Genomes and Genes
Experts and Doctors on rats in Montréal, Quebec, Canada
Locale: Montréal, Quebec, Canada
Publications465 found, 100 shown here
- Stewart L, Stifani S. Dendritic localization of the transcriptional co-repressor Groucho/TLE1 in cortical and cerebellar neurons. Brain Res Mol Brain Res. 2005;140:106-10 pubmed..These results demonstrate that TLE1 expression occurs in the mature nervous system and suggest that this protein may perform new functions outside of the nucleus in selected cortical and cerebellar neurons. ..
- Tahvildari B, Fransen E, Alonso A, Hasselmo M. Switching between "On" and "Off" states of persistent activity in lateral entorhinal layer III neurons. Hippocampus. 2007;17:257-63 pubmed..The neuronal ability to switch "On" and "Off" persistent activity may facilitate the concurrent representation of temporally segregated information arriving in the EC and being directed toward the hippocampus. ..
- Wild G, Searles L, Koski K, Drozdowski L, Begum Hasan J, Thomson A. Oral polyamine administration modifies the ontogeny of hexose transporter gene expression in the postnatal rat intestine. Am J Physiol Gastrointest Liver Physiol. 2007;293:G453-60 pubmed..Thus, 3 days of oral polyamine administration induces the precocious maturation of glucose transporters in the postnatal rat small intestine, which may be mediated by alterations in ODC expression. ..
- Almarestani L, Longo G, Ribeiro Da Silva A. Autonomic fiber sprouting in the skin in chronic inflammation. Mol Pain. 2008;4:56 pubmed publisher..The increased peptidergic fiber innervation and the ectopic autonomic fibers found in the upper dermis may have a role in the pain-related behavior displayed by these animals. ..
- Jain M, Choi A, Neibert K, Maysinger D. Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system. Nanomedicine (Lond). 2009;4:277-90 pubmed publisher..Complex multicellular model systems, along with homogenous cell models, should be utilized in standard screening and monitoring procedures for evaluating nanomaterial safety. ..
- Archbold G, Bouton M, Nader K. Evidence for the persistence of contextual fear memories following immediate extinction. Eur J Neurosci. 2010;31:1303-11 pubmed publisher..Overall, the results provide little evidence that extinction conducted immediately after conditioning destroys or erases the original memory trace. ..
- Laferriere A, Pitcher M, Haldane A, Huang Y, Cornea V, Kumar N, et al. PKM? is essential for spinal plasticity underlying the maintenance of persistent pain. Mol Pain. 2011;7:99 pubmed publisher..These results suggest spinal PKM? is essential for the maintenance of persistent pain by sustaining spinal nociceptive plasticity. ..
- Taylor A, Osikowicz M, Ribeiro Da Silva A. Consequences of the ablation of nonpeptidergic afferents in an animal model of trigeminal neuropathic pain. Pain. 2012;153:1311-9 pubmed publisher..This was an unexpected finding, as it has been suggested that nonpeptidergic fibers play a major role in mechanical pain, and suggests that these fibers play a complex role in the development of neuropathic pain. ..
- An J, Beauchemin N, Albanese J, Abney T, Sullivan A. Use of a rat cDNA probe specific for the Y chromosome to detect male-derived cells. J Androl. 1997;18:289-93 pubmed..In addition, a cDNA probe that is specific for the rat Sry gene might be valuable in studies of fetal male sexual development or the study of spermiogenesis. ..
- Jia J, Han Q, Borregaard N, Lollike K, Cygler M. Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. J Mol Biol. 2000;300:1271-81 pubmed..Electrostatic potential distribution shows significant differences between grancalcin and calpain domain VI demonstrating their distinct character. ..
- Szabo S, Blier P. Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. Eur J Neurosci. 2001;13:2077-87 pubmed..In conclusion, sustained NA reuptake blockade by reboxetine lead to profound alterations in the function of NA neurons and of 5-HT receptors modulating their firing activity. ..
