Experts and Doctors on cytoplasm in Toronto, Ontario, Canada


Locale: Toronto, Ontario, Canada
Topic: cytoplasm

Top Publications

  1. Czuczman M, Fattouh R, van Rijn J, Canadien V, Osborne S, Muise A, et al. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 2014;509:230-4 pubmed publisher
    ..Our results indicate that PS-targeted therapeutics may be useful in the fight against infections by L. monocytogenes and other bacteria that use similar strategies of cell-to-cell spread during infection. ..
  2. Assi J, Srivastava G, Matta A, Chang M, Walfish P, Ralhan R. Transglutaminase 2 overexpression in tumor stroma identifies invasive ductal carcinomas of breast at high risk of recurrence. PLoS ONE. 2013;8:e74437 pubmed publisher
    ..Accumulation of TG2 in tumor stroma is an independent risk factor for identifying breast cancer patients at high risk of recurrence. TG2 overexpression in tumor stroma may serve as a predictor of poor prognosis for IDC of the breast. ..
  3. Chithrani B, Stewart J, Allen C, Jaffray D. Intracellular uptake, transport, and processing of nanostructures in cancer cells. Nanomedicine. 2009;5:118-27 pubmed
    ..These findings can be used to tailor nanoscale devices for effective cell targeting and delivery. ..
  4. O Dowd B, Nguyen T, Ji X, George S. D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation. Biochem Biophys Res Commun. 2013;431:586-9 pubmed publisher
    ..Any pairing of these three D(5) receptor glutamic acids were sufficient for heteromer formation. These identified residues in D(5) and D(2) receptors are oppositely charged and likely interact by electrostatic interactions. ..
  5. Robertson J, Sanelli T, Xiao S, Yang W, Horne P, Hammond R, et al. Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS. Neurosci Lett. 2007;420:128-32 pubmed
    ..Our findings indicate that the process of motor neuron degeneration in mutant SOD1 transgenic mice is unlikely to involve the abnormalities of TDP-43 described in the human disease. ..
  6. Fan L, Sebe A, Péterfi Z, Masszi A, Thirone A, Rotstein O, et al. Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway. Mol Biol Cell. 2007;18:1083-97 pubmed
    ..These studies define a new mechanism whereby cell contacts regulate epithelial-myofibroblast transition via Rho-ROK-phospho-MLC-dependent nuclear accumulation of MRTF. ..
  7. Pollex E, Anger G, Hutson J, Koren G, Piquette Miller M. Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism. Drug Metab Dispos. 2010;38:740-4 pubmed publisher
    ..05). Our results indicate that the Q141K variant of ABCG2 may have the potential to alter the placental pharmacokinetics of glyburide used in pregnancy. ..
  8. Li C, MacDonald J, Wei R, Ray J, Lau K, Kandel C, et al. Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. BMC Genomics. 2007;8:92 pubmed
    ..SAMD9 was recently found to be mutated in normophosphatemic familial tumoral calcinosis. In this study, we studied the gene structure and function of SAMD9, and its paralogous gene, SAMD9L, and examined these in a variety of species...
  9. deSouza L, Shen Y, Bognar A. Disruption of cytoplasmic and mitochondrial folylpolyglutamate synthetase activity in Saccharomyces cerevisiae. Arch Biochem Biophys. 2000;376:299-312 pubmed

More Information


  1. Pham E, Mills E, Truong K. A synthetic photoactivated protein to generate local or global Ca(2+) signals. Chem Biol. 2011;18:880-90 pubmed publisher
    ..Our photoactivation system can be used to generate spatially and temporally precise Ca(2+) signals and to engineer synthetic proteins that respond to specific Ca(2+) signals. ..
  2. Killeen M, Tong J, Krizus A, Steven R, Scott I, Pawson T, et al. UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev Biol. 2002;251:348-66 pubmed
    ..Our data also show that part of the ZU-5 motif is required for UNC-40-independent signaling of UNC-5. ..
