Experts and Doctors on hela cells in Toronto, Ontario, Canada


Locale: Toronto, Ontario, Canada
Topic: hela cells

Top Publications

  1. Smith A, Heo W, Braun V, Jiang X, Macrae C, Casanova J, et al. A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium. J Cell Biol. 2007;176:263-8 pubmed
    ..Our studies demonstrate that a complex network of Rab GTPases controls endocytic progression to lysosomes and that this is modulated by S. Typhimurium to allow its intracellular growth. ..
  2. Wasylnka J, Bakowski M, Szeto J, Ohlson M, Trimble W, Miller S, et al. Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication. Infect Immun. 2008;76:2722-35 pubmed publisher
    ..These studies reveal a novel role for myosin II in controlling SCV dynamics during infection and suggest that SopB activates myosin II. ..
  3. Spagnuolo P, Hu J, Hurren R, Wang X, Gronda M, Sukhai M, et al. The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 2010;115:4824-33 pubmed publisher
    ..Therefore, flubendazole is a novel microtubule inhibitor that displays preclinical activity in leukemia and myeloma. ..
  4. Carraro Lacroix L, Jaumouillé V, Fairn G, Grinstein S. A weak base-generating system suitable for selective manipulation of lysosomal pH. Traffic. 2011;12:1490-500 pubmed publisher
    ..This approach, which can be extended to other organelles, enables the analysis of the role of pH in selected compartments, without the confounding effects of global disturbances in pH or vesicular traffic. ..
  5. Mazhab Jafari M, Marshall C, Ho J, Ishiyama N, Stambolic V, Ikura M. Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J Biol Chem. 2014;289:12195-201 pubmed publisher
    ..Rheb G63A stimulated phosphorylation of the mTORC1 substrate p70S6 kinase more strongly than wild-type, thus offering a new tool for mammalian target of rapamycin (mTOR) signaling. ..
  6. McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, et al. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature. 1997;385:357-61 pubmed
  7. Travassos L, Carneiro L, Ramjeet M, Hussey S, Kim Y, Magalhaes J, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol. 2010;11:55-62 pubmed publisher
    ..Our results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease. ..
  8. Wang Y, Nartiss Y, Steipe B, McQuibban G, Kim P. ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy. 2012;8:1462-76 pubmed publisher
    ..Together, our results suggest that ROS-induced mitochondrial damage may be an important upstream activator of mitophagy. ..
  9. Dellaire G, Eskiw C, Dehghani H, Ching R, Bazett Jones D. Mitotic accumulations of PML protein contribute to the re-establishment of PML nuclear bodies in G1. J Cell Sci. 2006;119:1034-42 pubmed
    ..The recycling of PML protein from one cell cycle to the next via mitotic accumulations may represent a common mechanism for the partitioning of other nuclear bodies during mitosis...

More Information

Publications180 found, 100 shown here

  1. Ming A, Yoo E, Vorontsov E, Altamentova S, Kilkenny D, Rocheleau J. Dynamics and Distribution of Klotho? (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex. J Biol Chem. 2012;287:19997-20006 pubmed publisher
    ..Overall, these data suggest that KLB and FGFR1 form a 1:1 heterocomplex independent of the galectin lattice that transitions to a 1:2 complex upon the addition of FGF21. ..
  2. Hart T, Moffat J. BAGEL: a computational framework for identifying essential genes from pooled library screens. BMC Bioinformatics. 2016;17:164 pubmed publisher
    ..BAGEL shows high sensitivity and specificity even across screens performed by different labs using different libraries and reagents. ..
  3. Goudreault M, D Ambrosio L, Kean M, Mullin M, Larsen B, Sanchez A, et al. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics. 2009;8:157-71 pubmed publisher
    ..We have thus identified several novel PP2A-containing protein complexes, including a large assembly linking kinases and phosphatases to a gene mutated in human disease. ..
  4. Wilde A. "HURP on" we're off to the kinetochore!. J Cell Biol. 2006;173:829-31 pubmed
    ..However, three recent papers (Koffa et al., 2006; Sillje et al., 2006; Wong and Fang, 2006) have identified a single factor, HURP, that may encompass both of these properties. ..
