Genomes and Genes
Experts and Doctors on proteins in Toronto, Ontario, Canada
Locale: Toronto, Ontario, Canada
Publications241 found, 100 shown here
- Hu P, Jiang H, Emili A. Predicting protein functions by relaxation labelling protein interaction network. BMC Bioinformatics. 2010;11 Suppl 1:S64 pubmed publisher..The better predictive power of our method gives new insights about the importance of the dependence between functional terms in protein functional prediction. ..
- Evren S, Dermen A, Lockwood G, Fleshner N, Sweet J. Immunohistochemical examination of the mTORC1 pathway in high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinomas (PCa): a tissue microarray study (TMA). Prostate. 2010;70:1429-36 pubmed publisher..mTOR inhibitors may be an effective treatment for HGPIN and PCa. The extent of mTOR expression in an individual patient would determine the effective use of mTOR inhibitors as a potential therapeutic strategy. ..
- Lee C, Goncalves L, Wells P. Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture. Toxicol Sci. 2011;122:146-56 pubmed publisher..However, DNA repair-deficient ogg1 knockout mice proved resistant to TD-initiated embryopathies in culture and teratogenesis in vivo, indicating that the resistance of mice is not due to a higher level of DNA repair. ..
- Lee J, Geddes K, Streutker C, Philpott D, Girardin S. Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo. Infect Immun. 2012;80:2645-54 pubmed publisher..Thus, PGLYRP2 plays a protective role in vivo in the control of S. Typhimurium infection through a Nod1/Nod2-independent mechanism. ..
- Northcott P, Shih D, Peacock J, Garzia L, Morrissy A, Zichner T, et al. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012;488:49-56 pubmed publisher..Numerous targetable SCNAs, including recurrent events targeting TGF-Î² signalling in Group 3, and NF-ÎºB signalling in Group 4, suggest future avenues for rational, targeted therapy. ..
- Mahadevan K, Zhang H, Akef A, Cui X, Gueroussov S, Cenik C, et al. RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins. PLoS Biol. 2013;11:e1001545 pubmed publisher..ALREX-elements thus act as nucleotide platforms to coordinate various steps of post-transcriptional regulation for the majority of mRNAs that encode secreted proteins. ..
- Makawita S, Dimitromanolakis A, Soosaipillai A, Soleas I, Chan A, Gallinger S, et al. Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9. BMC Cancer. 2013;13:404 pubmed publisher..92 in Sets A and B, respectively). Additional serum biomarkers, particularly SYCN and REG1B, when combined with CA19.9, show promise as improved diagnostic indicators of pancreatic cancer, which therefore warrants further validation. ..
- Anderson D, Koch C, Grey L, Ellis C, Moran M, Pawson T. Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science. 1990;250:979-82 pubmed
- Gaedigk R, Duncan A, Miyazaki I, Robinson B, Dosch H. ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22. Cytogenet Cell Genet. 1994;66:274-6 pubmed..We previously identified islet cell protein p69 as a candidate autoimmune target in IDDM. Here we describe a human genomic p69 fragment which allowed us to map the gene (ICA1) to chromosome 7p22. ..
- Gavish H, dos Santos C, Buchwald M. A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein. Hum Mol Genet. 1993;2:123-6 pubmed..The physiological significance of this mutation is thus confirmed. ..
- Motoyama J, Liu J, Mo R, Ding Q, Post M, Hui C. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet. 1998;20:54-7 pubmed..These results indicate that Gli2 and Gli3 possess specific and overlapping functions in Shh signalling during foregut development, and suggest that mutations in GLI genes may be involved in human foregut malformations. ..
- Bochkarev A, Bochkareva E, Frappier L, Edwards A. The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding. EMBO J. 1999;18:4498-504 pubmed..The structure also suggests a mechanism for RPA trimer formation. ..
- Lechardeur D, Drzymala L, Sharma M, Zylka D, Kinach R, Pacia J, et al. Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD). J Cell Biol. 2000;150:321-34 pubmed..We conclude that a complex mechanism, involving the recognition of the NLSs of both ICAD and CAD, accounts for the constitutive accumulation of CAD/ICAD in the nucleus, where caspase-3-dependent regulation of CAD activity takes place. ..
- Kimura Y, Hart A, Hirashima M, Wang C, Holmyard D, Pittman J, et al. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J Exp Med. 2002;195:941-52 pubmed..These results indicate that Hzf plays important roles in regulating the synthesis of alpha-granule substances and/or their packing into alpha-granules during the process of megakaryopoiesis. ..
