Genomes and Genes
Experts and Doctors on protein binding in Montréal, Quebec, Canada
Locale: Montréal, Quebec, Canada
Topic: protein binding
Publications287 found, 100 shown here
- Boisvert F, Rhie A, Richard S, Doherty A. The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. Cell Cycle. 2005;4:1834-41 pubmed..Our findings identify the GAR motif as a region required for 53BP1 DNA binding activity and as the site of methylation by PRMT1. ..
- Steiger H, Gauvin L, Joober R, Israel M, Ng Ying Kin N, Bruce K, et al. Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relatives. Neuropsychopharmacology. 2006;31:1785-92 pubmed..We propose that, under conducive circumstances, such a trait may increase risk of binge-eating behavior, or associated symptoms of affective or behavioral dysregulation. ..
- Robitaille G, Henault J, Christin M, Senecal J, Raymond Y. The nuclear autoantigen CENP-B displays cytokine-like activities toward vascular smooth muscle cells. Arthritis Rheum. 2007;56:3814-26 pubmed..These novel biologic roles of the nuclear autoantigen CENP-B open up a new perspective for studying the pathogenic role of anti-CENP-B autoantibodies. ..
- Di Lello P, Miller Jenkins L, Mas C, Langlois C, Malitskaya E, Fradet Turcotte A, et al. p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH. Proc Natl Acad Sci U S A. 2008;105:106-11 pubmed..These results point to an important interplay between the general transcription factor TFIIEalpha and the tumor suppressor protein p53 in regulating transcriptional activation that may be modulated by the phosphorylation status of p53. ..
- Min T, Vedadi M, Watson D, Wasney G, Munger C, Cygler M, et al. Specificity of Campylobacter jejuni adhesin PEB3 for phosphates and structural differences among its ligand complexes. Biochemistry. 2009;48:3057-67 pubmed publisher..On the basis of our findings, we suggest that PEB3 is a transport protein that may function in utilization of 3-PG or other phosphate-containing molecules from the host. ..
- Therrien C, Di Fulvio S, Pickles S, Sinnreich M. Characterization of lipid binding specificities of dysferlin C2 domains reveals novel interactions with phosphoinositides. Biochemistry. 2009;48:2377-84 pubmed publisher..The remainder of the C2 domains exhibited weaker and Ca(2+)-independent binding to PS and no significant binding to phosphoinositides. ..
- Scrivens P, Shahrzad N, Moores A, Morin A, Brunet S, Sacher M. TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. Traffic. 2009;10:724-36 pubmed publisher..Taken together these results indicate that TRAPPC2L and its yeast ortholog YEL048c are novel TRAPP-interacting proteins that may modulate the function of the TRAPP II complex. ..
- Bhagatji P, Leventis R, Rich R, Lin C, Silvius J. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. Biophys J. 2010;99:3327-35 pubmed publisher..Multiple cellular proteins thus control the dynamics of membrane association and intercompartmental movement of K-ras to an important degree even under basal cellular conditions. ..
- Marat A, Ioannou M, McPherson P. Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton. Mol Biol Cell. 2012;23:163-75 pubmed publisher..Thus, whereas connecdenn 1 and 2 activate Rab35 for endosomal trafficking, connecdenn 3 uniquely activates Rab35 for its role in actin regulation. ..
- Maddox P, Corbett K, Desai A. Structure, assembly and reading of centromeric chromatin. Curr Opin Genet Dev. 2012;22:139-47 pubmed publisher..Here we review recent structural and biochemical work on CENP-A, and advances in understanding the mechanisms that propagate and read centromeric chromatin domains. ..
- Gottlieb B, Beitel L, Nadarajah A, Paliouras M, Trifiro M. The androgen receptor gene mutations database: 2012 update. Hum Mutat. 2012;33:887-94 pubmed publisher..The database is available on the internet (http://androgendb.mcgill.ca), and a web-based LSDB with the variants using the Leiden Open Variation Database platform is available at http://www.lovd.nl/AR. ..
- Mondragón Rodríguez S, Trillaud Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, et al. Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation. J Biol Chem. 2012;287:32040-53 pubmed publisher..Based on our results, we propose that the physiologically occurring phosphorylation of tau could serve as a regulatory mechanism to prevent NMDA receptor overexcitation. ..
