Genomes and Genes
Experts and Doctors on molecular sequence data in Toronto, Ontario, Canada
Locale: Toronto, Ontario, Canada
Topic: molecular sequence data
Publications396 found, 100 shown here
- Mar L, Rivkin E, Kim D, Yu J, Cordes S. A genetic screen for mutations that affect cranial nerve development in the mouse. J Neurosci. 2005;25:11787-95 pubmed
- Gardzinski P, Lee D, Fei G, Hui K, Huang G, Sun H, et al. The role of synaptotagmin I C2A calcium-binding domain in synaptic vesicle clustering during synapse formation. J Physiol. 2007;581:75-90 pubmed
- Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, et al. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell. 2007;129:1165-76 pubmed..This spatial variability may accommodate diverse acceptor lysine geometries in both substrates and the elongating ubiquitin chain and thereby increase catalytic efficiency. ..
- Kwok T, Hui K, Kostelecki W, Ricker N, Selman G, Feng Z, et al. A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels. PLoS Genet. 2008;4:e1000067 pubmed publisher..elegans as a screening tool to identify residues important for DHP interaction with mammalian Ca(v)1 channels. ..
- Baxter J, Moeder W, Urquhart W, Shahinas D, Chin K, Christendat D, et al. Identification of a functionally essential amino acid for Arabidopsis cyclic nucleotide gated ion channels using the chimeric AtCNGC11/12 gene. Plant J. 2008;56:457-69 pubmed publisher..This suggests that AtCNGC11/12 suppressors could be a useful tool for discovering important residues not only for plant CNGCs but also for CNGCs in general. ..
- Stathopulos P, Zheng L, Ikura M. Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics. J Biol Chem. 2009;284:728-32 pubmed publisher..We postulate that distinct oligomerization dynamics of STIM isoforms have evolved to adapt to differential roles in Ca(2+) homeostasis and signaling. ..
- Cardarelli L, Lam R, Tuite A, Baker L, Sadowski P, Radford D, et al. The crystal structure of bacteriophage HK97 gp6: defining a large family of head-tail connector proteins. J Mol Biol. 2010;395:754-68 pubmed publisher..We have also identified gp7 of HK97 as a homologue of gp16 of phage SPP1, which is the second component of the connector of this phage. These proteins are members of another large protein family involved in connector assembly. ..
- Xu C, Bian C, Lam R, Dong A, Min J. The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain. Nat Commun. 2011;2:227 pubmed publisher..Furthermore, we demonstrate that CFP1 has a preference for a guanosine nucleotide following the CpG motif. ..
- Marsh A, Willer D, Ambagala A, Dzamba M, Chan J, Pilon R, et al. Genomic sequencing and characterization of cynomolgus macaque cytomegalovirus. J Virol. 2011;85:12995-3009 pubmed publisher..Similar to HCMV, CyCMV does not produce the RhCMV-specific viral homologue of cyclooxygenase-2. This newly characterized CMV may provide a novel model in which to study CMV biology and HCMV vaccine development...
- Helsen C, Glover J. Insight into molecular basis of curing of [PSI+] prion by overexpression of 104-kDa heat shock protein (Hsp104). J Biol Chem. 2012;287:542-56 pubmed publisher..These results provide new insight into the enigmatic specificity of Hsp104-mediated curing of yeast prions and sheds light on the limitations of the ability of Hsp104 to eliminate aggregates produced by other aggregation-prone proteins. ..
- Cawthorn T, Moreno J, Dharsee M, Tran Thanh D, Ackloo S, Zhu P, et al. Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival. PLoS ONE. 2012;7:e30992 pubmed publisher..In addition HSP90B1 appears to identify a group of patients with distant metastasis with otherwise good prognostic features. ..
- Kulleperuma K, Smith S, Morgan D, Musset B, Holyoake J, Chakrabarti N, et al. Construction and validation of a homology model of the human voltage-gated proton channel hHV1. J Gen Physiol. 2013;141:445-65 pubmed publisher..Both modeling and experimental data indicate that in the open state, Arg(211), the third Arg residue in the S4 helix in hH(V)1, remains accessible to the internal solution and is located near the charge transfer center, Phe(150)...
