Genomes and Genes
Experts and Doctors on animals in Hamilton, Ontario, Canada
Locale: Hamilton, Ontario, Canada
Publications559 found, 100 shown here
- Gill N, Ashkar A. Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2. J Virol. 2009;83:918-26 pubmed publisher..Our data suggest that overexpression of IL-15 results in a reduced CD4(+) T cell-mediated adaptive immune response against genital HSV-2. ..
- Cameron H, Foster W. Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in Her2/neu transgenic mice. PLoS ONE. 2009;4:e4303 pubmed publisher..Dieldrin exposure also altered the expression of BNDF and TrkB, novel modulators of cancer pathogenesis. ..
- Bassett J, Swift S, Bramson J. Optimizing vaccine-induced CD8(+) T-cell immunity: focus on recombinant adenovirus vectors. Expert Rev Vaccines. 2011;10:1307-19 pubmed publisher..Results from upcoming Phase II clinical trials will be important for determining whether rHuAd5 T-cell vaccines are effective in humans and should help identify correlates of CD8(+) T-cell protection. ..
- Jobse B, Rhem R, McCurry C, Wang I, Labiris N. Imaging lung function in mice using SPECT/CT and per-voxel analysis. PLoS ONE. 2012;7:e42187 pubmed publisher..Per-voxel analysis and the ability to non-invasively assess lung function will aid in the investigation of chronic lung disease models and drug efficacy studies. ..
- Wu R, Pasyk M, Wang B, Forsythe P, Bienenstock J, Mao Y, et al. Spatiotemporal maps reveal regional differences in the effects on gut motility for Lactobacillus reuteri and rhamnosus strains. Neurogastroenterol Motil. 2013;25:e205-14 pubmed publisher..Effects are not necessarily the same in colon and jejunum. Further research is needed on the detailed effects of the strains on enteric neuron currents for each gut region. ..
- Wong M, Mutch D, McNicholas P. Two-way learning with one-way supervision for gene expression data. BMC Bioinformatics. 2017;18:150 pubmed publisher..Initial results using real data show that this biclustering technique provides a novel approach for biomarker discovery by enabling blood to be used as a surrogate for hard-to-obtain tissues. ..
- Hollis L, McGeer J, McDonald D, Wood C. Effects of long term sublethal Cd exposure in rainbow trout during soft water exposure: implications for biotic ligand modelling. Aquat Toxicol. 2000;51:93-105 pubmed..e. acute gill surface binding model or Biotic Ligand Model) does work for soft and hard water exposures but there are complications when applying the model to fish chronically exposed to cadmium...
- Scott G, Sloman K, Rouleau C, Wood C. Cadmium disrupts behavioural and physiological responses to alarm substance in juvenile rainbow trout (Oncorhynchus mykiss). J Exp Biol. 2003;206:1779-90 pubmed
- Niyogi S, Wood C. Kinetic analyses of waterborne Ca and Cd transport and their interactions in the gills of rainbow trout (Oncorhynchus mykiss) and yellow perch (Perca flavescens), two species differing greatly in acute waterborne Cd sensitivity. J Comp Physiol B. 2004;174:243-53 pubmed..Moreover, interspecific differences in acute waterborne Cd sensitivity can be explained, at least in part, by the differential nature of interactions between waterborne Ca and Cd transport in fish gills. ..
- Frasier T, Wilson P, White B. Rapid screening of microsatellite markers for polymorphisms using SYBR green I and a DNA sequencer. Biotechniques. 2004;36:408-9 pubmed
- Koeberle P, Gauldie J, Ball A. Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-beta on the survival of axotomized retinal ganglion cells. Neuroscience. 2004;125:903-20 pubmed..Our results suggest that interleukin-10 and interleukin-4 may help prevent neurodegeneration caused by the activation of glial cells after CNS injury. ..
- Torgerson D, Singh R. Rapid evolution through gene duplication and subfunctionalization of the testes-specific alpha4 proteasome subunits in Drosophila. Genetics. 2004;168:1421-32 pubmed publisher..Newly duplicated genes that are freer from selective constraints may provide a mechanism for developing new interactions and a pathway for the evolution of new genes...
