Experts and Doctors on fibroblasts in Toronto, Ontario, Canada


Locale: Toronto, Ontario, Canada
Topic: fibroblasts

Top Publications

  1. Lamhonwah A, Gravel R. Propionicacidemia: absence of alpha-chain mRNA in fibroblasts from patients of the pccA complementation group. Am J Hum Genet. 1987;41:1124-31 pubmed
  2. Kim S, Mao P, Gagliardi M, Bedard P. C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. Mol Cell Biol. 1999;19:5718-31 pubmed
    ..Therefore, we have identified C/EBPbeta as a key activator of a growth arrest-specific gene in CEF and implicated an essential fatty acid, linoleic acid, in regulation of the QRU and the p20K lipocalin gene. ..
  3. Ong S, Dilworth S, Hauck Schmalenberger I, Pawson T, Kiefer F. ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation. EMBO J. 2001;20:6327-36 pubmed
    ..Therefore, PymT activation of ShcA-Grb2 signaling is critical for endothelial transformation, and PymT can stimulate Grb2 signaling to both the MAP kinase and PI3K pathways. ..
  4. Goldberg H, Huszár T, Mozes M, Rosivall L, Mucsi I. Overexpression of the type II transforming growth factor-beta receptor inhibits fibroblasts proliferation and activates extracellular signal regulated kinase and c-Jun N-terminal kinase. Cell Biol Int. 2002;26:165-74 pubmed
    ..In conclusion, our system is an excellent tool to study the molecular mechanisms of growth inhibition by TGF-beta in fibroblasts. Activation of JNK and ERK, or modulation of PDGF receptor expression may be involved in this process. ..
  5. Tropak M, Reid S, Guiral M, Withers S, Mahuran D. Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients. J Biol Chem. 2004;279:13478-87 pubmed
    ..Therefore, pharmacological chaperones could provide a novel approach to the treatment of adult Tay-Sachs and possibly Sandhoff diseases...
  6. Ungrin M, Harrington L. Strict control of telomerase activation using Cre-mediated inversion. BMC Biotechnol. 2006;6:10 pubmed
    ..This binary expression system thus provides a useful genetic means to strictly regulate the expression of a given gene, or to control the expression of at least two different genes in a mutually exclusive manner. ..
  7. You H, Yamamoto K, Mak T. Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci U S A. 2006;103:9051-6 pubmed
    ..Our data also suggest that PUMA and Bax are required for p53-dependent apoptosis in manner that is independent of p53 transcriptional activity. ..
  8. Galligan C, Baig E, Bykerk V, Keystone E, Fish E. Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity. Genes Immun. 2007;8:480-91 pubmed
    ..Signature RA FLS cell gene expression profiles may provide insights into disease pathogenesis and have utility in diagnosis, prognosis and drug responsiveness. ..
  9. Song H, Yoon C, Kattman S, Dengler J, Masse S, Thavaratnam T, et al. Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Proc Natl Acad Sci U S A. 2010;107:3329-34 pubmed publisher
    ..Our results support the use of EHT as a model system to accelerate development of cardiac cell therapy strategies. ..

More Information

Publications144 found, 100 shown here

  1. Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls J, et al. The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010;285:6770-80 pubmed publisher
    ..These results suggest that Nedd4-1 is a suppressor of Tsp1 and that increased levels of Tsp-1 in the Nedd4-1 knock-out mice may have contributed to the developmental defect observed in the embryos. ..
  2. Rosario C, Ko M, Haffani Y, Gladdy R, Paderova J, Pollett A, et al. Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A. 2010;107:6888-93 pubmed publisher
    ..These findings represent an advance in our understanding of genetic predisposition to HCC, which continues to increase in incidence globally and particularly in North America. ..
  3. Navab R, Strumpf D, Bandarchi B, Zhu C, Pintilie M, Ramnarine V, et al. Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc Natl Acad Sci U S A. 2011;108:7160-5 pubmed publisher
    ..Six of these 14 genes could be induced by TGF-?1 in NF. The results establish the prognostic impact of CAF-associated gene-expression changes in NSCLC patients. ..
