Experts and Doctors on membrane proteins in Toronto, Ontario, Canada

Summary

Locale: Toronto, Ontario, Canada
Topic: membrane proteins

Top Publications

  1. Tanentzapf G, Tepass U. Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat Cell Biol. 2003;5:46-52 pubmed
  2. Torok D, Patel N, Jebailey L, Thong F, Randhawa V, Klip A, et al. Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts. J Cell Sci. 2004;117:5447-55 pubmed
    ..These results suggest that insulin and PDGF rely differently on the actin cytoskeleton and on tetanus-toxin-sensitive VAMPs for mobilizing GLUT4. ..
  3. van Tuyl M, Groenman F, Kuliszewski M, Ridsdale R, Wang J, Tibboel D, et al. Overexpression of lunatic fringe does not affect epithelial cell differentiation in the developing mouse lung. Am J Physiol Lung Cell Mol Physiol. 2005;288:L672-82 pubmed
    ..Collectively, the data suggest that Lunatic fringe does not play a significant role in determining cell fate in fetal airway epithelium. ..
  4. Sedgmen B, Dawicki W, Gommerman J, Pfeffer K, Watts T. LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice. Int Immunol. 2006;18:797-806 pubmed
    ..Taken together, these data suggest that LIGHT is dispensable for the acquired immune response to influenza virus in mice with no effect on the induction, maintenance or reactivation of CD8+ T cell memory. ..
  5. Fish J, Matouk C, Yeboah E, Bevan S, Khan M, Patil K, et al. Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase. J Biol Chem. 2007;282:15652-66 pubmed
  6. Blasutig I, New L, Thanabalasuriar A, Dayarathna T, Goudreault M, Quaggin S, et al. Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol. 2008;28:2035-46 pubmed publisher
    ..Together, these data identify pYDXV/Nck signaling as a potent and portable mechanism for physiological and pathological actin regulation. ..
  7. Goudreault M, D Ambrosio L, Kean M, Mullin M, Larsen B, Sanchez A, et al. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics. 2009;8:157-71 pubmed publisher
    ..We have thus identified several novel PP2A-containing protein complexes, including a large assembly linking kinases and phosphatases to a gene mutated in human disease. ..
  8. Jones R, Ndhlovu L, Barbour J, Sheth P, Jha A, Long B, et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med. 2008;205:2763-79 pubmed publisher
    ..Blocking the Tim-3 signaling pathway restored proliferation and enhanced cytokine production in HIV-1-specific T cells. Thus, Tim-3 represents a novel target for the therapeutic reversal of HIV-1-associated T cell dysfunction. ..
  9. Bagherie Lachidan M, Wright S, Kelly S. Claudin-8 and -27 tight junction proteins in puffer fish Tetraodon nigroviridis acclimated to freshwater and seawater. J Comp Physiol B. 2009;179:419-31 pubmed publisher
    ..These data provide some insight into the duplication history of cldn8 and cldn27 genes in fishes and suggest a possible role for claudin-8 and -27 proteins in the osmoregulatory strategies of euryhaline teleosts...

More Information

Publications177 found, 100 shown here

  1. Hagerman K, Ruan H, Edamura K, Matsuura T, Pearson C, Wang Y. The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions. Gene. 2009;434:29-34 pubmed publisher
    ..These differences may contribute to phenotypic variation seen between families having pure and interrupted SCA10 repeats, as well as the overall genetic instability at the SCA10 locus. ..
  2. Khatri I, Alexander C, Brandenburg K, Fournier K, Mach J, Rietschel E, et al. Induction of tolerogenic vs immunogenic dendritic cells (DCs) in the presence of GM-CSF is regulated by the strength of signaling from monophosphoryl lipid A (MPLA) in association with glutathione and fetal hemoglobin gamma-chain. Immunol Lett. 2009;124:44-9 pubmed publisher
    ..Addition of anti-TLR or anti-MD-1 mAbs to DCs developing in this mixture (Hgbgamma+GSH+MPLA), suggests that one effect of (GSH+Hgbgamma) on MPLA stimulation may involve altered signaling through TLR4. ..
  3. Tsoporis J, Overgaard C, Izhar S, Parker T. S100B modulates the hemodynamic response to norepinephrine stimulation. Am J Hypertens. 2009;22:1048-53 pubmed publisher
    ..Thus, absence of S100B is associated with attenuation of the hemodynamic response to catecholamines, in contradistinction to, the augmented cardiac hypertrophy and smooth muscle cell proliferation. ..
