Experts and Doctors on rna interference in Toronto, Ontario, Canada


Locale: Toronto, Ontario, Canada
Topic: rna interference

Top Publications

  1. Avitzur Y, Guo C, Mastropaolo L, Bahrami E, Chen H, Zhao Z, et al. Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology. 2014;146:1028-39 pubmed publisher
    ..Defects in the phosphatidylinositol 4-kinase-TTC7A-EFR3 homolog B pathway are involved in the pathogenesis of VEOIBD. ..
  2. Rebbapragada A, Benchabane H, Wrana J, Celeste A, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol. 2003;23:7230-42 pubmed
    ..Thus, our results reveal a strikingly specific antagonism of BMP7-mediated processes by myostatin and suggest that myostatin is an important regulator of adipogenesis. ..
  3. Gao M, Liao E, Yu B, Wang Y, Zhen M, Derry W. The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans. Cell Death Differ. 2008;15:1054-62 pubmed publisher
    ..Our results uncover a novel role for the SCF(FSN-1) E3 ubiquitin ligase in the regulation of cep-1-dependent germ cell apoptosis. ..
  4. Quintela Fandino M, Arpaia E, Brenner D, Goh T, Yeung F, Blaser H, et al. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proc Natl Acad Sci U S A. 2010;107:2622-7 pubmed publisher
    ..Our investigation of HUNK suggests that the interaction between PP2A and CFL-1 may be a target for antimetastasis therapy, particularly for basal breast cancers. ..
  5. Wang J, Weaver I, Gauthier Fisher A, Wang H, He L, Yeomans J, et al. CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain. Dev Cell. 2010;18:114-25 pubmed publisher
  6. Tole S, Durkan A, Huang Y, Liu G, Leung A, Jones L, et al. Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion. Am J Physiol Cell Physiol. 2010;298:C1469-80 pubmed publisher
    ..The dual effect of TP allows CX(3)CL1 to recruit leukocytes to sites of vascular inflammation while enhancing their adhesion once recruited. ..
  7. Fritz J, Girardin S, Philpott D. Innate immune defense through RNA interference. Sci STKE. 2006;2006:pe27 pubmed
    ..This down-regulation then increases the plant's resistance to infection. Whether RNAi mechanisms also exist for combating bacterial diseases in animals remains an intriguing question for future studies. ..
  8. McGill M, Dho S, Weinmaster G, McGlade C. Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem. 2009;284:26427-38 pubmed publisher
    ..Our data suggest that Numb inhibits Notch1 activity by regulating post-endocytic sorting events that lead to Notch1 degradation. ..
  9. Rasmussen B, Breen D, Luo P, Cheung G, Yang C, Sun B, et al. Duodenal activation of cAMP-dependent protein kinase induces vagal afferent firing and lowers glucose production in rats. Gastroenterology. 2012;142:834-843.e3 pubmed publisher
    ..We identified a neural glucoregulatory function of duodenal PKA signaling. ..

More Information

Publications137 found, 100 shown here

  1. Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla P, et al. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol. 2008;295:H1377-84 pubmed publisher
    ..ACE2-based treatment approaches may be a novel approach to limit aberrant vascular responses and atherothrombosis. ..
  2. Ito S, Greiss S, Gartner A, Derry W. Cell-nonautonomous regulation of C. elegans germ cell death by kri-1. Curr Biol. 2010;20:333-8 pubmed publisher
    ..Interestingly, we find that kri-1 regulates cell death in a cell-nonautonomous manner, revealing a novel regulatory role for nondying cells in eliciting cell death in response to DNA damage. ..
  3. Singh K, Shukla P, Quan A, Al Omran M, Lovren F, Pan Y, et al. BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis. J Thorac Cardiovasc Surg. 2013;146:949-960.e4 pubmed publisher
    ..Translational studies evaluating endothelial function and atherosclerosis in individuals with BRCA1 mutations are suggested. ..
