Experts and Doctors on mice in Ottawa, Ontario, Canada

Summary

Locale: Ottawa, Ontario, Canada
Topic: mice

Top Publications

  1. Gont A, Hanson J, Lavictoire S, Parolin D, Daneshmand M, Restall I, et al. PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1. Oncotarget. 2013;4:1266-79 pubmed
    ..Thus PTEN loss, acting via atypical protein kinase C activation and Lgl inactivation, helps to maintain GTICs in an undifferentiated state. ..
  2. Lortie K, Huang D, Chakravarthy B, Comas T, Hou S, Lin Chao S, et al. The gas7 protein potentiates NGF-mediated differentiation of PC12 cells. Brain Res. 2005;1036:27-34 pubmed
    ..The ability of gas7 to potentiate neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in the injured or diseased brain, such as following stroke. ..
  3. Artemenko Y, Gagnon A, Aubin D, Sorisky A. Anti-adipogenic effect of PDGF is reversed by PKC inhibition. J Cell Physiol. 2005;204:646-53 pubmed
  4. Jiang S, Sheldrick M, Desbois A, Slinn J, Hou S. Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo. Mol Cell Biol. 2007;27:1696-705 pubmed
    ..Taken together, these findings support a model in which E2F1 targets NRP-1 to modulate axonal damage and neuronal death in response to cerebral ischemia. ..
  5. Ryan S, Harris C, Mo F, Lee H, Hou S, Bazan N, et al. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. J Neurochem. 2007;103:88-97 pubmed
  6. Khacho M, Mekhail K, Pilon Larose K, Payette J, Lee S. Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor. Mol Cell Biol. 2008;28:302-14 pubmed
  7. Savory J, Bouchard N, Pierre V, Rijli F, De Repentigny Y, Kothary R, et al. Cdx2 regulation of posterior development through non-Hox targets. Development. 2009;136:4099-110 pubmed publisher
    ..We propose a model wherein Cdx2 functions as an integrator of caudalizing information by coordinating axial elongation and somite patterning through Hox-independent and -dependent pathways, respectively. ..
  8. Chakravarthy B, Gaudet C, Menard M, Brown L, Atkinson T, LaFerla F, et al. Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human A?(1-42) and tau. Biochem Biophys Res Commun. 2012;427:218-22 pubmed publisher
    ..These observations raise the important possibility that structural and functional changes in granule cell cilia might have a role in AD. ..
  9. Pépin D, Paradis F, Perez Iratxeta C, Picketts D, Vanderhyden B. The imitation switch ATPase Snf2l is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells. Biol Reprod. 2013;88:142 pubmed publisher
    ..These results begin to establish a role for SNF2L in the precise coordination of gene expression in granulosa cells during folliculogenesis and its broader implications in fertility. ..

More Information

Publications455 found, 100 shown here

  1. Liu Y, Wang J, Avanzato V, Bakkum Gamez J, Russell S, Bell J, et al. Oncolytic vaccinia virotherapy for endometrial cancer. Gynecol Oncol. 2014;132:722-9 pubmed publisher
    ..VV appears to be most active in type II EC. Novel therapies are needed for the highly lethal type II EC histologies and further development of a VV clinical trial in type II EC is warranted. ..
  2. DiDonato C, Parks R, Kothary R. Development of a gene therapy strategy for the restoration of survival motor neuron protein expression: implications for spinal muscular atrophy therapy. Hum Gene Ther. 2003;14:179-88 pubmed
  3. Kuang S, Kuroda K, Le Grand F, Rudnicki M. Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell. 2007;129:999-1010 pubmed
    ..These results provide critical insights into satellite cell biology and open new avenues for therapeutic treatment of neuromuscular diseases...