  4. Goicoechea S, Garcia Mata R, Staub J, Valdivia A, Sharek L, McCulloch C, et al. Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. Oncogene. 2014;33:1265-73 pubmed publisher
    ..Together, these results identify a novel molecular signaling pathway that may provide new molecular targets for the inhibition of pancreatic cancer metastasis. ..
  5. Han H, Irimia M, Ross P, Sung H, Alipanahi B, David L, et al. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 2013;498:241-5 pubmed publisher
  6. Wang Y, Ning H, Ren F, Zhang Y, Rong Y, Wang Y, et al. GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis. Mol Cell. 2014;53:752-65 pubmed publisher
    ..Thus, GdX converts TC45, a nonspecific phosphatase, into a STAT3-specific phosphatase by bridging an association between TC45 and STAT3. ..
  7. Rigat B, Wang W, Leung A, Mahuran D. Two mechanisms for the recapture of extracellular GM2 activator protein: evidence for a major secretory form of the protein. Biochemistry. 1997;36:8325-31 pubmed
    ..These molecules makeup the secreted forms of the protein in normal human fibroblasts. ..
  8. Khan M, Van Dyk J, Yeung I, Hill R. Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol. 2003;66:95-102 pubmed
  9. Blasutig I, New L, Thanabalasuriar A, Dayarathna T, Goudreault M, Quaggin S, et al. Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol. 2008;28:2035-46 pubmed publisher
    ..Together, these data identify pYDXV/Nck signaling as a potent and portable mechanism for physiological and pathological actin regulation. ..
  10. Mak B, Wang Q, Laschinger C, Lee W, Ron D, Harding H, et al. Novel function of PERK as a mediator of force-induced apoptosis. J Biol Chem. 2008;283:23462-72 pubmed publisher
    ..We conclude that force-induced apoptosis depends on a novel function of PERK that occurs in addition to its canonical role in the unfolded protein response. ..
  11. Baig E, Fish E. Distinct signature type I interferon responses are determined by the infecting virus and the target cell. Antivir Ther. 2008;13:409-22 pubmed
    ..The extent of IFN response to viral infection influences the subsequent biological outcome: a robust IFN response prescribes a level of resistance, whereas a poor IFN response contributes towards a permissive phenotype for infection. ..
  12. Poon R, Nik S, Ahn J, Slade L, Alman B. Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. BMC Cell Biol. 2009;10:38 pubmed publisher
    ..beta-catenin plays dominant role regulating cell motility, while transforming growth factor beta plays a dominant role regulating the induction of collagen lattice contraction. ..
  13. Maj M, Tkachyova I, Patel P, Addis J, Mackay N, Levandovskiy V, et al. Oxidative stress alters the regulatory control of p66Shc and Akt in PINK1 deficient cells. Biochem Biophys Res Commun. 2010;399:331-5 pubmed publisher
    ..The stable transfection of PINK1 in the fibroblasts which display the null phenotype ameliorates the hyper-phosphorylation of p66(Shc). ..
  14. Zolkipli Z, Pedersen C, Lamhonwah A, Gregersen N, Tein I. Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants. PLoS ONE. 2011;6:e17534 pubmed publisher
    ..We recommend rigorous temperature control in SCADD patients during acute illness. Antioxidants and Bezafibrate may also prove instrumental in their management. ..
  15. Ji J, Ng S, Sharma V, Neculai D, Hussein S, Sam M, et al. Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells. Stem Cells. 2012;30:435-40 pubmed publisher
    ..Thus the factor induced reprogramming stress contributes to a significant proportion of the mutation load of iPSCs. ..
  16. Karagiannis G, Petraki C, Prassas I, Saraon P, Musrap N, Dimitromanolakis A, et al. Proteomic signatures of the desmoplastic invasion front reveal collagen type XII as a marker of myofibroblastic differentiation during colorectal cancer metastasis. Oncotarget. 2012;3:267-85 pubmed
    ..Collagen type XII is a novel candidate marker of myofibroblasts, and/or cancer cells undergoing dedifferentiation. ..
