Experts and Doctors on molecular sequence data in Halifax, Nova Scotia, Canada


Locale: Halifax, Nova Scotia, Canada
Topic: molecular sequence data

Top Publications

  1. Haeryfar S, Al Alwan M, Mader J, Rowden G, West K, Hoskin D. Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit. J Immunol. 2003;171:69-77 pubmed
  2. Walsh D, Papke R, Doolittle W. Archaeal diversity along a soil salinity gradient prone to disturbance. Environ Microbiol. 2005;7:1655-66 pubmed
    ..We speculate that ecosystem disturbance -- in the form of salinity fluctuations -- is one mechanism for maintaining a diverse community of haloarchaea at Salt Spring. ..
  3. Dickinson A, Croll R, Voronezhskaya E. Development of embryonic cells containing serotonin, catecholamines, and FMRFamide-related peptides in Aplysia californica. Biol Bull. 2000;199:305-15 pubmed
    ..californica presents new opportunities for a better understanding of the ontogeny and phylogeny of both behavioral and neuronal function in this important model species. ..
  4. Tanifuji G, Onodera N, Wheeler T, Dlutek M, Donaher N, Archibald J. Complete nucleomorph genome sequence of the nonphotosynthetic alga Cryptomonas paramecium reveals a core nucleomorph gene set. Genome Biol Evol. 2011;3:44-54 pubmed publisher
    ..This result suggests that similar reductive processes have taken place in unrelated lineages of nucleomorph-containing algae...
  5. Bedard K, Jaquet V, Krause K. NOX5: from basic biology to signaling and disease. Free Radic Biol Med. 2012;52:725-34 pubmed publisher
    ..This review takes a look back at some historical aspects of the discovery of NOX5 and summarizes our current understanding of the enzyme. ..
  6. Xu Q, Singer R, Johnston G. Sug1 modulates yeast transcription activation by Cdc68. Mol Cell Biol. 1995;15:6025-35 pubmed
    ..Consistent with this hypothesis, we find that Sug1 represses transcription in vivo. ..
  7. Tanifuji G, Kim E, Onodera N, Gibeault R, Dlutek M, Cawthorn R, et al. Genomic characterization of Neoparamoeba pemaquidensis (Amoebozoa) and its kinetoplastid endosymbiont. Eukaryot Cell. 2011;10:1143-6 pubmed publisher
    ..The genome of this "Ichthyobodo-related organism" was found to be unexpectedly large, with at least 11 chromosomes between 1.0 and 3.5 Mbp and a total genome size of at least 25 Mbp. ..
  8. Guernsey D, Jiang H, Bedard K, Evans S, Ferguson M, Matsuoka M, et al. Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease. PLoS Genet. 2010;6: pubmed publisher
    ..Other ubiquitin ligases play documented roles in neurodegenerative diseases. LRSAM1 is a strong candidate for the causal gene for the genetic disorder in our kindred. ..
  9. McCarthy T, Li X, Sinal C. Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids. J Biol Chem. 2005;280:23232-42 pubmed
    ..These data support a regulatory role for the VDR in the protection of colon cells from bile acid toxicity through regulation of the Mrp3 expression. ..

More Information


  1. Bullerwell C, Burger G, Gott J, Kourennaia O, Schnare M, Gray M. Abundant 5S rRNA-like transcripts encoded by the mitochondrial genome in amoebozoa. Eukaryot Cell. 2010;9:762-73 pubmed publisher
    ..We posit that currently unrecognized 5S-like RNAs may exist in other mitochondrial systems in which a conventional 5S rRNA cannot be identified...
  2. Johnston G, Prendergast J, Singer R. The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles. J Cell Biol. 1991;113:539-51 pubmed
    ..Bulk secretion continues in mutant cells, although secretory vesicles accumulate. The MYO2 myosin thus may function as the molecular motor to transport secretory vesicles along actin cables to the site of bud development. ..
  3. Borza T, Stone C, Rise M, Bowman S, Johnson S. Atlantic cod (Gadus morhua) CC chemokines: Diversity and expression analysis. Dev Comp Immunol. 2010;34:904-13 pubmed publisher
    ..Tissue specificity, and the level of induction, varied broadly; for example, GmSCYA123 was at least 4-fold up-regulated by both inducers in all tissues analyzed, whereas pIC increased the expression of GmSCYA124 in liver over 1500 times...