  4. Wang Y, Jones Tabah J, Chakravarty P, Stewart A, Muotri A, Laposa R, et al. Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation. Cell Rep. 2016;14:2554-61 pubmed publisher
    ..In addition to shedding light on cellular mechanisms underlying CS and pointing to future avenues for pharmacological intervention, these data suggest an important role for SYT9 in neuronal differentiation. ..
  5. Dufner A, Pownall S, Mak T. Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. Proc Natl Acad Sci U S A. 2006;103:988-93 pubmed
    ..In summary, our results indicate that CARD6 is a regulator of NF-kappaB activation that modulates the functions of RIP kinase family members. ..
  6. Matthews J, Wihlén B, Heldring N, MacPherson L, Helguero L, Treuter E, et al. Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes. Biochem J. 2007;406:343-53 pubmed
    ..Our results provide further evidence that AHR agonists induce ERalpha promoter occupancy at AHR target genes through indirect activation of ERalpha, and support a role for ERalpha in AHR transactivation. ..
  7. Miller B, Lau G, Grouios C, Mollica E, Barrios Rodiles M, Liu Y, et al. Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol Syst Biol. 2009;5:315 pubmed publisher
    ..Thus, integrated physical and functional mapping in mammalian cells can identify signaling components with high confidence and provides unanticipated insights into pathway regulators. ..
  8. Bahadorani S, Bahadorani P, Marcon E, Walker D, Hilliker A. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Dis Model Mech. 2010;3:84-91 pubmed publisher
    ..Taken together, these results highlight the role of DmATP7-mediated copper uptake in the neurodevelopment of Drosophila melanogaster and provide a framework for the analysis of potential gene interactions influencing Menkes disease. ..
  9. Assaily W, Rubinger D, Wheaton K, Lin Y, Ma W, Xuan W, et al. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell. 2011;44:491-501 pubmed publisher
    ..Lpin1 provides a critical link between p53 and metabolism that may be an important component in mediating the tumor suppressor function of p53. ..
  10. Lund N, Milev M, Wong R, Sanmuganantham T, Woolaway K, Chabot B, et al. Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression. Nucleic Acids Res. 2012;40:3663-75 pubmed publisher
  11. Liu Y, Templeton D. Involvement of CaMK-II? and gelsolin in Cd(2+) -dependent cytoskeletal effects in mesangial cells. J Cell Physiol. 2013;228:78-86 pubmed publisher
    ..We conclude that cytoskeletal effects of Cd in mesangial cells are partially mediated by Cd-dependent activation of CaMK-II?, binding of CaMK-II? and gelsolin to actin filaments, and cleavage of gelsolin. ..
  12. Kreso A, van Galen P, Pedley N, Lima Fernandes E, Frelin C, Davis T, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014;20:29-36 pubmed publisher
    ..Targeting the BMI-1-related self-renewal machinery provides the basis for a new therapeutic approach in the treatment of colorectal cancer. ..
  13. Li Y, Liang C, Wong K, Jin K, Zhang Z. Inferring probabilistic miRNA-mRNA interaction signatures in cancers: a role-switch approach. Nucleic Acids Res. 2014;42:e76 pubmed publisher
  14. Li H, Chang L, Du W, Gupta S, Khorshidi A, SEFTON M, et al. Anti-microRNA-378a enhances wound healing process by upregulating integrin beta-3 and vimentin. Mol Ther. 2014;22:1839-50 pubmed publisher
    ..Thus, we have demonstrated that knockdown of miR-378a increased the expression of its target proteins, vimentin, and ?3 integrin, which accelerated fibroblast migration and differentiation in vitro and enhanced wound healing in vivo. ..
  15. Ross A, Li M, Yu B, Gao M, Derry W. The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Cell Death Differ. 2011;18:1140-9 pubmed publisher
    ..Although ee1-1 mutants exhibit hypersensitivity to genotoxic stress they do not appear to be defective in DNA repair, suggesting a distinct role for EEL-1 in promoting damage-induced apoptosis in the germline. ..