  17. Rajshankar D, Sima C, Wang Q, Goldberg S, Kazembe M, Wang Y, et al. Role of PTP? in the destruction of periodontal connective tissues. PLoS ONE. 2013;8:e70659 pubmed publisher
    ..We conclude that inflammation-induced connective tissue degradation involving fibroblasts requires functionally active PTP? and in part is mediated by IL-1? signaling through focal adhesions. ..
  18. Jankowski A, Kim J, Collins R, Daneman R, Walton P, Grinstein S. In situ measurements of the pH of mammalian peroxisomes using the fluorescent protein pHluorin. J Biol Chem. 2001;276:48748-53 pubmed
  19. Huynh K, Gershenzon E, Grinstein S. Cholesterol accumulation by macrophages impairs phagosome maturation. J Biol Chem. 2008;283:35745-55 pubmed publisher
    ..These findings indicate that cholesterol accumulation can have a detrimental effect on phagosome maturation by impairing the activation of Rab7, sequestering it and its effectors in cholesterol-enriched multilamellar compartments. ..
  20. Francia G, Emmenegger U, Kerbel R. Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy. Cancer Cell. 2009;15:3-5 pubmed publisher
    ..In this issue of Cancer Cell, Crawford et al. (2009) report that tumors resistant to anti-VEGF therapy stimulate tumor-associated fibroblasts to express proangiogenic PDGF-C, implicating it as a potential therapeutic target. ..
  21. Hinz B. Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis. Curr Rheumatol Rep. 2009;11:120-6 pubmed
    ..This discovery opens new paths to prevent progression of fibrosis by specifically interfering with the stress perception and transmission mechanisms of the myofibroblast. ..
  22. Maj M, Sriskandarajah N, Hung V, Browne I, Shah B, Weadge A, et al. Identification of drug candidates which increase cytochrome c oxidase activity in deficient patient fibroblasts. Mitochondrion. 2011;11:264-72 pubmed publisher
    ..These libraries have revealed four examples which elevated the activities of COX in NIH-3T3 fibroblasts and in fibroblasts from patients with COX defects independent of the peroxisome proliferator activated receptor family. ..
  23. Fluri D, Tonge P, Song H, Baptista R, Shakiba N, Shukla S, et al. Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures. Nat Methods. 2012;9:509-16 pubmed publisher
    ..This method is an important step toward the development of robust PSC generation, expansion and differentiation technology. ..
  24. Smith C, Berry D, McGlade C. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. J Cell Sci. 2013;126:1366-80 pubmed publisher
    ..Together these data suggest that RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. ..
  25. Ondovcik S, Tamblyn L, McPherson J, Wells P. Sensitivity to methylmercury toxicity is enhanced in oxoguanine glycosylase 1 knockout murine embryonic fibroblasts and is dependent on cellular proliferation capacity. Toxicol Appl Pharmacol. 2013;270:23-30 pubmed publisher
    ..Accordingly, variations in cellular proliferative capacity and interindividual variability in repair activity may modulate the risk of toxicological consequences following MeHg exposure. ..
  26. Slaats G, Isabella C, Kroes H, Dempsey J, Gremmels H, Monroe G, et al. MKS1 regulates ciliary INPP5E levels in Joubert syndrome. J Med Genet. 2016;53:62-72 pubmed publisher
    ..Mutations in INPP5E also cause JS, so our findings in patient fibroblasts support the notion that loss of INPP5E function, due to either mutation or mislocalisation, is a key mechanism underlying JS, downstream of MKS1 and ARL13B. ..
  27. Tan J, Dunn J, Jaeken J, Schachter H. Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development. Am J Hum Genet. 1996;59:810-7 pubmed
    ..The data indicate that CDGS type II is an autosomal recessive disease and that complex Asn-linked glycans are essential for normal neurological development. ..