  4. Watts J, Huo H, Bai Y, Ehsani S, Jeon A, Won A, et al. Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. PLoS Pathog. 2009;5:e1000608 pubmed publisher
  5. Volchuk A, Ron D. The endoplasmic reticulum stress response in the pancreatic β-cell. Diabetes Obes Metab. 2010;12 Suppl 2:48-57 pubmed publisher
    ..Both could contribute to β-cell failure in diabetes. We also explore the therapeutic potential of targeting the UPR to preserve β-cell function. ..
  6. Chasiotis H, Kelly S. Effect of cortisol on permeability and tight junction protein transcript abundance in primary cultured gill epithelia from stenohaline goldfish and euryhaline trout. Gen Comp Endocrinol. 2011;172:494-504 pubmed publisher
    ..Taken together, data suggest a conservative role for cortisol in the endocrine regulation of paracellular permeability across the goldfish gill that may relate to stenohalinity. ..
  7. Whitney J, Colvin K, Marmont L, Robinson H, Parsek M, Howell P. Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa. J Biol Chem. 2012;287:23582-93 pubmed publisher
  8. Glowacka W, Alberts P, Ouchida R, Wang J, Rotin D. LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. J Biol Chem. 2012;287:27691-702 pubmed publisher
    ..They also highlight a role for the endosomal/lysosomal system in regulating signaling via cytokine and pattern recognition receptors. ..
  9. Srejic L, Hutchison W, Aarts M. Uncoupling PSD-95 interactions leads to rapid recovery of cortical function after focal stroke. J Cereb Blood Flow Metab. 2013;33:1937-43 pubmed publisher
    ..05). Tat-NR2B9c significantly reduces stroke-related cortical dysfunction as evidenced by greater recovery of fEPs and EEG power; illustrating the immediate effects of the compound on poststroke brain function. ..
  10. Huang X, Taeb S, Jahangiri S, Emmenegger U, Tran E, Bruce J, et al. miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1. Cancer Res. 2013;73:6972-86 pubmed publisher
    ..Finally, miR-95 expression was increased in human prostate and breast cancer specimens compared with normal tissue. Together, our work reveals miR-95 expression as a critical determinant of radiation resistance in cancer cells. ..
  11. Stathopulos P, Schindl R, Fahrner M, Zheng L, Gasmi Seabrook G, Muik M, et al. STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun. 2013;4:2963 pubmed publisher
    ..We conclude that SOCE is activated through dynamic interplay between STIM1 and Orai1 helices. ..
  12. Xu W, Cohen Woods S, Chen Q, Noor A, Knight J, Hosang G, et al. Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1. BMC Med Genet. 2014;15:2 pubmed publisher
  13. Dummer R, Schadendorf D, Ascierto P, Arance A, Dutriaux C, Di Giacomo A, et al. Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2017;18:435-445 pubmed publisher
    ..Binimetinib might represent a new treatment option for patients with NRAS-mutant melanoma after failure of immunotherapy. Array BioPharma and Novartis Pharmaceuticals Corporation. ..
  14. Leung Hagesteijn C, Spence A, Stern B, Zhou Y, Su M, Hedgecock E, et al. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell. 1992;71:289-99 pubmed
    ..Mosaic analysis shows that unc-5 acts in migrating cells and pioneering neurons. We propose that UNC-5 is a transmembrane receptor expressed on the surface of motile cells and growth cones to guide dorsal movements. ..
  15. Chabot B, Stephenson D, Chapman V, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. 1988;335:88-9 pubmed
    ..In addition, these observations provide the first example of a germ-line mutation in a mammalian proto-oncogene and implicate the c-kit gene as a candidate for the W locus. ..
  16. Whittle W, Gibb W, Challis J. The characterization of human amnion epithelial and mesenchymal cells: the cellular expression, activity and glucocorticoid regulation of prostaglandin output. Placenta. 2000;21:394-401 pubmed
    ..PG output and its regulation appears to differ within these two amnion cell types, dependent upon (1) substrate availability and (2) the regulation of PGHS activity. ..
  17. Merz D, Alves G, Kawano T, Zheng H, Culotti J. UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling. Dev Biol. 2003;256:173-86 pubmed
    ..We propose that UNC-52 serves dual roles in C. elegans larval development in the maintenance of muscle structure and the regulation of growth factor-like signaling pathways. ..