- Berry D, Nash P, Liu S, Pawson T, McGlade C. A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr Biol. 2002;12:1336-41 pubmed..These results provide a molecular explanation for the specific role of Gads in T cell receptor signaling, and identify a discrete subclass of SH3 domains whose binding is dependent on a core R-X-X-K motif. ..
- Sadl V, Jin F, Yu J, Cui S, Holmyard D, Quaggin S, et al. The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells. Dev Biol. 2002;249:16-29 pubmed..However, these observations alone are unlikely to account for the aberrant podocyte foot process formation. Thus, Kreisler must regulate other unknown genes required for podocyte function and with possible roles in kidney disease. ..
- Pan Y, Kislinger T, Gramolini A, Zvaritch E, Kranias E, MacLennan D, et al. Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics. Proc Natl Acad Sci U S A. 2004;101:2241-6 pubmed..These data demonstrate that Ca2+ dysregulation, leading to elevated or depressed cardiac contractility, induces compensatory biochemical responses. ..
- Li C, MacDonald J, Wei R, Ray J, Lau K, Kandel C, et al. Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. BMC Genomics. 2007;8:92 pubmed..SAMD9 was recently found to be mutated in normophosphatemic familial tumoral calcinosis. In this study, we studied the gene structure and function of SAMD9, and its paralogous gene, SAMD9L, and examined these in a variety of species...
- Lu H, Koshkin V, Allister E, Gyulkhandanyan A, Wheeler M. Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes. 2010;59:448-59 pubmed publisher..CONCLUSIONS We provide novel evidence for a critical role of defective mitochondrial oxidative phosphorylation and morphology in the pathology of insulin resistance-induced beta-cell failure. ..
- Zhukova N, Naqvi A. Williams-Beuren Syndrome and Burkitt Leukemia. J Pediatr Hematol Oncol. 2013;35:e30-2 pubmed publisher..Here, we report Burkitt Leukemia in an 8-year-old boy with WBS. In this patient, constitutional deletion of chromosome 7q11.23 including BCL7B was confirmed. WBS may predispose patients to Burkitt Leukemia. ..
- Kittanakom S, Arnoldo A, Brown K, Wallace I, Kunavisarut T, Torti D, et al. Miniature short hairpin RNA screens to characterize antiproliferative drugs. G3 (Bethesda). 2013;3:1375-87 pubmed publisher..This cost-effective approach to mammalian knockdown screens, combined with the increasing maturation of RNAi technology will expand the accessibility of similar approaches in academic settings. ..
- Rottapel R, Reedijk M, Williams D, Lyman S, Anderson D, Pawson T, et al. The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol. 1991;11:3043-51 pubmed..These results suggest that Kit autophosphorylation and its physical association with a unique subset of cytoplasmic signaling proteins are critical for mammalian development. ..
- van der Geer P, Wiley S, Lai V, Olivier J, Gish G, Stephens R, et al. A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides. Curr Biol. 1995;5:404-12 pubmed..In this way, Shc may function as an adaptor protein to bring two tyrosine-phosphorylated proteins together. ..
- Lai K, Olivier J, Gish G, Henkemeyer M, McGlade J, Pawson T. A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase. Mol Cell Biol. 1995;15:4810-8 pubmed
- Demetriou M, Binkert C, Sukhu B, Tenenbaum H, Dennis J. Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist. J Biol Chem. 1996;271:12755-61 pubmed..In summary, these experiments define the TRH1 peptide loop as a cytokine-binding domain in both TbetaRII and fetuin and suggest that fetuin is a natural antagonist of TGF-beta and BMP activities. ..
- Harrington L, Zhou W, McPhail T, Oulton R, Yeung D, Mar V, et al. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 1997;11:3109-15 pubmed..These results suggest that telomerase is an evolutionarily conserved multisubunit complex composed of both structural and catalytic subunits. ..
- Steven R, Kubiseski T, Zheng H, Kulkarni S, Mancillas J, Ruiz Morales A, et al. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell. 1998;92:785-95 pubmed..Our results suggest that UNC-73 acts cell autonomously in a protein complex to regulate actin dynamics during cell and growth cone migrations. ..
- Cumming R, Lightfoot J, Beard K, Youssoufian H, O Brien P, Buchwald M. Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nat Med. 2001;7:814-20 pubmed..The prevention of protein oxidation by FANCC reveals a novel mechanism of enzyme regulation during apoptosis and has implications for the treatment of degenerative diseases with thiol reducing agents. ..