- Colwill K, Pawson T, Andrews B, Prasad J, Manley J, Bell J, et al. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 1996;15:265-75 pubmed..Overexpression of the active Clk/Sty kinase caused a redistribution of SR proteins within the nucleus. These results suggest that Clk/Sty kinase directly regulates the activity and compartmentalization of SR splicing factors. ..
- Ching Ying Wong J, Alon N, Buchwald M. Cloning of the bovine and rat Fanconi anemia group C cDNA. Mamm Genome. 1997;8:522-5 pubmed
- Lin Y, Ma W, Benchimol S. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat Genet. 2000;26:122-7 pubmed..Overexpression of Pidd inhibited cell growth in a p53-like manner by inducing apoptosis. Antisense inhibition of Pidd expression attenuated p53-mediated apoptosis. Our data suggest that Pidd is an effector of p53-dependent apoptosis. ..
- Tanentzapf G, Smith C, McGlade J, Tepass U. Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis. J Cell Biol. 2000;151:891-904 pubmed..Together with previous data showing that Crb is required for the formation of a zonula adherens, these findings indicate a mutual dependency of apical and lateral polarization mechanisms. ..
- Claudio J, Masih Khan E, Tang H, Goncalves J, Voralia M, Li Z, et al. A molecular compendium of genes expressed in multiple myeloma. Blood. 2002;100:2175-86 pubmed..GenBank Accession numbers include BF169967-BF176369, BF185966-BF185969, and BF177280-BF177455. ..
- Sajjan U, Liu L, Lu A, Spilker T, Forstner J, LiPuma J. Lack of cable pili expression by cblA-containing Burkholderia cepacia complex. Microbiology. 2002;148:3477-84 pubmed
- Ganss B, Teo W, Chen H, Poon T. Krox-26 is a novel C2H2 zinc finger transcription factor expressed in developing dental and osteogenic tissues. Connect Tissue Res. 2002;43:161-6 pubmed..These results suggest Krox-26 as a potential regulator of gene transcription during the development of teeth and the craniofacial skeleton. ..
- Yousef G, Diamandis E. Tissue kallikreins: new players in normal and abnormal cell growth?. Thromb Haemost. 2003;90:7-16 pubmed..For example, hK6, 10 and 11 are promising serological markers for ovarian cancer diagnosis. KLK10 may act as a tumor suppressor. In addition to their diagnostic and prognostic values, kallikreins may also be good therapeutic targets. ..
- Ahmad K, Melnick A, Lax S, Bouchard D, Liu J, Kiang C, et al. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell. 2003;12:1551-64 pubmed..Two SMRT fragments bind symmetrically to the BCL6 BTB homodimer and, in combination with biochemical and in vivo data, the structure provides insight into the basis of transcriptional repression by this critical B cell lymphoma protein. ..
- Du G, Avila G, Sharma P, Khanna V, Dirksen R, MacLennan D. Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1). J Biol Chem. 2004;279:37566-74 pubmed..Thus, this region may act as a negative regulatory module that increases the energy barrier for Ca(2+) release channel opening. ..
- Chen D, Gorczynski R. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. Transplantation. 2005;79:282-8 pubmed..In addition to defining the importance of N-terminal epitopes for CD200 function, rank comparison of mAbs for FACS staining of CD200 expressed on various cell types indicates heterogeneity in expressed CD200. ..
- Rothfels K, Tanny J, Molnár E, Friesen H, Commisso C, Segall J. Components of the ESCRT pathway, DFG16, and YGR122w are required for Rim101 to act as a corepressor with Nrg1 at the negative regulatory element of the DIT1 gene of Saccharomyces cerevisiae. Mol Cell Biol. 2005;25:6772-88 pubmed..Interestingly, Rim101 was processed in bro1 and doa4 strains but was unable to mediate efficient repression. ..
- Thomson S, Williams D. Delineation of the lectin site of the molecular chaperone calreticulin. Cell Stress Chaperones. 2005;10:242-51 pubmed..This provides the first direct demonstration of the importance of CRT's lectin site in suppressing the aggregation of nonnative glycoproteins. ..