  4. Pejcic Karapetrovic B, Gurnani K, Russell M, Finlay B, Sad S, Krishnan L. Pregnancy impairs the innate immune resistance to Salmonella typhimurium leading to rapid fatal infection. J Immunol. 2007;179:6088-96 pubmed
    ..Thus, highly virulent pathogens may use placental invasion to alter systemic host resistance to infection. ..
  5. KuoLee R, Zhou H, Harris G, Zhao X, Qiu H, Patel G, et al. Inhibition of airway eosinophilia and pulmonary pathology in a mouse model of allergic asthma by the live vaccine strain of Francisella tularensis. Clin Exp Allergy. 2008;38:1003-15 pubmed publisher
  6. Ryan S, Whitehead S, Swayne L, Moffat T, Hou W, Ethier M, et al. Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci U S A. 2009;106:20936-41 pubmed publisher
    ..Together, these data provide mechanistic insight into how disruptions in lipid metabolism can determine neuronal response to accumulating oligomeric amyloid-beta(42). ..
  7. Miura P, Coriati A, Belanger G, De Repentigny Y, Lee J, Kothary R, et al. The utrophin A 5'-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2. Hum Mol Genet. 2010;19:1211-20 pubmed publisher
    ..The trans-factors and signaling pathways driving skeletal-muscle specific IRES-mediated translation of utrophin A could provide unique targets for developing pharmacological-based DMD therapies. ..
  8. Evgin L, Vaha Koskela M, Rintoul J, Falls T, Le Boeuf F, Barrett J, et al. Potent oncolytic activity of raccoonpox virus in the absence of natural pathogenicity. Mol Ther. 2010;18:896-902 pubmed publisher
    ..RCNV treatment also prolonged survival in treatment-resistant models of brain tumors and decreased tumor burden by systemic administration in models of lung metastasis...
  9. Ryan S, Bhanot K, Ferrier A, De Repentigny Y, Chu A, Blais A, et al. Microtubule stability, Golgi organization, and transport flux require dystonin-a2-MAP1B interaction. J Cell Biol. 2012;196:727-42 pubmed publisher
    ..These cellular aberrations are apparent in prephenotype dorsal root ganglia and primary sensory neurons from dt mice, suggesting they are causal in the disorder. ..
  10. Krishnan L, Nguyen T, McComb S. From mice to women: the conundrum of immunity to infection during pregnancy. J Reprod Immunol. 2013;97:62-73 pubmed publisher
    ..Murine feto-placental infection provides an effective way to evaluate new intervention strategies for managing infections during pregnancy, adverse fetal outcome and long-term effects on the offspring and mother. ..
  11. Ghahremani M, Keramaris E, Shree T, Xia Z, Davis R, Flavell R, et al. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. J Biol Chem. 2002;277:35586-96 pubmed
    ..Finally, c-Jun activation is independent of p53 and Bax. Accordingly, we propose that c-Jun is regulated by the JNK and CDK pathways and that both must be activated for efficient c-Jun activation to occur. ..
  12. Gill U, Chu I, Ryan J, Feeley M. Polybrominated diphenyl ethers: human tissue levels and toxicology. Rev Environ Contam Toxicol. 2004;183:55-97 pubmed
    ..However, no toxicokinetics data are available for humans, and the actual margin of safety may be much smaller if based on levels in critical target organs or tissues. ..
  13. Krishnan L, Gurnani K, Dicaire C, van Faassen H, Zafer A, Kirschning C, et al. Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2. J Immunol. 2007;178:2396-406 pubmed
    ..Thus, an archaeosome adjuvant vaccine represents an alternative to live vectors for inducing CD8(+) T cell memory...
