Experts and Doctors on molecular chaperones in Guelph, Ontario, Canada

Summary

Locale: Guelph, Ontario, Canada
Topic: molecular chaperones

Top Publications

  1. Bedecarrats G, Kaiser U. Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. Semin Reprod Med. 2007;25:368-78 pubmed
    ..Furthermore, given that it was recently demonstrated that pharmacological chaperones can rescue altered receptor function in vitro, potential therapeutic approaches are also discussed. ..
  2. Hodgson J, Arif B, Krell P. Role of interactions between Autographa californica multiple nucleopolyhedrovirus procathepsin and chitinase chitin-binding or active-site domains in viral cathepsin processing. J Virol. 2013;87:3471-83 pubmed publisher
  3. Nichols K, Kirby G. Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress. Biochem Pharmacol. 2008;75:1230-9 pubmed
    ..These findings do not support a central role for generalized cellular oxidative stress in the regulation of CYP2A5 and suggest that additional factors related to G6PD-deficiency, such as ER stress, may be involved. ..
  4. Kirby K, Jensen L, Binnington J, Hilliker A, Ulloa J, Culotta V, et al. Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. J Biol Chem. 2008;283:35393-401 pubmed publisher
    ..Such variation in mechanisms of copper activation of SOD1 could reflect evolutionary responses to unique oxygen and/or copper environments faced by divergent species. ..

Detail Information

Publications4

  1. Bedecarrats G, Kaiser U. Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. Semin Reprod Med. 2007;25:368-78 pubmed
    ..Furthermore, given that it was recently demonstrated that pharmacological chaperones can rescue altered receptor function in vitro, potential therapeutic approaches are also discussed. ..
  2. Hodgson J, Arif B, Krell P. Role of interactions between Autographa californica multiple nucleopolyhedrovirus procathepsin and chitinase chitin-binding or active-site domains in viral cathepsin processing. J Virol. 2013;87:3471-83 pubmed publisher
  3. Nichols K, Kirby G. Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress. Biochem Pharmacol. 2008;75:1230-9 pubmed
    ..These findings do not support a central role for generalized cellular oxidative stress in the regulation of CYP2A5 and suggest that additional factors related to G6PD-deficiency, such as ER stress, may be involved. ..
  4. Kirby K, Jensen L, Binnington J, Hilliker A, Ulloa J, Culotta V, et al. Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. J Biol Chem. 2008;283:35393-401 pubmed publisher
    ..Such variation in mechanisms of copper activation of SOD1 could reflect evolutionary responses to unique oxygen and/or copper environments faced by divergent species. ..