- Rosenberg Zand R, Jenkins D, Diamandis E. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim Acta. 2001;312:213-9 pubmed..Several of these natural products demonstrate weak steroid hormone activity. ..
- Ho A, Li Q, Hakem R, Mak T, Zacksenhaus E. Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific. EMBO J. 2004;23:460-72 pubmed..Therefore, loss of pRb elicits apoptosome-dependent and apoptosome-independent cell death, and the requirement and coupling of caspase-9 to Apaf1 are both context-dependent. ..
- Mohammed F, Smookler D, Taylor S, Fingleton B, Kassiri Z, Sanchez O, et al. Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet. 2004;36:969-77 pubmed..Dysregulation of TNF occurred specifically in Timp3(-/-), and not Timp1(-/-) mice. These data indicate that TIMP3 is a crucial innate negative regulator of TNF in both tissue homeostasis and tissue response to injury. ..
- Zhu C, Popova S, Brown E, Barsyte Lovejoy D, Navab R, Shih W, et al. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc Natl Acad Sci U S A. 2007;104:11754-9 pubmed
- Cochrane A, Murley L, Gao M, Wong R, Clayton K, Brufatto N, et al. Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function. Virology. 2009;388:103-11 pubmed publisher..The results suggest that Nap-1 may influence Rev function by increasing the availability of Rev. ..
- Mills E, Truong K. Rate and extent of protein localization is controlled by peptide-binding domain association kinetics and morphology. Protein Sci. 2009;18:1252-60 pubmed publisher..This work provides a basis for explaining the different characteristics (rate and extent) of protein transport and localization in cells as a consequence of the kinetics and morphology of the transport mechanism. ..
- Wells P, McCallum G, Lam K, Henderson J, Ondovcik S. Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits. Birth Defects Res C Embryo Today. 2010;90:103-9 pubmed publisher..Protection may be variably dependent upon such factors as the nature of the teratogen and its concentration within the embryo, the stage of development, the species, strain, gender, target tissue and cell type, among other factors. ..
- Lemak A, Gutmanas A, Chitayat S, Karra M, Fares C, Sunnerhagen M, et al. A novel strategy for NMR resonance assignment and protein structure determination. J Biomol NMR. 2011;49:27-38 pubmed publisher..This integrated method was implemented and refined on over 30 high quality structures of proteins ranging from 5.5 to 16.5 kDa in size. ..
- Louria Hayon I, Frelin C, Ruston J, Gish G, Jin J, Kofler M, et al. Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. Proc Natl Acad Sci U S A. 2013;110:20599-604 pubmed publisher..IL-11 therefore drives a pathway that enhances HSPC radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk. ..
- Larose L, Gish G, Pawson T. Construction of an SH2 domain-binding site with mixed specificity. J Biol Chem. 1995;270:3858-62 pubmed..This study suggests that phosphotyrosine sites can be tailored to bind one or more SH2 domains with high affinity, depending on the combination of residues in the +1 to +5 positions. ..
- Simon H, Mills G, Kozlowski M, Hogg D, Branch D, Ishimi Y, et al. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. Biochem J. 1994;297 ( Pt 2):389-97 pubmed
- Paulson R, Bernstein A. A genetic linkage map of the mouse chromosome 9 region encompassing the Friend virus susceptibility gene 2. Mamm Genome. 1998;9:381-4 pubmed
- Velazquez L, Gish G, van der Geer P, Taylor L, Shulman J, Pawson T. The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3. Blood. 2000;96:132-8 pubmed..These results indicate that Shc undergoes an interdependent series of pTyr-mediated interactions in IL-3-stimulated mast cells, resulting in the recruitment of proteins that regulate the Ras pathway and phospholipid metabolism. ..
- Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, et al. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J. 2000;19:4976-85 pubmed..However, T2K has a unique role in the activation of NF-kappaB-directed transcription, apparently independent of I-kappaB degradation and NF-kappaB DNA binding. ..
- Scorilas A, Yousef G, Jung K, Rajpert De Meyts E, Carsten S, Diamandis E. Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. Biochem Biophys Res Commun. 2001;285:400-8 pubmed..These observations suggest a role of TSKS in testicular physiology, most probably in the process of spermatogenesis or spermiogenesis. ..
- Guo Z, Yikang S, Yoshida H, Mak T, Zacksenhaus E. Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis. Cancer Res. 2001;61:8395-400 pubmed..Our results indicate that Apaf-1 plays a critical role in apoptosis in a subset of tissues and that both E2F1:p53:Apaf-1-dependent and -independent apoptotic pathways operate downstream of Rb. ..