  14. St Michael F, Cairns C, Filion A, Neelamegan D, Lacelle S, Cox A. Investigating the candidacy of lipopolysaccharide-based glycoconjugates as vaccines to combat Mannheimia haemolytica. Glycoconj J. 2011;28:397-410 pubmed publisher
  15. McQuaid R, Audet M, Jacobson Pick S, Anisman H. Environmental enrichment influences brain cytokine variations elicited by social defeat in mice. Psychoneuroendocrinology. 2013;38:987-96 pubmed publisher
  16. Amirouche A, Tadesse H, Miura P, Belanger G, Lunde J, Cote J, et al. Converging pathways involving microRNA-206 and the RNA-binding protein KSRP control post-transcriptionally utrophin A expression in skeletal muscle. Nucleic Acids Res. 2014;42:3982-97 pubmed publisher
    ..Our study thus reveals that two apparent negative post-transcriptional pathways can act distinctively as molecular switches causing repression or activation of utrophin A expression. ..
  17. Monemdjou S, Hofmann W, Kozak L, Harper M. Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice. Am J Physiol Endocrinol Metab. 2000;279:E941-6 pubmed
    ..Thus the altered kinetics of the mitochondrial proton leak in skeletal muscle of UCP1-deficient mice indicate a thermogenic mechanism favoring the lean phenotype of the UCP1-deficient mouse...
  18. Hebb A, Zacharko R, Gauthier M, Trudel F, Laforest S, Drolet G. Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice. Eur J Neurosci. 2004;20:2415-29 pubmed
    ..Indeed, increased ENK availability in mesolimbic sites may promote behavioral responses that detract from the aversiveness of the stressor experience. ..
  19. Tanphaichitr N, Carmona E, Bou Khalil M, Xu H, Berger T, Gerton G. New insights into sperm-zona pellucida interaction: involvement of sperm lipid rafts. Front Biosci. 2007;12:1748-66 pubmed
    ..A number of ZP binding molecules are also present in sperm lipid rafts. In this review, we have provided an argument that sperm lipid rafts may be the platforms on the sperm surface for ZP interaction. ..
  20. Wang M, Kiss R, Franklin V, McBride H, Whitman S, Marcel Y. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res. 2007;48:633-45 pubmed
    ..This indicates a greater efficiency of HDL than lipid-poor apoA-I in interstitial fluid in controlling in vivo RCT. These assays, taken together, emphasize the importance of mediators of diffusional cholesterol efflux in RCT...
  21. Tadesse H, Deschenes Furry J, Boisvenue S, Cote J. KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy. Hum Mol Genet. 2008;17:506-24 pubmed
    ..Our results suggest SMN can act as a molecular chaperone for methylated proteins involved in RNA metabolism and provide new insights into the pathophysiology of SMA. ..
  22. Haque M, Thomas K, D Souza C, Callaghan S, Kitada T, Slack R, et al. Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci U S A. 2008;105:1716-21 pubmed publisher
    ..Thus, our findings indicate that Pink1 plays a functional role in the survival of neurons and that cytoplasmic targets, in addition to its other actions in the mitochondria, may be important for this protective effect. ..
  23. Altman E, Chandan V, Larocque S, Aubry A, Logan S, Vinogradov E, et al. Effect of the HP0159 ORF mutation on the lipopolysaccharide structure and colonizing ability of Helicobacter pylori. FEMS Immunol Med Microbiol. 2008;53:204-13 pubmed publisher
    ..Colonization studies with HP0159 mutants of two mouse-colonizing strains, SS1 and M6, confirmed their inability to successfully colonize the murine stomach...
  24. Abramovici H, Mojtabaie P, Parks R, Zhong X, Koretzky G, Topham M, et al. Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell. 2009;20:2049-59 pubmed publisher
  25. Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W. Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy. PLoS ONE. 2010;5:e13349 pubmed publisher
    ..A live vaccine strain (LVS) derived from the less virulent holarctica subspecies confers incomplete protection against aerosol challenge with subsp. tularensis. Moreover, correlates of protection have not been established for LVS...
  26. Troy T, Arabzadeh A, Turksen K. Re-assessing K15 as an epidermal stem cell marker. Stem Cell Rev. 2011;7:927-34 pubmed publisher
    ..Thus, the data suggest caution in using K15 alone to delineate epidermal stem cells, and underscore the need for further investigation of K15 and other markers in epidermal cell subpopulations. ..