  18. Bolotin S, Fuller J, Bast D, de Azavedo J. The two-component system sivS/R regulates virulence in Streptococcus iniae. FEMS Immunol Med Microbiol. 2007;51:547-54 pubmed
    ..This study demonstrates that SivS/R regulates virulence in vivo, and controls the expression of a number of genes in S. iniae. ..
  19. Sing A, Pannell D, Karaiskakis A, Sturgeon K, Djabali M, Ellis J, et al. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell. 2009;138:885-97 pubmed publisher
    ..Thus, we provide evidence that similar to invertebrates, PREs act as entry sites for PcG/trxG chromatin remodeling in vertebrates. ..
  20. Zhang L, Volchuk A. p24 family type 1 transmembrane proteins are required for insulin biosynthesis and secretion in pancreatic beta-cells. FEBS Lett. 2010;584:2298-304 pubmed publisher
    ..These results suggest that p24delta1 and possibly other p24 family proteins are required for normal insulin biosynthesis and subsequent secretion in pancreatic beta-cells. ..
  21. Bakowski M, Braun V, Lam G, Yeung T, Heo W, Meyer T, et al. The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole. Cell Host Microbe. 2010;7:453-62 pubmed publisher
    ..Moreover, inducible reduction of negative charge rescues DeltasopB bacteria-containing SCVs from fusion with lysosomes. These results reveal a membrane-charge-based mechanism used by S. Typhimurium to control SCV maturation...
  22. Beites C, Xie H, Bowser R, Trimble W. The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Nat Neurosci. 1999;2:434-9 pubmed
    ..Transfection of HIT-T15 cells with wild-type CDCrel-1 inhibited secretion, whereas GTPase dominant-negative mutants enhanced secretion. These data suggest that septins may regulate vesicle dynamics through interactions with syntaxin. ..
  23. Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, et al. Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP. Neurobiol Aging. 2002;23:187-94 pubmed
    ..These results suggest that, in mice, a marked reduction of PS1-facilitated gamma-secretase activity is not detrimental to normal brain development. ..
  24. Lei G, Xue S, Chery N, Liu Q, Xu J, Kwan C, et al. Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. EMBO J. 2002;21:2977-89 pubmed
    ..Conversely, the blockade of endogenous PTPalpha inhibits NMDA receptor activity and the induction of long-term potentiation in hippocampal neurones. Thus, PTPalpha is a novel up-regulator of synaptic strength in the CNS. ..
  25. Godt D, Tepass U. Organogenesis: keeping in touch with the germ cells. Curr Biol. 2003;13:R683-5 pubmed
    ..DE-cadherin and its novel regulator, the transmembrane protein Fear of Intimacy, have been found to control the adhesive interactions between germline and somatic cells that lead to gonad formation in Drosophila. ..
  26. Du M, Zhou W, Beatty L, Weksberg R, Sadowski P. The KCNQ1OT1 promoter, a key regulator of genomic imprinting in human chromosome 11p15.5. Genomics. 2004;84:288-300 pubmed
    ..Mutation of the CCAAT boxes produced impairment of promoter activity. Transfection and gel mobility shift experiments suggest that binding of the factor NF-Y to the CCAAT boxes is important for promoter activity. ..
  27. Saibil S, Deenick E, Ohashi P. The sound of silence: modulating anergy in T lymphocytes. Curr Opin Immunol. 2007;19:658-64 pubmed
    ..Thus, the emerging view is that T cell anergy is a dynamic state whose establishment and maintenance can be influenced by numerous different signaling pathways. ..
  28. Carneiro L, Travassos L, Soares F, Tattoli I, Magalhaes J, Bozza M, et al. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe. 2009;5:123-36 pubmed publisher
  29. Wang J, Tsui H, Beier F, Tsui F. The CPPDD-associated ANKH M48T mutation interrupts the interaction of ANKH with the sodium/phosphate cotransporter PiT-1. J Rheumatol. 2009;36:1265-72 pubmed publisher
    ..Our results suggested that there is a coordinated interrelationship between 2 key participants of Pi and PPi metabolism, ANKH and PiT-1. ..
  30. Senisterra G, Ghanei H, Khutoreskaya G, Dobrovetsky E, Edwards A, Prive G, et al. Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering. J Biomol Screen. 2010;15:314-20 pubmed publisher
  31. Vali B, Jones R, Sakhdari A, Sheth P, Clayton K, Yue F, et al. HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression. Eur J Immunol. 2010;40:2493-505 pubmed publisher
    ..These data demonstrate that co-expression of Tim-3 and PD-1 may play a significant role in HCV-specific T-cell dysfunction, especially in the setting of HIV co-infection. ..