  16. Mak A, Nixon A, Moffat J. The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription. Cancer Res. 2012;72:1929-34 pubmed publisher
    ..Together, our findings show AF4-dependent regulation of CD133 expression, which is required for the growth of ALL cells. CD133 may therefore represent a therapeutic target in a subset of cancers. ..
  17. Izrailit J, Berman H, Datti A, Wrana J, Reedijk M. High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGF? pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci U S A. 2013;110:1714-9 pubmed publisher
    ..These data demonstrate a dominant role for TRB3 and MAPK-ERK/TGF? pathways as Notch regulators in breast cancer, establishing TRB3 as a potential therapeutic target. ..
  18. Kittanakom S, Arnoldo A, Brown K, Wallace I, Kunavisarut T, Torti D, et al. Miniature short hairpin RNA screens to characterize antiproliferative drugs. G3 (Bethesda). 2013;3:1375-87 pubmed publisher
    ..This cost-effective approach to mammalian knockdown screens, combined with the increasing maturation of RNAi technology will expand the accessibility of similar approaches in academic settings. ..
  19. Currie K, Pearson B. Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians. Development. 2013;140:3577-88 pubmed publisher
  20. Notaro A, Sabella S, Pellerito O, Vento R, Calvaruso G, Giuliano M. The secreted protein acidic and rich in cysteine is a critical mediator of cell death program induced by WIN/TRAIL combined treatment in osteosarcoma cells. Int J Oncol. 2016;48:1039-44 pubmed publisher
    ..In conclusion, to the best of our knowledge, our results are the first to show that WIN-dependent increase in the level of SPARC plays a critical role in sensitizing osteosarcoma cells to TRAIL action. ..
  21. Monkewich S, Lin H, Fabian M, Xu W, Na H, Ray D, et al. The p92 polymerase coding region contains an internal RNA element required at an early step in Tombusvirus genome replication. J Virol. 2005;79:4848-58 pubmed
    ..Together, these results suggest that IRE activity is required in the cytosol at an early step in the viral replication process, such as template recruitment and/or replicase complex assembly. ..
  22. Fairn G, Grinstein S. Cell biology. A one-sided signal. Science. 2008;320:458-60 pubmed publisher
  23. Thirone A, Speight P, Zulys M, Rotstein O, Szaszi K, Pedersen S, et al. Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response. Am J Physiol Cell Physiol. 2009;296:C463-75 pubmed publisher
  24. MacPherson L, Matthews J. Inhibition of aryl hydrocarbon receptor-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor ? expression in human breast cancer cells. Cancer Lett. 2010;299:119-29 pubmed publisher
    ..Both compounds also inhibited AHR-dependent transcription in ER?-negative MDA-MB-231 and BT-549 breast cancer cells. These data show that ER? does not contribute to the AHR-inhibitory activities of resveratrol and kaempferol. ..
  25. Johnston W, Krizus A, Dennis J. Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans. Curr Biol. 2010;20:1932-7 pubmed publisher
    ..Together, our results show that eggshell chitin is required to prevent polyspermy in C. elegans, in addition to its previously reported requirement in polar body extrusion and polarization of the zygote. ..
  26. Fang L, Du W, Yang W, Rutnam Z, Peng C, Li H, et al. MiR-93 enhances angiogenesis and metastasis by targeting LATS2. Cell Cycle. 2012;11:4352-65 pubmed publisher
    ..These findings demonstrated that miR-93 promoted tumor angiogenesis and metastasis by suppressing LATS2 expression. Our results suggest that the inhibition of miR-93 function may be a feasible approach to repress tumor metastasis. ..
  27. Arora P, Wang Y, Bresnick A, Dawson J, Janmey P, McCulloch C. Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions. Mol Biol Cell. 2013;24:734-47 pubmed publisher
    ..The Ca(2+) -dependent interaction of gelsolin and NMMIIA in turn enables actin remodeling and enhances collagen degradation by phagocytosis. ..