- Charfi C, Levros L, Edouard E, Rassart E. Characterization and identification of PARM-1 as a new potential oncogene. Mol Cancer. 2013;12:84 pubmed publisher..In addition, PARM-1 increases ERK1/2, but more importantly AKT and STAT3 phosphorylation. Our results strongly suggest the oncogenic potential of PARM-1. ..
- Ma Q, Tan J, Cui X, Luo D, Yu M, Liang C, et al. Residues R(199)H(200) of prototype foamy virus transactivator Bel1 contribute to its binding with LTR and IP promoters but not its nuclear localization. Virology. 2014;449:215-23 pubmed publisher..Collectively, our findings suggest that R(199)H(200) directly participate in Bel1 binding to viral promoter DNA and are indispensible for Bel1 transactivation activity. ..
- Klein H, Abu Arish A, Trinh N, Luo Y, Wiseman P, Hanrahan J, et al. Investigating CFTR and KCa3.1 Protein/Protein Interactions. PLoS ONE. 2016;11:e0153665 pubmed publisher..Altogether, these results suggest 1) that the physical interaction KCa3.1/CFTR can occur early during the biogenesis of both proteins and 2) that KCa3.1 and CFTR form a dynamic complex, the formation of which depends on internal Ca2+. ..
- Muñoz Escobar J, Kozlov G, Gehring K. Crystal structure of the UBR-box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding. Protein Sci. 2017;26:2092-2097 pubmed publisher..Analysis of the structure suggests that the absence of N-terminal residue binding arises from the lack of an amino acid binding pocket. ..
- Lamorte L, Kamikura D, Park M. A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein. Oncogene. 2000;19:5973-81 pubmed..We propose that the loss of adhesion dependent signals required for cell cycle progression is compensated through Met induced Gab1/Crk signals. ..
- Peschard P, Fournier T, Lamorte L, Naujokas M, Band H, Langdon W, et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell. 2001;8:995-1004 pubmed..We propose the uncoupling of c-Cbl from RTKs as a mechanism contributing to their oncogenic activation. ..
- Servant M, Grandvaux N, tenOever B, Duguay D, Lin R, Hiscott J. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J Biol Chem. 2003;278:9441-7 pubmed..The inability of the phosphospecific antibody to detect Ser(396) phosphorylation in lipopolysaccharide-treated cells suggests that other major pathways may be involved in IRF-3 activation following Toll-like receptor 4 stimulation. ..
- Lu Y, Zi X, Zhao Y, Pollak M. Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells. Biochem Biophys Res Commun. 2004;313:709-15 pubmed..They are consistent with the view that the IGF-IR mediated attenuation of trastuzumab-induced growth inhibition we recently described is dependent on IGF-I-induced PI3K signaling rather than IGF-I-induced MAPK signaling. ..
- Grant M, Patel R, Kumar U. The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors. J Biol Chem. 2004;279:38636-43 pubmed..Understanding the mechanisms by which GPCRs dimerize holds promise for improvements in drug design and efficacy. ..
- tenOever B, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, et al. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol. 2004;78:10636-49 pubmed..Induction of IKKepsilon potentially functions as a component of the amplification mechanism involved in the establishment of the antiviral state. ..
- Tocilj A, Schrag J, Li Y, Schneider B, Reitzer L, Matte A, et al. Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli. J Biol Chem. 2005;280:15800-8 pubmed
- Archambault D, St Louis M, Martin S. Binding of cellular proteins to the leader RNA of equine arteritis virus. Virus Genes. 2005;30:121-5 pubmed..Results from competition gel mobility shift assays using overlapping cold RNA probes spanning the leader RNA (+) strand indicated that nt 140-206 are not necessary for binding to cell proteins. ..
- Harfouche R, Malak N, Brandes R, Karsan A, Irani K, Hussain S. Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling. FASEB J. 2005;19:1728-30 pubmed
- Lee J, Gravel M, Zhang R, Thibault P, Braun P. Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein. J Cell Biol. 2005;170:661-73 pubmed..Accordingly, cultured OLs from CNP-deficient mice extend smaller outgrowths with less arborized processes. We propose that CNP is an important component of the cytoskeletal machinery that directs process outgrowth in OLs. ..
- Shahbazian D, Roux P, Mieulet V, Cohen M, Raught B, Taunton J, et al. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 2006;25:2781-91 pubmed..Phosphorylation of eIF4B on Ser422 by RSK and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3. ..