  32. Ostojic O, O Leary M, Singh K, Menzies K, Vainshtein A, Hood D. The effects of chronic muscle use and disuse on cardiolipin metabolism. J Appl Physiol (1985). 2013;114:444-52 pubmed publisher
    ..These data suggest that chronic muscle use and disuse modify the expression of mRNAs encoding CL metabolism enzymes. Our data also illustrate, for the first time, that PPAR? coactivator-1? regulates the CL metabolism pathway in muscle. ..
  33. Meng J, Ma X, Tao H, Jin X, Witvliet D, Mitchell J, et al. Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. Dev Cell. 2017;41:180-194.e7 pubmed publisher
    ..MYRF-1 and MYRF-2 are the first genes identified to be indispensable for promoting synaptic rewiring in C. elegans. These findings reveal a molecular mechanism underlying synaptic rewiring and developmental circuit plasticity. ..
  34. Khatri I, Kovacs S, Forstner J. Cloning of the cDNA for a rat intestinal Na+/dicarboxylate cotransporter reveals partial sequence homology with a rat intestinal mucin. Biochim Biophys Acta. 1996;1309:58-62 pubmed
    ..Mucin-related sequences in transporter proteins have not been described before. ..
  35. Foster L, Yeung B, Mohtashami M, Ross K, Trimble W, Klip A. Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation. Biochemistry. 1998;37:11089-96 pubmed
    ..Importantly, PKA but not casein kinase II phosphorylation of syntaxin-4 disrupted its binding to SNAP23. We hypothesize that PKA may modulate syntaxin-4-dependent SNARE complex formation to regulate exocytosis in non-neuronal cells. ..
  36. Donoviel D, Donoviel M, Fan E, Hadjantonakis A, Bernstein A. Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998;78:203-7 pubmed
    ..5 and E17.5 in the acini of the pancreas, and moderate in the epithelial cells of the gut villi. We localized the SEL-1L protein to the cytosol, possibly in intracellular vesicles, in a beta-islet-derived tumor cell line (RinM). ..
  37. Lin D, Gish G, Songyang Z, Pawson T. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem. 1999;274:3726-33 pubmed
  38. Guy R, Maguire G, Crandall I, Connelly P, Kain K. Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36. Atherosclerosis. 2001;155:19-28 pubmed
  39. Foussias G, Taylor S, Yousef G, Tropak M, Ordon M, Diamandis E. Cloning and molecular characterization of two splice variants of a new putative member of the Siglec-3-like subgroup of Siglecs. Biochem Biophys Res Commun. 2001;284:887-99 pubmed
  40. Yeh E, Dermer M, Commisso C, Zhou L, McGlade C, Boulianne G. Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr Biol. 2001;11:1675-9 pubmed
    ..These data suggest that the role of Neu is to target components of the N-Dl pathway for ubiquitination, allowing for propagation and/or regulation of the signal. ..
  41. Scorilas A, Levesque M, Ashworth L, Diamandis E. Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene. Gene. 2002;289:191-9 pubmed
    ..It is also ubiquitously expressed in tissues and in ZR-75-1 breast cancer cells and LNCaP prostate carcinoma cells as a smaller variant generated by splicing out of an exon encoding 22 amino acids in the hinge region of the protein. ..
  42. Tepass U, Godt D, Winklbauer R. Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries. Curr Opin Genet Dev. 2002;12:572-82 pubmed
    ..Further, several examples demonstrate that cell sorting in vivo can be driven by Eph/ephrin signalling and by the differential expression of cadherins that modulate cell adhesion and motility. ..
  43. Claudio J, Masih Khan E, Tang H, Goncalves J, Voralia M, Li Z, et al. A molecular compendium of genes expressed in multiple myeloma. Blood. 2002;100:2175-86 pubmed
    ..GenBank Accession numbers include BF169967-BF176369, BF185966-BF185969, and BF177280-BF177455. ..
  44. Collins R, Schreiber A, Grinstein S, Trimble W. Syntaxins 13 and 7 function at distinct steps during phagocytosis. J Immunol. 2002;169:3250-6 pubmed
    ..These results indicate that syntaxins 13 and 7 are both required for interaction of endosomes and/or lysosomes with the phagosome, but play distinct roles in the maturation process. ..