  28. Lant B, Derry W. Methods for detection and analysis of apoptosis signaling in the C. elegans germline. Methods. 2013;61:174-82 pubmed publisher
    ..We also present the limitations of these methods, and suggest complimentary techniques in order that researchers new to the field can comprehensively assess apoptosis phenotypes in the C. elegans germline. ..
  29. Samuel N, Sayad A, Wilson G, Lemire M, Brown K, Muthuswamy L, et al. Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma. Pancreas. 2013;42:1016-26 pubmed publisher
    ..3 locus, which harbors this gene, suggesting that ECT2 may play an oncogenic role in the PDAC neoplastic process. ..
  30. Truong D, Brabant D, Bashkurov M, Wan L, Braun V, Heo W, et al. Formin-mediated actin polymerization promotes Salmonella invasion. Cell Microbiol. 2013;15:2051-63 pubmed publisher
    ..Together, our studies revealan important phospho-dependent FHOD1 actin polymerization pathway in Salmonella invasion. ..
  31. Huang X, Taeb S, Jahangiri S, Emmenegger U, Tran E, Bruce J, et al. miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1. Cancer Res. 2013;73:6972-86 pubmed publisher
    ..Finally, miR-95 expression was increased in human prostate and breast cancer specimens compared with normal tissue. Together, our work reveals miR-95 expression as a critical determinant of radiation resistance in cancer cells. ..
  32. Lin A, Pearson B. Planarian yorkie/YAP functions to integrate adult stem cell proliferation, organ homeostasis and maintenance of axial patterning. Development. 2014;141:1197-208 pubmed publisher
    ..Together, our data show that yki is a key gene in planarians that integrates stem cell proliferation control, organ homeostasis, and the spatial patterning of tissues. ..
  33. Kawano T, Zheng H, Merz D, Kohara Y, Tamai K, Nishiwaki K, et al. C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV. Development. 2009;136:1433-42 pubmed publisher
    ..Genetic data also suggest that MIG-6S and non-fibrillar network collagen IV play antagonistic roles to ensure normal phase 2 DTC guidance. ..
  34. Guo C, Senzel A, Li K, Feng Z. De novo protein synthesis of syntaxin-1 and dynamin-1 in long-term memory formation requires CREB1 gene transcription in Lymnaea stagnalis. Behav Genet. 2010;40:680-93 pubmed publisher
    ..stagnalis. Our study thus offers new insights into the molecular mechanisms that mediate CREB1-dependent long-term memory formation. ..
  35. Hai J, Zhu C, Bandarchi B, Wang Y, Navab R, Shepherd F, et al. L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer. Clin Cancer Res. 2012;18:1914-24 pubmed publisher
    ..L1CAM is a novel prometastatic gene in NSCLC, and its downregulation may effectively suppress NSCLC tumor growth and metastasis. Targeted inhibition of L1CAM may be a novel therapy for NSCLC. ..
  36. Terakawa Y, Agnihotri S, Golbourn B, Nadi M, Sabha N, Smith C, et al. The role of drebrin in glioma migration and invasion. Exp Cell Res. 2013;319:517-28 pubmed publisher
    ..Our results suggest that drebrin contributes to the maintenance of cell shape, and may play an important role in glioma cell motility. ..
  37. Shah A, Xia L, Goldberg H, Lee K, Quaggin S, Fantus I. Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells. J Biol Chem. 2013;288:6835-48 pubmed publisher
    ..TxNIP is a critical component of the HG-ROS signaling pathway, required for the induction of mitochondrial and total cell ROS and the NADPH oxidase isoform, Nox4. TxNIP is a potential target to prevent DN. ..
  38. Mak A, Blakely K, Williams R, Penttilä P, Shukalyuk A, Osman K, et al. CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope. J Biol Chem. 2011;286:41046-56 pubmed publisher
    ..Our study identifies a set of genes involved in CD133 N-glycosylation as a direct contributing factor to cell surface AC133 recognition and provides biochemical evidence for the function and structure of CD133 N-glycans. ..
