Experts and Doctors on endodeoxyribonucleases in Toronto, Ontario, Canada
Locale: Toronto, Ontario, Canada
Popović A, Wu B, Arrowsmith C, Edwards A, Davidson A, Maxwell K. Structural and biochemical characterization of phage ? FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity. J Biol Chem. 2012;287:32085-95 pubmed publisher
..Finally, we present a novel model for the mechanism of gpFI chaperone activity in the DNA packaging reaction of phage ?. ..
Abraham J, Lemmers B, Hande M, Moynahan M, Chahwan C, Ciccia A, et al
. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J. 2003;22:6137-47 pubmed
..Most importantly, Eme1 deficiency led to spontaneous genomic instability. These results reveal that mammalian Eme1 plays a key role in DNA repair and the maintenance of genome integrity. ..
Roberts T, Kobor M, Bastin Shanower S, Ii M, Horte S, Gin J, et al
. Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell. 2006;17:539-48 pubmed
Chabi B, Ljubicic V, Menzies K, Huang J, Saleem A, Hood D. Mitochondrial function and apoptotic susceptibility in aging skeletal muscle. Aging Cell. 2008;7:2-12 pubmed
..These data suggest that the age-related sarcopenia and muscle fatigability are associated with enhanced ROS production, increased mitochondrial apoptotic susceptibility and reduced transcriptional drive for mitochondrial biogenesis...
Mistry H, Gibson L, Yun J, Sarras H, Tamblyn L, McPherson J. Interplay between Np95 and Eme1 in the DNA damage response. Biochem Biophys Res Commun. 2008;375:321-5 pubmed publisher
..Taken together, these findings link Mus81-Eme1 with the replication-associated chromatin modifier functions of Np95 in the cellular response to DNA damage. ..
Babu M, Beloglazova N, Flick R, Graham C, Skarina T, Nocek B, et al
. A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol Microbiol. 2011;79:484-502 pubmed publisher
Kala S, Cumby N, Sadowski P, Hyder B, Kanelis V, Davidson A, et al
. HNH proteins are a widespread component of phage DNA packaging machines. Proc Natl Acad Sci U S A. 2014;111:6022-7 pubmed publisher
..Bioinformatic analysis reveals that the role of HNH proteins in terminase function is widespread among long-tailed phages and is uniquely required for the activity of the Terminase_1 family of large terminase proteins. ..
Kumar A, Beloglazova N, Bundalovic Torma C, Phanse S, Deineko V, Gagarinova A, et al
. Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli. Cell Rep. 2016;14:648-661 pubmed publisher
..Analyses of pan-bacterial conservation patterns suggest that DDR mechanisms and functional relationships are near universal, highlighting a modular and highly adaptive genomic stress response. ..