- Beauchemin N, Draber P, Dveksler G, Gold P, Gray Owen S, Grunert F, et al. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res. 1999;252:243-9 pubmed
- Boivin B, Chevalier D, Villeneuve L, Rousseau E, Allen B. Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes. J Biol Chem. 2003;278:29153-63 pubmed..Hence, cardiac nuclei possess both ETAR and ETBR subtypes, which are functional with respect to ligand binding and are coupled to signaling mechanisms within the nuclear membrane. ..
- Bouchard J, Moore S, Tritsch N, Roux P, Shekarabi M, Barker P, et al. Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. J Neurosci. 2004;24:3040-50 pubmed
- Pladys P, Lahaie I, Cambonie G, Thibault G, Lê N, Abran D, et al. Role of brain and peripheral angiotensin II in hypertension and altered arterial baroreflex programmed during fetal life in rat. Pediatr Res. 2004;55:1042-9 pubmed..These data demonstrate a major tonic role of brain and peripheral RAS on hypertension associated with antenatal nutrient deprivation. ..
- Benkirane K, Amiri F, Diep Q, El Mabrouk M, Schiffrin E. PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. Am J Physiol Heart Circ Physiol. 2006;290:H390-7 pubmed..Modulation of these pathways by PPAR-gamma activators may contribute to regression of vascular remodeling in hypertension. ..
- Saragovi H. Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex. J Neurochem. 2005;95:1472-80 pubmed..We speculate that neurotrophic deficits may be a shared mechanism for cognitive decline in aging and Alzheimer's disease. ..
- Hao W, Takano T, Guillemette J, Papillon J, Ren G, Cybulsky A. Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J Biol Chem. 2006;281:3075-84 pubmed..Attenuation of the protective aspects of the endoplasmic reticulum stress response by SLK may contribute to its proapoptotic effect. ..
- Hamam B, Sinai M, Poirier G, Chapman C. Cholinergic suppression of excitatory synaptic responses in layer II of the medial entorhinal cortex. Hippocampus. 2007;17:103-13 pubmed
- Ferdinandi E, Brazeau P, High K, Procter B, Fennell S, Dubreuil P. Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue. Basic Clin Pharmacol Toxicol. 2007;100:49-58 pubmed..The adverse treatment-related effects in dogs appear to be associated with sustained exposure to supraphysiological levels of growth hormone and IGF-1 induced by prolonged TH9507 treatment. ..
- Dias J, Ismael M, Pilon M, de Champlain J, Ferrari B, Carayon P, et al. The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Br J Pharmacol. 2007;152:280-7 pubmed..Thus, orally active non-peptide B(1) receptor antagonists should have clinical therapeutic potential in the treatment of sensory polyneuropathy. ..
- Cameron N, Shahrokh D, Del Corpo A, Dhir S, Szyf M, Champagne F, et al. Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care. J Neuroendocrinol. 2008;20:795-801 pubmed publisher..The tissue-specific nature of such effects may underlie the co-ordinated variation in multiple forms of reproductive function, resulting in distinct reproductive strategies. ..
- Marcangione C, Rompre P. Topographical Fos induction within the ventral midbrain and projection sites following self-stimulation of the posterior mesencephalon. Neuroscience. 2008;154:1227-41 pubmed publisher..They provide additional support for the functional link between neurons that support PM and VTA self-stimulation, and offer topographical guidance to future attempts at their identification. ..
- Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay P, Meloche S. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. J Cell Physiol. 2008;217:778-88 pubmed publisher..Our results demonstrate the importance of activation loop phosphorylation in the regulation of ERK3/ERK4 function and highlight differences in the regulation of atypical MAP kinases as compared to classical family members. ..
- Khatchadourian A, Maysinger D. Lipid droplets: their role in nanoparticle-induced oxidative stress. Mol Pharm. 2009;6:1125-37 pubmed publisher..Results from these studies suggest that oleic acid-induced LD in PC12 cells are dynamic and adaptive organelles, which provide energy to starving cells and facilitate their rescue under starvation and exposure to metallic nanoparticles...