- Fabian M, White K. Analysis of a 3'-translation enhancer in a tombusvirus: a dynamic model for RNA-RNA interactions of mRNA termini. RNA. 2006;12:1304-14 pubmed..These results indicate that the 5'-3' RNA-RNA interaction is likely disrupted by scanning ribosomal subunits and suggest a dynamic model for the interaction of mRNA termini during active translation...
- Takeuchi J, Bruneau B. Irxl1, a divergent Iroquois homeobox family transcription factor gene. Gene Expr Patterns. 2007;7:51-6 pubmed..We conclude that Irxl1 is a newly identified highly divergent member of the Irx gene family with specific expression patterns in mouse embryogenesis. ..
- Saridakis V, Shahinas D, Xu X, Christendat D. Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum. J Mol Biol. 2008;377:655-67 pubmed publisher..Electrophoretic mobility shift assay and biophysical analyses further suggest that salicylate inactivates MTH313 and prevents it from binding to its promoter region...
- Kuzmin A, Jarvi K, Lo K, Spencer L, Chow G, Macleod G, et al. Identification of potentially damaging amino acid substitutions leading to human male infertility. Biol Reprod. 2009;81:319-26 pubmed publisher..All of the novel mutations were in a heterozygous configuration, suggesting that they may be de novo mutations with dominant negative properties. ..
- Findlay G, Smith M, Lanner F, Hsiung M, Gish G, Petsalaki E, et al. Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 2013;152:1008-20 pubmed publisher..This optimized system ensures that PrE lineage commitment occurs in a timely and selective manner during embryogenesis. ..
- Mattera R, Guardia C, Sidhu S, Bonifacino J. Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. J Biol Chem. 2015;290:30736-49 pubmed publisher..In addition to revealing critical aspects of this coat, our findings extend the paradigm of peptide-ear interactions, previously established for clathrin-AP-1/AP-2 coats, to a non-clathrin coat. ..
- Van Tol H, Wu C, Guan H, Ohara K, Bunzow J, Civelli O, et al. Multiple dopamine D4 receptor variants in the human population. Nature. 1992;358:149-52 pubmed..Such variation among humans may underlie individual differences in susceptibility to neuropsychiatric disease and in responsiveness to antipsychotic medication. ..
- Leung Hagesteijn C, Spence A, Stern B, Zhou Y, Su M, Hedgecock E, et al. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell. 1992;71:289-99 pubmed..Mosaic analysis shows that unc-5 acts in migrating cells and pioneering neurons. We propose that UNC-5 is a transmembrane receptor expressed on the surface of motile cells and growth cones to guide dorsal movements. ..
- Heffernan M, Yousefi S, Dennis J. Molecular characterization of P2B/LAMP-1, a major protein target of a metastasis-associated oligosaccharide structure. Cancer Res. 1989;49:6077-84 pubmed..However, in two experimental models of metastasis, where changes in branching of oligosaccharides on P2B/LAMP-1 have been shown to occur, comparable levels of P2B/LAMP-1 mRNA were found in both metastatic and nonmetastatic cell lines. ..
- Henkemeyer M, Rossi D, Holmyard D, Puri M, Mbamalu G, Harpal K, et al. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature. 1995;377:695-701 pubmed..Thus rasGAP and neurofibromin act together to regulate Ras activity during embryonic development. ..
- Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher W, Leow C, et al. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet. 1997;16:283-8 pubmed..Ectopic expression of murine manic fringe or radical fringe in Drosophila results in phenotypes that resemble those seen in Notch mutants. ..
- Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, et al. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J. 1997;16:6325-36 pubmed..Our results suggest that ENaC function is regulated by ubiquitination, and propose a paradigm for ubiquitination-mediated regulation of ion channels. ..
- Michalickova K, Susic M, Willing M, Wenstrup R, Cole W. Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce ehlers-danlos syndrome type I. Hum Mol Genet. 1998;7:249-55 pubmed..Our findings show that heterozygous mutations of the COL5A2 gene can produce the EDS type I phenotype. They also suggest that type V collagen plays a more important role in collagen fibrillogenesis of dermis than that of bone. ..