- Li T, Paudel H. 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9. Neurosci Lett. 2007;414:203-8 pubmed..Ser9-phosphorylated GSK3beta on the other hand phosphorylates tau significantly only in the presence of 14-3-3zeta. Our data demonstrate that 14-3-3zeta mediates tau phosphorylation by Ser9-phosphorylated GSK3beta in HEK-293 cells. ..
- Huang K, Yasruel Z, Guerin C, Holland P, Nalbantoglu J. Interaction of the Coxsackie and adenovirus receptor (CAR) with the cytoskeleton: binding to actin. FEBS Lett. 2007;581:2702-8 pubmed..We previously demonstrated that CAR interacts with microtubules. These data suggest a role for CAR in processes requiring dynamic reorganization of the cytoskeleton such as neurite outgrowth and cell migration. ..
- Joch M, Ase A, Chen C, MacDonald P, Kontogiannea M, Corera A, et al. Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol Biol Cell. 2007;18:3105-18 pubmed
- Salin Cantegrel A, Shekarabi M, Holbert S, Dion P, Rochefort D, Laganiere J, et al. HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3. Hum Mol Genet. 2008;17:2703-11 pubmed publisher..This physical and functional association between the co-transporter and CK-B is, therefore, the first protein-protein interaction identified to be potentially involved in the pathophysiology of HMSN/ACC. ..
- Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay P, Meloche S. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. J Cell Physiol. 2008;217:778-88 pubmed publisher..Our results demonstrate the importance of activation loop phosphorylation in the regulation of ERK3/ERK4 function and highlight differences in the regulation of atypical MAP kinases as compared to classical family members. ..
- Caron C, Spring K, Laramée M, Chabot C, Cloutier M, Gu H, et al. Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells. Cell Signal. 2009;21:943-53 pubmed publisher..Altogether, these results underscore the non-redundant and essential roles of Gab1 and Gab2 in endothelial cells, and suggest major contributions of these proteins during in vivo angiogenesis. ..
- Sasarman F, Brunel Guitton C, Antonicka H, Wai T, Shoubridge E. LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria. Mol Biol Cell. 2010;21:1315-23 pubmed publisher..These results implicate LRPPRC in posttranscriptional mitochondrial gene expression as part of a ribonucleoprotein complex that regulates the stability and handling of mature mRNAs. ..
- Srour M, Rivière J, Pham J, Dube M, Girard S, Morin S, et al. Mutations in DCC cause congenital mirror movements. Science. 2010;328:592 pubmed publisher..Functional analysis of the mutant DCC protein from the French Canadian family revealed a defect in netrin-1 binding. Thus, DCC has an important role in lateralization of the human nervous system. ..
- Wang Y, Lacroix G, Haines J, Doukhanine E, Almazan G, Richard S. The QKI-6 RNA binding protein localizes with the MBP mRNAs in stress granules of glial cells. PLoS ONE. 2010;5: pubmed publisher..Our findings define the QKI isoforms as Ago2-interacting proteins. We also identify the QKI-6 isoform as a new component of stress granules in glial cells. ..
- Fung S, Nishimura T, Sasarman F, Shoubridge E. The conserved interaction of C7orf30 with MRPL14 promotes biogenesis of the mitochondrial large ribosomal subunit and mitochondrial translation. Mol Biol Cell. 2013;24:184-93 pubmed publisher..Our results demonstrate that, although the interaction between C7orf30 and MRPL14 has been evolutionarily conserved, human C7orf30 is, on the contrary, essential for mitochondrial ribosome biogenesis and mitochondrial translation. ..
- Jin J, Hu H, Li H, Yu J, Xiao Y, Brittain G, et al. Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity. Immunity. 2014;40:342-54 pubmed publisher..These findings reveal an unexpected function of the noncanonical NF-κB pathway and highlight an important mechanism regulating antiviral innate immunity. ..
- Paudel H. The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase. J Biol Chem. 1997;272:1777-85 pubmed..Taken together, these results suggest that in neurons, phosphorylase kinase may be one of the kinases that participate in the phosphorylation of tau. ..
- Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, et al. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev. 2001;15:3104-17 pubmed..E4orf6/E1B55K failed to induce the degradation of p53 at the nonpermissive temperature. Thus, our results identify a novel role for the Cullin-based machinery in regulation of p53. ..
- Bordeleau M, Cencic R, Lindqvist L, Oberer M, Northcote P, Wagner G, et al. RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem Biol. 2006;13:1287-95 pubmed..We demonstrate that Pateamine A is a chemical inducer of dimerization that forces an engagement between eIF4A and RNA and prevents eIF4A from participating in the ribosome-recruitment step of translation initiation. ..