- Singh R, Kulathinal R. Male sex drive and the masculinization of the genome. Bioessays. 2005;27:518-25 pubmed publisher..Male sex-drive theory complements the female-choice theory of sexual selection and allows for the genetic variation of costly sexual traits to be continuously replenished...
- Dey B, Stalker L, Schnerch A, Bhatia M, Taylor Papidimitriou J, Wynder C. The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. Mol Cell Biol. 2008;28:5312-27 pubmed publisher..These findings demonstrate a role for KDM5b in the choice between proliferation and differentiation during development. ..
- Epand R, Epand R, Savage P. Ceragenins (cationic steroid compounds), a novel class of antimicrobial agents. Drug News Perspect. 2008;21:307-11 pubmed publisher..Factors contributing to the mechanism of action of these agents are discussed. The ceragenins are a class of agents with many properties to make them favorable for application as antiinfective agents. ..
- Denisova G, Denisov D, Evelegh C, Weissgram M, Beck J, Foley S, et al. Characterizing complex polysera produced by antigen-specific immunization through the use of affinity-selected mimotopes. PLoS ONE. 2009;4:e5309 pubmed publisher..This strategy is useful as a tool for monitoring immunity following vaccination and can also be used to define relevant epitopes for the creation of novel vaccines. ..
- Boudreau J, Bridle B, Stephenson K, Jenkins K, Brunellière J, Bramson J, et al. Recombinant vesicular stomatitis virus transduction of dendritic cells enhances their ability to prime innate and adaptive antitumor immunity. Mol Ther. 2009;17:1465-72 pubmed publisher..Our findings identify DeltaM51-VSV as both an efficient gene-delivery vector and a maturation agent allowing DC vaccines to overcome immunosuppression in the tumor-bearing host. ..
- Bridle B, Boudreau J, Lichty B, Brunellière J, Stephenson K, Koshy S, et al. Vesicular stomatitis virus as a novel cancer vaccine vector to prime antitumor immunity amenable to rapid boosting with adenovirus. Mol Ther. 2009;17:1814-21 pubmed publisher..Furthermore, VSV-hDCT could increase DCT-specific T-cell responses primed by Ad-hDCT, suggesting VSV is efficient for both priming and boosting of the immune response against a self-tumor antigen. ..
- Dewitte Orr S, Collins S, Bauer C, Bowdish D, Mossman K. An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses. PLoS Pathog. 2010;6:e1000829 pubmed publisher..Furthermore, the implications of a cell surface receptor capable of recognizing extracellular RNA may exceed beyond viral immunity to mediating other important innate immune functions. ..
- Koboldt D, Staisch J, Thillainathan B, Haines K, Baird S, Chamberlin H, et al. A toolkit for rapid gene mapping in the nematode Caenorhabditis briggsae. BMC Genomics. 2010;11:236 pubmed publisher..We also show that molecular markers can be useful tools to improve the C. briggsae genome sequence assembly. Our polymorphism resource promises to accelerate genetic and functional studies of C. briggsae genes. ..
- Abdul Careem M, Mian M, Yue G, Gillgrass A, Chenoweth M, Barra N, et al. Critical role of natural killer cells in lung immunopathology during influenza infection in mice. J Infect Dis. 2012;206:167-77 pubmed publisher..1(+) cell-depleted wild-type mice than in that from control mice. Our data suggest that NK cells significantly augment pulmonary inflammation, contributing to the pathogenesis of influenza infection...
- Caron N, Munsie L, Keillor J, Truant R. Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells. PLoS ONE. 2012;7:e44159 pubmed publisher..Future applications of this biosensor could be to discover small molecules that specifically alter TG2 conformation to affect GDP/GTP or calcium binding. ..