- Boncoeur E, Tardif V, Tessier M, Morneau F, Lavoie J, Gendreau Berthiaume E, et al. Modulation of epithelial sodium channel activity by lipopolysaccharide in alveolar type II cells: involvement of purinergic signaling. Am J Physiol Lung Cell Mol Physiol. 2010;298:L417-26 pubmed publisher..Together, these findings demonstrate an important role of extracellular ATP signaling in the response of epithelial cells to LPS. ..
- Pellicelli M, Taheri M, St Louis M, Bériault V, DesGroseillers L, Boileau G, et al. PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4. J Cell Physiol. 2012;227:2378-87 pubmed publisher..These results underline the important role of E4BP4 in osteoblastic cells and further define the repression mechanism of PHEX gene by PTHrP(1-34). ..
- Farah C, Sossin W. A new mechanism of action of a C2 domain-derived novel PKC inhibitor peptide. Neurosci Lett. 2011;504:306-10 pubmed publisher..This inhibition was removed by R273H mutation in the C1b domain and by phosphatidic acid, which can both remove C2-domain mediated inhibition suggesting that the peptide can regulate C1-C2 domain interactions. ..
- Vaniotis G, Glazkova I, Merlen C, Smith C, Villeneuve L, Chatenet D, et al. Regulation of cardiac nitric oxide signaling by nuclear ?-adrenergic and endothelin receptors. J Mol Cell Cardiol. 2013;62:58-68 pubmed publisher..Furthermore, we have demonstrated the potential utility of caged receptor ligands in selectively modulating signaling via endogenous intracellular G protein-coupled receptors. ..
- Rosenzweig D, Chicatun F, Nazhat S, Quinn T. Cartilaginous constructs using primary chondrocytes from continuous expansion culture seeded in dense collagen gels. Acta Biomater. 2013;9:9360-9 pubmed publisher..Chondrocytes grown in CE culture and seeded in dense collagen gels produce more cartilaginous matrix with superior mechanical properties, making them more suitable than SS cultured cells for tissue engineering applications. ..
- Dawe G, Musgaard M, Andrews E, Daniels B, Aurousseau M, Biggin P, et al. Defining the structural relationship between kainate-receptor deactivation and desensitization. Nat Struct Mol Biol. 2013;20:1054-61 pubmed publisher..This sequence of events is absent from AMPA-type iGluRs; thus, cations are identified as gatekeepers of KAR gating, a role unique among even closely related LGICs. ..
- Zhang D, Qi Y, Klyubin I, Ondrejcak T, Sarell C, Cuello A, et al. Targeting glutamatergic and cellular prion protein mechanisms of amyloid Î²-mediated persistent synaptic plasticity disruption: Longitudinal studies. Neuropharmacology. 2017;121:231-246 pubmed publisher..Overall, the present findings support the ongoing development of therapeutics for early Alzheimer's disease based on these complementary approaches. ..
- Wang Y, Brulé E, Silander T, Bak B, Joustra S, Bernard D. The short mRNA isoform of the immunoglobulin superfamily, member 1 gene encodes an intracellular glycoprotein. PLoS ONE. 2017;12:e0180731 pubmed publisher..Whether the protein plays intracellular functions or is trafficked through the secretory pathway under certain physiologic or pathophysiologic conditions has yet to be determined. ..
- Jankowski M, Rachelska G, Donghao W, McCann S, Gutkowska J. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Proc Natl Acad Sci U S A. 2001;98:11765-70 pubmed..Changes in plasma ANP correlated with changes in ANP content in the right atrium, as demonstrated by RIA. Increased ANP expression and secretion in response to ERalpha activation may be a protective mechanism in the heart. ..
- Elvira G, Massie B, DesGroseillers L. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons. J Neurochem. 2006;96:105-17 pubmed..They also suggest that one of these roles may be linked to Staufen2(62)-containing RNA granule formation in the nucleus and/or to their nucleo-cytoplasmic shuttling. ..
- Fortin M, Ferrari N, Higgins M, Séguin S, Allam M, Allakhverdi Z, et al. Effects of antisense oligodeoxynucleotides targeting CCR3 on the airway response to antigen in rats. Oligonucleotides. 2006;16:203-12 pubmed..Topical inhibition of CCR3 expression, using an AS-ODN, could represent a novel approach for the treatment of asthma. ..