  45. Guo G, Morrison D, Licht J, Quaggin S. WT1 activates a glomerular-specific enhancer identified from the human nephrin gene. J Am Soc Nephrol. 2004;15:2851-6 pubmed
    ..Taken together, these results suggest that WT1 may be required for regulation of the NPHS1 gene in vivo. ..
  46. Eppert K, Wunder J, Aneliunas V, Tsui L, Scherer S, Andrulis I. Altered expression and deletion of RMO1 in osteosarcoma. Int J Cancer. 2005;114:738-46 pubmed
    ..Northern blot analysis indicated that RMO1 mRNA is ubiquitously expressed in tissues except for peripheral blood leukocytes. These data suggest that RMO1 may be a candidate for a protein involved in inhibiting tumor progression. ..
  47. Chen F, Hasegawa H, Schmitt Ulms G, Kawarai T, Bohm C, Katayama T, et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature. 2006;440:1208-12 pubmed
    ..Here we report that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity. ..
  48. Lamhonwah A, Hawkins C, Tam C, Wong J, Mai L, Tein I. Expression patterns of the organic cation/carnitine transporter family in adult murine brain. Brain Dev. 2008;30:31-42 pubmed
  49. Dokainish H, Gavicherla B, Shen Y, Ireton K. The carboxyl-terminal SH3 domain of the mammalian adaptor CrkII promotes internalization of Listeria monocytogenes through activation of host phosphoinositide 3-kinase. Cell Microbiol. 2007;9:2497-516 pubmed
    ..Taken together, our results indicate that the CrkII SH3C domain engages a cellular ligand that regulates PI 3 kinase activity and host cell surface rearrangements. ..
  50. Lo P, Chen J, Stefflova K, Warren M, Navab R, Bandarchi B, et al. Photodynamic molecular beacon triggered by fibroblast activation protein on cancer-associated fibroblasts for diagnosis and treatment of epithelial cancers. J Med Chem. 2009;52:358-68 pubmed publisher
    ..This study suggests that the FAP-PPB is a potentially useful tool for epithelial cancer detection and treatment. ..
  51. Badouel C, Gardano L, Amin N, Garg A, Rosenfeld R, Le Bihan T, et al. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell. 2009;16:411-20 pubmed publisher
    ..These data lead to a new model whereby Expanded functions downstream of Warts, in concert with 14-3-3 proteins to sequester Yorkie in the cytoplasm, inhibiting growth activity of the Hippo pathway. ..
  52. Tulumello D, Deber C. Positions of polar amino acids alter interactions between transmembrane segments and detergents. Biochemistry. 2011;50:3928-35 pubmed publisher
  53. Babu M, Aoki H, Chowdhury W, Gagarinova A, Graham C, Phanse S, et al. Ribosome-dependent ATPase interacts with conserved membrane protein in Escherichia coli to modulate protein synthesis and oxidative phosphorylation. PLoS ONE. 2011;6:e18510 pubmed publisher
    ..Our results suggest that RbbA appears to function together with YhjD as part of a regulatory network that impacts bacterial oxidative phosphorylation and translation efficiency. ..
  54. Xu K, Usary J, Kousis P, Prat A, Wang D, Adams J, et al. Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell. 2012;21:626-41 pubmed publisher
    ..Thus, reduced LFNG expression facilitates JAG/NOTCH luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote BLBC. ..
  55. Leung Hagesteijn C, Erdmann N, Cheung G, Keats J, Stewart A, Reece D, et al. Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. Cancer Cell. 2013;24:289-304 pubmed publisher
    ..These results reveal the tumor progenitor structure in MM and highlight its role in therapeutic failure. ..
  56. Czuczman M, Fattouh R, van Rijn J, Canadien V, Osborne S, Muise A, et al. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 2014;509:230-4 pubmed publisher
    ..Our results indicate that PS-targeted therapeutics may be useful in the fight against infections by L. monocytogenes and other bacteria that use similar strategies of cell-to-cell spread during infection. ..
  57. Olivier J, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, et al. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell. 1993;73:179-91 pubmed
    ..The conservation of these signaling proteins during evolution indicates that this is a general mechanism for linking tyrosine kinases to Ras. ..
  58. Henkemeyer M, Orioli D, Henderson J, Saxton T, Roder J, Pawson T, et al. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 1996;86:35-46 pubmed
    ..These results indicate that Nuk, a receptor that binds transmembrane ligands, plays a critical and unique role in the pathfinding of specific axons in the mammalian central nervous system. ..
  59. Chan S, Zheng H, Su M, Wilk R, Killeen M, Hedgecock E, et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell. 1996;87:187-95 pubmed
    ..Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells. ..