- Spencer G, Yu X, Khan I, Grover A. Expression of isoforms of internal Ca2+ pump in cardiac, smooth muscle and non-muscle tissues. Biochim Biophys Acta. 1991;1063:15-20 pubmed
- Sakic B, Maric I, Koeberle P, Millward J, Szechtman H, Maric D, et al. Increased TUNEL staining in brains of autoimmune Fas-deficient mice. J Neuroimmunol. 2000;104:147-54 pubmed
- Sabourin L, Rudnicki M. The molecular regulation of myogenesis. Clin Genet. 2000;57:16-25 pubmed..This has put forward the hypothesis that these factors also play specific biological roles following muscle injury and repair. ..
- Soderholm J, Yang P, Ceponis P, Vohra A, Riddell R, Sherman P, et al. Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine. Gastroenterology. 2002;123:1099-108 pubmed..These findings suggest that chronic psychological stress can be an initiating factor in intestinal inflammation by impairing mucosal defenses against luminal bacteria and highlight the importance of mast cells in this process. ..
- Kwan C, Zhang W, Deyama T, Nishibe S. Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:206-11 pubmed..Results of our study offer a plausible mechanistic basis for the vasorelaxing action of Eucommia ulmoides Oliv., which may account for its well-documented antihypertensive action...
- Sondhi S, Castellano J, Chong V, Rogoza R, Skoblenick K, Dyck B, et al. cDNA array reveals increased expression of glucose-dependent insulinotropic polypeptide following chronic clozapine treatment: role in atypical antipsychotic drug-induced adverse metabolic effects. Pharmacogenomics J. 2006;6:131-40 pubmed..These results suggest that adverse metabolic effects associated with clozapine treatment may be related to its ability to increase intestinal gene expression for GIP. ..
- Hunter M, Wang A, McKay D. Helminth infection enhances disease in a murine TH2 model of colitis. Gastroenterology. 2007;132:1320-30 pubmed..Here the ability of the rat tapeworm Hymenolepis diminuta to affect the course of oxazolone-induced colitis (a TH2 model) was assessed...
- Ferreira V, Nazli A, Mossman K, Kaushic C. Proinflammatory cytokines and chemokines - but not interferon-? - produced in response to HSV-2 in primary human genital epithelial cells are associated with viral replication and the presence of the virion host shutoff protein. Am J Reprod Immunol. 2013;70:199-212 pubmed publisher..Viral factors such as replication and the presence of the VHS protein play important roles in regulating innate antiviral responses against HSV-2 from primary GECs. ..
- Forsythe P. Microbes taming mast cells: Implications for allergic inflammation and beyond. Eur J Pharmacol. 2016;778:169-75 pubmed publisher..Further investigation of mast cell regulation by non-pathogenic or symbiotic bacteria will likely lead to a greater understanding of host microbiota interaction and the role of the microbiome in health and disease. ..
- Robinson S, Donaldson Kabwe N, Dvorkin Gheva A, Longo J, He L, Daniel J. The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes. Biochem Biophys Res Commun. 2017;493:416-421 pubmed publisher..Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes. ..
- Swirski F, Sajic D, Robbins C, Gajewska B, Jordana M, Stampfli M. Chronic exposure to innocuous antigen in sensitized mice leads to suppressed airway eosinophilia that is reversed by granulocyte macrophage colony-stimulating factor. J Immunol. 2002;169:3499-506 pubmed..This study shows that exposure to innocuous Ag alone does not lead to persistent eosinophilic airway inflammation, but rather to abrogated eosinophilia. This suppression can be reversed by GM-CSF. ..
- Akiho H, Deng Y, Blennerhassett P, Kanbayashi H, Collins S. Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology. 2005;129:131-41 pubmed..Here, we investigate the mechanisms underlying the maintenance of this hypercontractility in the postinfective (PI) state...
- Hassan J, Busto M, Iyengar B, Campos A. Behavioral characterization and genetic analysis of the Drosophila melanogaster larval response to light as revealed by a novel individual assay. Behav Genet. 2000;30:59-69 pubmed..Finally, we demonstrate that this response to light can be mediated by rhodopsins other than the blue absorbing Rh1. ..