- Ahboucha S, Jiang W, Chatauret N, Mamer O, Baker G, Butterworth R. Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis. Neurogastroenterol Motil. 2008;20:949-57 pubmed publisher..Pharmacological approaches using agents that either reduce neurosteroid synthesis or modulate the neurosteroid site on GABA-A receptor could offer new therapeutic tools for the management and treatment of HE. ..
- Panuccio G, Curia G, Colosimo A, Cruccu G, Avoli M. Epileptiform synchronization in the cingulate cortex. Epilepsia. 2009;50:521-36 pubmed publisher..In addition, mu-opioid receptors appear to modulate both excitatory and inhibitory mechanisms, thus influencing epileptiform synchronization in the ACC. ..
- Alain T, Lun X, Martineau Y, Sean P, Pulendran B, Petroulakis E, et al. Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proc Natl Acad Sci U S A. 2010;107:1576-81 pubmed publisher..These results demonstrate that reducing type I IFNs through inhibition of mTORC1 is an effective strategy to augment the therapeutic activity of VSV(DeltaM51). ..
- Mogil J. The surprising empathic abilities of rodents. Trends Cogn Sci. 2012;16:143-4 pubmed publisher..By demonstrating empathy-based helping behavior in rats, a recently published study has provided clear-cut evidence that pro-social behaviors are not limited to humans. ..
- Pouliot M, Talbot S, Sénécal J, Dotigny F, Vaucher E, Couture R. Ocular application of the kinin B1 receptor antagonist LF22-0542 inhibits retinal inflammation and oxidative stress in streptozotocin-diabetic rats. PLoS ONE. 2012;7:e33864 pubmed publisher..Hence, topical application of kinin B(1)R antagonist appears a highly promising novel approach for the treatment of diabetic retinopathy. ..
- Singh K, Mukherjee A, De Vouge M, Mukherjee B. Differential processing of osteopontin transcripts in rat kidney- and osteoblast-derived cell lines. J Biol Chem. 1992;267:23847-51 pubmed..In addition, we demonstrate that, in contrast to most transformed cells, levels of OP expression are significantly reduced in KNRK cells as compared to NRK cells...
- Wada I, Rindress D, Cameron P, Ou W, Doherty J, Louvard D, et al. SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Biol Chem. 1991;266:19599-610 pubmed..We propose that the function of the complex is to regulate Ca(2+)-dependent retention mechanisms for luminal proteins of the endoplasmic reticulum. ..
- Moukhles H, Carbonetto S. Dystroglycan contributes to the formation of multiple dystrophin-like complexes in brain. J Neurochem. 2001;78:824-34 pubmed..Thus in the brain, unlike in muscle, the association of syntrophin with dystrophin is not crucial for the DAP complex which suggests that it may be associated with other proteins. ..
- Gianoulakis C. Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism. J Psychiatry Neurosci. 2001;26:304-18 pubmed
- Ahboucha S, Pomier Layrargues G, Butterworth R. Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy. Metab Brain Dis. 2004;19:241-51 pubmed..These findings suggest the presence of nonbenzodiazepine substances (possibly neurosteroids) with positive allosteric modulatory properties at the GABA-A receptor complex in brain in hepatic encephalopathy. ..
- Mounier C, Dumas V, Posner B. Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins. Endocrinology. 2006;147:2383-91 pubmed..In conclusion, we have found that in rat liver, insulin inhibition of IGFBP-1 mRNA levels can occur in the absence of the phosphorylation of Foxo1/Foxo3, whereas activation of the mTOR pathway is both necessary and sufficient. ..
- Duong C, Charron S, Xiao C, Hamet P, Ménard A, Roy J, et al. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Mamm Genome. 2006;17:1147-61 pubmed..The discovery of individual Km and Cakm QTLs will likely facilitate the identification of mechanisms underlying renal, cardiac, and/or aortic hypertrophy independent of hypertension. ..