  27. Whitehead S, Chan K, Gangaraju S, Slinn J, Li J, Hou S. Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery. PLoS ONE. 2011;6:e20808 pubmed publisher
    ..Taken together, the data suggest that brain region specific expression of gangliosides, particularly with respect to hydrocarbon length, may play a role in neuronal responses to injury. ..
  28. Ha A, Perez Iratxeta C, Liu H, Mears A, Wallace V. Identification of Wnt/?-catenin modulated genes in the developing retina. Mol Vis. 2012;18:645-56 pubmed
    ..This data set of Li(+)-modulated genes provides a valuable resource for characterizing the Wnt/ ?-catenin regulated gene network in eyecup patterning. ..
  29. Julian L, Vandenbosch R, Pakenham C, Andrusiak M, Nguyen A, McClellan K, et al. Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. Cell Stem Cell. 2013;12:440-52 pubmed publisher
    ..Our results demonstrate a mechanism by which E2f3a and E2f3b differentially regulate Sox2 dosage in neural precursors, a finding that may have broad implications for the regulation of diverse stem cell populations. ..
  30. Julian L, Delaney S, Wang Y, Goldberg A, Dore C, Yockell Lelièvre J, et al. Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis. Cancer Res. 2017;77:5491-5502 pubmed publisher
    ..i>Cancer Res; 77(20); 5491-502. ©2017 AACR. ..
  31. Weeratna R, Brazolot Millan C, McCluskie M, Davis H. CpG ODN can re-direct the Th bias of established Th2 immune responses in adult and young mice. FEMS Immunol Med Microbiol. 2001;32:65-71 pubmed
    ..These data suggest that CpG ODN have the ability to augment both humoral and cell mediated immune responses and override the Th2 bias created by alum, even in very young animals, which are known to have a Th2 biased immune system. ..
  32. Wang Y, Dakubo G, Howley P, Campsall K, Mazarolle C, Shiga S, et al. Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat Neurosci. 2002;5:831-2 pubmed
    ..Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina. ..
  33. Huh M, Parker M, Scime A, Parks R, Rudnicki M. Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol. 2004;166:865-76 pubmed
    ..Therefore, Rb plays a crucial role in the switch from proliferation to differentiation rather than maintenance of the terminally differentiated state. ..
  34. Ghorbani M, Nass T, Azizi A, Soare C, Aucoin S, Giulivi A, et al. Comparison of antibody- and cell-mediated immune responses after intramuscular hepatitis C immunizations of BALB/c mice. Viral Immunol. 2005;18:637-48 pubmed
    ..In contrast, group C did not show an increase in anti-HCV antibodies, but did show a proliferative response. ..
  35. Hailesellasse Sene K, Porter C, Palidwor G, Perez Iratxeta C, Muro E, Campbell P, et al. Gene function in early mouse embryonic stem cell differentiation. BMC Genomics. 2007;8:85 pubmed
    ..The data generated constitute a valuable resource for further studies. All DNA microarray data used in this study are available in the StemBase database of stem cell gene expression data 1 and in the NCBI's GEO database. ..
  36. Boily G, Seifert E, Bevilacqua L, He X, Sabourin G, Estey C, et al. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE. 2008;3:e1759 pubmed publisher
    ..Thus, SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction. ..
  37. Ghanem N, Yu M, Poitras L, Rubenstein J, Ekker M. Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer. Dev Biol. 2008;322:415-24 pubmed publisher
  38. Zhang Y, Parsanejad M, Huang E, Qu D, Aleyasin H, Rousseaux M, et al. Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage. J Neurochem. 2010;112:497-510 pubmed publisher
    ..Taken together, our results demonstrate that Pim-1 kinase plays a central role in DNA damage-evoked neuronal death by regulating aberrant neuronal cell cycle activation. ..