  5. Bronte Tinkew D, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, et al. Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res. 2009;69:632-9 pubmed publisher
    ..Collectively, these results indicate that H. pylori CagA activates the STAT3 signaling pathway in vitro and in vivo, providing a potential mechanism by which chronic H. pylori infection promotes the development of gastric cancer. ..
  6. Sarkari F, Sanchez Alcaraz T, Wang S, Holowaty M, Sheng Y, Frappier L. EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog. 2009;5:e1000624 pubmed publisher
    ..The results indicate that USP7 can stimulate EBNA1-DNA interactions and that EBNA1 can alter histone modification at oriP through recruitment of USP7. ..
  7. Harrington L, Zhou W, McPhail T, Oulton R, Yeung D, Mar V, et al. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 1997;11:3109-15 pubmed
    ..These results suggest that telomerase is an evolutionarily conserved multisubunit complex composed of both structural and catalytic subunits. ..
  8. Fuse K, Chan G, Liu Y, Gudgeon P, Husain M, Chen M, et al. Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production. Circulation. 2005;112:2276-85 pubmed
    ..Absence of MyD88 confers host protection possibly through novel direct activation of IRF-3 and IFN-beta. ..
  9. Calarco J, Xing Y, Cáceres M, Calarco J, Xiao X, Pan Q, et al. Global analysis of alternative splicing differences between humans and chimpanzees. Genes Dev. 2007;21:2963-75 pubmed
    ..The results of this study thus support an important role for alternative splicing in establishing differences between humans and chimpanzees. ..
  10. Tattoli I, Sorbara M, Yang C, Tooze S, Philpott D, Girardin S. Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J. 2013;32:3066-78 pubmed publisher
    ..Thus, our results uncover a critical role for Listeria phospholipases C in the inhibition of autophagic flux, favouring bacterial escape from host autophagic defense. ..
  11. Beattie T, Zhou W, Robinson M, Harrington L. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol Biol Cell. 2000;11:3329-40 pubmed
    ..These results establish that the human telomerase RT possesses unique polymerization determinants that distinguish it from other RTs. ..
  12. Rosonina E, Ip J, Calarco J, Bakowski M, Emili A, McCracken S, et al. Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo. Mol Cell Biol. 2005;25:6734-46 pubmed
    ..Collectively, these results suggest that the recruitment of PSF to activated promoters and the pol II CTD provides a mechanism by which transcription and pre-mRNA processing are coordinated within the cell. ..
  13. Gomez Ferreria M, Bashkurov M, Mullin M, Gingras A, Pelletier L. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. Cell Cycle. 2012;11:3555-8 pubmed publisher
  14. Salmena L, Lam V, McPherson J, Goldenberg G. Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression. Biochem Pharmacol. 2001;61:795-802 pubmed
    ..This study provides evidence for a role of the ubiquitin-proteasome pathway in the cell cycle-dependent regulation of topo IIalpha expression. ..
  15. Ambekar C, Das B, Yeger H, Dror Y. SBDS-deficiency results in deregulation of reactive oxygen species leading to increased cell death and decreased cell growth. Pediatr Blood Cancer. 2010;55:1138-44 pubmed publisher
    ..Increased baseline and Fas-mediated ROS levels in SBDS-deficient cells can enhance the sensitivity to Fas stimulation. By balancing ROS levels, antioxidants can improve cell growth and survival in SBDS-deficient cells. ..
  16. Lee Y, Jeon H, Lee J, Hong J, Do I, Choi C, et al. Dynamin 2 Inhibitors as Novel Therapeutic Agents Against Cervical Cancer Cells. Anticancer Res. 2016;36:6381-6388 pubmed
    ..Targeting dynamin 2 may be a promising new approach for the treatment of cervical cancer. ..
  17. Ma N, Tikhomirov G, Kelley S. Nucleic acid-passivated semiconductor nanocrystals: biomolecular templating of form and function. Acc Chem Res. 2010;43:173-80 pubmed publisher
    ..Overall, this approach could make nanocrystal lumiphores more readily accessible to researchers working in the biological sciences. ..