- Ramos A, Ho W, Forte S, Dickson K, Boutilier J, Favell K, et al. Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription. J Neurosci. 2007;27:1498-506 pubmed..We propose that stress-induced Sp1 accumulation that results from reductions in Sp1 turnover rate contributes to injury-induced gene expression. ..
- Millecamps M, Coderre T. Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome--type I. Eur J Pharmacol. 2008;583:97-102 pubmed publisher..These results are consistent with findings that complex region pain syndrome-I pain is refractory to most standard analgesic treatments. ..
- Lesage F, Brieu N, Dubeau S, Beaumont E. Optical imaging of vascular and metabolic responses in the lumbar spinal cord after T10 transection in rats. Neurosci Lett. 2009;454:105-9 pubmed publisher..In conclusion, our results indicate that new avenues quantifying the influence of vascular plumbing will have to be developed to explore the efficacy of rehabilitation and pharmacological therapies by haemodynamic imaging. ..
- Larocque D, Fragoso G, Huang J, Mushynski W, Loignon M, Richard S, et al. The QKI-6 and QKI-7 RNA binding proteins block proliferation and promote Schwann cell myelination. PLoS ONE. 2009;4:e5867 pubmed publisher..Our findings suggest that the QKI-6 and QKI-7 RNA binding proteins are positive regulators of PNS myelination and show that the QKI RNA binding proteins play a key role in Schwann cell differentiation and myelination. ..
- Ochoa Sanchez R, Rainer Q, Comai S, Spadoni G, Bedini A, Rivara S, et al. Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39:318-25 pubmed publisher..These results demonstrated, for the first time, the anxiolytic properties of UCM765 and suggest that MT(2)-receptors may be considered a novel target for the development of anxiolytic drugs. ..
- Paul A, Shao W, Abbasi S, Shum Tim D, Prakash S. PAMAM dendrimer-baculovirus nanocomplex for microencapsulated adipose stem cell-gene therapy: in vitro and in vivo functional assessment. Mol Pharm. 2012;9:2479-88 pubmed publisher..6 ± 6.1%) compared to that in MC+ASC-MGFP (38.8 ± 5.3%) and MC groups (31.5 ± 3.3%). Collectively, these data demonstrate the feasibility of this system for improved stem cell therapy applications...
- Gaudette F, Hamadjida A, Bédard D, Nuara S, Beaudry F, Huot P. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY-354,740 in rat and marmoset plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:392-398 pubmed publisher..0mg/kg or lower in both species. ..
- Rabbani S, Rajwans N, Achbarou A, Murthy K, Goltzman D. Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts. FEBS Lett. 1994;338:69-74 pubmed..These studies provide the tools for examining uPAR function in fibrinolysis, tumor invasion and metastasis in the rat and for identifying the mechanism of species specificity in uPA actions. ..
- Ammarguellat F, Larouche I, Schiffrin E. Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism. Circulation. 2001;103:319-24 pubmed..These results support the hypothesis of a role for endothelin-1 in cardiac collagen deposition in mineralocorticoid hypertension, which may have pathophysiological and pharmacological implications in hypertensive heart disease. ..
- Millette E, Demeilliers B, Wu R, Laplante M, El Midaoui A, Moreau P, et al. Comparison of the cardiovascular protection by omapatrilat and lisinopril treatments in DOCA-salt hypertension. J Hypertens. 2003;21:125-35 pubmed..However, despite similar antihypertensive efficacy, omapatrilat was superior to lisinopril in improving the endothelial-dependent coronary dilatation, suggesting a better vascular protection in the DOCA-salt model of hypertension. ..
- Popeski N, Amir S, Diorio J, Woodside B. Prolactin and oxytocin interaction in the paraventricular and supraoptic nuclei: effects on oxytocin mRNA and nitric oxide synthase. J Neuroendocrinol. 2003;15:687-96 pubmed..Together, these data suggest that the increased capacity to produce nitric oxide in the SON and PVN during late pregnancy is dependent on prolactin stimulating oxytocin gene mRNA and hence intranuclear oxytocin release. ..