  39. Siu A, Virtanen C, Jongstra J. PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells. Oncotarget. 2011;2:1134-44 pubmed
    ..These experiments define a novel biological function of PIM-1 as a co-regulator of EGFR signaling and suggest that PIM inhibitors may be used in combination therapies to increase the efficacy of EGFR tyrosine kinase inhibitors. ..
  40. Yang J, O Donnell L, Durocher D, Brown G. RMI1 promotes DNA replication fork progression and recovery from replication fork stress. Mol Cell Biol. 2012;32:3054-64 pubmed publisher
    ..These findings reveal direct roles of RMI1 in DNA replication and the replication stress response, which could explain the molecular basis for its involvement in suppressing sister chromatid exchange and tumorigenesis. ..
  41. Al Mahrouki A, Giles A, Hashim A, Kim H, El Falou A, Rowe Magnus D, et al. Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism. PLoS ONE. 2017;12:e0181951 pubmed publisher
  42. Ramani A, Chuluunbaatar T, Verster A, Na H, Vu V, Pelte N, et al. The majority of animal genes are required for wild-type fitness. Cell. 2012;148:792-802 pubmed publisher
    ..This is a higher proportion than for yeast genes, and we suggest that the source of negative selection is different in animals and in unicellular eukaryotes. ..
  43. O Brien C, Kreso A, Ryan P, Hermans K, Gibson L, Wang Y, et al. ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. Cancer Cell. 2012;21:777-92 pubmed publisher
    ..Additionally, silencing of ID1 and ID3 increases sensitivity of CC-ICs to the chemotherapeutic agent oxaliplatin, linking tumor initiation function with chemotherapy resistance. ..
  44. Cen B, Xiong Y, Song J, Mahajan S, DuPont R, McEachern K, et al. The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. 2014;34:2517-32 pubmed publisher
    ..These results suggest that Pim inhibitors may have an important role in the treatment of patients where MET is driving tumor biology. ..
  45. Arpaia E, Blaser H, Quintela Fandino M, Duncan G, Leong H, Ablack A, et al. The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene. 2012;31:884-96 pubmed publisher
  46. Bousette N, Abbasi C, Chis R, Gramolini A. Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis. J Cell Physiol. 2014;229:374-83 pubmed publisher
    ..In conclusion, this is the first study to demonstrate CNX has a specific role in cardiomyocyte viability and Ca(2+) cycling through its effects on ER stress, apoptosis and Ca(2+) channel expression. ..
  47. Hwang I, Watson I, Der S, Ohh M. Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response. J Virol. 2006;80:10712-23 pubmed
    ..These results reveal a previously unrecognized role of HIF in the antiviral response by promoting the expression of the IFN-beta gene and other genes with antiviral activity upon viral infection. ..
  48. Evans A, Russell R, Roche O, Burry T, Fish J, Chow V, et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol. 2007;27:157-69 pubmed
    ..These findings reveal a critical HIF-dependent molecular pathway connecting VHL, an established "gatekeeper" of the renal epithelium, with a major epithelial tumor suppressor, E-cadherin. ..
  49. Smith C, Dho S, Donaldson J, Tepass U, McGlade C. The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell. 2004;15:3698-708 pubmed
    ..In addition, we present evidence that Numb has a novel function in endosomal recycling and intracellular trafficking of receptors. ..
  50. Capurro M, Li F, Filmus J. Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog. EMBO Rep. 2009;10:901-7 pubmed publisher
    ..8% bigger than the Ihh-null mice. Consistent with the role of GPC3 in Hh endocytosis and degradation, the Gpc3-null mice show increased levels of Ihh protein and signalling, but similar levels of Ihh messenger RNA. ..