- Clément J, Bibeau Poirier A, Gravel S, Grandvaux N, Bonneil E, Thibault P, et al. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol. 2008;82:3984-96 pubmed publisher..Importantly, our study establishes a molecular link between the role of serine 339 in IRF-3 homodimerization, CBP association, and its destabilization. ..
- Plante G, Thérien I, Manjunath P. Characterization of recombinant murine binder of sperm protein homolog 1 and its role in capacitation. Biol Reprod. 2012;87:20, 1-11 pubmed publisher..These results show that murine epididymal BSPH1 shares many biochemical and functional characteristics with BSP proteins secreted by seminal vesicles of ungulates, and suggest that it might play a similar role in sperm functions...
- Bour S, Boulerice F, Wainberg M. Inhibition of gp160 and CD4 maturation in U937 cells after both defective and productive infections by human immunodeficiency virus type 1. J Virol. 1991;65:6387-96 pubmed..Expression of gp160 is thus necessary and sufficient to cause CD4 receptor down-modulation for both productively and defectively infected cells. ..
- Christendat D, Turnbull J. Identifying groups involved in the binding of prephenate to prephenate dehydrogenase from Escherichia coli. Biochemistry. 1999;38:4782-93 pubmed..The order of stability is wild-type = R294Q > K178Q > R286A > K178R. The least unstable mutants have reduced mutase and dehydrogenase activities. ..
- Li Q, Imataka H, Morino S, Rogers G, Richter Cook N, Merrick W, et al. Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol Cell Biol. 1999;19:7336-46 pubmed..These functional differences between eIF4AI and eIF4AIII suggest that eIF4AIII might play an inhibitory role in translation under physiological conditions. ..
- Moriarty T, Huard S, Dupuis S, Autexier C. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol Cell Biol. 2002;22:1253-65 pubmed..Our results suggest that functional hTERT complementation requires intact RID2 and RT domains on the same hTERT molecule and is dependent on hTR and the N terminus. ..
- Luo M, Duchaine T, DesGroseillers L. Molecular mapping of the determinants involved in human Staufen-ribosome association. Biochem J. 2002;365:817-24 pubmed..Thus the results are consistent with a putative role for Stau(55) in the regulation of translation. ..
- Larocque D, Pilotte J, Chen T, Cloutier F, Massie B, Pedraza L, et al. Nuclear retention of MBP mRNAs in the quaking viable mice. Neuron. 2002;36:815-29 pubmed..MBP mRNA export defect leads to a reduction in the MBP levels and their improper cellular targeting to the periphery. Our findings suggest that QKI participates in myelination by regulating the mRNA export of key protein components...
- Laganiere J, Deblois G, Giguere V. Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells. Mol Endocrinol. 2005;19:1584-92 pubmed
- Ho J, Cocolakis E, Dumas V, Posner B, Laporte S, Lebrun J. The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction. EMBO J. 2005;24:3247-58 pubmed
- Gingras D, Michaud M, Di Tomasso G, Béliveau E, Nyalendo C, Beliveau R. Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells. FEBS Lett. 2008;582:399-404 pubmed publisher..The interaction of MT1-MMP with p130Cas at the cell periphery suggests the existence of a close interplay between pericellular proteolysis and signaling pathways involved in EC migration. ..
- Cencic R, Hall D, Robert F, Du Y, Min J, Li L, et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A. 2011;108:1046-51 pubmed publisher..Molecular modeling experiments provide insight into the mechanism of action of this small molecule inhibitor. Our experiments validate targeting the eIF4F complex as a strategy for cancer therapy to modulate chemosensitivity. ..
- Barbelanne M, Song J, Ahmadzai M, Tsang W. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Hum Mol Genet. 2013;22:2482-94 pubmed publisher..Our results uncover the underlying molecular basis of disease and provide novel insights into mitigating NPHP5 deficiency. ..
- Lu X, Goke J, Sachs F, Jacques P, Liang H, Feng B, et al. SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells. Nat Cell Biol. 2013;15:1141-1152 pubmed publisher..Furthermore, we show that SON is bound to these transcripts in vivo. In summary, we connect a splicing-regulatory network for accurate transcript production to the maintenance of pluripotency and self-renewal of hESCs. ..