- Jiang Z, Mak T, Sen G, Li X. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A. 2004;101:3533-8 pubmed..Therefore, double-stranded RNA-induced TLR3/TRIF-mediated NF-kappaB and IRF3 activation diverge at TRIF. ..
- Roberts E, Lau C, da Silveira T, Yang S. Developmental expression of Commd1 in the liver of the Jackson toxic milk mouse. Biochem Biophys Res Commun. 2007;363:921-5 pubmed..Cytosolic NF-kappaB rose then dropped precipitously at 5-6 months. In tx-j mice hepatic copper accumulation leads to decreased Xiap, increased Commd1; these responses ultimately fail to prevent progressive apoptotic cell damage. ..
- Gerth C, Zawadzki R, Werner J, Heon E. Retinal morphology in patients with BBS1 and BBS10 related Bardet-Biedl Syndrome evaluated by Fourier-domain optical coherence tomography. Vision Res. 2008;48:392-9 pubmed..This is the first report of in-vivo micro-structural analysis of retinal layers in patients with BBS. Mutations in different BBS genes seem to be associated with similar micro-structural changes in retinal layers. ..
- Cameron J, Janer A, Levandovskiy V, Mackay N, Rouault T, Tong W, et al. Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes. Am J Hum Genet. 2011;89:486-95 pubmed publisher..Our results demonstrate that both play essential roles in the production of [Fe-S] centers for the normal maturation of lipoate-containing 2-oxoacid dehydrogenases, and for the assembly of the respiratory chain complexes. ..
- Ellis J, Barrios Rodiles M, Colak R, Irimia M, Kim T, Calarco J, et al. Tissue-specific alternative splicing remodels protein-protein interaction networks. Mol Cell. 2012;46:884-92 pubmed publisher..Collectively, our results provide evidence that regulated alternative exons frequently remodel interactions to establish tissue-dependent PPI networks. ..
- Bernardi L, Frangipane F, Smirne N, Colao R, Puccio G, Curcio S, et al. Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in southern Italy. Neurobiol Aging. 2012;33:2948.e1-2948.e10 pubmed publisher..We report an unusually high FTD prevalence in the investigated population, but a low prevalence of Alzheimer's disease. We confirm the heterogeneity of FTD phenotype associated with different GRN mutations. ..
- Harpur B, Zayed A. Accelerated evolution of innate immunity proteins in social insects: adaptive evolution or relaxed constraint?. Mol Biol Evol. 2013;30:1665-74 pubmed publisher..These results are consistent with the reduced complement of innate immune genes found in social insects and support the hypothesis that some aspect of eusociality renders canonical innate immunity superfluous. ..
- Li Y, Goldenberg A, Wong K, Zhang Z. A probabilistic approach to explore human miRNA targetome by integrating miRNA-overexpression data and sequence information. Bioinformatics. 2014;30:621-8 pubmed publisher..TargetScore is available at Bioconductor: http://www.bioconductor.org/packages/devel/bioc/html/TargetScore.html. ..
- Hesketh G, Youn J, Samavarchi Tehrani P, Raught B, Gingras A. Parallel Exploration of Interaction Space by BioID and Affinity Purification Coupled to Mass Spectrometry. Methods Mol Biol. 2017;1550:115-136 pubmed publisher..Here we describe the parallel implementation of both BioID and FLAG AP-MS allowing simultaneous exploration of both spatial and temporal aspects of protein interaction networks. ..
- Krasnoshtein F, Buchwald M. Developmental expression of the Fac gene correlates with congenital defects in Fanconi anemia patients. Hum Mol Genet. 1996;5:85-93 pubmed..As well, expression in rapidly dividing progenitors is consistent with hypotheses regarding the nature of the basic defect in FA: a role of the protein in DNA repair or protection from oxygen toxicity. ..
- Saoulli K, Lee S, Cannons J, Yeh W, Santana A, Goldstein M, et al. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J Exp Med. 1998;187:1849-62 pubmed..Thus 4-1BB, via the TRAF2 molecule, can provide CD28-independent costimulatory signals to resting T cells. ..
- Vincent J, Petek E, Thevarkunnel S, Kolozsvari D, Cheung J, Patel M, et al. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. Genomics. 2002;80:283-94 pubmed..The RAY1/ST7 may generate at least 18 possible isoforms, with many more arising if other sense-strand exons from ST7OT3 and ST7 OT4 are used in a selective and possibly tissue-specific manner. ..