  28. Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol. 1998;8:279-82 pubmed
    ..These findings provide direct evidence in support of the telomere hypothesis, indicating that telomere length is one factor that can determine the replicative life span of human cells. ..
  29. Sheng W, Wang G, Wang Y, Liang J, Wen J, Zheng P, et al. The roles of versican V1 and V2 isoforms in cell proliferation and apoptosis. Mol Biol Cell. 2005;16:1330-40 pubmed
    ..These results were confirmed by silencing the expression of versican V1 with small interfering RNA (siRNA), which abolished V1-enhanced cell proliferation and V1-induced reduction of apoptosis. ..
  30. Cameron J, Maj M, Levandovskiy V, Barnett C, Blaser S, Mackay N, et al. Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype. Hum Genet. 2009;125:319-26 pubmed publisher
    ..We conclude that the severity of the clinical course associated with PDP1 deficiency can be quite variable depending on the exact nature of the molecular defect. ..
  31. Luoto K, Meng A, Wasylishen A, Zhao H, Coackley C, Penn L, et al. Tumor cell kill by c-MYC depletion: role of MYC-regulated genes that control DNA double-strand break repair. Cancer Res. 2010;70:8748-59 pubmed publisher
    ..Our results suggest that anti-MYC agents may target cells to prevent genetic instability but would not lead to differential radiosensitization or chemosensitization...
  32. Neiman Zenevich J, Stuart S, Abdel Nour M, Girardin S, Mogridge J. Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome. Infect Immun. 2017;85: pubmed publisher
    ..Infections of either Listeria or Shigella activated NLRP1B in the RAW264.7 murine macrophage line, which expresses endogenous NLRP1B. We conclude that NLRP1B senses cellular infection by distinct invasive pathogens. ..
  33. Hinek A, Smith A, Cutiongco E, Callahan J, Gripp K, Weksberg R. Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kD elastin-binding protein. Am J Hum Genet. 2000;66:859-72 pubmed
    ..We also present evidence that loss of EBP from fibroblasts of Costello syndrome patients is associated with an unusually high rate of cellular proliferation. ..
  34. Cheon S, Cheah A, Turley S, Nadesan P, Poon R, Clevers H, et al. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A. 2002;99:6973-8 pubmed
  35. Ilangumaran S, Finan D, La Rose J, Raine J, Silverstein A, de Sepulveda P, et al. A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts. J Immunol. 2002;169:5010-20 pubmed
  36. Papp S, Dziak E, Michalak M, Opas M. Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins. J Cell Biol. 2003;160:475-9 pubmed
    ..The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca2+ signals, Ca2+ homeostasis, and protein folding and quality control. ..
  37. Otulakowski G, Duan W, Sarangapani A, Gandhi S, O Brodovich H. Glucocorticoid-mediated repression of REDD1 mRNA expression in rat fetal distal lung epithelial cells. Pediatr Res. 2009;65:514-9 pubmed publisher
    ..These studies indicate that REDD1 expression in response to hypoxia and DEX is cell-type specific and that physiologically appropriate levels of PO2 should be used when investigating fetal lung development. ..
  38. Sodek K, Ringuette M, Brown T. Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype. Int J Cancer. 2009;124:2060-70 pubmed publisher
    ..Preventing the formation of ovarian cancer spheroids may represent a novel strategy to improve the efficacy of existing therapeutics...
  39. Maegawa G, Tropak M, Buttner J, Rigat B, Fuller M, Pandit D, et al. Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease. J Biol Chem. 2009;284:23502-16 pubmed publisher
    ..Thus, ABX has the biochemical characteristics of a safe and effective enzyme enhancement therapy agent for the treatment of patients with the most common GD genotypes...
  40. Forrester L, Nagy A, Sam M, Watt A, Stevenson L, Bernstein A, et al. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Proc Natl Acad Sci U S A. 1996;93:1677-82 pubmed
    ..These studies demonstrate the potential of this induction gene trap approach for identifying and mutating genes downstream of signal transduction pathways. ..