  18. Jiang Z, Mak T, Sen G, Li X. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A. 2004;101:3533-8 pubmed
    ..Therefore, double-stranded RNA-induced TLR3/TRIF-mediated NF-kappaB and IRF3 activation diverge at TRIF. ..
  19. Sarantis H, Gray Owen S. The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway. Cell Microbiol. 2007;9:2167-80 pubmed
  20. Shi Y, Liu Y, Murdin A, Raudonikiene Mancevski A, Ayach B, Yu Z, et al. Chlamydophila pneumoniae inhibits differentiation of progenitor adipose cells and impairs insulin signaling. J Infect Dis. 2008;197:439-48 pubmed publisher
    ..We demonstrate for the first time that C. pneumoniae can infect murine pre- and postdifferentiated adipocytes and, through a TNF-alpha-mediated inflammatory mechanism, can impair differentiation and insulin signaling. ..
  21. Asai K, Platt C, Cochrane A. Control of HIV-1 env RNA splicing and transport: investigating the role of hnRNP A1 in exon splicing silencer (ESS3a) function. Virology. 2003;314:229-42 pubmed
    ..Consistent with this hypothesis, replacement of ESS3a with consensus hnRNP A1 binding sites was found to be insufficient to block Rev-mediated RNA export. ..
  22. Ni Z, Karaskov E, Yu T, Callaghan S, Der S, Park D, et al. Apical role for BRG1 in cytokine-induced promoter assembly. Proc Natl Acad Sci U S A. 2005;102:14611-6 pubmed
    ..Furthermore, BRG1 is required for IFN-induced restriction enzyme and DNase I accessibility at promoters. Thus, BRG1 has an apical role in cytokine-induced promoter assembly, acting upstream of STAT complexes at multiple IFN target loci. ..
  23. Goldenberg N, Grinstein S, Silverman M. Golgi-bound Rab34 is a novel member of the secretory pathway. Mol Biol Cell. 2007;18:4762-71 pubmed
    ..Further, brefeldin A treatment revealed that Rab34 effects intra-Golgi transport, not exit from the trans-Golgi network. Collectively, these results define Rab34 as a novel member of the secretory pathway acting at the Golgi. ..
  24. Booth J, Telio D, Liao E, McCaw S, Matsuo T, Grinstein S, et al. Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. J Biol Chem. 2003;278:14037-45 pubmed
  25. Block G, Eskiw C, Dellaire G, Bazett Jones D. Transcriptional regulation is affected by subnuclear targeting of reporter plasmids to PML nuclear bodies. Mol Cell Biol. 2006;26:8814-25 pubmed
    ..Our findings demonstrate that transient transcription assays are sensitive to the subnuclear localization of the transgene plasmid. ..
  26. Couzens A, Saridakis V, Scheid M. The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity. Biochem J. 2009;419:141-8 pubmed publisher
    ..These results support the rationale for development of small-molecule inhibitors designed to block ROCK activation by selectively interfering with hydrophobic motif-mediated activation-state transition and dimer formation. ..
  27. Roy D, Power A, Bourgeois Daigneault M, Falls T, Ferreira L, Stern A, et al. Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy. J Control Release. 2015;220:210-221 pubmed publisher
    ..These transporters have immense therapeutic potential as they can be modified to express large banks of biotherapeutics with complementary activities that enhance anti-tumor activity. ..
  28. Smith A, Cirulis J, Casanova J, Scidmore M, Brumell J. Interaction of the Salmonella-containing vacuole with the endocytic recycling system. J Biol Chem. 2005;280:24634-41 pubmed
    ..We also demonstrate the utility of using Salmonella invasion as a model of endosomal recycling events. ..
  29. Liu J, Fairn G, Ceccarelli D, Sicheri F, Wilde A. Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin. Curr Biol. 2012;22:64-9 pubmed publisher
    ..These data demonstrate that the anillin PH domain has two functions: targeting anillin to the furrow by binding to PI(4,5)P(2) to maintain furrow organization and recruiting septins to the furrow. ..
  30. Cochrane A. HIV-1 Rev function and RNA nuclear-cytoplasmic export. Methods Mol Biol. 2014;1087:103-14 pubmed publisher
    ..Here, I describe procedures to evaluate each of these aspects of Rev/Rex function. ..