- Carbone M, Mackay N, Ling M, Cole D, Douglas C, Rigat B, et al. Amerindian pyruvate carboxylase deficiency is associated with two distinct missense mutations. Am J Hum Genet. 1998;62:1312-9 pubmed..These data provide the first characterization of the human PC gene structure, the identification of common pathogenic mutations, and the demonstration of a founder effect in the Ojibwa and Cree patients...
- Snow B, Hall R, Krumins A, Brothers G, Bouchard D, Brothers C, et al. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. J Biol Chem. 1998;273:17749-55 pubmed..The presence of an alternatively spliced PDZ domain within RGS12 suggests a mechanism by which RGS proteins may target specific G-protein-coupled receptor systems for desensitization. ..
- Bochkarev A, Bochkareva E, Frappier L, Edwards A. The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding. EMBO J. 1999;18:4498-504 pubmed..The structure also suggests a mechanism for RPA trimer formation. ..
- Heon E, Priston M, Schorderet D, Billingsley G, Girard P, Lubsen N, et al. The gamma-crystallins and human cataracts: a puzzle made clearer. Am J Hum Genet. 1999;65:1261-7 pubmed..There is no direct evidence, to date, that up-regulation of a pseudogene causes cataracts. To our knowledge, these findings are the first evidence of an involvement of CRYGC and support the role of CRYGD in human cataract formation. ..
- Khatri I, Ho C, Specian R, Forstner J. Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1321-30 pubmed..In a mouse model of human cystic fibrosis, both soluble Muc3 and goblet cell Muc2 were increased in amount and hypersecreted. Thus Muc2 and Muc3 contribute to the excess intestinal luminal mucus of cystic fibrosis mice...
- Cannons J, Lau P, Ghumman B, DeBenedette M, Yagita H, Okumura K, et al. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J Immunol. 2001;167:1313-24 pubmed..These data support the idea that CD28 plays a primary role in initial T cell expansion, whereas 4-1BB/4-1BBL sustains both CD4 and CD8 T cell responses, as well as enhances cell division and T cell effector function. ..
- Claudio J, Zhu Y, Benn S, Shukla A, McGlade C, Falcioni N, et al. HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells. Oncogene. 2001;20:5373-7 pubmed..Cell lines and primary cells from acute myeloid leukemias and multiple myeloma patients express HACS1. Immunostaining and cellular fractionation studies localized the HACS1 protein predominantly to the cytoplasm. ..
- Lam B, Sage T, Bianchi F, Blumwald E. Role of SH3 domain-containing proteins in clathrin-mediated vesicle trafficking in Arabidopsis. Plant Cell. 2001;13:2499-512 pubmed..Hence, AtSH3P1 may perform regulatory and/or scaffolding roles during the transition of fission and the uncoating of clathrin-coated vesicles. ..
- Abdelhaleem M. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. Leuk Res. 2002;26:945-54 pubmed..An alternatively spliced message lacking exon 4 in the coding region is present in several tissues. Our results suggest that DDX32 is a novel gene, which might play a role in normal and/or abnormal lymphopoiesis. ..
- Ljutic B, Carlyle J, Zuniga Pflucker J. Identification of upstream cis-acting regulatory elements controlling lineage-specific expression of the mouse NK cell activation receptor, NKR-P1C. J Biol Chem. 2003;278:31909-17 pubmed..These results identify the minimal upstream cis-acting elements, and point to a complex regulatory mechanism involved in the lineage-specific control of NKR-P1C expression in NK lymphocytes. ..
- Khorchid A, Inouye M, Ikura M. Structural characterization of Escherichia coli sensor histidine kinase EnvZ: the periplasmic C-terminal core domain is critical for homodimerization. Biochem J. 2005;385:255-64 pubmed
- Mongroo P, Johnstone C, Naruszewicz I, Leung Hagesteijn C, Sung R, Carnio L, et al. Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer. Oncogene. 2004;23:8959-70 pubmed..These results indicated that ParvB inhibits ILK signaling downstream of receptor tyrosine kinases. Our results suggest that loss of ParvB expression is a novel mechanism for upregulating ILK activity in tumors. ..