- Zhang D, Qi Y, Klyubin I, Ondrejcak T, Sarell C, Cuello A, et al. Targeting glutamatergic and cellular prion protein mechanisms of amyloid Î²-mediated persistent synaptic plasticity disruption: Longitudinal studies. Neuropharmacology. 2017;121:231-246 pubmed publisher..Overall, the present findings support the ongoing development of therapeutics for early Alzheimer's disease based on these complementary approaches. ..
- Quittot N, Nguyen P, Neree A, Lussier M, Bourgault S. Identification of a conformational heparin-recognition motif on the peptide hormone secretin: key role for cell surface binding. Biochem J. 2017;474:2249-2260 pubmed publisher..The present study identifies secretin as a novel GAG-binding polypeptide and opens new research direction on the functional role of GAGs in the biology of secretin. ..
- Lin R, Genin P, Mamane Y, Sgarbanti M, Battistini A, Harrington W, et al. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene. 2001;20:800-11 pubmed..These results illustrate that vIRF-1 is able to block the early stages of the IFN response to virus infection by interfering with the activation of IRF-3 responsive, immediate early IFN genes. ..
- Morello J, Salahpour A, Petaja Repo U, Laperriere A, Lonergan M, Arthus M, et al. Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus. Biochemistry. 2001;40:6766-75 pubmed
- Khaleghpour K, Kahvejian A, De Crescenzo G, Roy G, Svitkin Y, Imataka H, et al. Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Mol Cell Biol. 2001;21:5200-13 pubmed..Significantly, only the central Paip2 fragment, which binds with high affinity to the PABP RRM region, inhibits PABP binding to poly(A) RNA and translation. ..
- Milutinovic S, Zhuang Q, Szyf M. Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification. J Biol Chem. 2002;277:20974-8 pubmed..Our results strengthen the role of PCNA as a factor coordinating DNA replication and epigenetic inheritance. ..
- Kornblatt J, Marchal S, Rezaei H, Balny C. Characterization of a complex formed between human plasminogen and recombinant sheep prion: pressure and thermal sensitivity of complex formation. Cell Mol Biol (Noisy-le-grand). 2004;50:387-96 pubmed..In the absence of proteolytic inhibitors, plasminogen slowly cleaved the prion protein. ..
- Bhattacharjya S, Xu P, Gingras R, Shaykhutdinov R, Wu C, Whiteway M, et al. Solution structure of the dimeric SAM domain of MAPKKK Ste11 and its interactions with the adaptor protein Ste50 from the budding yeast: implications for Ste11 activation and signal transmission through the Ste50-Ste11 complex. J Mol Biol. 2004;344:1071-87 pubmed..The dimeric structure of the Ste11 SAM and its interactions with the Ste50 SAM may have important roles in the regulation and activation of the Ste11 kinase and signal transmission and amplifications through the Ste50-Ste11 complex. ..
- Lindner H, Nadeau G, Matte A, Michel G, Menard R, Cygler M. Site-directed mutagenesis of the active site region in the quinate/shikimate 5-dehydrogenase YdiB of Escherichia coli. J Biol Chem. 2005;280:7162-9 pubmed..Our improved understanding of the medically and agriculturally important quinate/shikimate 5-dehydrogenase family at the molecular level may prove useful in the development of novel herbicides and antimicrobial agents. ..
- Reintsch W, Habring Mueller A, Wang R, Schohl A, Fagotto F. beta-Catenin controls cell sorting at the notochord-somite boundary independently of cadherin-mediated adhesion. J Cell Biol. 2005;170:675-86 pubmed..Based on these results, we propose that the boundary itself is the result of cell-autonomous changes in contact behavior that do not rely on differences in absolute levels of adhesion. ..
- Sabatier L, Chen D, Fagotto Kaufmann C, Hubmacher D, McKee M, Annis D, et al. Fibrillin assembly requires fibronectin. Mol Biol Cell. 2009;20:846-58 pubmed publisher..Mapping studies revealed that the major binding interaction between fibrillins and fibronectin involves the collagen/gelatin-binding region between domains FNI(6) and FNI(9). ..
- Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, et al. The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. PLoS Pathog. 2009;5:e1000650 pubmed publisher..Thus, Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection. ..
- Sampson H, Robert R, Liao J, Matthes E, Carlile G, Hanrahan J, et al. Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR. Chem Biol. 2011;18:231-42 pubmed publisher..We show that RDR1 treatment partially rescues F508del-CFTR function in both cells and in an F508del-CF mouse model. Thus, RDR1 is a pharmacological chaperone of F508del-CFTR and represents a novel scaffold for drug development. ..