  31. Shahnazari S, Namolovan A, Mogridge J, Kim P, Brumell J. Bacterial toxins can inhibit host cell autophagy through cAMP generation. Autophagy. 2011;7:957-65 pubmed
    ..These findings demonstrate that cAMP-elevating toxins, representing a large group of bacterial virulence factors, can inhibit host autophagy to suppress immune responses and modulate host cell physiology. ..
  32. Teodoro T, Odisho T, Sidorova E, Volchuk A. Pancreatic ?-cells depend on basal expression of active ATF6?-p50 for cell survival even under nonstress conditions. Am J Physiol Cell Physiol. 2012;302:C992-1003 pubmed publisher
    ..These results suggest that ATF6? may have a role in maintaining ?-cell survival even in the absence of ER stress. ..
  33. Naeeni A, Conte M, Bayfield M. RNA chaperone activity of human La protein is mediated by variant RNA recognition motif. J Biol Chem. 2012;287:5472-82 pubmed publisher
    ..This work delineates the structural elements required for La-mediated RNA chaperone activity and provides a basis for understanding how La can enhance the folding of its various RNA targets...
  34. Mazhab Jafari M, Marshall C, Ishiyama N, Ho J, Di Palma V, Stambolic V, et al. An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis. Structure. 2012;20:1528-39 pubmed publisher
    ..We demonstrate that the opposing functions of Tyr35 in the intrinsic and GAP-stimulated GTP catalysis are critical for optimal mTORC1 regulation. ..
  35. Kim M, Froese C, Xie H, Trimble W. Uncovering principles that control septin-septin interactions. J Biol Chem. 2012;287:30406-13 pubmed publisher
    ..In addition, all promiscuous septin pairwise interactions occur at the G interface. These findings suggest that G interface interactions must occur before NC interactions during polymer formation. ..
  36. Comartin D, Gupta G, Fussner E, Coyaud E, Hasegan M, Archinti M, et al. CEP120 and SPICE1 cooperate with CPAP in centriole elongation. Curr Biol. 2013;23:1360-6 pubmed publisher
    ..Furthermore, CEP120 or CPAP overexpression results in excessive centriole elongation, a process dependent on CEP120, SPICE1, and CPAP. Our findings identify a shared function for these proteins in centriole length control. ..
  37. Wang H, Gao M, Li L, Wang B, Hori N, Sato K. Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. Genomics. 2007;89:59-69 pubmed
    ..ZCRB1 mRNA expression is specifically elevated in hepatocarcinoma HepG2 cells. These data provide new clues for further understanding of morphine dependence, heat shock, and hepatocarcinoma. ..
  38. Braun V, Wong A, Landekic M, Hong W, Grinstein S, Brumell J. Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole. Cell Microbiol. 2010;12:1352-67 pubmed publisher
    ..Moreover, the formation of Salmonella-induced filaments (Sifs) was altered by SNX3 knock-down. Therefore, SNX3 plays a significant role in regulating the maturation of SCVs. ..
  39. Shih S, Barbulovic Nad I, Yang X, Fobel R, Wheeler A. Digital microfluidics with impedance sensing for integrated cell culture and analysis. Biosens Bioelectron. 2013;42:314-20 pubmed publisher
    ..We propose that this system will be useful for the growing number of scientists who are seeking methods other than fluorescence or cell sorting to analyze adherent cells in situ. ..
  40. Marchant D, Bellac C, Moraes T, Wadsworth S, Dufour A, Butler G, et al. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat Med. 2014;20:493-502 pubmed publisher
    ..These findings suggest that inhibiting extracellular MMP-12 could be a new avenue for the development of antiviral treatments...
  41. Dokainish H, Gavicherla B, Shen Y, Ireton K. The carboxyl-terminal SH3 domain of the mammalian adaptor CrkII promotes internalization of Listeria monocytogenes through activation of host phosphoinositide 3-kinase. Cell Microbiol. 2007;9:2497-516 pubmed
    ..Taken together, our results indicate that the CrkII SH3C domain engages a cellular ligand that regulates PI 3 kinase activity and host cell surface rearrangements. ..