  3. Hamam A, Lew R. Electrical phenotypes of calcium transport mutant strains of a filamentous fungus, Neurospora crassa. Eukaryot Cell. 2012;11:694-702 pubmed publisher
    ..Thus, although Ca(2+) homeostasis is perturbed in the nca-2 mutant (B. J. Bowman et al., Eukaryot. Cell 10:654-661, 2011), the phenotype does not extend to tip growth or to osmoregulation but is revealed by lower H(+)-ATPase activity. ..
  4. Kenigsberg S, Lima P, Maghen L, Wyse B, Lackan C, Cheung A, et al. The elusive MAESTRO gene: Its human reproductive tissue-specific expression pattern. PLoS ONE. 2017;12:e0174873 pubmed publisher
    ..A better understanding of the tissue-specific MRO isoforms expression patterns and the unique structure of the protein may provide important insights into the function of this gene and possibly to the pathophysiology of PCOS. ..
  5. Asa S, Ramyar L, Murphy P, Li A, Ezzat S. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Mol Endocrinol. 2001;15:589-99 pubmed
    ..GFG represents a novel mechanism involved in restraining pituitary tumor cell growth while promoting hormonal activity. ..
  6. Cochrane A. HIV-1 Rev function and RNA nuclear-cytoplasmic export. Methods Mol Biol. 2014;1087:103-14 pubmed publisher
    ..Here, I describe procedures to evaluate each of these aspects of Rev/Rex function. ..
  7. Ralhan R, Cao J, Lim T, Macmillan C, Freeman J, Walfish P. EpCAM nuclear localization identifies aggressive thyroid cancer and is a marker for poor prognosis. BMC Cancer. 2010;10:331 pubmed publisher
    ..Thus nuclear Ep-ICD localization may serve as a useful biomarker for aggressive TC and may represent a novel diagnostic, prognostic and therapeutic target for aggressive TC. ..
  8. Pike K, Ratcliffe M. Dual requirement for the Ig alpha immunoreceptor tyrosine-based activation motif (ITAM) and a conserved non-Ig alpha ITAM tyrosine in supporting Ig alpha beta-mediated B cell development. J Immunol. 2005;174:2012-20 pubmed
    ..However, coexpression of the cytoplasmic domain of Igbeta partially complemented the Igalpha Y3 mutation, rescuing higher levels of BLNK phosphorylation and, more strikingly, supporting B cell development. ..
  9. Boudrault C, Bazinet R, Kang J, Ma D. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. Neurochem Int. 2010;56:585-9 pubmed publisher
    ..02), but cPLA(2) expression levels did not change. Our results suggest that this model could be used to investigate mechanisms by which n-3 PUFA regulate neuroinflammation. ..
  10. Cole D, Vieth R, Trang H, Wong B, Hendy G, Rubin L. Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene. Mol Genet Metab. 2001;72:168-74 pubmed
    ..The A986S polymorphism is also a potential predisposing factor in disorders of bone and mineral metabolism. ..
  11. Balestrini J, Chaudhry S, Sarrazy V, Koehler A, Hinz B. The mechanical memory of lung myofibroblasts. Integr Biol (Camb). 2012;4:410-21 pubmed publisher
    ..This priming effect has important implications for the progression and persistence of aggressive fibrotic diseases such as idiopathic pulmonary fibrosis. ..
  12. Watson I, Blanch A, Lin D, Ohh M, Irwin M. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J Biol Chem. 2006;281:34096-103 pubmed
  13. Pham N, Schwock J, Iakovlev V, Pond G, Hedley D, Tsao M. Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis. BMC Cancer. 2008;8:43 pubmed publisher
    ..The ERK pathway activation appears also increased in duct epithelia adjacent to carcinoma, suggesting tumor micro-environmental effects. ..