  60. Holland S, Gale N, Gish G, Roth R, Songyang Z, Cantley L, et al. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J. 1997;16:3877-88 pubmed
    ..These results identify an EphB2-activated signalling cascade involving proteins that potentially play a role in axonal guidance and control of cytoskeletal architecture. ..
  61. Lal G, Ash C, Hay K, Redston M, Kwong E, Hancock B, et al. Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. Cancer Res. 2001;61:6131-6 pubmed
    ..Therefore, specific COX-2 inhibitors may be useful as chemopreventive and therapeutic agents in humans at risk for colorectal neoplasia...
  62. Wong W, Newell E, Jugloff D, Jones O, Schlichter L. Cell surface targeting and clustering interactions between heterologously expressed PSD-95 and the Shal voltage-gated potassium channel, Kv4.2. J Biol Chem. 2002;277:20423-30 pubmed
    ..This work represents the first evidence that a member of the Shal subfamily of Kv channels can bind to PSD-95, with functional consequences. ..
  63. Xuan W, Lamhonwah A, Librach C, Jarvi K, Tein I. Characterization of organic cation/carnitine transporter family in human sperm. Biochem Biophys Res Commun. 2003;306:121-8 pubmed
    ..7+/-20.5 pmol/min/mg protein; n=18). Identification of individuals with defective sperm carnitine transport may provide potentially treatable etiologies of male infertility, responsive to L-carnitine supplementation. ..
  64. Arundine M, Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium. 2003;34:325-37 pubmed
    ..Thus, we summarize the importance of Ca(2+) regulation in mammalian neurons and the excitotoxicity hypothesis, and focus on the molecular determinants of glutamate receptor-mediated excitotoxic mechanisms. ..
  65. Muller D, Klempan T, De Luca V, Sicard T, Volavka J, Czobor P, et al. The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia. Neurosci Lett. 2005;379:81-9 pubmed
    ..Weight changes do not seem to be associated with polymorphism of the SNAP-25 gene, however, replication in independent samples is warranted. ..
  66. Smith A, Cirulis J, Casanova J, Scidmore M, Brumell J. Interaction of the Salmonella-containing vacuole with the endocytic recycling system. J Biol Chem. 2005;280:24634-41 pubmed
    ..We also demonstrate the utility of using Salmonella invasion as a model of endosomal recycling events. ..
  67. Connor A, Berger S, Narendran A, Keystone E. Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts. Arthritis Res Ther. 2006;8:R94 pubmed
    ..The results may also partly explain the therapeutic effect of atorvastatin in patients with RA. ..
  68. Dickson B, Mulligan A, Zhang H, Lockwood G, O Malley F, Egan S, et al. High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol. 2007;20:685-93 pubmed
  69. Jia D, Rahbar R, Fish E. Interferon-inducible Stat2 activation of JUND and CLDN4: mediators of IFN responses. J Interferon Cytokine Res. 2007;27:559-65 pubmed
    ..Our data suggest that JUND and CLDN4 are critical mediators of the antiproliferative and antiviral effects of type I IFNs and further confirm the functional importance of the DNA-binding domain of Stat2. ..
  70. Zheng L, Stathopulos P, Li G, Ikura M. Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2. Biochem Biophys Res Commun. 2008;369:240-6 pubmed publisher
    ..Our biophysical studies reveal a structural stability difference in the EF-SAM region between STIM1 and STIM2, which may account for their different biological functions. ..
  71. McPherson J, Sarras H, Lemmers B, Tamblyn L, Migon E, Matysiak Zablocki E, et al. Essential role for Bclaf1 in lung development and immune system function. Cell Death Differ. 2009;16:331-9 pubmed publisher
    ..Our findings show a critical role for Bclaf1 in developmental processes independent of apoptosis. ..
  72. Tiwari A, Zai C, Meltzer H, Lieberman J, Muller D, Kennedy J. Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients. Hum Psychopharmacol. 2010;25:253-9 pubmed publisher
    ..However, we observed a marginal effect of the rs17047764 and rs7566605 in the African-American sample. Since the latter observations were generated in a relatively small sample set, further replication studies are warranted. ..
  73. Rotin D, Staub O. Role of the ubiquitin system in regulating ion transport. Pflugers Arch. 2011;461:1-21 pubmed publisher
    ..We also briefly discuss the role of ubiquitin like molecules (such as SUMO) in such regulation, for which much less is known so far. ..
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