  42. Kim M, Froese C, Estey M, Trimble W. SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission. J Cell Biol. 2011;195:815-26 pubmed publisher
    ..These data suggest that mammalian SEPT9 holds a terminal position in the septin octamers, mediating abscission-specific polymerization during cytokinesis. ..
  43. Wong J, Li P, Klamut H. A novel p53 transcriptional repressor element (p53TRE) and the asymmetrical contribution of two p53 binding sites modulate the response of the placental transforming growth factor-beta promoter to p53. J Biol Chem. 2002;277:26699-707 pubmed
    ..A p53 suppressor element and asymmetric p53 binding sites may participate determining the activation thresholds of p53-responsive promoters in a cell- and context-specific manner. ..
  44. Lechardeur D, Dougaparsad S, Nemes C, Lukacs G. Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells. J Biol Chem. 2005;280:40216-25 pubmed
    ..In apoptotic cells, endogenous and exogenous CAD forms limited oligomers, representing the active nuclease. A model is proposed for the rearrangement of the DFF subunit stoichiometry in cells undergoing programmed cell death. ..
  45. Su M, Lee D, Ganss B, Sodek J. Stereochemical analysis of the functional significance of the conserved inverted CCAAT and TATA elements in the rat bone sialoprotein gene promoter. J Biol Chem. 2006;281:9882-90 pubmed
    ..Thus, the precise location and orientation of the CCAAT element is necessary for optimizing basal transcription of the bone sialoprotein gene. ..
  46. Sadovski O, Jaikaran A, Samanta S, Fabian M, Dowling R, Sonenberg N, et al. A collection of caged compounds for probing roles of local translation in neurobiology. Bioorg Med Chem. 2010;18:7746-52 pubmed publisher
  47. Huang J, Birmingham C, Shahnazari S, Shiu J, Zheng Y, Smith A, et al. Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy. 2011;7:17-26 pubmed
    ..Our data suggest that antibacterial autophagy occurs at omegasomes and reveal that the Rab1 GTPase plays a crucial role in mammalian autophagy. ..
  48. Dho S, Trejo J, Siderovski D, McGlade C. Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell. 2006;17:4142-55 pubmed
    ..Our data indicate that membrane localization of Numb is dynamically regulated by GPCR-activated phospholipid hydrolysis and PKC-dependent phosphorylation events. ..
  49. Milyavsky M, Gan O, Trottier M, Komosa M, Tabach O, Notta F, et al. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell. 2010;7:186-97 pubmed publisher
    ..Our data reveal distinct physiological roles of p53 that together ensure optimal HSC function: apoptosis regulation and prevention of gammaH2AX foci accumulation upon HSC self-renewal. ..
  50. Wallace I, Urbanus M, Luciani G, Burns A, Han M, Wang H, et al. Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chem Biol. 2011;18:1273-83 pubmed publisher
    ..As community resources, the ~7500 growth-inhibitory molecules have been made commercially available and the computational model and filter used are provided. ..
  51. Truong D, Brabant D, Bashkurov M, Wan L, Braun V, Heo W, et al. Formin-mediated actin polymerization promotes Salmonella invasion. Cell Microbiol. 2013;15:2051-63 pubmed publisher
    ..Together, our studies revealan important phospho-dependent FHOD1 actin polymerization pathway in Salmonella invasion. ..
  52. Sakwe A, Nguyen T, Athanasopoulos V, Shire K, Frappier L. Identification and characterization of a novel component of the human minichromosome maintenance complex. Mol Cell Biol. 2007;27:3044-55 pubmed
    ..The results indicate that multicellular eukaryotes contain two types of hexameric MCM complexes with unique properties and functions. ..
  53. Ni Z, Abou El Hassan M, Xu Z, Yu T, Bremner R. The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers. Nat Immunol. 2008;9:785-93 pubmed publisher
    ..Like BRG1, each remote element was critical for the induction of CIITA expression. Thus, BRG1 regulates CIITA through many interdependent remote enhancers, not through the promoter alone. ..
