Experts and Doctors on retinoblastoma protein in London, Ontario, Canada

Summary

Locale: London, Ontario, Canada
Topic: retinoblastoma protein

Top Publications

  1. Apostolova M, Ivanova I, Dagnino C, D Souza S, Dagnino L. Active nuclear import and export pathways regulate E2F-5 subcellular localization. J Biol Chem. 2002;277:34471-9 pubmed
    ..This region excludes the DNA- and the p130-binding domains. Thus, the subcellular distribution of E2F-5 is tightly regulated in intact cells, through multiple functional domains that direct nucleocytoplasmic shuttling of this protein. ..
  2. Isaac C, Francis S, Martens A, Julian L, Seifried L, Erdmann N, et al. The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol. 2006;26:3659-71 pubmed
    ..These results demonstrate the surprising finding that pRb uses the LXCXE binding cleft to control chromatin structure for the regulation of events beyond the G(1)-to-S-phase transition. ..
  3. Francis S, Bergsied J, Isaac C, Coschi C, Martens A, Hojilla C, et al. A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol. 2009;29:4455-66 pubmed publisher
    ..Taken together, our work demonstrates a unique functional connection between pRB and TGF-beta in growth control and mammary gland development. ..
  4. Talluri S, Isaac C, Ahmad M, Henley S, Francis S, Martens A, et al. A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence. Mol Cell Biol. 2010;30:948-60 pubmed publisher
    ..Remarkably, this reveals that pRB recruits chromatin regulators primarily to engage a stress-responsive G(1) arrest program. ..
  5. Coschi C, Martens A, Ritchie K, Francis S, Chakrabarti S, Berube N, et al. Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev. 2010;24:1351-63 pubmed publisher
    ..These data reveal a new mechanism of tumor suppression, facilitated by pRB, in which genome stability is maintained by proper condensation of mitotic chromosomes. ..
  6. Francis S, Chakrabarti S, Dick F. A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. PLoS ONE. 2011;6:e16434 pubmed publisher
    ..Our work demonstrates that negative growth control by pRB acts as a crucial barrier against oncogenic transformation. Strikingly, our data also reveals that this tumor suppressive effect is context-dependent. ..
  7. Carnevale J, Palander O, Seifried L, Dick F. DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol. 2012;32:900-12 pubmed publisher
    ..Our data suggest that DNA damage signals alter pRB and E2F1 to engage them in functions leading to apoptotic induction that are distinct from pRB-E2F regulation in cell cycle control. ..
  8. Talluri S, Dick F. Regulation of transcription and chromatin structure by pRB: here, there and everywhere. Cell Cycle. 2012;11:3189-98 pubmed publisher
    ..In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains. ..
  9. Dick F, Rubin S. Molecular mechanisms underlying RB protein function. Nat Rev Mol Cell Biol. 2013;14:297-306 pubmed publisher
    ..These advances and new structural studies are combining to define the multifunctionality of RB. ..
  10. Cecchini M, Thwaites M, Talluri S, MacDonald J, Passos D, Chong J, et al. A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice. Mol Cell Biol. 2014;34:2029-45 pubmed publisher
    ..This suggests that non-E2F-, pRB-dependent pathways may have a more relevant role in proliferative control than previously identified. ..

Detail Information

Publications10

  1. Apostolova M, Ivanova I, Dagnino C, D Souza S, Dagnino L. Active nuclear import and export pathways regulate E2F-5 subcellular localization. J Biol Chem. 2002;277:34471-9 pubmed
    ..This region excludes the DNA- and the p130-binding domains. Thus, the subcellular distribution of E2F-5 is tightly regulated in intact cells, through multiple functional domains that direct nucleocytoplasmic shuttling of this protein. ..
  2. Isaac C, Francis S, Martens A, Julian L, Seifried L, Erdmann N, et al. The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol. 2006;26:3659-71 pubmed
    ..These results demonstrate the surprising finding that pRb uses the LXCXE binding cleft to control chromatin structure for the regulation of events beyond the G(1)-to-S-phase transition. ..
  3. Francis S, Bergsied J, Isaac C, Coschi C, Martens A, Hojilla C, et al. A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol. 2009;29:4455-66 pubmed publisher
    ..Taken together, our work demonstrates a unique functional connection between pRB and TGF-beta in growth control and mammary gland development. ..
  4. Talluri S, Isaac C, Ahmad M, Henley S, Francis S, Martens A, et al. A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence. Mol Cell Biol. 2010;30:948-60 pubmed publisher
    ..Remarkably, this reveals that pRB recruits chromatin regulators primarily to engage a stress-responsive G(1) arrest program. ..
  5. Coschi C, Martens A, Ritchie K, Francis S, Chakrabarti S, Berube N, et al. Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev. 2010;24:1351-63 pubmed publisher
    ..These data reveal a new mechanism of tumor suppression, facilitated by pRB, in which genome stability is maintained by proper condensation of mitotic chromosomes. ..
  6. Francis S, Chakrabarti S, Dick F. A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. PLoS ONE. 2011;6:e16434 pubmed publisher
    ..Our work demonstrates that negative growth control by pRB acts as a crucial barrier against oncogenic transformation. Strikingly, our data also reveals that this tumor suppressive effect is context-dependent. ..
  7. Carnevale J, Palander O, Seifried L, Dick F. DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol. 2012;32:900-12 pubmed publisher
    ..Our data suggest that DNA damage signals alter pRB and E2F1 to engage them in functions leading to apoptotic induction that are distinct from pRB-E2F regulation in cell cycle control. ..
  8. Talluri S, Dick F. Regulation of transcription and chromatin structure by pRB: here, there and everywhere. Cell Cycle. 2012;11:3189-98 pubmed publisher
    ..In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains. ..
  9. Dick F, Rubin S. Molecular mechanisms underlying RB protein function. Nat Rev Mol Cell Biol. 2013;14:297-306 pubmed publisher
    ..These advances and new structural studies are combining to define the multifunctionality of RB. ..
  10. Cecchini M, Thwaites M, Talluri S, MacDonald J, Passos D, Chong J, et al. A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice. Mol Cell Biol. 2014;34:2029-45 pubmed publisher
    ..This suggests that non-E2F-, pRB-dependent pathways may have a more relevant role in proliferative control than previously identified. ..