  39. MacDonald R, Debiais Thibaud M, Martin K, Poitras L, Tay B, Venkatesh B, et al. Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice. BMC Evol Biol. 2010;10:157 pubmed publisher
  40. Rosu Myles M, Fair J, Pearce N, Mehic J. Non-multipotent stroma inhibit the proliferation and differentiation of mesenchymal stromal cells in vitro. Cytotherapy. 2010;12:818-30 pubmed publisher
  41. Poitras L, Yu M, Lesage Pelletier C, MacDonald R, Gagné J, Hatch G, et al. An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain. Development. 2010;137:3089-97 pubmed publisher
    ..This study illustrates the clear functional consequences of a single nucleotide variation in an ultraconserved non-coding sequence in the context of developmental abnormalities associated with disease. ..
  42. Haque M, Mount M, Safarpour F, Abdel Messih E, Callaghan S, Mazerolle C, et al. Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. J Biol Chem. 2012;287:23162-70 pubmed publisher
  43. Tao Y, Liu X. Deficiency of ovarian ornithine decarboxylase contributes to aging-related egg aneuploidy in mice. Aging Cell. 2013;12:42-9 pubmed publisher
    ..7% to 5.3%. Therefore, ovarian ODC deficiency might be an important etiology of maternal aging-related aneuploidies, and peri-ovulatory putrescine supplementation might reduce the risk of aneuploid conceptions in older women. ..
  44. Allen A, Messier C. Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice. Behav Brain Res. 2013;240:95-102 pubmed publisher
    ..The results tend to support the plastic association between mechanisms of energy supply and plastic reorganization of neurons following a new training experience. ..
  45. Giamberardino A, Labib M, Hassan E, Tetro J, Springthorpe S, Sattar S, et al. Ultrasensitive norovirus detection using DNA aptasensor technology. PLoS ONE. 2013;8:e79087 pubmed publisher
    ..The lead aptamer candidate and the aptasensor platform show promise for the rapid detection and identification of noroviruses in environmental and clinical samples. ..
  46. Lagacé M, Xuan J, Young S, McRoberts C, Maier J, Rajcan Separovic E, et al. Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript. Genomics. 2001;77:181-8 pubmed
    ..This testis-specific transcript contains a putative open reading frame (ORF) that is homologous to the carboxy-terminal end of BIRC4; overexpression of this ORF shows protective effects against BAX-induced apoptosis. ..
  47. Levine D, Iacovitti M, Robertson S, Mokhtar G. Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol. 2006;290:R975-81 pubmed
    ..These studies show that SNGFR is elevated in this mouse model of DM2, is suppressed by nNOS inhibition, and is modulated by TGF influences that are altered by the diabetic state and responsive to changes in extracellular fluid volume. ..
  48. Rogaeva A, Ou X, Jafar Nejad H, Lemonde S, Albert P. Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene. J Biol Chem. 2007;282:20897-905 pubmed
    ..Allele-specific regulation of DRD2 expression by Freud-1 may possibly associate with psychiatric disorders or mental retardation. ..
  49. Jarinova O, Hatch G, Poitras L, Prudhomme C, Grzyb M, Aubin J, et al. Functional resolution of duplicated hoxb5 genes in teleosts. Development. 2008;135:3543-53 pubmed publisher
    ..Our results highlight the importance of interactions between CNEs in the execution of complementary subfunctions of duplicated genes. ..
  50. Gyamera Acheampong C, Vasilescu J, Figeys D, Mbikay M. PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation. Fertil Steril. 2010;93:1112-23 pubmed publisher
    ..More investigation is needed to determine how and to what extent these changes might contribute to the loss of fertilizing ability of PCSK4-null sperm. ..
  51. Le Grand F, Jones A, Seale V, Scime A, Rudnicki M. Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell. 2009;4:535-47 pubmed publisher
    ..Therefore, Wnt7a signaling through the planar cell polarity pathway controls the homeostatic level of satellite stem cells and hence regulates the regenerative potential of muscle...