  54. Wang J, Warner J, Erdmann N, Lansdorp P, Harrington L, Dick J. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. Proc Natl Acad Sci U S A. 2005;102:14398-403 pubmed
  55. Rujkijyanont P, Watanabe K, Ambekar C, Wang H, Schimmer A, Beyene J, et al. SBDS-deficient cells undergo accelerated apoptosis through the Fas-pathway. Haematologica. 2008;93:363-71 pubmed publisher
    ..Our work provides new data about the pro-survival properties of SBDS, whose inhibition results in accelerated apoptosis through the Fas pathway. ..
  56. Soros V, Carvajal H, Richard S, Cochrane A. Inhibition of human immunodeficiency virus type 1 Rev function by a dominant-negative mutant of Sam68 through sequestration of unspliced RNA at perinuclear bundles. J Virol. 2001;75:8203-15 pubmed
    ..We demonstrate that Sam68DeltaC causes perinuclear accumulation of unspliced HIV env RNA and propose that Sam68DeltaC inhibits Rev activity by sequestering Rev-responsive RNA away from the translation apparatus. ..
  57. Yamada T, Carson A, Caniggia I, Umebayashi K, Yoshimori T, Nakabayashi K, et al. Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. J Biol Chem. 2005;280:18283-90 pubmed
    ..Moreover, APG9L2 is a vertebrate-specific gene that may have gained critical roles in mammalian-specific developmental events, such as placentation, through rapid evolution. ..
  58. Kay J, Koivusalo M, Ma X, Wohland T, Grinstein S. Phosphatidylserine dynamics in cellular membranes. Mol Biol Cell. 2012;23:2198-212 pubmed publisher
    ..Our data provide new insights into properties of PS inside cells and suggest mechanisms to account for the subcellular distribution and function of this phospholipid. ..
  59. O Donnell L, Panier S, Wildenhain J, Tkach J, Al Hakim A, Landry M, et al. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell. 2010;40:619-31 pubmed publisher
    ..These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks. ..
  60. Blanch A, Robinson F, Watson I, Cheng L, Irwin M. Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity. PLoS ONE. 2013;8:e66436 pubmed publisher
    ..These findings identify a novel mechanism of regulation of the p53 family of proteins by eEF1A1 providing additional insight into potential targets to sensitize tumors to chemotherapy. ..
  61. Couzens A, Knight J, Kean M, Teo G, Weiss A, Dunham W, et al. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013;6:rs15 pubmed publisher
    ..Collectively, our results indicated that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo signaling, providing a putative mechanism for pathway regulation. ..
  62. Suen T, Goss P. Transcription of BRCA1 is dependent on the formation of a specific protein-DNA complex on the minimal BRCA1 Bi-directional promoter. J Biol Chem. 1999;274:31297-304 pubmed
  63. Liu P, Aitken K, Kong Y, Opavsky M, Martino T, Dawood F, et al. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med. 2000;6:429-34 pubmed
    ..These data identify a previously unknown function of Src family kinases and indicate that p56lck is the essential host factor that controls the replication and pathogenicity of CVB3. ..
  64. Ronaldson P, Bendayan R. HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells. J Neurochem. 2008;106:1298-313 pubmed publisher
    ..Our observation of increased GSH/GSSG efflux in response to gp120 treatment implies that Mrp isoforms may be involved in regulating the oxidative stress response in glial cells. ..
  65. Zheng L, Stathopulos P, Schindl R, Li G, Romanin C, Ikura M. Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry. Proc Natl Acad Sci U S A. 2011;108:1337-42 pubmed publisher
    ..Together, our data suggest that divergent Ca(2+)- and SAM-dependent stabilization of the EF-SAM fold contributes to the disparate regulation of store-operated Ca(2+) entry by STIM1 and STIM2. ..
  66. Johswich K, McCaw S, Islam E, Sintsova A, Gu A, Shively J, et al. In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa. PLoS Pathog. 2013;9:e1003509 pubmed publisher
  67. Prosser S, Sahota N, Pelletier L, Morrison C, Fry A. Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis. J Cell Biol. 2015;209:339-48 pubmed publisher
    ..Hence, Nek5 is required for the loss of centrosome linker proteins and enhanced microtubule nucleation that lead to timely centrosome separation and bipolar spindle formation in mitosis. ..