- Michael I, Kurlender L, Memari N, Yousef G, Du D, Grass L, et al. Intron retention: a common splicing event within the human kallikrein gene family. Clin Chem. 2005;51:506-15 pubmed..The first six centromeric members of the KLK gene family have splice variants that retain intron III. Some variants show tissue-specific expression. The KLK15 splice variant appears to be a candidate biomarker for prostate cancer. ..
- Pereira S, Baker A. A molecular timescale for galliform birds accounting for uncertainty in time estimates and heterogeneity of rates of DNA substitutions across lineages and sites. Mol Phylogenet Evol. 2006;38:499-509 pubmed..We also point out that galliform fossils may not be as useful for point calibrations as was previously suggested, but instead may be better employed as priors for the estimation of node ages under a Bayesian approach...
- Cheng E, Collins C, Berru M, Shulman M. A system for precise analysis of transcription-regulating elements of immunoglobulin genes. BMC Biotechnol. 2005;5:27 pubmed..5 fold among independent transfectants, and expression is greatly (> 50 fold) increased by inclusion of the IgH intronic enhancer. This system is suitable for precise analysis of the regulatory elements of the immunoglobulin loci. ..
- Tulumello D, Deber C. SDS micelles as a membrane-mimetic environment for transmembrane segments. Biochemistry. 2009;48:12096-103 pubmed publisher..The molecular characteristics of SDS-peptide complexes may thus portend a corresponding role for similar TM sequences in the in vivo assembly of polytopic membrane proteins...
- Romano J, Dubos C, Prouse M, Wilkins O, Hong H, Poole M, et al. AtMYB61, an R2R3-MYB transcription factor, functions as a pleiotropic regulator via a small gene network. New Phytol. 2012;195:774-86 pubmed publisher..Taken together, these findings suggest that AtMYB61 links the transcriptional control of multiple aspects of plant resource allocation...
- Andrade D, Paton T, Turnbull J, Marshall C, Scherer S, Minassian B. Mutation of the CLN6 gene in teenage-onset progressive myoclonus epilepsy. Pediatr Neurol. 2012;47:205-8 pubmed publisher..This work also exemplifies the potentiality of next-generation sequencing in the genetic identification and diagnosis of patients with neurologic diseases of unknown cause. ..
- Mak A, Pehar M, Nixon A, Williams R, Uetrecht A, Puglielli L, et al. Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. J Mol Biol. 2014;426:2175-82 pubmed publisher..Taken together, we suggest that lysine acetylation on predicted extracellular residues plays a key role in expression and trafficking of CD133 protein to the cell surface and can be targeted to disrupt CD133 regulation and function. ..
- Strathdee C, Gavish H, Shannon W, Buchwald M. Cloning of cDNAs for Fanconi's anaemia by functional complementation. Nature. 1992;356:763-7 pubmed..The predicted FACC polypeptide does not contain any motifs common to other proteins and so represents a new gene involved in the cellular response to DNA damage. ..
- O Dowd B, Heiber M, Chan A, Heng H, Tsui L, Kennedy J, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 1993;136:355-60 pubmed..PCR analysis of somatic cell lines found APJ-related sequences to be only present on chromosome 11, and high-resolution mapping by fluorescence in situ hybridization (FISH) sublocalized APJ on band q12. ..
- van der Geer P, Wiley S, Gish G, Lai V, Stephens R, White M, et al. Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. Proc Natl Acad Sci U S A. 1996;93:963-8 pubmed
- Guha A, Lau N, Huvar I, Gutmann D, Provias J, Pawson T, et al. Ras-GTP levels are elevated in human NF1 peripheral nerve tumors. Oncogene. 1996;12:507-13 pubmed..Neurofibromin was not expressed in NF1 sarcomas, in support of its important negative Ras regulatory role in the pathogenesis of NF1 peripheral nerve tumors. ..
- Piao X, Paulson R, van der Geer P, Pawson T, Bernstein A. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc Natl Acad Sci U S A. 1996;93:14665-9 pubmed..Thus, this mutation activates the oncogenic potential of Kit by a novel mechanism involving an alteration in Kit substrate recognition and the degradation of SHP-1, an attenuator of the Kit signaling pathway. ..
- Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass M, et al. A mammalian telomerase-associated protein. Science. 1997;275:973-7 pubmed..The identification of TP1 suggests that telomerase-associated proteins are conserved from ciliates to humans. ..