- Huang H, Sidhu S. Studying binding specificities of peptide recognition modules by high-throughput phage display selections. Methods Mol Biol. 2011;781:87-97 pubmed publisher..These high-throughput methods greatly expedite the study of PRM families on a genome-wide scale. ..
- Lambert J, Ivosev G, Couzens A, Larsen B, Taipale M, Lin Z, et al. Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods. 2013;10:1239-45 pubmed publisher..We show that AP-SWATH is a robust label-free approach to characterize such changes and propose a scalable pipeline for systems biology studies. ..
- Koch C, Moran M, Anderson D, Liu X, Mbamalu G, Pawson T. Multiple SH2-mediated interactions in v-src-transformed cells. Mol Cell Biol. 1992;12:1366-74 pubmed..These results show that SH2 domains bind directly to tyrosine-phosphorylated proteins and that the Src SH2 domain can bind phosphorylated targets of the v-Src kinase domain.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Xie B, Wang W, Mahuran D. A Cys138-to-Arg substitution in the GM2 activator protein is associated with the AB variant form of GM2 gangliosidosis. Am J Hum Genet. 1992;50:1046-52 pubmed..We conclude that the T412----C transition in the GM2 Activator gene of the patient is responsible for the disease phenotype. ..
- Dumont D, Gradwohl G, Fong G, Auerbach R, Breitman M. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors. Oncogene. 1993;8:1293-301 pubmed
- Snow B, Betts L, Mangion J, Sondek J, Siderovski D. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. Proc Natl Acad Sci U S A. 1999;96:6489-94 pubmed
- Botuyan M, Koth C, Mer G, Chakrabartty A, Conaway J, Conaway R, et al. Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C. Proc Natl Acad Sci U S A. 1999;96:9033-8 pubmed..These results suggest a structural basis for the interaction of an F-box-containing protein with a SKP1 homologue and the modulation of this interaction by the tumor suppressor VHL. ..
- Suen T, Goss P. Transcription of BRCA1 is dependent on the formation of a specific protein-DNA complex on the minimal BRCA1 Bi-directional promoter. J Biol Chem. 1999;274:31297-304 pubmed
- Dickstein J, Moldofsky H, Hay J. Brain-blood permeability: TNF-alpha promotes escape of protein tracer from CSF to blood. Am J Physiol Regul Integr Comp Physiol. 2000;279:R148-51 pubmed..No significant changes were observed in control animals treated with saline. The data suggest that TNF-alpha promotes the clearance of protein macromolecules from the CSF to the venous blood...
- Koch U, Lacombe T, Holland D, Bowman J, Cohen B, Egan S, et al. Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity. 2001;15:225-36 pubmed..These data identify Lunatic Fringe as a potent regulator of Notch-1 during the T/B lineage decision and show that an important function of Notch-1 in T cell commitment is to suppress B cell development in the thymus. ..
- Velazquez L, Cheng A, Fleming H, Furlonger C, Vesely S, Bernstein A, et al. Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med. 2002;195:1599-611 pubmed..These data implicate Lnk as playing an important role in hematopoiesis and in the regulation of growth factor and cytokine receptor-mediated signaling. ..
- Paterson A, Wang K, Lupea D, St George Hyslop P, Pei Y. Recurrent fetal loss associated with bilineal inheritance of type 1 autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2002;40:16-20 pubmed..Given a 25% chance for mutant homozygosity in the offspring of this family, our findings suggest that homozygosity of PKD1 mutations in humans is embryonically lethal, as recently documented in Pkd1 knockout mice. ..
- Misquitta C, Chen T, Grover A. Control of protein expression through mRNA stability in calcium signalling. Cell Calcium. 2006;40:329-46 pubmed..We anticipate that these novel modes of control of protein expression will form an emerging area of research that may explore the central role of Ca(2+) in cell function during development and in disease. ..
- Wang C, Navab R, Iakovlev V, Leng Y, Zhang J, Tsao M, et al. Abelson interactor protein-1 positively regulates breast cancer cell proliferation, migration, and invasion. Mol Cancer Res. 2007;5:1031-9 pubmed..These data suggest that ABI-1 plays an important role in the spread of breast cancer and that this role may be mediated via the phosphatidylinositol 3-kinase pathway. ..
