Experts and Doctors on catalytic domain in Hamilton, Ontario, Canada

Summary

Locale: Hamilton, Ontario, Canada
Topic: catalytic domain

Top Publications

  1. Burger S, Thompson D, Ayers P. Quantum mechanics/molecular mechanics strategies for docking pose refinement: distinguishing between binders and decoys in cytochrome C peroxidase. J Chem Inf Model. 2011;51:93-101 pubmed publisher
    ..This work highlights the importance of including polarization effects through QM/MM and of sampling with MD to refine a set of initial docked poses. ..
  2. Morar M, Bhullar K, Hughes D, Junop M, Wright G. Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB. Structure. 2009;17:1649-1659 pubmed publisher
    ..The LinB structure provides an evolutionary link to ancient nucleotide polymerases and suggests that, like protein kinases and acetyltransferases, these are proto-resistance elements from which drug resistance can evolve. ..
  3. Shulga Y, Topham M, Epand R. Study of arachidonoyl specificity in two enzymes of the PI cycle. J Mol Biol. 2011;409:101-12 pubmed publisher
    ..We demonstrate that the acyl chain dependence of this phosphatidic acid activation is dependent on the substrate. This is the first demonstration of a motif that endows specificity for an acyl chain in enzymes DGK? and PIP5K I?. ..
  4. Iyengar B, Roote J, Campos A. The tamas gene, identified as a mutation that disrupts larval behavior in Drosophila melanogaster, codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-gamma125). Genetics. 1999;153:1809-24 pubmed
    ..Sequencing of mutant alleles demonstrated that tamas codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-gamma125). ..
  5. Berti P, Chindemi P. Catalytic residues and an electrostatic sandwich that promote enolpyruvyl shikimate 3-phosphate synthase (AroA) catalysis. Biochemistry. 2009;48:3699-707 pubmed publisher
    ..Thus, K22 had roles in both substrate-binding and transition-state stabilization. These results support the identification of E341 and K22 as general acid/base catalytic residues. ..
  6. Lung M, Shulga Y, Ivanova P, Myers D, Milne S, Brown H, et al. Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol. J Biol Chem. 2009;284:31062-73 pubmed publisher
    ..This novel mechanism of enzyme regulation within a signaling pathway could serve as a template for the regulation of enzymes in other pathways in the cell. ..
  7. D Souza K, Epand R. Catalytic activity and acyl-chain selectivity of diacylglycerol kinase ? are modulated by residues in and near the lipoxygenase-like motif. J Mol Biol. 2012;416:619-28 pubmed publisher
    ..In addition to the LOX-like motif, adjacent residues also contribute to selectivity for diacylglycerols with specific acyl-chain compositions, such as those found in the phosphatidylinositol cycle. ..
  8. Roddick L, Bhakta V, Sheffield W. Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition. BMC Biochem. 2013;14:31 pubmed publisher
    ..Our results suggest that HCII 1-75 binds thrombin exosite 1 and orients the attached serpin scaffold for more efficient interaction with the active site of thrombin than the HV3 triskaidecapeptide. ..
  9. Iwanczyk J, Damjanovic D, Kooistra J, Leong V, Jomaa A, Ghirlando R, et al. Role of the PDZ domains in Escherichia coli DegP protein. J Bacteriol. 2007;189:3176-86 pubmed

More Information

Publications11

  1. Taylor P, Blakely K, De Leon G, Walker J, McArthur F, Evdokimova E, et al. Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. J Biol Chem. 2008;283:2835-45 pubmed
    ..We postulate GmhA acts through an enediol-intermediate isomerase mechanism. ..
  2. Jackson S, Zhang F, Chindemi P, Junop M, Berti P. Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions . Biochemistry. 2009;48:11715-23 pubmed publisher
    ..Cys115 appears to have an important role in forming the staged conformation. The staged conformation appears to be one step in a complex choreography of release of the product from MurA. ..