  4. Brown M, Kolisko M, Silberman J, Roger A. Aggregative multicellularity evolved independently in the eukaryotic supergroup Rhizaria. Curr Biol. 2012;22:1123-7 pubmed publisher
    ..Here we demonstrate, by phylogenomic analyses of a 159-protein data set, that G. vulgaris is a member of Rhizaria and is thus the first member of this eukaryote supergroup known to be capable of aggregative multicellularity. ..
  5. Boucher Y, Douady C, Sharma A, Kamekura M, Doolittle W. Intragenomic heterogeneity and intergenomic recombination among haloarchaeal rRNA genes. J Bacteriol. 2004;186:3980-90 pubmed
    ..We suggest that intragenomic heterogeneity of rRNA operons is an ancient and stable trait in several lineages of the Halobacteriales. The impact of this phenomenon on the taxonomy of extremely halophilic archaea is discussed...
  6. Sharma M, Denovan Wright E, Degrave A, Thisse C, Thisse B, Wright J. Sequence, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2004;138:391-8 pubmed
    ..Expression in YSL, liver or pancreas has not been previously reported for fish or mammalian I-FABP genes and may be related to specific physiological differences between fishes and mammals. ..
  7. Simard D, Hewitt K, Lunn F, Iyengar A, Bearne S. Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis. Eur J Biochem. 2003;270:2195-206 pubmed
    ..This suggests that Arg429 plays a role in both GTP-dependent activation and GTP binding. ..
  8. Guernsey D, Jiang H, Hussin J, Arnold M, Bouyakdan K, Perry S, et al. Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Am J Hum Genet. 2010;87:40-51 pubmed publisher
    ..Like some other MCPH genes, CEP152 shows signatures of positive selection in the human lineage. CEP152 is a strong candidate for the causal gene underlying MCPH4 and may be an important gene in the evolution of human brain size. ..
  9. Henneberry A, Wright M, McMaster C. The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity. Mol Biol Cell. 2002;13:3148-61 pubmed
  10. Toptchieva A, Sisson G, Bryden L, Taylor D, Hoffman P. An inducible tellurite-resistance operon in Proteus mirabilis. Microbiology. 2003;149:1285-95 pubmed
    ..based on screening for high level Te(r) and preliminary PCR analysis. Thus, a chromosomally located inducible tellurite resistance operon appears to be a common feature of the genus Proteus. ..
  11. Noyce R, Delpeut S, Richardson C. Dog nectin-4 is an epithelial cell receptor for canine distemper virus that facilitates virus entry and syncytia formation. Virology. 2013;436:210-20 pubmed publisher
    ..Finally, dog nectin-4 also promotes syncytia formation, which could be inhibited by siRNA treatment. These data confirm that dog nectin-4 can be used by CDV to gain entry into epithelial cells, and facilitate virus spread...
  12. Smith D, Lee R. Mitochondrial genome of the colorless green alga Polytomella capuana: a linear molecule with an unprecedented GC content. Mol Biol Evol. 2008;25:487-96 pubmed publisher
    ..capuana mitochondrial genome, we describe recombination-based scenarios of how intact linear mtDNA conformations can be converted into the fragmented forms found in other Polytomella taxa...
  13. Liu X, Yang J. Bacterial thymidylate synthase with intein, group II Intron, and distinctive ThyX motifs. J Bacteriol. 2004;186:6316-9 pubmed
    ..One ThyX sequence has an intein in its ThyX motif that was shown to do protein splicing and a group II intron in its gene, suggesting a hot spot for these self-splicing mobile elements. ..
  14. Tsoi S, Park K, Kay H, O Brien T, Podor E, Sun G, et al. Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in Atlantic salmon during Aeromonas salmonicida infection. Vet Immunol Immunopathol. 2006;109:183-7 pubmed publisher
  15. Inagaki Y, Blouin C, Susko E, Roger A. Assessing functional divergence in EF-1alpha and its paralogs in eukaryotes and archaebacteria. Nucleic Acids Res. 2003;31:4227-37 pubmed
    ..We re-assess the available genetic data for HBS1 in light of our analyses, and propose that this protein may function in stop codon-independent peptide release. ..
