rehabilitation and pharmacological therapies by haemodynamic imaging. ..
  59. Larocque D, Fragoso G, Huang J, Mushynski W, Loignon M, Richard S, et al. The QKI-6 and QKI-7 RNA binding proteins block proliferation and promote Schwann cell myelination. PLoS ONE. 2009;4:e5867 pubmed publisher
    ..Our findings suggest that the QKI-6 and QKI-7 RNA binding proteins are positive regulators of PNS myelination and show that the QKI RNA binding proteins play a key role in Schwann cell differentiation and myelination. ..
  60. Ochoa Sanchez R, Rainer Q, Comai S, Spadoni G, Bedini A, Rivara S, et al. Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39:318-25 pubmed publisher
    ..These results demonstrated, for the first time, the anxiolytic properties of UCM765 and suggest that MT(2)-receptors may be considered a novel target for the development of anxiolytic drugs. ..
  61. Paul A, Shao W, Abbasi S, Shum Tim D, Prakash S. PAMAM dendrimer-baculovirus nanocomplex for microencapsulated adipose stem cell-gene therapy: in vitro and in vivo functional assessment. Mol Pharm. 2012;9:2479-88 pubmed publisher
    ..6 ± 6.1%) compared to that in MC+ASC-MGFP (38.8 ± 5.3%) and MC groups (31.5 ± 3.3%). Collectively, these data demonstrate the feasibility of this system for improved stem cell therapy applications...
  62. Gaudette F, Hamadjida A, Bédard D, Nuara S, Beaudry F, Huot P. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY-354,740 in rat and marmoset plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:392-398 pubmed publisher
    ..0mg/kg or lower in both species. ..
  63. Rabbani S, Rajwans N, Achbarou A, Murthy K, Goltzman D. Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts. FEBS Lett. 1994;338:69-74 pubmed
    ..These studies provide the tools for examining uPAR function in fibrinolysis, tumor invasion and metastasis in the rat and for identifying the mechanism of species specificity in uPA actions. ..
  64. Ammarguellat F, Larouche I, Schiffrin E. Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism. Circulation. 2001;103:319-24 pubmed
    ..These results support the hypothesis of a role for endothelin-1 in cardiac collagen deposition in mineralocorticoid hypertension, which may have pathophysiological and pharmacological implications in hypertensive heart disease. ..
  65. Millette E, Demeilliers B, Wu R, Laplante M, El Midaoui A, Moreau P, et al. Comparison of the cardiovascular protection by omapatrilat and lisinopril treatments in DOCA-salt hypertension. J Hypertens. 2003;21:125-35 pubmed
    ..However, despite similar antihypertensive efficacy, omapatrilat was superior to lisinopril in improving the endothelial-dependent coronary dilatation, suggesting a better vascular protection in the DOCA-salt model of hypertension. ..
  66. Popeski N, Amir S, Diorio J, Woodside B. Prolactin and oxytocin interaction in the paraventricular and supraoptic nuclei: effects on oxytocin mRNA and nitric oxide synthase. J Neuroendocrinol. 2003;15:687-96 pubmed
    ..Together, these data suggest that the increased capacity to produce nitric oxide in the SON and PVN during late pregnancy is dependent on prolactin stimulating oxytocin gene mRNA and hence intranuclear oxytocin release. ..
  67. Abdouh M, Khanjari A, Abdelazziz N, Ongali B, Couture R, Hasséssian H. Early upregulation of kinin B1 receptors in retinal microvessels of the streptozotocin-diabetic rat. Br J Pharmacol. 2003;140:33-40 pubmed
    ..These results suggest that kinin receptors may be potential targets for therapeutics to treat retinopathies. ..
  68. Palijan A, Dutil J, Deng A. Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Physiol Genomics. 2003;15:1-8 pubmed
    ..Interestingly, the combined effect of the -BP QTL and +BP QTL alleles was "-" in S.L1, implying that the "-" QTL is epistatic to "+" QTL. ..
  69. Noël G, Belda M, Guadagno E, Micoud J, Klocker N, Moukhles H. Dystroglycan and Kir4.1 coclustering in retinal Müller glia is regulated by laminin-1 and requires the PDZ-ligand domain of Kir4.1. J Neurochem. 2005;94:691-702 pubmed
    ..Thus, in the basal lamina laminin is an essential regulator involved in clearing excess potassium released during neuronal activity, thereby contributing to the maintenance of normal synaptic transmission in the retina. ..
  70. Segall L, Mezzetti A, Scanzano R, Gargus J, Purisima E, Blostein R. Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. Proc Natl Acad Sci U S A. 2005;102:11106-11 pubmed
  71. McDavid S, Lund J, Auclair F, Kolta A. Morphological and immunohistochemical characterization of interneurons within the rat trigeminal motor nucleus. Neuroscience. 2006;139:1049-59 pubmed
    ..This procedure marked commissural fibers and interneurons in the contralateral trigeminal motor nucleus. Together these results conclusively support the existence of interneurons in the trigeminal motor nucleus. ..
  72. Hashim S, Li Y, Anand Srivastava M. Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways. Am J Physiol Heart Circ Physiol. 2006;291:H3144-53 pubmed
  73. Pilorget A, Demeule M, Barakat S, Marvaldi J, Luis J, Beliveau R. Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. J Neurochem. 2007;100:1203-10 pubmed
  74. Huynh H, Servant N, Chalifour L. Ubiquinol-cytochrome-c reductase 7.2 kDa protein of mitochondrial complex III is steroid-responsive and increases in cardiac hypertrophy and hypertension. Can J Physiol Pharmacol. 2007;85:986-96 pubmed
    ..We conclude that UCCR7.2 is a steroid hormone-responsive gene in the heart, with expression increased in cardiac hypertrophy and in response to hypertension. ..
  75. Moffatt P, Gaumond M, Salois P, Sellin K, Bessette M, Godin E, et al. Bril: a novel bone-specific modulator of mineralization. J Bone Miner Res. 2008;23:1497-508 pubmed publisher
    ..Thus, we identified Bril as a novel osteoblast protein and showed a role in mineralization, possibly identifying a new regulatory pathway in bone formation. ..
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