- Zarghami N, Grass L, Diamandis E. Steroid hormone regulation of prostate-specific antigen gene expression in breast cancer. Br J Cancer. 1997;75:579-88 pubmed..Our tissue culture system is a highly sensitive in vitro method for evaluating the biological activity of candidate compounds having agonist and antagonist steroid hormone activity. ..
- Seet L, Cho S, Hessel A, Dumont D. Molecular cloning of multiple isoforms of synaptojanin 2 and assignment of the gene to mouse chromosome 17A2-3.1. Biochem Biophys Res Commun. 1998;247:116-22 pubmed..In addition, we have mapped synaptojanin 2 to mouse chromosome 17 band A2-3.1 by fluorescence in situ hybridization. ..
- Lee J, Cornell K, Riscoe M, Howell P. Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Acta Crystallogr D Biol Crystallogr. 2001;57:150-2 pubmed..On the basis of density calculations, two monomers are predicted per asymmetric unit (Matthews coefficient, V(M) = 2.37 A(3) Da(-1)), with a solvent content of 48%. ..
- Jheon A, Ganss B, Cheifetz S, Sodek J. Characterization of a novel KRAB/C2H2 zinc finger transcription factor involved in bone development. J Biol Chem. 2001;276:18282-9 pubmed..These studies, therefore, have identified a novel zinc finger transcription factor in bone that can modulate Runx2 activity and osteogenic differentiation. ..
- Wang Q, Ko K, Kapus A, McCulloch C, Ellen R. A spirochete surface protein uncouples store-operated calcium channels in fibroblasts: a novel cytotoxic mechanism. J Biol Chem. 2001;276:23056-64 pubmed..Actin filament rearrangement coincident with conformational uncoupling of store-operated calcium fluxes is a novel mechanism by which surface proteins and toxins of pathogenic microorganisms may damage host cells. ..
- Scorilas A, Kyriakopoulou L, Yousef G, Ashworth L, Kwamie A, Diamandis E. Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. Genomics. 2001;72:217-21 pubmed..We also identified one splice variant of BCL2L12 that is primarily expressed in skeletal muscle. ..
- Tong J, Elowe S, Nash P, Pawson T. Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity. J Biol Chem. 2003;278:6111-9 pubmed..The behavior of EphB2 variants with mutations in the JM region and kinase domains suggests an intricate pattern of regulation and target recognition by Eph receptors. ..
- Tsay M, Fatemi N, Narindrasorasak S, Forbes J, Sarkar B. Identification of the "missing domain" of the rat copper-transporting ATPase, atp7b: insight into the structural and metal binding characteristics of its N-terminal copper-binding domain. Biochim Biophys Acta. 2004;1688:78-85 pubmed
- Garces R, Wu N, Gillon W, Pai E. Anabaena circadian clock proteins KaiA and KaiB reveal a potential common binding site to their partner KaiC. EMBO J. 2004;23:1688-98 pubmed..Notably, the functionally relevant residues Arg 69 of KaiA and Arg 23 of KaiB align well in space. The apparent structural similarities suggest that KaiA and KaiB may compete for a potential common binding site on KaiC. ..
- Smith C, Dho S, Donaldson J, Tepass U, McGlade C. The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell. 2004;15:3698-708 pubmed..In addition, we present evidence that Numb has a novel function in endosomal recycling and intracellular trafficking of receptors. ..
- Stavrinides J, Guttman D. Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326. J Bacteriol. 2004;186:5101-15 pubmed..syringae strains. Comparative genomic analyses of these and other P. syringae plasmids suggest a role for recombination and integrative elements in driving plasmid evolution. ..
- Wang L, Li G, Sugita S. A central kinase domain of type I phosphatidylinositol phosphate kinases is sufficient to prime exocytosis: isoform specificity and its underlying mechanism. J Biol Chem. 2005;280:16522-7 pubmed
- MacDonald D, Weerapura M, Beazely M, Martin L, Czerwinski W, Roder J, et al. Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src. J Neurosci. 2005;25:11374-84 pubmed..RACK1 serves as a hub for PKC, Fyn, and Src and facilitates the regulation of basal NMDAR activity in CA1 hippocampal neurons. ..