  68. Gao Y, Jheon A, Nourkeyhani H, Kobayashi H, Ganss B. Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene. Gene. 2004;341:101-10 pubmed
    ..13 by fluorescent in situ hybridization (FISH). The identification and initial characterization of the SP7 gene will facilitate the study of the molecular regulation of osteoblast differentiation in humans. ..
  69. Abou El Hassan M, Bremner R. A rapid simple approach to quantify chromosome conformation capture. Nucleic Acids Res. 2009;37:e35 pubmed publisher
    ..Our data suggest that basal and induced looping is a involving remote enhancers is a common mechanism at IFNgamma-regulated targets. ..
  70. Athukorala Y, Trang S, Kwok C, Yuan Y. Antiproliferative and Antioxidant Activities and Mycosporine-Like Amino Acid Profiles of Wild-Harvested and Cultivated Edible Canadian Marine Red Macroalgae. Molecules. 2016;21:E119 pubmed publisher
    ..Thus, extracts rich in low-polarity usujirene and polar palythine and asterina-330 MAAs were antiproliferative as inducers of apoptosis in HeLa cells. ..
  71. Fish J, Matouk C, Rachlis A, Lin S, Tai S, D Abreo C, et al. The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. J Biol Chem. 2005;280:24824-38 pubmed
    ..Taken together, these findings provide strong evidence that the endothelial cell-specific expression of eNOS is controlled by cell-specific histone modifications. ..
  72. Cochrane A, Murley L, Gao M, Wong R, Clayton K, Brufatto N, et al. Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function. Virology. 2009;388:103-11 pubmed publisher
    ..The results suggest that Nap-1 may influence Rev function by increasing the availability of Rev. ..
  73. Fan X, Tkachyova I, Sinha A, Rigat B, Mahuran D. Characterization of the biosynthesis, processing and kinetic mechanism of action of the enzyme deficient in mucopolysaccharidosis IIIC. PLoS ONE. 2011;6:e24951 pubmed publisher
    ..e., N-acetyltransferase does not operate through a ping-pong mechanism as previously reported. We confirm this conclusion by demonstrating experimentally that no acetylated enzyme intermediate is formed during the reaction. ..
  74. Huang H, Zeqiraj E, Dong B, Jha B, Duffy N, Orlicky S, et al. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Mol Cell. 2014;53:221-34 pubmed publisher
    ..The involvement of the pseudokinase domain of RNase L in 2-5A sensing, nucleotide binding, dimerization, and ribonuclease functions highlights the evolutionary adaptability of the eukaryotic protein kinase fold. ..
  75. Fan X, Zhang H, Zhang S, Bagshaw R, Tropak M, Callahan J, et al. Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C). Am J Hum Genet. 2006;79:738-44 pubmed
    ..Mutational analyses of two MPS IIIC cell lines identified a splice-junction mutation that accounted for three mutant alleles, and a single base-pair insertion accounted for the fourth. ..
  76. Escribano D az C, Orthwein A, Fradet Turcotte A, Xing M, Young J, Tk J, et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell. 2013;49:872-83 pubmed publisher
    ..This work therefore identifies a cell cycle-regulated circuit, underpinned by RIF1 and BRCA1, that governs DSB repair pathway choice to ensure that NHEJ dominates in G1 and HR is favored from S phase onward...
  77. Schlam D, Bohdanowicz M, Chatgilialoglu A, Chatilialoglu A, Steinberg B, Ueyama T, et al. Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. J Biol Chem. 2013;288:23090-104 pubmed publisher
    ..The resulting heterogeneity in phagosome responsiveness could enable the survival of a fraction of invading microorganisms. ..
  78. Plant P, Correa J, Goldenberg N, Bain J, Batt J. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. Biochem J. 2009;419:57-63 pubmed publisher
    ..MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown. ..
  79. Priston M, Kozlowski K, Gill D, Letwin K, Buys Y, Levin A, et al. Functional analyses of two newly identified PITX2 mutants reveal a novel molecular mechanism for Axenfeld-Rieger syndrome. Hum Mol Genet. 2001;10:1631-8 pubmed
    ..We conclude that increased activity of one PITX2 allele may be as physiologically disruptive as a mutation that nullifies a PITX2 allele, with either condition resulting in ARS. ..