- Porter L, Cukier I, Lee J. Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis. Blood. 2003;101:1928-33 pubmed..Our observations are consistent with the idea that localization of cyclin B1 is among the factors determining the cellular decision to undergo apoptosis in response to DNA damage. ..
- Li S, Reinprecht I, Fahnestock M, Racine R. Activity-dependent changes in synaptophysin immunoreactivity in hippocampus, piriform cortex, and entorhinal cortex of the rat. Neuroscience. 2002;115:1221-9 pubmed..This demonstrates that different populations of sprouting axons are labeled by these two techniques, and suggests that activation-induced sprouting extends well beyond the hippocampal mossy fiber system. ..
- Richards J, Heigenhauser G, Wood C. Exercise and recovery metabolism in the Pacific spiny dogfish (Squalus acanthias). J Comp Physiol B. 2003;173:463-74 pubmed
- Barbara G, De Giorgio R, Stanghellini V, Corinaldesi R, Cremon C, Gerard N, et al. Neutral endopeptidase (EC 188.8.131.52) downregulates the onset of intestinal inflammation in the nematode infected mouse. Gut. 2003;52:1457-64 pubmed
- Wright G. Mechanisms of resistance to antibiotics. Curr Opin Chem Biol. 2003;7:563-9 pubmed
- Hoang Q, Sicheri F, Howard A, Yang D. Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature. 2003;425:977-80 pubmed..On the basis of our findings, we propose a model of osteocalcin binding to hydroxyapatite and draw parallels with other proteins that engage crystal lattices. ..
- Seidlitz E, Korbie D, Marien L, Richardson M, Singh G. Quantification of anti-angiogenesis using the capillaries of the chick chorioallantoic membrane demonstrates that the effect of human angiostatin is age-dependent. Microvasc Res. 2004;67:105-16 pubmed..This not only demonstrates the important effects on neo-angiogenesis compared to mature vessels, but also illustrates the potential of the CAM to readily provide a means for such a comparison. ..
- Cirone P, Bourgeois J, Shen F, Chang P. Combined immunotherapy and antiangiogenic therapy of cancer with microencapsulated cells. Hum Gene Ther. 2004;15:945-59 pubmed..Thus, the concept of a "cocktail" strategy, with microencapsulation delivering multiple antitumor recombinant molecules to improve efficacy, is validated. ..
- Robbins C, Pouladi M, Fattouh R, Dawe D, Vujicic N, Richards C, et al. Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization. J Immunol. 2005;175:2834-42 pubmed..MTS, therefore, plays a disparate role in the development of allergic responses, inducing a heightened state of allergen-specific sensitization, but dampening local immune inflammatory processes in the lung. ..
- Begbie M, Mamdani A, Gataiance S, Eltringham Smith L, Bhakta V, Hortelano G, et al. An important role for the activation peptide domain in controlling factor IX levels in the blood of haemophilia B mice. Thromb Haemost. 2005;94:1138-47 pubmed..Our results suggest that deletion of the multiple sites of fIX post-translational modification found within the activation peptide eliminated important fIX clearance motifs. ..
- Macpherson A, Smith K. Mesenteric lymph nodes at the center of immune anatomy. J Exp Med. 2006;203:497-500 pubmed
- Dixit D, Zarate N, Liu L, Boreham D, Huizinga J. Interstitial cells of Cajal and adaptive relaxation in the mouse stomach. Am J Physiol Gastrointest Liver Physiol. 2006;291:G1129-36 pubmed..ICC-IM may be involved in regulation of (distention-induced) myogenic tone. ..
- Szewczyk M, Davis K, Samson S, Simpson F, Rangachari P, Grover A. Ca2+-pumps and Na2+-Ca2+-exchangers in coronary artery endothelium versus smooth muscle. J Cell Mol Med. 2007;11:129-38 pubmed..The differences between EC and SMC should be considered in therapeutic interventions of cardiovascular diseases. ..