  16. Russell A, Schnare M, Gray M. A large collection of compact box C/D snoRNAs and their isoforms in Euglena gracilis: structural, functional and evolutionary insights. J Mol Biol. 2006;357:1548-65 pubmed
  17. Xu Y, Liu Y, Ridgway N, McMaster C. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. J Biol Chem. 2001;276:18407-14 pubmed
  18. Kim E, Park J, Simpson A, Matsunaga S, Watanabe M, Murakami A, et al. Complex array of endobionts in Petalomonas sphagnophila, a large heterotrophic euglenid protist from Sphagnum-dominated peatlands. ISME J. 2010;4:1108-20 pubmed publisher
    ..Our study adds significantly to the growing evidence for complex and dynamic protist-bacterial associations in nature...
  19. Denovan Wright E, Pierce M, Wright J. Nucleotide sequence of cDNA clones coding for a brain-type fatty acid binding protein and its tissue-specific expression in adult zebrafish (Danio rerio). Biochim Biophys Acta. 2000;1492:221-6 pubmed
    ..In situ hybridization revealed that the B-FABP mRNA was expressed in the periventricular gray zone of the optic tectum of the adult zebrafish brain. ..
  20. Ragan M, Logsdon J, Sensen C, Charlebois R, Doolittle W. An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes. FEMS Microbiol Lett. 1996;144:151-5 pubmed
    ..The nuclear localization signal and negatively charged carboxy-terminus characteristic of eukaryotic pelota-like proteins are absent from the S. solfataricus homolog, and hence may be indicative of the acquired eukaryotic function(s)...
  21. Chen J, Liu L, Pohajdak B. Cloning a cDNA from human NK/T cells which codes for a protein with high proline content. Biochim Biophys Acta. 1995;1264:19-22 pubmed
    ..A polyclonal antiserum raised against recombinant B4-2 recognizes a 32-34 kDa protein in lymphocytes. ..
  22. Shmulevitz M, Gujar S, Ahn D, Mohamed A, Lee P. Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis. J Virol. 2012;86:7403-13 pubmed publisher
    ..Our studies reveal that oncolytic potency of reovirus can be improved through distinct mutations that increase the infectivity of reovirus particles...
  23. Liu L, Pohajdak B. Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7. Biochim Biophys Acta. 1992;1132:75-8 pubmed
    ..SEC7 is a large protein (2008 amino acids) found on Golgi vesicles that plays a role in protein transport. ..
  24. Sun Q, Zhang F, Wafa K, Baptist T, Pasumarthi K. A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway. J Cell Sci. 2009;122:1563-73 pubmed publisher
    ..We show that D2SV-induced cell cycle exit can be rescued by overexpression of D-type and B-type cyclins. We suggest that protein aggregation may be a major block for cardiomyocyte cell cycle reactivation. ..
  25. Smith D, Lee R. Low nucleotide diversity for the expanded organelle and nuclear genomes of Volvox carteri supports the mutational-hazard hypothesis. Mol Biol Evol. 2010;27:2244-56 pubmed publisher
    ..carteri contributed to a low V. carteri population size and thus a reduced 2N(g)?. Complete mitochondrial and plastid genome maps for V. carteri are also presented and compared with those of C. reinhardtii...
  26. Sharma M, Saxena V, Liu R, Thisse C, Thisse B, Denovan Wright E, et al. Differential expression of the duplicated cellular retinoic acid-binding protein 2 genes (crabp2a and crabp2b) during zebrafish embryonic development. Gene Expr Patterns. 2005;5:371-9 pubmed
  27. Hu Y, Bojikova Fournier S, King A, MacRae T. The structural stability and chaperone activity of artemin, a ferritin homologue from diapause-destined Artemia embryos, depend on different cysteine residues. Cell Stress Chaperones. 2011;16:133-41 pubmed publisher
  28. Langelaan D, Reddy T, Banks A, Dellaire G, Dupre D, Rainey J. Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking. Biochim Biophys Acta. 2013;1828:1471-83 pubmed publisher
  29. Covello P, Gray M. Silent mitochondrial and active nuclear genes for subunit 2 of cytochrome c oxidase (cox2) in soybean: evidence for RNA-mediated gene transfer. EMBO J. 1992;11:3815-20 pubmed
    ..Comparison of soybean mitochondrial and nuclear cox2 sequences clearly indicates that in an ancestor of soybean, cox2 was transferred from the mitochondrion to the nucleus via a C-to-U edited RNA intermediate. ..