  14. Alli Z, Ackerley C, Chen Y, Al Saud B, Abdelhaleem M. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. Exp Mol Pathol. 2006;81:245-8 pubmed
    ..These results suggest that DHX32 is a putative RNA helicase that might be involved in regulating nuclear and mitochondrial gene expression. ..
  15. Tkach J, Glover J. Nucleocytoplasmic trafficking of the molecular chaperone Hsp104 in unstressed and heat-shocked cells. Traffic. 2008;9:39-56 pubmed
    ..Based on these observations, we propose that Hsp104 continues to access the nucleus during severe heat shock using a karyopherin-independent mechanism. ..
  16. Chow W, Hou G, Bendeck M. Glycogen synthase kinase 3beta regulation of nuclear factor of activated T-cells isoform c1 in the vascular smooth muscle cell response to injury. Exp Cell Res. 2008;314:2919-29 pubmed publisher
    ..We conclude that NFATc1 promotes the vSMC response to injury, and that inhibition of GSK3beta is required for the activation of NFAT during wound repair. ..
  17. Cheng S, Liu W, Mercado M, Ezzat S, Asa S. Expression of the melanoma-associated antigen is associated with progression of human thyroid cancer. Endocr Relat Cancer. 2009;16:455-66 pubmed publisher
    ..The use of TMA analyses identifies IHC techniques that are translatable to the clinical setting for prognostic assessment of patients with thyroid cancer. ..
  18. Ramirez R, Sah R, Liu J, Rose R, Backx P. Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials. Basic Res Cardiol. 2011;106:967-77 pubmed publisher
  19. Kunavisarut T, Kak I, Macmillan C, Ralhan R, Walfish P. Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma. BMC Cancer. 2012;12:523 pubmed publisher
    ..In addition, ESLI had the potential to identify metastatic behavior in PTMC which could serve as a valuable tool for solving a current dilemma in clinical practice. ..
  20. Qudrat A, Truong K. Engineering Synthetic Proteins to Generate Ca2+ Signals in Mammalian Cells. ACS Synth Biol. 2017;6:582-590 pubmed publisher
    ..Thus, using this design strategy, it is possible to engineer proteins to generate a Ca2+ signal to rewire a wide range of extracellular stimuli to a wide range of Ca2+-activated processes. ..
  21. Song Y, Ailenberg M, Silverman M. Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia. Mol Biol Cell. 1999;10:1609-19 pubmed
    ..Taken together, our data suggest that hmunc13 serves as a diacylglycerol-activated, PKC-independent signaling pathway capable of inducing apoptosis and that this pathway may contribute to the renal cell complications of hyperglycemia. ..
  22. St Pierre B, Liu X, Kha L, Zhu X, Ryan O, Jiang Z, et al. Conserved and specific functions of mammalian ssu72. Nucleic Acids Res. 2005;33:464-77 pubmed
    ..Despite high conservation, hssu72 was unable to rescue an ssu72 lethal mutation in yeast. Together, our results highlight conserved and mammalian specific characteristics of mammalian ssu72. ..
  23. Pike K, Iacampo S, Friedmann J, Ratcliffe M. The cytoplasmic domain of Ig alpha is necessary and sufficient to support efficient early B cell development. J Immunol. 2004;172:2210-8 pubmed
  24. Khatri I, Ho C, Specian R, Forstner J. Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1321-30 pubmed
    ..In a mouse model of human cystic fibrosis, both soluble Muc3 and goblet cell Muc2 were increased in amount and hypersecreted. Thus Muc2 and Muc3 contribute to the excess intestinal luminal mucus of cystic fibrosis mice...
  25. Ralhan R, He H, So A, Tripathi S, Kumar M, Hasan M, et al. Nuclear and cytoplasmic accumulation of Ep-ICD is frequently detected in human epithelial cancers. PLoS ONE. 2010;5:e14130 pubmed publisher
    ..Development of a robust high throughput assay for Ep-ICD will facilitate the determination of its diagnostic, prognostic and therapeutic relevance in epithelial cancers. ..