- Krause M, Riddell M, Gordon C, Imam S, Cafarelli E, Hawke T. Diabetic myopathy differs between Ins2Akita+/- and streptozotocin-induced Type 1 diabetic models. J Appl Physiol (1985). 2009;106:1650-9 pubmed publisher..Ins2(Akita+/-) diabetic muscle despite similarity in hyperglycemia/hypoinsulinemia, raising concerns of our current state of knowledge regarding the effects of T1DM on skeletal muscle. ..
- Buttigieg J, Brown S, Holloway A, Nurse C. Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha. J Neurosci. 2009;29:7137-47 pubmed publisher..The therapeutic potential of K(ATP) channel blockers was validated in experiments in which hypoxia-induced neonatal mortality in nicotine-exposed pups was significantly reduced after pretreatment with glibenclamide. ..
- Kolozsi E, MacKenzie R, Roullet F, deCatanzaro D, Foster J. Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice. Neuroscience. 2009;163:1201-10 pubmed publisher..This lowered expression may be linked to autistic-like behavioral phenotype observed in the VPA mice. ..
- Dyrda P, Tazzeo T, Doharris L, Nilius B, Roman H, Lauzon A, et al. Acute response of airway muscle to extreme temperature includes disruption of actin-myosin interaction. Am J Respir Cell Mol Biol. 2011;44:213-21 pubmed publisher..We conclude that extreme temperatures (such as those used in bronchial thermoplasty) directly disrupt actin-myosin interactions, likely through a denaturation of the motor protein, leading to an immediate loss of ASM cell function. ..
- Pistilli M, Petrik J, Holloway A, Crankshaw D. Immunohistochemical and functional studies on calcium-sensing receptors in rat uterine smooth muscle. Clin Exp Pharmacol Physiol. 2012;39:37-42 pubmed publisher..However, the pharmacological profile of inhibition of contractility by CaS ligands is not consistent with a role for CaS in the regulation of uterine contractility in the rat. ..
- Stephenson K, Barra N, Davies E, Ashkar A, Lichty B. Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity. Cancer Gene Ther. 2012;19:238-46 pubmed publisher..Overall, the transient localized expression of IL-15 in the tumour by an oncolytic virus was able to induce stronger anti-tumoral immunity in a murine model of colon carcinoma. ..
- Silva M, Bercik P. Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells. Lab Invest. 2012;92:937-48 pubmed publisher..We demonstrated that macrophages are related with bronchiolar GCH, and that they induced MUC5B and inhibited MUC5AC in HBEC, suggesting a role for them in the pathogenesis of airway MUC5B-related GCH. ..
- Cooper C, Mulder D, Allison S, Pilar A, Coombes B. The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA. BMC Microbiol. 2013;13:221 pubmed publisher..This work completes the characterization of the chaperone complement within SPI-2 and identifies SscA as the chaperone for the SseC translocon. ..
- Jeyanathan M, Afkhami S, Khera A, Mandur T, Damjanovic D, Yao Y, et al. CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine-Induced T Cells to Both the Lung Parenchyma and Airway. J Immunol. 2017;199:2555-2569 pubmed publisher..Our findings offer new insights into mucosal T cell biology and have important implications in vaccine strategies against pulmonary TB and other intracellular infections in the lung. ..
- Sakic B, Szechtman H, Denburg S, Denburg J. Immunosuppressive treatment prevents behavioral deficit in autoimmune MRL-lpr mice. Physiol Behav. 1995;58:797-802 pubmed..The effect of cyclophosphamide in the MRL-lpr group is believed to reflect the suppression of pathogenic immune factor(s) that alter behavior during the onset of autoimmune disease. ..
- Jones N, Killian K. Exercise limitation in health and disease. N Engl J Med. 2000;343:632-41 pubmed
- Coombes B, Wickham M, Mascarenhas M, Gruenheid S, Finlay B, Karmali M. Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains. Appl Environ Microbiol. 2008;74:2153-60 pubmed publisher..These results and methods offer a molecular risk assessment strategy to rapidly recognize and respond to non-O157 STEC strains from environmental and animal sources that might pose serious public health risks to humans. ..