  30. Shmulevitz M, Epand R, Epand R, Duncan R. Structural and functional properties of an unusual internal fusion peptide in a nonenveloped virus membrane fusion protein. J Virol. 2004;78:2808-18 pubmed
    ..The preservation of a predicted loop structure in the fusion peptide of this unusual nonenveloped virus membrane fusion protein supports an imperative role for a kinked fusion peptide motif in biological membrane fusion...
  31. Andersson J, Roger A. Evolutionary analyses of the small subunit of glutamate synthase: gene order conservation, gene fusions, and prokaryote-to-eukaryote lateral gene transfers. Eukaryot Cell. 2002;1:304-10 pubmed
  32. Yang K, Han L, Vining L. Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2. J Bacteriol. 1995;177:6111-7 pubmed
    ..When cultures of the disruption mutants were ethanol stressed, they overproduced the antibiotic. From these results it was concluded that expression of the jadomycin B biosynthesis genes are negatively regulated by jadR2. ..
  33. Keeling P, Doolittle W. Evidence that eukaryotic triosephosphate isomerase is of alpha-proteobacterial origin. Proc Natl Acad Sci U S A. 1997;94:1270-5 pubmed
    ..Among these eukaryotic genes are some from deeply branching, amitochondrial eukaryotes (namely Giardia), which further suggests that this event took place quite early in eukaryotic evolution...
  34. Nesbo C, L Haridon S, Stetter K, Doolittle W. Phylogenetic analyses of two "archaeal" genes in thermotoga maritima reveal multiple transfers between archaea and bacteria. Mol Biol Evol. 2001;18:362-75 pubmed publisher
    ..For hyperthermophiles, we hypothesize that LGT may be as much a consequence as the cause of adaptation to hyperthermophily...
  35. Fan J, Lee R. Mitochondrial genome of the colorless green alga Polytomella parva: two linear DNA molecules with homologous inverted repeat Termini. Mol Biol Evol. 2002;19:999-1007 pubmed publisher
    ..eugametos) as the outgroup, we conclude that the nonsynonymous nucleotide substitution rate in the mitochondrial protein-coding genes of P. parva is on an average about 3.3 times that of the C. reinhardtii counterparts...
  36. Liu R, Denovan Wright E, Wright J. Structure, linkage mapping and expression of the heart-type fatty acid-binding protein gene (fabp3 ) from zebrafish (Danio rerio). Eur J Biochem. 2003;270:3223-34 pubmed
    ..Inspection of the 5' upstream sequence of the zebrafish fabp3 gene revealed a number of cis elements that may be involved in the expression of the zebrafish fabp3 gene in oocytes and liver. ..
  37. Reith M, Douglas S. Localization of beta-phycoerythrin to the thylakoid lumen of Cryptomonas phi does not involve a signal peptide. Plant Mol Biol. 1990;15:585-92 pubmed
    ..These data suggest that a novel mechanism may be involved in directing cryptomonad biliproteins to the thylakoid lumen. ..
  38. Boer P, Gray M. Genes encoding a subunit of respiratory NADH dehydrogenase (ND1) and a reverse transcriptase-like protein (RTL) are linked to ribosomal RNA gene pieces in Chlamydomonas reinhardtii mitochondrial DNA. EMBO J. 1988;7:3501-8 pubmed
    ..We suggest a model, involving reverse transcription of rRNAs and insertion of the resulting cDNAs into the mitochondrial genome, that might account for the pattern of dispersed rRNA gene pieces in C. reinhardtii mitochondrial DNA. ..
  39. Dixon B, Mansour M, Pohajdak B. Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Cytogenet Cell Genet. 1993;63:42-4 pubmed
    ..The human gene B2-1 has significant homology to the yeast gene SEC7. By PCR analysis of a human x rodent hybrid panel, the B2-1 gene was assigned to chromosome 17. Fluorescence in situ hybridization localized the gene to 17qter. ..