  26. Whittaker K, Ding D, Fisher W, Lipshitz H. Different 3' untranslated regions target alternatively processed hu-li tai shao (hts) transcripts to distinct cytoplasmic locations during Drosophila oogenesis. J Cell Sci. 1999;112 ( Pt 19):3385-98 pubmed
    ..This transcript class encodes the Drosophila orthologue of mammalian adducin. ..
  27. Lee D, Lança A, Cheng R, Nguyen T, Ji X, Gobeil F, et al. Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem. 2004;279:7901-8 pubmed
    ..This discovery of apelin, AT(1), and B(2) receptors with agonist-independent nuclear translocation suggests major unanticipated roles for these receptors in cell signaling and function. ..
  28. Claudio J, Zhu Y, Benn S, Shukla A, McGlade C, Falcioni N, et al. HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells. Oncogene. 2001;20:5373-7 pubmed
    ..Cell lines and primary cells from acute myeloid leukemias and multiple myeloma patients express HACS1. Immunostaining and cellular fractionation studies localized the HACS1 protein predominantly to the cytoplasm. ..
  29. Li Z, Nieuwenhuis E, Nien W, Zhang X, Zhang J, Puviindran V, et al. Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. Development. 2012;139:4152-61 pubmed publisher
    ..These studies establish Sufu and Kif7 as crucial components in the regulation of Gli2 localization and activity, and illustrate their overlapping functions in skin development and tumor suppression. ..
  30. Zacksenhaus E, Jiang Z, Phillips R, Gallie B. Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product. EMBO J. 1996;15:5917-27 pubmed
  31. Houry W. Chaperone-assisted protein folding in the cell cytoplasm. Curr Protein Pept Sci. 2001;2:227-44 pubmed
    ..Several advances have recently been made in characterizing the structure and function of all of these chaperone systems. These advances have provided us with a better understanding of the protein folding process in the cell. ..
  32. Catalano A, Poloz Y, O Day D. Dictyostelium puromycin-sensitive aminopeptidase A is a nucleoplasmic nucleomorphin-binding protein that relocates to the cytoplasm during mitosis. Histochem Cell Biol. 2011;136:677-88 pubmed publisher
    ..These results are interpreted in terms of the inter-relationship between NumA1 and PsaA in cell function in Dictyostelium. ..
  33. Kruger J, Fukushima T, Cherepanov V, Borregaard N, Loeve C, Shek C, et al. Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. J Biol Chem. 2002;277:2620-8 pubmed
    ..Taken together, our results indicate that MEG2 is a polyphosphoinositide-activated tyrosine phosphatase that may be involved in signaling events regulating phagocytosis, an essential antimicrobial function in the innate immune response. ..
  34. Yee K, Moore S, Midmer M, Zanke B, Tong F, Hedley D, et al. NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. Biochem Biophys Res Commun. 2003;308:784-92 pubmed
    ..NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin-dependent kinases. ..
  35. Vafopoulou X. Ecdysteroid receptor (EcR) is associated with microtubules and with mitochondria in the cytoplasm of prothoracic gland cells of Rhodnius prolixus (Hemiptera). Arch Insect Biochem Physiol. 2009;72:249-62 pubmed publisher
    ..e., in non-genomic actions of ecdysone. These findings align EcR more closely with steroid hormone receptors in vertebrates. ..
  36. Tonkikh A, Carlen P. Impaired presynaptic cytosolic and mitochondrial calcium dynamics in aged compared to young adult hippocampal CA1 synapses ameliorated by calcium chelation. Neuroscience. 2009;159:1300-8 pubmed publisher
    ..These results support the hypothesis that increasing intracellular calcium neuronal buffering in aged rats ameliorates age-related impaired presynaptic Ca regulation. ..