- Wang J, Beauchemin M, Bertrand R. Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint. Cell Cycle. 2012;11:2159-69 pubmed publisher..It also highlights that DNA damage affects the dynamic composition of the nucleolus, which now emerges as a piece of the DNA damage response. ..
- González Morales N, Holenka T, Schock F. Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion. PLoS Genet. 2017;13:e1006880 pubmed publisher..Thus, Z-discs require filamin to withstand the strong contractile forces acting on them. ..
- Shkolny D, Brown T, Punnett H, Kaufman M, Trifiro M, Pinsky L. Characterization of alternative amino acid substitutions at arginine 830 of the androgen receptor that cause complete androgen insensitivity in three families. Hum Mol Genet. 1995;4:515-21 pubmed..We conclude that arginine-830 is important for A-R complex stability, and that its replacement by glutamine or leucine yields distinctive functional aberrations.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Truant R, Antunovic J, Greenblatt J, Prives C, Cromlish J. Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. J Virol. 1995;69:1851-9 pubmed..To explain these results, we propose that localization of HBx to a promoter by interaction with DNA-bound p53 enables a repression domain in HBx to directly contact the basal transcription machinery and thereby repress transcription. ..
- Berrou L, Klein H, Bernatchez G, Parent L. A specific tryptophan in the I-II linker is a key determinant of beta-subunit binding and modulation in Ca(V)2.3 calcium channels. Biophys J. 2002;83:1429-42 pubmed..Altogether these results suggest that W386 is critical for beta-subunit binding and modulation of HVA Ca(2+) channels. ..
- Gales C, Van Durm J, Schaak S, Pontier S, Percherancier Y, Audet M, et al. Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes. Nat Struct Mol Biol. 2006;13:778-86 pubmed..This conformational change may represent the movement required to allow nucleotide exit from the G alpha subunit, thus reflecting the initial activation event. ..
- Ivanisevic L, Zheng W, Woo S, Neet K, Saragovi H. TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligand. J Biol Chem. 2007;282:16754-63 pubmed..This study demonstrates that Trk signaling is more complex than previously thought because it involves several receptor subdomains and hot spots. ..
- Annan R, Wu C, Waller D, Whiteway M, Thomas D. Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination. Eukaryot Cell. 2008;7:1441-9 pubmed publisher..These data identify Rho5p as being a target of Msi1p/Npr1p regulation and describe a regulatory circuit involving phosphorylation and ubiquitination. ..
- Millward J, Holst P, Høgh Petersen M, Thomsen A, Christensen J, Owens T. The murine gammaherpesvirus-68 chemokine-binding protein M3 inhibits experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010;224:45-50 pubmed publisher..These results suggest that M3 may represent a novel therapeutic approach to neuroinflammatory disease. ..
- Lukashova V, Szabo E, Jinadasa T, Mokhov A, Litchfield D, Orlowski J. CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis. J Biol Chem. 2011;286:11456-68 pubmed publisher..These data demonstrate that discrete elements of an elaborate sorting signal in NHE5 contribute to ?-arrestin2 binding and trafficking along the recycling endosomal pathway. ..
- Ernst C, Nagy C, Kim S, Yang J, Deng X, Hellstrom I, et al. Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry. 2011;70:312-9 pubmed publisher..These results suggest that alterations of astrocyte connexins might be involved in the suicide process and provide further evidence implicating astrocytes in psychopathology. ..
- Li H, Bergeron S, Juncker D. Microarray-to-microarray transfer of reagents by snapping of two chips for cross-reactivity-free multiplex immunoassays. Anal Chem. 2012;84:4776-83 pubmed publisher..This new liquid handling format can be easily adapted to other applications that require transfer of minute amounts of different reagents in parallel. ..
- Cote J, Turner C, Tremblay M. Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST. J Biol Chem. 1999;274:20550-60 pubmed..Thus, we propose that PTP-PEST, by a competition with the ligand of paxillin in the focal adhesion complex, could contribute to the removal of paxillin from the adhesion sites and consequently promote focal adhesion turnover. ..
- Shanmugam K, Green N, Rambaldi I, Saragovi H, Featherstone M. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. Mol Cell Biol. 1999;19:7577-88 pubmed..ix) The stability of DNA binding by all trimers is enhanced relative to the heterodimers. These findings suggest novel functions for PBX and MEIS in modulating the function of DNA-bound MEIS-HOX and PBX-HOX heterodimers, respectively. ..
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