- Abdouh M, Khanjari A, Abdelazziz N, Ongali B, Couture R, Hasséssian H. Early upregulation of kinin B1 receptors in retinal microvessels of the streptozotocin-diabetic rat. Br J Pharmacol. 2003;140:33-40 pubmed..These results suggest that kinin receptors may be potential targets for therapeutics to treat retinopathies. ..
- Palijan A, Dutil J, Deng A. Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Physiol Genomics. 2003;15:1-8 pubmed..Interestingly, the combined effect of the -BP QTL and +BP QTL alleles was "-" in S.L1, implying that the "-" QTL is epistatic to "+" QTL. ..
- Noël G, Belda M, Guadagno E, Micoud J, Klocker N, Moukhles H. Dystroglycan and Kir4.1 coclustering in retinal Müller glia is regulated by laminin-1 and requires the PDZ-ligand domain of Kir4.1. J Neurochem. 2005;94:691-702 pubmed..Thus, in the basal lamina laminin is an essential regulator involved in clearing excess potassium released during neuronal activity, thereby contributing to the maintenance of normal synaptic transmission in the retina. ..
- Segall L, Mezzetti A, Scanzano R, Gargus J, Purisima E, Blostein R. Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. Proc Natl Acad Sci U S A. 2005;102:11106-11 pubmed
- McDavid S, Lund J, Auclair F, Kolta A. Morphological and immunohistochemical characterization of interneurons within the rat trigeminal motor nucleus. Neuroscience. 2006;139:1049-59 pubmed..This procedure marked commissural fibers and interneurons in the contralateral trigeminal motor nucleus. Together these results conclusively support the existence of interneurons in the trigeminal motor nucleus. ..
- Hashim S, Li Y, Anand Srivastava M. Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways. Am J Physiol Heart Circ Physiol. 2006;291:H3144-53 pubmed
- Pilorget A, Demeule M, Barakat S, Marvaldi J, Luis J, Beliveau R. Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. J Neurochem. 2007;100:1203-10 pubmed
- Huynh H, Servant N, Chalifour L. Ubiquinol-cytochrome-c reductase 7.2 kDa protein of mitochondrial complex III is steroid-responsive and increases in cardiac hypertrophy and hypertension. Can J Physiol Pharmacol. 2007;85:986-96 pubmed..We conclude that UCCR7.2 is a steroid hormone-responsive gene in the heart, with expression increased in cardiac hypertrophy and in response to hypertension. ..
- Moffatt P, Gaumond M, Salois P, Sellin K, Bessette M, Godin E, et al. Bril: a novel bone-specific modulator of mineralization. J Bone Miner Res. 2008;23:1497-508 pubmed publisher..Thus, we identified Bril as a novel osteoblast protein and showed a role in mineralization, possibly identifying a new regulatory pathway in bone formation. ..
- Viel E, Benkirane K, Javeshghani D, Touyz R, Schiffrin E. Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol. 2008;295:H281-8 pubmed publisher..Our findings demonstrate the involvement of ET(A) receptor-modulated O(2)(*-) derived from XO and from mitochondrial oxidative enzymes in arteries from DOCA-salt rats. ..
- Guillemard V, Ivanisevic L, Garcia A, Scholten V, Lazo O, Bronfman F, et al. An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors. Dev Neurobiol. 2010;70:150-64 pubmed publisher..mAb 2B7 defines a previously unknown neurotrophin receptor functional hot spot; that exclusively generates survival signals; that can be activated by non-dimeric ligands; and potentially unmasks a site for p75-TrkC interactions. ..
- Lebrun Julien F, Bertrand M, De Backer O, Stellwagen D, Morales C, Di Polo A, et al. ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proc Natl Acad Sci U S A. 2010;107:3817-22 pubmed publisher..We conclude that proNGF activates a non-cell-autonomous signaling pathway that causes TNFalpha-dependent death of retinal neurons in vivo. ..