  37. Khine A, Tam P, Nutikka A, Lingwood C. Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity. Glycobiology. 2004;14:701-12 pubmed
    ..These studies indicate both a caveolae-dependent and independent pathway for VT1 access to the TGN/Golgi from the cell surface and two noninterconverting pools of membrane Gb3. ..
  38. Ochotny N, Voronov I, Owen C, Aubin J, Manolson M. The R740S mutation in the V-ATPase a3 subunit results in osteoclast apoptosis and defective early-stage autophagy. J Cell Biochem. 2013;114:2823-33 pubmed publisher
  39. Lee C, Mullen Grey A, Riddick D. Loss of hepatic aryl hydrocarbon receptor protein in adrenalectomized rats does not involve altered levels of the receptor's cytoplasmic chaperones. Can J Physiol Pharmacol. 2013;91:1154-7 pubmed publisher
    ..These results suggest that the loss of rat hepatic AHR protein following ADX cannot be explained by changes in the levels of the receptor's cytoplasmic chaperone proteins. ..
  40. Balakier H, Sojecki A, Motamedi G, Librach C. Time-dependent capability of human oocytes for activation and pronuclear formation during metaphase II arrest. Hum Reprod. 2004;19:982-7 pubmed
    ..0001), which suggests the existence of chromosomal abnormalities. Human oocytes progressively develop the ability for full activation and normal development during the MII arrest stage. ..
  41. Chen G, Tisayakorn S, Jorgensen C, D Ambrosio L, Goudreault M, Gingras A. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. J Biol Chem. 2008;283:29273-84 pubmed publisher
    ..PP4R3, and alpha4, and that the regulatory subunits of PP4c have evolved different modes of interaction with the catalytic subunit. ..
  42. Desai R, Sarpal R, Ishiyama N, Pellikka M, Ikura M, Tepass U. Monomeric ?-catenin links cadherin to the actin cytoskeleton. Nat Cell Biol. 2013;15:261-73 pubmed publisher
  43. Ianzano L, Young E, Zhao X, Chan E, Rodriguez M, Torrado M, et al. Loss of function of the cytoplasmic isoform of the protein laforin (EPM2A) causes Lafora progressive myoclonus epilepsy. Hum Mutat. 2004;23:170-6 pubmed
  44. Popovic Z, Templeton D. Iron accumulation and iron-regulatory protein activity in human hepatoma (HepG2) cells. Mol Cell Biochem. 2004;265:37-45 pubmed
    ..HepG2 cells are able to limit iron accumulation upon higher or prolonged exposure to NTBI, apparently independent of the IRP mechanism. ..
  45. Pongoski J, Asai K, Cochrane A. Positive and negative modulation of human immunodeficiency virus type 1 Rev function by cis and trans regulators of viral RNA splicing. J Virol. 2002;76:5108-20 pubmed
  46. Badouel C, Gardano L, Amin N, Garg A, Rosenfeld R, Le Bihan T, et al. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell. 2009;16:411-20 pubmed publisher
    ..These data lead to a new model whereby Expanded functions downstream of Warts, in concert with 14-3-3 proteins to sequester Yorkie in the cytoplasm, inhibiting growth activity of the Hippo pathway. ..
  47. Lim C, Seet B, Ingham R, Gish G, Matskova L, Winberg G, et al. The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction. Biochemistry. 2007;46:9874-85 pubmed publisher
    ..The ability of K15 to associate with ITSN2 suggests a new role for the K15 viral protein in intracellular protein trafficking...
  48. Bacopulos S, Amemiya Y, Yang W, Zubovits J, Burger A, Yaffe M, et al. Effects of partner proteins on BCA2 RING ligase activity. BMC Cancer. 2012;12:63 pubmed publisher
    ..The interaction between BCA2 and hHR23a in breast cancer cells stabilizes BCA2. High expression of BCA2 is correlated with grade in breast cancer, suggesting regulation of this E3 ligase is important to cancer progression. ..