  51. Trzcinska Daneluti A, Nguyen L, Jiang C, Fladd C, UEHLING D, Prakesch M, et al. Use of kinase inhibitors to correct ?F508-CFTR function. Mol Cell Proteomics. 2012;11:745-57 pubmed publisher
  52. Radulovich N, Leung L, Ibrahimov E, Navab R, Sakashita S, Zhu C, et al. Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma. Oncogene. 2015;34:4238-47 pubmed publisher
    ..In contrast, the downregulation of endogenous CCDC68 in MIAPaca-2 cells increased tumor growth rate. These effects were not observed with the deletion-containing isoform, CCDC68Δ(69-114). ..
  53. Lickert H, Takeuchi J, Von Both I, Walls J, McAuliffe F, Adamson S, et al. Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature. 2004;432:107-12 pubmed
  54. Wang P, Wang Q, Sun J, Wu J, Li H, Zhang N, et al. POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP. J Biol Chem. 2009;284:26456-65 pubmed publisher
    ..Our study therefore identifies a novel mechanism by which cAMP regulates hormone-gene expression and suggests that ubiquitously expressed Oct-1 may play a role in metabolic homeostasis by functioning as a sensor for cAMP...
  55. Drewlo S, Czikk M, Baczyk D, Lye S, Kingdom J. Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi. Hum Reprod. 2011;26:1025-34 pubmed publisher
    ..TIMP4 is a downstream target of GCM1 that may link the consequences of reduced GCM-1-directed trophoblast differentiation to histologic and functional components of disordered placentation in sPE. ..
  56. Yang X, Rutnam Z, Jiao C, Wei D, Xie Y, Du J, et al. An anti-let-7 sponge decoys and decays endogenous let-7 functions. Cell Cycle. 2012;11:3097-108 pubmed publisher
    ..The ability of anti-let-7 to regulate multiple members of the let-7 family allows us to observe their multiple functions using a single reagent. This approach can be applied to other family members with conserved sequences. ..
  57. Palanivel R, Fang X, Park M, Eguchi M, Pallan S, De Girolamo S, et al. Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Cardiovasc Res. 2007;75:148-57 pubmed
    ..These results clearly demonstrate that gAd and fAd mediate distinct and time-dependent effects on cardiomyocyte energy metabolism via AdipoR1 and AdipoR2. ..
  58. Ezzat S, Zheng L, Florez J, Stefan N, Mayr T, Hliang M, et al. The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes. Cell Metab. 2013;17:929-40 pubmed publisher
    ..We also show in humans that the FGFR4-R388 allele enhances islet function and may protect against type 2 diabetes. These data support a common genetic link underlying cancer and hyperinsulinemia. ..
  59. Jagannathan M, Nguyen T, Gallo D, Luthra N, Brown G, Saridakis V, et al. A role for USP7 in DNA replication. Mol Cell Biol. 2014;34:132-45 pubmed publisher
    ..This role of USP7 mirrors the previously described role for MCM-BP in MCM complex unloading and suggests that USP7 works with MCM-BP to unload MCM complexes from chromatin at the end of S phase. ..
  60. Zhang Y, Baig E, Williams D. Functions of ERp57 in the folding and assembly of major histocompatibility complex class I molecules. J Biol Chem. 2006;281:14622-31 pubmed
    ..Interestingly, depletion of another thiol oxidoreductase, ERp72, had no detectable effect on class I biogenesis, consistent with a specialized role for ERp57 in this process. ..
  61. Chow W, Hou G, Bendeck M. Glycogen synthase kinase 3beta regulation of nuclear factor of activated T-cells isoform c1 in the vascular smooth muscle cell response to injury. Exp Cell Res. 2008;314:2919-29 pubmed publisher
    ..We conclude that NFATc1 promotes the vSMC response to injury, and that inhibition of GSK3beta is required for the activation of NFAT during wound repair. ..
  62. Akay A, Di Doménico T, Suen K, Nabih A, Parada G, Larance M, et al. The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Dev Cell. 2017;42:241-255.e6 pubmed publisher
    ..Thus, Aquarius and HRDE-1 act as gatekeepers coordinating gene expression and genome defense. ..