  52. Troy T, Arabzadeh A, Larivière N, Enikanolaiye A, Turksen K. Dermatitis and aging-related barrier dysfunction in transgenic mice overexpressing an epidermal-targeted claudin 6 tail deletion mutant. PLoS ONE. 2009;4:e7814 pubmed publisher
    ..These results suggest that the normally robust injury response mechanism of the epidermis is lost in the aging Involucrin-Cldn6-CDelta196 transgenic epidermis, and provide a model for evaluation of aging-related skin changes. ..
  53. Boudreau E, Labib S, Bertrand A, Decostre V, Bolongo P, Sylvius N, et al. Lamin A/C mutants disturb sumo1 localization and sumoylation in vitro and in vivo. PLoS ONE. 2012;7:e45918 pubmed publisher
    ..However, lamin A and C did not appear to be modified by sumo1. Our results suggest that mutant lamin A/C alters the dynamics of sumo1 and thus misregulation of sumoylation may be contributing to disease progression in laminopathies. ..
  54. Cox J, Fellows M, Hashizume T, White P. The utility of metabolic activation mixtures containing human hepatic post-mitochondrial supernatant (S9) for in vitro genetic toxicity assessment. Mutagenesis. 2016;31:117-30 pubmed publisher
  55. Jha J, Banal C, Okabe J, Gray S, Hettige T, Chow B, et al. NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy. Diabetes. 2017;66:2691-2703 pubmed publisher
    ..Collectively, this study provides evidence of a role for Nox5 and its derived ROS in promoting progression of diabetic nephropathy. ..
  56. Rayner K, Chen Y, McNulty M, Simard T, Zhao X, Wells D, et al. Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A. Circ Res. 2008;103:133-41 pubmed publisher
    ..HSP27 is atheroprotective, perhaps because of its ability to compete for the uptake of atherogenic lipids or attenuate inflammation. ..
  57. Luo W, Wilson A, Miller J. Characterization of a 52 kDa exoantigen of Penicillium chrysogenum and monoclonal antibodies suitable for its detection. Mycopathologia. 2010;169:15-26 pubmed publisher
    ..Surprisingly, it had not been reported as an allergen. The monoclonal antibodies developed have the potential for use in assays of P. chrysogenum antigens in spores and spore/mycelial fragments in dust. ..
  58. Gyamera Acheampong C, Sirois F, Denis N, Mishra P, Figeys D, Basak A, et al. The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone. Mol Cell Biochem. 2011;348:43-52 pubmed publisher
    ..These cells may lack the intracellular environment and the interacting molecules specific to testicular germ cells where this enzyme is normally expressed. ..
  59. Mailloux R, Dumouchel T, Aguer C, Dekemp R, Beanlands R, Harper M. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Biochem J. 2011;437:301-11 pubmed publisher
    ..Collectively, our findings link the anti-oxidative and metabolic functions of UCP3 through a surprising molecular connection with mitochondrial-bound HKII. ..
  60. Lafontaine C, Grainger S, Hess B, Béland M, Lohnes D. Cdx1 interacts physically with a subset of Hox proteins. Biochemistry. 2012;51:9698-705 pubmed publisher
    ..This study is the first example of Cdx-Hox protein interactions and suggests that such complexes may modulate Hox and/or Cdx function. ..
  61. Patterson Z, Khazall R, Mackay H, Anisman H, Abizaid A. Central ghrelin signaling mediates the metabolic response of C57BL/6 male mice to chronic social defeat stress. Endocrinology. 2013;154:1080-91 pubmed publisher
  62. Gangaraju S, Sultan K, Whitehead S, Nilchi L, Slinn J, Li X, et al. Cerebral endothelial expression of Robo1 affects brain infiltration of polymorphonuclear neutrophils during mouse stroke recovery. Neurobiol Dis. 2013;54:24-31 pubmed publisher
    ..During stroke recovery, a transient reduction in Robo1 expression on the cerebral endothelial cells allowed the uncontrolled infiltration of Slit1-expressing PMNs into the brain causing inflammatory reactions. ..