  41. Hakem R, Hakem A, Duncan G, Henderson J, Woo M, Soengas M, et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 1998;94:339-52 pubmed
    ..Comparison of the requirement for Casp9 and Casp3 in different apoptotic settings indicates the existence of at least four different apoptotic pathways in mammalian cells. ..
  42. D Addario M, Arora P, Fan J, Ganss B, Ellen R, McCulloch C. Cytoprotection against mechanical forces delivered through beta 1 integrins requires induction of filamin A. J Biol Chem. 2001;276:31969-77 pubmed
    ..We conclude that cells from mechanically active environments can couple diverse signals from forces applied through beta-integrins to up-regulate the production of cytoprotective cytoskeletal proteins, typified by filamin A. ..
  43. Ho A, Li Q, Hakem R, Mak T, Zacksenhaus E. Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific. EMBO J. 2004;23:460-72 pubmed
    ..Therefore, loss of pRb elicits apoptosome-dependent and apoptosome-independent cell death, and the requirement and coupling of caspase-9 to Apaf1 are both context-dependent. ..
  44. Wang J, Laschinger C, Zhao X, Mak B, Seth A, McCulloch C. Mechanical force activates eIF-2alpha phospho-kinases in fibroblast. Biochem Biophys Res Commun. 2005;330:123-30 pubmed
    ..We conclude that phospho-antibody screening is an efficient method for discovery of novel mechanical force-induced phospho-kinases and force can activate eIF-2alpha phospho-kinases in fibroblasts. ..
  45. Lee H, Overall C, McCulloch C, Sodek J. A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis. Mol Biol Cell. 2006;17:4812-26 pubmed
    ..In contrast to MT1-MMP, the gelatinolytic activity of MMP-2 was not required for collagen phagocytosis. These studies demonstrate a pivotal role of catalytically active MT1-MMP in preparing collagen fibrils for phagocytic degradation. ..
  46. Zhang H, Fan X, Bagshaw R, Zhang L, Mahuran D, Callahan J. Lysosomal membranes from beige mice contain higher than normal levels of endoplasmic reticulum proteins. J Proteome Res. 2007;6:240-9 pubmed
    ..Our results suggest that LYST may play a role in either preventing inappropriate incorporation of proteins into the lysosomal membrane or in membrane recycling/maturation. ..
  47. Fawcett J, Georgiou J, Ruston J, Bladt F, Sherman A, Warner N, et al. Nck adaptor proteins control the organization of neuronal circuits important for walking. Proc Natl Acad Sci U S A. 2007;104:20973-8 pubmed
    ..Our data indicate that Nck adaptors couple pTyr guidance signals to cytoskeletal events required for the ipsilateral projections of spinal cord neurons and thus for normal limb movement. ..
  48. Hinz B. Mechanical aspects of lung fibrosis: a spotlight on the myofibroblast. Proc Am Thorac Soc. 2012;9:137-47 pubmed publisher
    ..Interfering with myofibroblast contraction and integrin-mediated force transmission to latent transforming growth factor-?1 and matrix proteins are here presented as possible therapeutic strategies to halt fibrosis. ..
  49. Mann I, Chatterjee R, Zhao J, He X, Weirauch M, Hughes T, et al. CG methylated microarrays identify a novel methylated sequence bound by the CEBPB|ATF4 heterodimer that is active in vivo. Genome Res. 2013;23:988-97 pubmed publisher
    ..This methodology can be used to identify new methylated DNA sequences preferentially bound by TFs, which may be functional in vivo. ..
  50. Wang Y, Li S, Guo J, Mihic A, Wu J, Sun L, et al. Role of miR-145 in cardiac myofibroblast differentiation. J Mol Cell Cardiol. 2014;66:94-105 pubmed publisher
    ..These observations provide a new approach to promote endogenous scar healing and contracture by stimulating the transdifferentiation of cardiac fibroblasts to myofibroblasts. ..