- Hassani O, Henny P, Lee M, Jones B. GABAergic neurons intermingled with orexin and MCH neurons in the lateral hypothalamus discharge maximally during sleep. Eur J Neurosci. 2010;32:448-57 pubmed publisher..They could accordingly dampen arousal with muscle tone and promote sleep, including PS with muscle atonia. ..
- Bullimore S, Siddiqui S, Donovan G, Martin J, Sneyd J, Bates J, et al. Could an increase in airway smooth muscle shortening velocity cause airway hyperresponsiveness?. Am J Physiol Lung Cell Mol Physiol. 2011;300:L121-31 pubmed publisher..We conclude that, if asthma involves an increase in ASM velocity, this could be an important factor in the associated AHR. ..
- Xiong X, Wang X, Li B, Chowdhury S, Lu Y, Srikant C, et al. Pancreatic islet-specific overexpression of Reg3? protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus. Am J Physiol Endocrinol Metab. 2011;300:E669-80 pubmed publisher..Our results suggest that Reg3? is unlikely an islet growth factor but a putative protector that prevents streptozotocin-induced damage by inducing the expression of specific genes. ..
- Platonova A, Koltsova S, Maksimov G, Grygorczyk R, Orlov S. The death of ouabain-treated renal epithelial C11-MDCK cells is not mediated by swelling-induced plasma membrane rupture. J Membr Biol. 2011;241:145-54 pubmed publisher..Thus, our results showed that the rupture of plasma membranes in ouabain-treated C11-MDCK cells was not directly caused by cell volume modulation evoked by Na?,K?-ATPase inhibition and inversion of the [Na?](i)/[K?](i) ratio. ..
- Tse Y, Bagot R, Hutter J, Wong A, Wong T. Modulation of synaptic plasticity by stress hormone associates with plastic alteration of synaptic NMDA receptor in the adult hippocampus. PLoS ONE. 2011;6:e27215 pubmed publisher..CORT-mediated slow-onset increase in GluN2A in hippocampal synapses could be a homeostatic mechanism to normalize synaptic plasticity following fast-onset stress-induced facilitation. ..
- Thompson S, Bushnell M. Rodent functional and anatomical imaging of pain. Neurosci Lett. 2012;520:131-9 pubmed publisher..Future directions in rodent pain imaging include miniaturized PET for the freely moving animal, as well as new MRI techniques that enable ongoing chronic pain imaging. ..
- Weigl Y, Harbour V, Robinson B, Dufresne L, Amir S. Peripheral circadian clocks--a conserved phenotype?. Chronobiol Int. 2013;30:559-76 pubmed publisher..Yet, additional posttranscriptional and translational events can contribute to the robustness and periodicity of the clock output. ..
- Lee S, Ann D, Wang E. Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. Biochem Biophys Res Commun. 1994;203:1371-7 pubmed..These results indicate that mouse and man contain a second member of the EF-1 alpha gene family, the S1 gene. They also suggest that our result obtained in rat may be extrapolated to mouse and man. ..
- Bhattacharya M, Peri K, Ribeiro da Silva A, Almazan G, Shichi H, Hou X, et al. Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope. J Biol Chem. 1999;274:15719-24 pubmed..These results define a possible molecular mechanism of action of nuclear EP3 receptors. ..
- Desrosiers R, Nguyen Q, Beliveau R. The carboxyl methyltransferase modifying G proteins is a metalloenzyme. Biochem Biophys Res Commun. 1999;261:790-7 pubmed..The finding that PPMT is a metalloenzyme may provide new insights into the functions played by this methyltransferase in signal transduction processes. ..
- Abbott F, Hellemans K. Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects. Behav Brain Res. 2000;112:177-86 pubmed..The central component of the antinociceptive effects may be related to activation of brain mechanisms that are involved in reinforcement...
- Hirai T, Bates J. Effects of deep inspiration on bronchoconstriction in the rat. Respir Physiol. 2001;127:201-15 pubmed..Our results thus suggest that the DIs that we administered were neither bronchodilatory nor bronchoprotective, but that they were able to reduce the amount of airway closure occurring following bronchoconstriction. ..