  40. Bricelj V, Connell L, Konoki K, Macquarrie S, Scheuer T, Catterall W, et al. Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Nature. 2005;434:763-7 pubmed
    ..Furthermore, global expansion of PSP to previously unaffected coastal areas might result in long-term changes to communities and ecosystems...
  41. Ikeda T, Gray M. Identification and characterization of T3/T7 bacteriophage-like RNA polymerase sequences in wheat. Plant Mol Biol. 1999;40:567-78 pubmed
  42. Chang Z, Sun Y, He J, Vining L. p-Aminobenzoic acid and chloramphenicol biosynthesis in Streptomyces venezuelae: gene sets for a key enzyme, 4-amino-4-deoxychorismate synthase. Microbiology. 2001;147:2113-26 pubmed
    ..The gene disruption results suggest that S. venezuelae may have a third set of genes encoding PABA synthase...
  43. Liu R, Denovan Wright E, Degrave A, Thisse C, Thisse B, Wright J. Spatio-temporal distribution of cellular retinol-binding protein gene transcripts (CRBPI and CRBPII) in the developing and adult zebrafish (Danio rerio). Eur J Biochem. 2004;271:339-48 pubmed
  44. Mann I, Wegrzyn J, Rajora O. Generation, functional annotation and comparative analysis of black spruce (Picea mariana) ESTs: an important conifer genomic resource. BMC Genomics. 2013;14:702 pubmed publisher
  45. Bielawski J. Detecting the signatures of adaptive evolution in protein-coding genes. Curr Protoc Mol Biol. 2013;Chapter 19:Unit 19.1. pubmed publisher
    ..Each activity includes an explicit analytical protocol based on programs provided by the Phylogenetic Analysis by Maximum Likelihood (PAML) package. ..
  46. Vats N, Lee S. Characterization of a copper-transport operon, copYAZ, from Streptococcus mutans. Microbiology. 2001;147:653-62 pubmed publisher
    ..By using a chloramphenicol acetyltransferase reporter gene fusion, the cop operon was shown to be negatively regulated by CopY and could be derepressed by Cu2+...
  47. Andersson J, Roger A. Evolution of glutamate dehydrogenase genes: evidence for lateral gene transfer within and between prokaryotes and eukaryotes. BMC Evol Biol. 2003;3:14 pubmed
  48. Robitaille J, MacDonald M, Kaykas A, Sheldahl L, Zeisler J, Dube M, et al. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet. 2002;32:326-30 pubmed
    ..In one of the mutants, altered subcellular trafficking led to defective signaling. These findings support a function for frizzled-4 in retinal angiogenesis and establish the first association between a Wnt receptor and human disease. ..
  49. Cameron M, Denovan Wright E, Sharma M, Wright J. Cellular retinol-binding protein type II (CRBPII) in adult zebrafish (Danio rerio). cDNA sequence, tissue-specific expression and gene linkage analysis. Eur J Biochem. 2002;269:4685-92 pubmed
  50. Wu H, Hu Z, Liu X. Protein trans-splicing by a split intein encoded in a split DnaE gene of Synechocystis sp. PCC6803. Proc Natl Acad Sci U S A. 1998;95:9226-31 pubmed
    ..The two intein sequences together reconstitute a split mini-intein that not only has intein-like sequence features but also exhibited protein trans-splicing activity when tested in Escherichia coli cells. ..
  51. Ro H, Xu L. Nucleotide sequences of a cDNA clone encoding mouse ribosomal protein S24. Nucleic Acids Res. 1991;19:6647 pubmed
  52. Simpson A, Lukes J, Roger A. The evolutionary history of kinetoplastids and their kinetoplasts. Mol Biol Evol. 2002;19:2071-83 pubmed
    ..Further understanding of the evolution of kinetoplast structure and RNA editing is hampered by a paucity of data from basal (i.e., clade 1) bodonids...
  53. Moore C, Curtis B, Mills T, Tanifuji G, Archibald J. Nucleomorph genome sequence of the cryptophyte alga Chroomonas mesostigmatica CCMP1168 reveals lineage-specific gene loss and genome complexity. Genome Biol Evol. 2012;4:1162-75 pubmed publisher
    ..g., proteasome-mediated protein degradation, in the four cryptophyte lineages examined. ..