  51. Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, et al. RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Proc Natl Acad Sci U S A. 2013;110:20982-7 pubmed publisher
    ..Our findings highlight the multistep roles of RNF168 in signaling DNA damage. ..
  52. Marchant D, Bilawchuk L, Nish G, Hegele R. Virus-induced signaling influences endosome trafficking, virus entry, and replication. Methods Enzymol. 2014;534:65-76 pubmed publisher
    ..We also describe how use of immunofluorescence confocal microscopy for imaging virus-host interactions provides a powerful approach for obtaining structural correlations that extend results of immunological and biochemical assays. ..
  53. Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, et al. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J. 2000;19:4976-85 pubmed
    ..However, T2K has a unique role in the activation of NF-kappaB-directed transcription, apparently independent of I-kappaB degradation and NF-kappaB DNA binding. ..
  54. D Addario M, Arora P, McCulloch C. Role of p38 in stress activation of Sp1. Gene. 2006;379:51-61 pubmed
    ..We conclude that stress activation of p38 phosphorylates Sp1 at specific threonine residues, modifications which in turn enhance the expression of Sp1-dependent genes. ..
  55. Rigat B, Mahuran D. Diltiazem, a L-type Ca(2+) channel blocker, also acts as a pharmacological chaperone in Gaucher patient cells. Mol Genet Metab. 2009;96:225-32 pubmed publisher
    ..However, at neutral pH, found in the endoplasmic reticulum, Diltiazem exhibited both of these properties. Thus Diltiazem exhibits the biochemical characteristics of a glucocerebrosidase pharmacological chaperone. ..
  56. Mitts T, Bunda S, Wang Y, Hinek A. Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin. J Invest Dermatol. 2010;130:2396-406 pubmed publisher
    ..We therefore propose that intra-lesional injection of these factors should be considered in therapy for disfiguring dermal lesions and especially in prevention of their recurrence after surgical excision. ..
  57. Martin C, Ahmad I, Klingseisen A, Hussain M, Bicknell L, Leitch A, et al. Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet. 2014;46:1283-1292 pubmed publisher
    ..Furthermore, we establish that different levels of impaired PLK4 activity result in growth and cilia phenotypes, providing a mechanism by which microcephaly disorders can occur with or without ciliopathic features. ..
  58. Suzuki H, Kalair W, Shivji G, Wang B, Toto P, Amerio P, et al. Impaired ultraviolet-B-induced cytokine induction in xeroderma pigmentosum fibroblasts. J Invest Dermatol. 2001;117:1151-5 pubmed
  59. Kainulainen T, Pender A, D Addario M, Feng Y, Lekic P, McCulloch C. Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces. J Biol Chem. 2002;277:21998-2009 pubmed
    ..We conclude that high amplitude forces delivered through integrins can promote apoptosis in a proportion of cells and that filamin A confers mechanoprotection by preventing membrane depolarization. ..
  60. Stavropoulos D, Bradshaw P, Li X, Pasic I, Truong K, Ikura M, et al. The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis. Hum Mol Genet. 2002;11:3135-44 pubmed
    ..Our results identify BLM as the first protein found to affect telomeric DNA synthesis exclusively in human ALT cells and suggest that BLM facilitates recombination-driven amplification of telomeres in ALT cells. ..
  61. Termei R, Laschinger C, Lee W, McCulloch C. Intercellular interactions between mast cells and fibroblasts promote pro-inflammatory signaling. Exp Cell Res. 2013;319:1839-51 pubmed publisher
    ..We conclude that mast cells adhere to fibroblasts and promote IL-8 secretion, which enhances neutrophil chemotaxis and the inflammatory response. ..
  62. Bradshaw P, Stavropoulos D, Meyn M. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat Genet. 2005;37:193-7 pubmed
    ..Our results implicate TRF2 in an initial stage of DSB recognition and processing that occurs before association of ATM with DSBs and activation of the ATM-dependent DSB response network. ..