  49. Paulson R, Jackson J, Immergluck K, Bishop J. The DFer gene of Drosophila melanogaster encodes two membrane-associated proteins that can both transform vertebrate cells. Oncogene. 1997;14:641-52 pubmed
    ..The products of Drosophila and vertebrate FER may be part of similar signaling pathways in the two species. ..
  50. Draker R, Sarcinella E, Cheung P. USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation. Nucleic Acids Res. 2011;39:3529-42 pubmed publisher
    ..Zub1 is associated with transcriptional activation of these genes. Together, these data provide novel insights into how H2A.Z ubiquitylation/deubiquitylation and USP10 function in AR-regulated gene expression. ..
  51. Shirodkar P, Fenton A, Meng L, Koch C. Identification and functional characterization of a Ku-binding motif in aprataxin polynucleotide kinase/phosphatase-like factor (APLF). J Biol Chem. 2013;288:19604-13 pubmed publisher
    ..These data suggest functional requirements for Ku and XRCC4 in APLF-dependent NHEJ and a unique role for Ku as a factor required to facilitate the nuclear retention of APLF. ..
  52. Giannoulias D, Alfaidy N, Holloway A, Gibb W, Sun M, Lye S, et al. Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy. J Clin Endocrinol Metab. 2002;87:5274-82 pubmed
    ..The lack of change in PGES indicates that alterations at other points along the pathway of arachidonic acid metabolism may be of greater importance in affecting local changes in PGE(2). ..
  53. Lew R. How does a hypha grow? The biophysics of pressurized growth in fungi. Nat Rev Microbiol. 2011;9:509-18 pubmed publisher
    ..However, as discussed in this Review, turgor and pressure have additional roles in hyphal growth, such as causing the mass flow of cytoplasm from the basal mycelial network towards the expanding hyphal tips at the colony edge. ..
  54. Pham N, Gal M, Bagshaw R, Mohr A, Chue B, Richardson T, et al. A comparative study of cytoplasmic granules imaged by the real-time microscope, Nile Red and Filipin in fibroblasts from patients with lipid storage diseases. J Inherit Metab Dis. 2005;28:991-1004 pubmed
    ..In summary, applying the RTM imaging system to fibroblasts enables differences between the various disease types to be seen and, in specific examples, a unique phenotype can be readily discerned. ..
  55. Connor A, Berger S, Narendran A, Keystone E. Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts. Arthritis Res Ther. 2006;8:R94 pubmed
    ..The results may also partly explain the therapeutic effect of atorvastatin in patients with RA. ..
  56. Hauck L, Harms C, Grothe D, An J, Gertz K, Kronenberg G, et al. Critical role for FoxO3a-dependent regulation of p21CIP1/WAF1 in response to statin signaling in cardiac myocytes. Circ Res. 2007;100:50-60 pubmed
    ..Taken together, our genetic and biochemical data delineate an essential function of p21 for statin-dependent inhibition of cardiac myocyte hypertrophy. ..
  57. Khatun R, Lakin Thomas P. Activation and localization of protein kinase C in Neurospora crassa. Fungal Genet Biol. 2011;48:465-73 pubmed publisher
    ..However, over-expression of NPKC did not lengthen the conidiation period, indicating that PKC in Neurospora may not be responsible for the lengthened period in low choline cultures. ..
  58. Huber R, O Day D. Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum. Histochem Cell Biol. 2011;136:177-89 pubmed publisher
    ..Together, this work provides new insight into the localization of Cdk5, its function during cell division, and its binding to a proteolytic enzyme in Dictyostelium. ..
  59. Elowe S, Holland S, Kulkarni S, Pawson T. Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. Mol Cell Biol. 2001;21:7429-41 pubmed
  60. Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, et al. The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A. 2008;105:8585-90 pubmed publisher
    ..Taken together, our results fail to support a role for Nedd4-1 as the E3 ligase regulating PTEN stability and subcellular localization. ..