  54. Borza T, Popescu C, Lee R. Multiple metabolic roles for the nonphotosynthetic plastid of the green alga Prototheca wickerhamii. Eukaryot Cell. 2005;4:253-61 pubmed
    ..Our data indicate a far more complex metabolism in P. wickerhamii's plastid compared with the metabolic pathways predicted to be located in the apicoplast of P. falciparum and the plastid of Helicosporidium sp...
  55. Edgell D, Klenk H, Doolittle W. Gene duplications in evolution of archaeal family B DNA polymerases. J Bacteriol. 1997;179:2632-40 pubmed
    ..Archaeal family B DNA polymerases together constitute a monophyletic subfamily whose evolution has been characterized by a number of gene duplication events...
  56. Zhang S, Barclay C, Alexander L, Geldenhuys L, Porter G, Casson A, et al. Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma. J Mol Med (Berl). 2007;85:1215-28 pubmed
    ..Our data implicate the FGF-AS b isoform in modulation of FGF-2 expression and clinical outcome in esophageal adenocarcinoma. ..
  57. Dacks J, Doolittle W. Novel syntaxin gene sequences from Giardia, Trypanosoma and algae: implications for the ancient evolution of the eukaryotic endomembrane system. J Cell Sci. 2002;115:1635-42 pubmed
    ..These speak to ancient events in the evolution of the syntaxin system and emphasize the universal role of the syntaxins in the eukaryotic intracellular compartment system...
  58. Liu R, Sharma M, Sun Q, Thisse C, Thisse B, Denovan Wright E, et al. Retention of the duplicated cellular retinoic acid-binding protein 1 genes (crabp1a and crabp1b) in the zebrafish genome by subfunctionalization of tissue-specific expression. FEBS J. 2005;272:3561-71 pubmed
    ..The differential and complementary expression patterns of the zebrafish crabp1a and crabp1b genes imply that subfunctionalization may be the mechanism for the retention of both crabp1 duplicated genes in the zebrafish genome. ..
  59. Richier L, Williton K, Clattenburg L, Colwill K, O Brien M, Tsang C, et al. NOS1AP associates with Scribble and regulates dendritic spine development. J Neurosci. 2010;30:4796-805 pubmed publisher
    ..Consistent with these observations, both full-length NOS1AP and the NOS1AP PTB domain influence Rac activity. Together these data suggest that NOS1AP plays an important role in the mammalian synapse. ..
  60. Matsuoka M, Infante C, Reith M, Cañavate J, Douglas S, Manchado M. Translational machinery of senegalese sole (Solea senegalensis Kaup) and Atlantic halibut (Hippoglossus hippoglossus L.): comparative sequence analysis of the complete set of 60s ribosomal proteins and their expression. Mar Biotechnol (NY). 2008;10:676-91 pubmed publisher
    ..The genomic resources and knowledge developed in this survey will be useful for the study of Pleuronectiformes evolution...
  61. Volkmann G, Liu X. Protein C-terminal labeling and biotinylation using synthetic peptide and split-intein. PLoS ONE. 2009;4:e8381 pubmed publisher
    ..The types of chemical labeling may be limited only by the ability of chemical synthesis to produce the small C-intein peptide containing the desired chemical groups. ..
  62. Belliveau D, Venkatachalam A, Thisse C, Thisse B, Ma H, Wright J. The duplicated retinol-binding protein 7 (rbp7) genes are differentially transcribed in embryos and adult zebrafish (Danio rerio). Gene Expr Patterns. 2010;10:167-76 pubmed publisher
    ..The distribution of rbp7a and rbp7b transcripts in embryos and adult zebrafish indicate that the cis-elements that control the transcriptional regulation of the rbp7a and rbp7b genes have diverged considerably since their duplication. ..
  63. Stechmann A, Hamblin K, Perez Brocal V, Gaston D, Richmond G, van der Giezen M, et al. Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes. Curr Biol. 2008;18:580-5 pubmed publisher
    ..These findings blur the boundaries between mitochondria, hydrogenosomes, and mitosomes, as currently defined, underscoring the disparate selective forces that shape these organelles in eukaryotes. ..
