Experts and Doctors on deoxyribonucleases in Toronto, Ontario, Canada
Locale: Toronto, Ontario, Canada
- Lechardeur D, Dougaparsad S, Nemes C, Lukacs G. Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells. J Biol Chem. 2005;280:40216-25 pubmed..In apoptotic cells, endogenous and exogenous CAD forms limited oligomers, representing the active nuclease. A model is proposed for the rearrangement of the DFF subunit stoichiometry in cells undergoing programmed cell death. ..
- Kumar A, Beloglazova N, Bundalovic Torma C, Phanse S, Deineko V, Gagarinova A, et al. Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli. Cell Rep. 2016;14:648-661 pubmed publisher..Analyses of pan-bacterial conservation patterns suggest that DDR mechanisms and functional relationships are near universal, highlighting a modular and highly adaptive genomic stress response. ..