  80. Eberhard Y, Gronda M, Hurren R, Datti A, MacLean N, Ketela T, et al. Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget. 2011;2:186-96 pubmed
    ..Thus, inhibition of SREBP1 or its downstream target fatty acid synthase sensitizes resistant cells to death ligands. ..
  81. Deosaran E, Larsen K, Hua R, Sargent G, Wang Y, Kim S, et al. NBR1 acts as an autophagy receptor for peroxisomes. J Cell Sci. 2013;126:939-52 pubmed publisher
    ..Although p62 is not required when NBR1 is in excess, its binding to NBR1 increases the efficiency of NBR1-mediated pexophagy. Together, these results suggest that NBR1 is the specific autophagy receptor for pexophagy...
  82. Gee M, Tsuchida R, Eichler Jonsson C, Das B, Baruchel S, Malkin D. Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid. Oncogene. 2005;24:8025-37 pubmed
    ..These data suggest that autocrine VEGF signalling likely influences RMS growth and its inhibition may be an effective treatment for RMS. ..
  83. Ronaldson P, Ashraf T, Bendayan R. Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways. Mol Pharmacol. 2010;77:644-59 pubmed publisher
    ..Furthermore, our results imply that both NF-kappaB and JNK signaling are involved in Mrp1 regulation during an HIV-1 associated inflammatory response. ..
  84. Benko S, Magalhaes J, Philpott D, Girardin S. NLRC5 limits the activation of inflammatory pathways. J Immunol. 2010;185:1681-91 pubmed publisher
    ..Strikingly, NLRC5 expression was also found to be critical for LPS-induced IL-10 production in RAW264.7 macrophages. Collectively, our results identify NLRC5 as a negative modulator of inflammatory pathways. ..
  85. Wang A, Forman Kay J, Luo Y, Luo M, Chow Y, Plumb J, et al. Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. Hum Mol Genet. 1997;6:2117-26 pubmed
    ..Hprp3p and Hprp4p have been shown to interact with each other and the first 100 amino acids of Hprp3p are not essential for this interaction. These experiments suggest that both Hprp3p and Hprp4p are components of human spliceosomes. ..
  86. McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson J, et al. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. J Biol Chem. 2005;280:42227-36 pubmed
    ..Co-immunoprecipitation and co-localization experiments, as well as combinatorial RNA interference in Caenorhabditis elegans, support the existence of conserved and functional interactions between SRm160 and cohesin. ..
  87. Jagannathan M, Sakwe A, Nguyen T, Frappier L. The MCM-associated protein MCM-BP is important for human nuclear morphology. J Cell Sci. 2012;125:133-43 pubmed publisher
    ..The results suggest that MCM-BP makes multiple contributions to human cells that are not limited to unloading of the MCM complex. ..
  88. McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, et al. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. J Cell Biol. 2000;150:309-20 pubmed
    ..Thus, DEK is a candidate factor for controlling postsplicing steps in gene expression that are influenced by the prior removal of an intron from pre-mRNA. ..
  89. Mistry H, Gibson L, Yun J, Sarras H, Tamblyn L, McPherson J. Interplay between Np95 and Eme1 in the DNA damage response. Biochem Biophys Res Commun. 2008;375:321-5 pubmed publisher
    ..Taken together, these findings link Mus81-Eme1 with the replication-associated chromatin modifier functions of Np95 in the cellular response to DNA damage. ..
  90. Koritzinsky M, Levitin F, van den Beucken T, Rumantir R, Harding N, Chu K, et al. Two phases of disulfide bond formation have differing requirements for oxygen. J Cell Biol. 2013;203:615-27 pubmed publisher
  91. Gonzalez Santos J, Wang A, Jones J, Ushida C, Liu J, Hu J. Central region of the human splicing factor Hprp3p interacts with Hprp4p. J Biol Chem. 2002;277:23764-72 pubmed
  92. McCaw S, Schneider J, Liao E, Zimmermann W, Gray Owen S. Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. Mol Microbiol. 2003;49:623-37 pubmed
    ..gonorrhoeae via either an efficient, ITAM phosphorylation-dependent process that resembles phagocytosis or a less efficient, tyrosine phosphorylation-independent mechanism. ..