  64. Richards R, Achenbach J, Short C, Kimball J, Reith M, Driedzic W, et al. Seasonal expressed sequence tags of rainbow smelt (Osmerus mordax) revealed by subtractive hybridization and the identification of two genes up-regulated during winter. Gene. 2008;424:56-62 pubmed publisher
    ..The mitochondrial solute carrier and FK506-binding protein results may relate to changes in cortisol action, as both are regulated by cortisol in other species...
  65. Iyengar A, Bearne S. Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase. Biochem J. 2003;369:497-507 pubmed
  66. Barberà M, Ruiz Trillo I, Tufts J, Bery A, Silberman J, Roger A. Sawyeria marylandensis (Heterolobosea) has a hydrogenosome with novel metabolic properties. Eukaryot Cell. 2010;9:1913-24 pubmed publisher
    ..Overall, these data suggest that Sawyeria marylandensis possesses a hydrogenosome of mitochondrial origin with a novel combination of biochemical and structural properties. ..
  67. Babity J, Armstrong J, Plumier J, Currie R, Robertson H. A novel seizure-induced synaptotagmin gene identified by differential display. Proc Natl Acad Sci U S A. 1997;94:2638-41 pubmed
    ..This novel, inducible synaptotagmin gene may provide a direct link between seizure-induced neuronal gene expression and subsequent modulation of synaptic structure and function. ..
  68. Gawryluk R, Gray M. Evidence for an early evolutionary emergence of gamma-type carbonic anhydrases as components of mitochondrial respiratory complex I. BMC Evol Biol. 2010;10:176 pubmed publisher
    ..However, relatively little is known about CI composition in the unicellular protists, the characterizations of which are essential to our understanding of CI evolution...
  69. Lee S, Pohajdak B. N-terminal targeting of guanine nucleotide exchange factors (GEF) for ADP ribosylation factors (ARF) to the Golgi. J Cell Sci. 2000;113 ( Pt 11):1883-9 pubmed
    ..Furthermore, ARNO and ARNO3 N termini also have the same capability of targeting to the Golgi. We conclude that the N-terminal, (&agr;)-helical, coiled-coil domain is used to target this family of proteins to the Golgi complex. ..
  70. Brassinga A, Siam R, McSween W, Winkler H, Wood D, Marczynski G. Conserved response regulator CtrA and IHF binding sites in the alpha-proteobacteria Caulobacter crescentus and Rickettsia prowazekii chromosomal replication origins. J Bacteriol. 2002;184:5789-99 pubmed
    ..Therefore, CtrA and IHF regulatory proteins have similar binding patterns in both replication origins, and we propose that CzcR is a global cell cycle regulator in R. prowazekii...
  71. Walsh D, Bapteste E, Kamekura M, Doolittle W. Evolution of the RNA polymerase B' subunit gene (rpoB') in Halobacteriales: a complementary molecular marker to the SSU rRNA gene. Mol Biol Evol. 2004;21:2340-51 pubmed
    ..In addition, we present a valuable phylogenetic framework encompassing a broad diversity of Halobacteriales, in which novel sequences can be inserted for evolutionary, ecological, or taxonomic investigations...
  72. Charlebois R, Lam W, Cline S, Doolittle W. Characterization of pHV2 from Halobacterium volcanii and its use in demonstrating transformation of an archaebacterium. Proc Natl Acad Sci U S A. 1987;84:8530-4 pubmed
    ..We describe PEG-mediated transformation of H. volcanii WFD11 with intact pHV2 and with a form of pHV2 marked by a 93-base-pair deletion generated in vitro...
  73. Greenwood S, Schnare M, Cook J, Gray M. Analysis of intergenic spacer transcripts suggests 'read-around' transcription of the extrachromosomal circular rDNA in Euglena gracilis. Nucleic Acids Res. 2001;29:2191-8 pubmed
    ..This result suggests the possibility of 'read-around' transcription, i.e. transcription that proceeds multiple times around the rDNA circle without termination...
  74. Boucher Y, Kamekura M, Doolittle W. Origins and evolution of isoprenoid lipid biosynthesis in archaea. Mol Microbiol. 2004;52:515-27 pubmed