  63. Amin M, Magnusson K, Kapus A, Glogauer M, Ellen R. Treponema denticola Msp-deduced peptide conjugate, P34BSA, promotes RhoA-dependent actin stress fiber formation independent of its internalization by fibroblasts. Cell Motil Cytoskeleton. 2008;65:406-21 pubmed publisher
    ..Hence, P34(BSA) may represent a novel tool to investigate RhoA-dependent processes, such as remodeling filamentous actin in eukaryotic cells. ..
  64. Papp S, Fadel M, Opas M. Dissecting focal adhesions in cells differentially expressing calreticulin: a microscopy study. Biol Cell. 2007;99:389-402 pubmed
  65. Ho A, Li Q, Okada H, Mak T, Zacksenhaus E. XIAP activity dictates Apaf-1 dependency for caspase 9 activation. Mol Cell Biol. 2007;27:5673-85 pubmed
    ..Thus, caspase 9 activation in response to intrinsic apoptotic stimuli can be uncoupled from Apaf-1 in vivo by XIAP antagonists. ..
  66. Woltjen K, Kim S, Nagy A. The piggyBac Transposon as a Platform Technology for Somatic Cell Reprogramming Studies in Mouse. Methods Mol Biol. 2016;1357:1-22 pubmed publisher
    ..These protocols are highlighted with examples from recent studies as to how PB has been, and continues to be, conducive to the dissection of reprogramming processes at the cellular and molecular levels. ..
  67. Coppolino M, Woodside M, Demaurex N, Grinstein S, St Arnaud R, Dedhar S. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature. 1997;386:843-7 pubmed
    ..Our results indicate that calreticulin is an essential modulator both of integrin adhesive functions and integrin-initiated signalling, but that it may not play a significant role in the storage of luminal calcium. ..
  68. Boehmelt G, Wakeham A, Elia A, Sasaki T, Plyte S, Potter J, et al. Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. EMBO J. 2000;19:5092-104 pubmed
    ..Interestingly, growth-impaired EMeg32(-/-) MEFs withstand a number of apoptotic stimuli and express activated PKB/AKT. Thus, EMeg32-dependent UDP-GlcNAc levels influence cell cycle progression and susceptibility to apoptotic stimuli. ..
  69. Ho A, Voura E, Soloway P, Watson K, Khokha R. MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function. J Biol Chem. 2001;276:40215-24 pubmed
    ..Our data provide provocative evidence that increased pericellular proteolysis impacts cell adhesion systems to offset normal contact inhibition, with subsequent effects on cell transformation and tumorigenesis. ..
  70. Menzies K, Robinson B, Hood D. Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects. Am J Physiol Cell Physiol. 2009;296:C355-62 pubmed publisher
    ..These results suggest that T(3) acts to reduce cellular oxidative stress, which may help attenuate ROS-mediated damage, along with improving mitochondrial function and energy status in cells with mtDNA defects. ..
  71. Bunda S, Wang Y, Mitts T, Liu P, Arab S, Arabkhari M, et al. Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt. J Biol Chem. 2009;284:16633-47 pubmed publisher
    ..In summary, the data we present reveal new details of an MR-independent cellular signaling pathway through which aldosterone stimulates elastogenesis in human cardiac fibroblasts. ..
  72. Masszi A, Speight P, Charbonney E, Lodyga M, Nakano H, Szaszi K, et al. Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol. 2010;188:383-99 pubmed publisher
    ..Thus, Smad3 is a critical timer/delayer of MF commitment in the epithelium, and EMyT can be dissected into Smad3-promoted (mesenchymal) and Smad3-inhibited (myogenic) phases. ..
  73. Soares F, Tattoli I, Wortzman M, Arnoult D, Philpott D, Girardin S. NLRX1 does not inhibit MAVS-dependent antiviral signalling. Innate Immun. 2013;19:438-48 pubmed publisher
    ..p. injection of Poly (I:C). Together, our results demonstrate that NLRX1 does not participate in the negative regulation of MAVS-dependent antiviral responses. ..
  74. Reedijk M, Liu X, Pawson T. Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor. Mol Cell Biol. 1990;10:5601-8 pubmed
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