- Irion S, Luche H, Gadue P, Fehling H, Kennedy M, Keller G. Identification and targeting of the ROSA26 locus in human embryonic stem cells. Nat Biotechnol. 2007;25:1477-82 pubmed..Through recombinase-mediated cassette exchange, we show replacement of the tdRFP cDNA with other cDNAs, providing a cell line in which transgenes can be readily introduced into a broadly expressed locus. ..
- Pena Castillo L, Tasan M, Myers C, Lee H, Joshi T, Zhang C, et al. A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol. 2008;9 Suppl 1:S2 pubmed publisher..The results show that currently available data for mammals allows predictions with both breadth and accuracy. Importantly, many highly novel predictions emerge for the 38% of mouse genes that remain uncharacterized. ..
- Tan J, Xu K, Cretegny K, Visan I, Yuan J, Egan S, et al. Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity. 2009;30:254-63 pubmed publisher..Our study has revealed that the Fringe-Notch2 interaction has important functions in vivo and provides insights into mechanisms regulating MZ B cell development. ..
- Danesh A, Cameron C, Le n A, Ran L, Xu L, Fang Y, et al. Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation. Virology. 2011;409:102-12 pubmed publisher..These signatures can be useful markers to evaluate the status of IFN responses during a viral infection and specific features of different viruses...
- Eng L, Ibrahim Zada I, Jarjanazi H, Savas S, Meschian M, Pritchard K, et al. Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines. BMC Med Genomics. 2011;4:18 pubmed publisher..These genetic variants represent promising biomarkers for predicting paclitaxel response and may play a significant role in the cellular response to paclitaxel. ..
- Bao J, Krylova S, Wilson D, Reinstein O, Johnson P, Krylov S. Kinetic capillary electrophoresis with mass-spectrometry detection (KCE-MS) facilitates label-free solution-based kinetic analysis of protein-small molecule binding. Chembiochem. 2011;12:2551-4 pubmed publisher..Due to the variety of KCE methods and MS modes available, the KCE-MS tandem is a highly versatile platform for label-free, solution-based kinetic studies of affinity interactions...
- Tourlakis M, Zhong J, Gandhi R, Zhang S, Chen L, Durie P, et al. Deficiency of Sbds in the mouse pancreas leads to features of Shwachman-Diamond syndrome, with loss of zymogen granules. Gastroenterology. 2012;143:481-92 pubmed publisher..Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes. SBDS therefore appears to be required for normal pancreatic development and function. ..
- Carter H, Hood D. Contractile activity-induced mitochondrial biogenesis and mTORC1. Am J Physiol Cell Physiol. 2012;303:C540-7 pubmed publisher..Our results suggest that mTORC1 activity is not integral for the increase in mitochondrial content elicited by CCA, but is required to maintain mitochondrial function and homeostasis in resting muscle. ..
- Slaats G, Isabella C, Kroes H, Dempsey J, Gremmels H, Monroe G, et al. MKS1 regulates ciliary INPP5E levels in Joubert syndrome. J Med Genet. 2016;53:62-72 pubmed publisher..Mutations in INPP5E also cause JS, so our findings in patient fibroblasts support the notion that loss of INPP5E function, due to either mutation or mislocalisation, is a key mechanism underlying JS, downstream of MKS1 and ARL13B. ..
- Suzuki A, Andrew D, Gonzalo J, Fukumoto M, Spellberg J, Hashiyama M, et al. CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein. Blood. 1996;87:3550-62 pubmed..Thus, we have identified an additional molecule(s) that might be involved in leukocyte trafficking. These results indicate that CD34 plays an important role in eosinophil trafficking into the lung. ..
- Donoviel D, Donoviel M, Fan E, Hadjantonakis A, Bernstein A. Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998;78:203-7 pubmed..5 and E17.5 in the acini of the pancreas, and moderate in the epithelial cells of the gut villi. We localized the SEL-1L protein to the cytosol, possibly in intracellular vesicles, in a beta-islet-derived tumor cell line (RinM). ..
- Ohteki T, Maki C, Koyasu S, Mak T, Ohashi P. Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol. 1999;162:3753-6 pubmed..Collectively, these data indicate that LFA-1 is required for the development of liver NKT cells, rather than the migration to and/or subsequent establishment of mature NKT cells in the liver. ..
- Krawczyk C, Bachmaier K, Sasaki T, Jones R, Snapper S, Bouchard D, et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000;13:463-73 pubmed..Thus, Cbl-b functions as a negative regulator of receptor clustering and raft aggregation in T cells. ..
- Joza N, Susin S, Daugas E, Stanford W, Cho S, Li C, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001;410:549-54 pubmed..Our data provide genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis. ..
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