  61. Shao L, Sun X, Xu L, Young L, Wang J. Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells. Life Sci. 2006;78:1317-23 pubmed
    ..These results also suggest that the mechanism of GRP78 increase induced by lithium and valproate may be different from that of thapsigargin. ..
  62. McLaren M, Marsh K, Cochrane A. Modulating HIV-1 RNA processing and utilization. Front Biosci. 2008;13:5693-707 pubmed
    ..The observations made underline the multiple fate decisions that must be made at each stage of the viral RNA metabolic pathway and highlight potential new avenues for controlling HIV-1 replication. ..
  63. Chen Y, Alli Z, Ackerley C, Al Saud B, Abdelhaleem M. Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32. Exp Mol Pathol. 2007;82:256-61 pubmed
    ..These findings suggest that dysregulated expression of DHX32 might lead to as of yet unknown changes in mitochondrial homeostasis manifested by cytoplasmic redistribution of the molecular chaperon Hsp60. ..
  64. Xie L, Zhu D, Kang Y, Liang T, He Y, Gaisano H. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. PLoS ONE. 2013;8:e67561 pubmed publisher
    ..Sec5 protein knockdown had little effect on predocked granules, unless vigorously stimulated by KCl depolarization. Taken together, newcomer insulin granules in ? cells are more sensitive than predocked granules to Sec5 regulation. ..
  65. Loo T, Bartlett M, Clarke D. Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains. J Biol Chem. 2004;279:38395-401 pubmed
    ..It appears that cross-talk between the cytoplasmic and the transmembrane domains is required for establishment of proper domain-domain interactions that occur during folding of ATP-binding cassette protein transporters. ..
  66. Perez Ordonez B, Huynh N, Berean K, Jordan R. Expression of mismatch repair proteins, beta catenin, and E cadherin in intestinal-type sinonasal adenocarcinoma. J Clin Pathol. 2004;57:1080-3 pubmed
    ..Despite their histological resemblance to colorectal adenocarcinomas, there is little information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs)...
  67. Weeks A, Okolowsky N, Golbourn B, Ivanchuk S, Smith C, Rutka J. ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells. Am J Pathol. 2012;181:662-74 pubmed publisher
    ..RASAL2 knockdown leads to a conversion to an amoeboid phenotype. Our studies reveal that ECT2 has a novel role in mesenchymal-amoeboid transition in human astrocytoma cells. ..
  68. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control. ..
  69. Tarnawsky S, Palazzo A. Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements. Mol Biosyst. 2012;8:2527-30 pubmed publisher
    ..Here we demonstrate that these elements promote efficient export and proper cytoplasmic localization only when they are found at the 5' end of the transcript. ..
  70. Quinn Z, Yang C, Wrana J, McDermott J. Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins. Nucleic Acids Res. 2001;29:732-42 pubmed
    ..Thus, the association between Smad2 and MEF2A may subserve a physical link between TGF-ss signalling and a diverse array of genes controlled by the MEF2 cis element. ..
  71. McNeil J, Bognar A, Pearlman R. In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae. Genetics. 1996;142:371-81 pubmed
    ..Inactivation of SHM1, SHM2 and ADE3 is required to render yeast auxotrophic for TMP and methionine, suggesting that TMP synthesized in mitochondria may be available to the cytoplasmic compartment. ..
  72. Chetty R, Jain D, Serra S. p120 catenin reduction and cytoplasmic relocalization leads to dysregulation of E-cadherin in solid pseudopapillary tumors of the pancreas. Am J Clin Pathol. 2008;130:71-6 pubmed publisher
    ..Aberrations and other alterations of the E-cadherin gene are unlikely to be responsible for the loss of E-cadherin in SPTs. ..
  73. Berube C, Boucher L, Ma W, Wakeham A, Salmena L, Hakem R, et al. Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A. 2005;102:14314-20 pubmed
    ..Our findings suggest that caspase-2 contributes to PIDD-mediated cell death, but that it is not the sole effector of this pathway. ..