  63. Watson I, Li B, Roche O, Blanch A, Ohh M, Irwin M. Chemotherapy induces NEDP1-mediated destabilization of MDM2. Oncogene. 2010;29:297-304 pubmed publisher
    ..These findings unveil the regulation of MDM2 stability through NEDP1 as a common molecular determinant governing chemotherapy-induced p53-dependent cell death. ..
  64. Thériault B, Pajovic S, Bernardini M, Shaw P, Gallie B. Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer. Int J Cancer. 2012;130:1844-54 pubmed publisher
    ..Dependence of OvCa cells on KIF14 for maintenance of in vitro colony formation suggests a role of KIF14 in promoting a tumorigenic phenotype, beyond its known role in proliferation. ..
  65. Khila A, Abouheif E, Rowe L. Function, developmental genetics, and fitness consequences of a sexually antagonistic trait. Science. 2012;336:585-9 pubmed publisher
  66. Zhu S, Pearson B. The Retinoblastoma pathway regulates stem cell proliferation in freshwater planarians. Dev Biol. 2013;373:442-52 pubmed publisher
    ..Together, these results showed that planarians use the conserved components of the Rb tumor suppressor pathway to control proliferation and cell survival...
  67. Hu M, Rosenblum N. Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development. 2005;132:215-25 pubmed
    ..These results provide novel insights into mechanisms by which interacting signaling pathways control transcription during the genesis of renal dysplasia. ..
  68. Wei W, Sun H, Olah M, Sun X, Czerwinska E, Czerwinski W, et al. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A. 2007;104:16323-8 pubmed
  69. Ketela T, Heisler L, Brown K, Ammar R, Kasimer D, Surendra A, et al. A comprehensive platform for highly multiplexed mammalian functional genetic screens. BMC Genomics. 2011;12:213 pubmed publisher
    ..We also provide detailed methodologies for pooled shRNA screen readout using GMAP and compare next-generation sequencing to GMAP (i.e. microarray) based deconvolution methods. ..
  70. Mak A, Nixon A, Kittanakom S, Stewart J, Chen G, Curak J, et al. Regulation of CD133 by HDAC6 promotes ?-catenin signaling to suppress cancer cell differentiation. Cell Rep. 2012;2:951-63 pubmed publisher
    ..Given that CD133 marks progenitor cells in a wide range of cancers, targeting CD133 may be a means to treat multiple cancer types. ..
  71. McCracken S, Longman D, Johnstone I, Caceres J, Blencowe B. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. J Biol Chem. 2003;278:44153-60 pubmed
    ..Our combined results provide evidence for an evolutionarily conserved interaction between SRm160 and the 3'-end cleavage machinery that functions independently of EJC formation. ..
  72. Arora P, Chan M, Anderson R, Janmey P, McCulloch C. Separate functions of gelsolin mediate sequential steps of collagen phagocytosis. Mol Biol Cell. 2005;16:5175-90 pubmed
  73. Dixon S, Alexander M, Fernandes R, Ricker N, Roy P. FGF negatively regulates muscle membrane extension in Caenorhabditis elegans. Development. 2006;133:1263-75 pubmed
    ..Our data are consistent with a model in which integrins and laminins are needed for directed muscle arm extension to the nerve cords, while FGF signaling provides a general mechanism to regulate muscle membrane extension. ..
  74. Li L, MacDonald P, Ahn D, Oudit G, Backx P, Brubaker P. Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1. Endocrinology. 2006;147:3318-25 pubmed
    ..These studies reveal a new role for PI3-Kgamma as a positive regulator of insulin secretion, and reinforce the importance of GLP-1 for the maintenance of normal beta-cell function. ..
  75. Podcheko A, Northcott P, Bikopoulos G, Lee A, Bommareddi S, Kushner J, et al. Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol. 2007;27:6484-96 pubmed
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