  63. Caravaggio J, Hasu M, MacLaren R, Thabet M, Raizman J, Veinot J, et al. Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice. Cardiovasc Pathol. 2013;22:458-64 pubmed publisher
    ..IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated A? and RAGE, and higher serum cholesterol in male, Ldlr(-/-) mice. ..
  64. Schild Poulter C, Pope L, Giffin W, Kochan J, Ngsee J, Traykova Andonova M, et al. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase. J Biol Chem. 2001;276:16848-56 pubmed
    ..These results suggest that Ku functions as a substrate docking protein for signaling by DNA-PK to homeodomain proteins from DNA ends. ..
  65. Fortin A, Cregan S, MacLaurin J, Kushwaha N, Hickman E, Thompson C, et al. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol. 2001;155:207-16 pubmed
    ..Together, these results demonstrate that Apaf1 is a key transcriptional target for p53 that plays a pivotal role in the regulation of apoptosis after neuronal injury. ..
  66. Bergeron F, Sirois F, Mbikay M. ACTH secretion by mouse corticotroph AtT20 cells is negatively modulated by the intracellular level of 7B2. FEBS Lett. 2002;512:259-62 pubmed
  67. Scime A, Grenier G, Huh M, Gillespie M, Bevilacqua L, Harper M, et al. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab. 2005;2:283-95 pubmed
    ..Therefore, p107 and pRb regulate PGC-1alpha expression to control the switch between white and brown adipocyte differentiation from a common pool of presumptive adult progenitors in fat tissue. ..
  68. Conte D, Holcik M, Lefebvre C, LaCasse E, Picketts D, Wright K, et al. Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Mol Cell Biol. 2006;26:699-708 pubmed
    ..Hence, cIAP2 is critical in the maintenance of a normal innate immune inflammatory response. ..
  69. Chen H, Schock S, Xu J, Safarpour F, Thompson C, Stewart A. Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia. Exp Cell Res. 2007;313:3106-16 pubmed
    ..Taken together, our studies reveal that LMO4 is a rapidly induced downstream effector of ATP signaling that promotes neuron survival from hypoxia. ..
  70. Halappanavar S, Stampfli M, Berndt Weis L, Williams A, Douglas G, Yauk C. Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart. Inhal Toxicol. 2009;21:78-85 pubmed
    ..Thus, gene expression profiling of heart tissue revealed a novel cardiovascular mechanism operating in response to MTS. Our results suggest a potential role for PAI-1 in MTS-induced cardiovascular pathology. ..
  71. Andrusiak M, McClellan K, Dugal Tessier D, Julian L, Rodrigues S, Park D, et al. Rb/E2F regulates expression of neogenin during neuronal migration. Mol Cell Biol. 2011;31:238-47 pubmed publisher
    ..These studies identify a novel mechanism through which Rb regulates transcription of a gene beyond the classical E2F targets to regulate events distinct from cell cycle progression. ..
  72. Savory J, Mansfield M, Rijli F, Lohnes D. Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7. Development. 2011;138:1361-70 pubmed publisher
    ..These findings illustrate a novel and pivotal role for Cdx function upstream of Ptk7 and neural tube closure in vertebrates. ..
  73. Cwinn M, Mazerolle C, McNeill B, Ringuette R, Thurig S, Hui C, et al. Suppressor of fused is required to maintain the multipotency of neural progenitor cells in the retina. J Neurosci. 2011;31:5169-80 pubmed publisher
    ..These data provide novel evidence that Sufu-mediated antagonism of Hh/Gli2 signaling is required to maintain RPC multipotency and identity. ..
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