- Noori A, Selvaganapathy P, Wilson J. Microinjection in a microfluidic format using flexible and compliant channels and electroosmotic dosage control. Lab Chip. 2009;9:3202-11 pubmed publisher..The study involved the injection of ultrapure water into the embryos in an E3 buffer, and resulted in embryos that showed normal development at 48 hours. ..
- Mian M, Ahmed A, Rad M, Babaian A, Bowdish D, Ashkar A. Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type. J Leukoc Biol. 2013;94:1025-36 pubmed publisher..These findings may augment in selecting the appropriate poly I:C type to design cell-type-specific potent adjuvants for vaccines against infectious diseases or cancers. ..
- McGray A, Hallett R, Bernard D, Swift S, Zhu Z, Teoderascu F, et al. Immunotherapy-induced CD8+ T cells instigate immune suppression in the tumor. Mol Ther. 2014;22:206-18 pubmed publisher..These novel observations that T cells produced by therapeutic intervention can instigate a rapid adaptive immunosuppressive response within the tumor have important implications for clinical implementation of immunotherapies. ..
- Nilsson M, Nissar A, Al Sajee D, Tarnopolsky M, Parise G, Lach B, et al. Xin is a marker of skeletal muscle damage severity in myopathies. Am J Pathol. 2013;183:1703-1709 pubmed publisher..The strong correlation between the degree of muscle damage and Xin immunoreactivity suggests that Xin may be a suitable outcome measure to evaluate disease progression and treatment effects in clinical trials. ..
- Bujak A, Crane J, Lally J, Ford R, Kang S, Rebalka I, et al. AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging. Cell Metab. 2015;21:883-90 pubmed publisher..These findings establish an essential requirement for skeletal muscle AMPK-mediated autophagy in preserving blood glucose levels during prolonged fasting as well as maintaining muscle integrity and mitochondrial function during aging. ..
- Zlitni A, Yin M, Janzen N, Chatterjee S, Lisok A, Gabrielson K, et al. Development of prostate specific membrane antigen targeted ultrasound microbubbles using bioorthogonal chemistry. PLoS ONE. 2017;12:e0176958 pubmed publisher..The results demonstrate both the feasibility of preparing PSMA-targeted MBs and the benefits of using bioorthogonal chemistry to create targeted US probes. ..
- Glover J, Andrews D, Subramani S, Rachubinski R. Mutagenesis of the amino targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo. J Biol Chem. 1994;269:7558-63 pubmed..cerevisiae thiolase to peroxisomes. ..
- Klement P, Carlsson S, Rak J, Liao P, Vlasin M, Stafford A, et al. The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model. J Thromb Haemost. 2003;1:587-94 pubmed..Thus, at maximally effective doses, melagatran causes less bleeding than hirudin in this model. These findings raise the possibility that some direct thrombin inhibitors are safer than others. ..
- Brown S, Kelly K, Daniel J, Nurse C. Hypoxia inducible factor (HIF)-2 alpha is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. J Neurochem. 2009;110:622-30 pubmed publisher..These data suggest that a basal level of HIF-2alpha function is required for the normal developmental expression of DDC and DbetaH in SA progenitor cells, and that loss of this function leads to impaired catecholamine biosynthesis. ..
- Bassett E, Williams T, Zacharias A, Gage P, Fuhrmann S, West Mays J. AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010;19:1791-804 pubmed publisher..In view of recent data showing that mutations in human TFAP2A result in similar eye defects, the current findings demonstrate that AP-2alpha KO mice provide a valuable model for human ocular disease...
- Wang L, Rodrigues N, Wu Y, Maslikowski B, Singh N, Lacroix S, et al. Pleiotropic action of AP-1 in v-Src-transformed cells. J Virol. 2011;85:6725-35 pubmed publisher..Therefore, AP-1 facilitated transformation by acting as a survival factor, by inhibiting premature entry into senescence, and by blocking the differentiation of v-Src-transformed CEF. ..