- Couto J, Gomez L, Wigg K, Cate Carter T, Archibald J, Anderson B, et al. The KIAA0319-like (KIAA0319L) gene on chromosome 1p34 as a candidate for reading disabilities. J Neurogenet. 2008;22:295-313 pubmed publisher..Additional studies in independent samples are now required to confirm these findings. ..
- Khoury H, Suarez Saiz F, Wu S, Minden M. An upstream insulator regulates DLK1 imprinting in AML. Blood. 2010;115:2260-3 pubmed publisher..Taken together, our data indicate that an insulator located 18 kb upstream of DLK1 plays an important role in regulating DLK1 imprinting. ..
- Shanbhag R, Kurabi A, Kwan J, Donaldson L. Solution structure of the carboxy-terminal Tudor domain from human Coilin. FEBS Lett. 2010;584:4351-6 pubmed publisher..Tudor domains have been noted previously to bind DNA, RNA and modified amino acids. The absence of these sequence and structural signatures in the Coilin Tudor domain supporting these established functions suggests an alternative role. ..
- Yang X, Rutnam Z, Jiao C, Wei D, Xie Y, Du J, et al. An anti-let-7 sponge decoys and decays endogenous let-7 functions. Cell Cycle. 2012;11:3097-108 pubmed publisher..The ability of anti-let-7 to regulate multiple members of the let-7 family allows us to observe their multiple functions using a single reagent. This approach can be applied to other family members with conserved sequences. ..
- Lee P, White K. Construction and characterization of an aureusvirus defective RNA. Virology. 2014;452-453:67-74 pubmed publisher..However, although similar, the CLSV D RNA and its components are distinct and provide insights into RNA-based specificity and mechanisms of function. ..
- Thomas G, Forbes J, Roberts E, Walshe J, Cox D. The Wilson disease gene: spectrum of mutations and their consequences. Nat Genet. 1995;9:210-7 pubmed..The mutations identified provide an explanation for at least part of the wide phenotypic variation observed in Wilson disease. ..
- Bagby S, Kim S, Maldonado E, Tong K, Reinberg D, Ikura M. Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. Cell. 1995;82:857-67 pubmed
- Tang S, Suen T, McInnes R, Buchwald M. Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins. J Biol Chem. 1998;273:25356-63 pubmed..These findings define 14-3-3eta as a functional modulator of the TLX-2 homeodomain transcription factor and suggest that the in vivo function of TLX-2 in neural differentiation is likely regulated by signaling mediated by 14-3-3eta. ..
- Claudio J, Liew C, Ma J, Heng H, Stewart A, Hawley R. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. Genomics. 1999;59:85-9 pubmed..Fluorescence in situ hybridization mapped WDR3 to human chromosome 1p12-p13, a region that is affected by chromosomal rearrangements in a number of hematologic malignancies and solid tumors. ..
- Suen T, Goss P. Transcription of BRCA1 is dependent on the formation of a specific protein-DNA complex on the minimal BRCA1 Bi-directional promoter. J Biol Chem. 1999;274:31297-304 pubmed
- Dorywalska M, Coukell B, Dharamsi A. Characterization and hetereologous expression of cDNAs encoding two novel closely related Ca(2+)-binding proteins in Dictyostelium discoideum. Biochim Biophys Acta. 2000;1496:356-61 pubmed..CBP4a and CBP4b mRNAs are expressed at the same stages of development as CBP1 mRNA. In addition, both novel proteins bind (45)Ca(2+) and interact with CBP1 in vitro in a Ca(2+)-dependent manner. ..
- Wong J, Alon N, Norga K, Kruyt F, Youssoufian H, Buchwald M. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Genomics. 2000;67:273-83 pubmed..The overlapping genomic organization between Zfp276 and Fanca may have relevance to the disease phenotype of FA. ..
- Abraham J, Lemmers B, Hande M, Moynahan M, Chahwan C, Ciccia A, et al. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J. 2003;22:6137-47 pubmed..Most importantly, Eme1 deficiency led to spontaneous genomic instability. These results reveal that mammalian Eme1 plays a key role in DNA repair and the maintenance of genome integrity. ..