- Natividad J, Hayes C, Motta J, Jury J, Galipeau H, Philip V, et al. Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950. Appl Environ Microbiol. 2013;79:7745-54 pubmed publisher..Treatment with this probiotic may enhance the mucosal barrier and protect the host from infection and inflammation. ..
- Kurella V, Tzou J, Coombs D, Ward M. Asymptotic analysis of first passage time problems inspired by ecology. Bull Math Biol. 2015;77:83-125 pubmed publisher..Results for the MFPT, the VMFPT, and splitting probability obtained from our hybrid methodology are validated with corresponding results computed from full numerical simulations of the underlying PDEs. ..
- Janssen L, Hansebout R. Pathogenesis of spinal cord injury and newer treatments. A review. Spine (Phila Pa 1976). 1989;14:23-32 pubmed..From this, a number of mechanisms accounting for the mediation and/or prevention of the secondary destructive response are synthesized. ..
- Sonnenfeld M, Jacobs J. Macrophages and glia participate in the removal of apoptotic neurons from the Drosophila embryonic nervous system. J Comp Neurol. 1995;359:644-52 pubmed..Some apoptotic cells are expelled from the CNS, which suggests that the removal of apoptotic cells can occur in the absence of macrophages. The number of subperineurial glia is unaffected by changes in the rate of neuronal apoptosis. ..
- Sakic B, Laflamme N, Crnic L, Szechtman H, Denburg J, Rivest S. Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction. J Neuroimmunol. 1999;96:80-91 pubmed..Furthermore, they support the parallel between chronic stress and chronic autoimmunity/inflammation, and suggest common central mechanisms relevant to endocrine function and behavior. ..
- Kwan C, Achike F. Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action. Acta Pharmacol Sin. 2002;23:1057-68 pubmed..TET is also known for its anti-inflammatory and anti-fibrogenic actions, which make TET and related compound potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis...
- Hossain G, van Thienen J, Werstuck G, Zhou J, Sood S, Dickhout J, et al. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem. 2003;278:30317-27 pubmed..Collectively, these findings provide evidence that TDAG51 is induced by homocysteine, promotes detachment-mediated PCD, and contributes to the development of atherosclerosis observed in hyperhomocysteinemia. ..
- Kurpios N, Sabolic N, Shepherd T, Fidalgo G, Hassell J. Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis. J Mammary Gland Biol Neoplasia. 2003;8:177-90 pubmed..Taken together these observations suggest that the PEA3 subfamily proteins play key regulatory roles in both mammary gland development and oncogenesis. ..
- Ye J, Zhu Y, Khan W, Van Snick J, Huizinga J. IL-9 enhances growth of ICC, maintains network structure and strengthens rhythmicity of contraction in culture. J Cell Mol Med. 2006;10:687-94 pubmed..Our data indicate that IL-9 promotes ICC growth in culture and it can be hypothesized that IL-9 is a critical factor in the maintenance of ICC health and ICC repair after injury. ..
- Dicu A, Topham M, Ottaway L, Epand R. Role of the hydrophobic segment of diacylglycerol kinase epsilon. Biochemistry. 2007;46:6109-17 pubmed..The major conclusions of this work are that the hydrophobic domain of DGKepsilon does not contribute to substrate specificity but plays a role in permanently sequestering the enzyme to a membrane. ..
- Feng B, He S, Zheng P, Wu L, Yang P. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol. 2007;171:537-47 pubmed..Blockade of TLR2 or NOD1 or treating mice with a mast cell stabilizer can efficiently inhibit PGN-induced-diarrhea, providing potential therapeutic significance. ..
- Clark D, Gorczynski R, Blajchman M. Transfusion-related immunomodulation due to peripheral blood dendritic cells expressing the CD200 tolerance signaling molecule and alloantigen. Transfusion. 2008;48:814-21 pubmed publisher..These data also indicate that tumor cell growth can be mediated by the stimulation of TGF-beta-producing cells and that TGF-beta may act by tumor cell growth stimulation, rather than by host immunosuppression. ..
- Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson M, et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science. 2009;325:617-20 pubmed publisher..Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms of inflammatory diseases where immune dysfunction is implicated. ..