Experts and Doctors on mice in Winnipeg, Manitoba, Canada

Summary

Locale: Winnipeg, Manitoba, Canada
Topic: mice

Top Publications

  1. Robertson M, Croze F, Schroedter I, Friesen H. Molecular cloning and expression of rat placental lactogen-I complementary deoxyribonucleic acid. Endocrinology. 1990;127:702-10 pubmed
    ..In situ hybridization studies indicated that mRNA for rPL-I was present in a few rapidly dividing cells as early as day 8 of gestation, and by day 9 could be localized to giant cells which surround the conceptus. ..
  2. Ogborn M, Sareen S, Tomobe K, Takahashi H, Crocker J. Renal tubule Na,K-ATPase polarity in different animal models of polycystic kidney disease. J Histochem Cytochem. 1995;43:785-90 pubmed
    ..This may contribute to abnormal fluid and electrolyte flux favoring cyst formation or may represent expression of a less differentiated renal tubule epithelial phenotype. ..
  3. Myal Y, Iwasiow B, Cosby H, Yarmill A, Blanchard A, Tsuyuki D, et al. Analysis of tissue- and hormone-specific regulation of the human prolactin-inducible protein/gross cystic disease fluid protein-15 gene in transgenic mice. J Mol Endocrinol. 1998;21:217-23 pubmed
    ..These studies demonstrate that the human gene with its 6.3 kb flanking sequences is able to confer gene expression in vivo in a tissue-specific and hormone-responsive manner. ..
  4. Wong A, Garrett K, Anderson J. Myoid cell density in the thymus is reduced during mdx dystrophy and after muscle crush. Biochem Cell Biol. 1999;77:33-40 pubmed
    ..Further experiments are required to determine whether thymic myoid cells are participants in distant muscle cell proliferation, new fiber formation, or the establishment of new stem cells in regenerated muscle. ..
  5. Anderson J. A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells. Mol Biol Cell. 2000;11:1859-74 pubmed
    ..A model proposes the hypothesis that NO release mediates satellite cell activation, possibly via shear-induced rapid increases in NOS activity that produce "NO transients." ..
  6. Modha G, Blanchard A, Iwasiow B, Mao X, Troup S, Adeyinka A, et al. Developmental changes in insulin-like growth factor I receptor gene expression in the mouse mammary gland. Endocr Res. 2004;30:127-40 pubmed
  7. Xu G, Liu D, Fan Y, Yang X, Korner H, Fu Y, et al. Lymphotoxin alpha beta 2 (membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice. J Immunol. 2007;179:5358-66 pubmed
    ..These results suggest that membrane lymphotoxin plays critical role in resistance to L. major by promoting effective T cell-mediated anti-Leishmania immunity. ..
  8. Saba R, Goodman C, Huzarewich R, Robertson C, Booth S. A miRNA signature of prion induced neurodegeneration. PLoS ONE. 2008;3:e3652 pubmed publisher
    ..In particular, a correlation between miRNA expression and putative gene targets involved in intracellular protein-degradation pathways and signaling pathways related to cell death, synapse function and neurogenesis was identified. ..
  9. Liu D, Zhang T, Marshall A, Okkenhaug K, Vanhaesebroeck B, Uzonna J. The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol. 2009;183:1921-33 pubmed publisher
    ..We also suggest that temporary pharmacological inhibition of this enzyme may be a very effective form of treatment against cutaneous leishmaniasis. ..

More Information

Publications272 found, 100 shown here

  1. Saba R, Gushue S, Huzarewich R, Manguiat K, Medina S, Robertson C, et al. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. PLoS ONE. 2012;7:e30832 pubmed publisher
    ..Based on our results, we propose a role for miR-146a as a potent modulator of microglial function by regulating the activation state during prion induced neurodegeneration. ..
  2. Saleh A, Chowdhury S, Smith D, Balakrishnan S, Tessler L, Schartner E, et al. Diabetes impairs an interleukin-1?-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons. Mol Brain. 2013;6:45 pubmed publisher
    ..Endogenous synthesis of IL-1? is diminished in nerve tissue in type 1 diabetes and we propose this defect triggers reduced STAT3 signaling and mitochondrial function leading to sup-optimal axonal regeneration and plasticity. ..
  3. Bagchi R, Roche P, Aroutiounova N, Espira L, Abrenica B, Schweitzer R, et al. The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype. BMC Biol. 2016;14:21 pubmed publisher
    ..Given the key role of this phenotype conversion in fibrotic disease, the identification of such novel transcriptional regulators may yield new targets for therapies for fibrosis...
  4. Kobinger G, Limberis M, Somanathan S, Schumer G, Bell P, Wilson J. Human immunodeficiency viral vector pseudotyped with the spike envelope of severe acute respiratory syndrome coronavirus transduces human airway epithelial cells and dendritic cells. Hum Gene Ther. 2007;18:413-22 pubmed
    ..Spike-pseudotyped HIV-based vector is a novel lung-directed gene transfer vehicle that holds promise for the treatment of genetic lung diseases such as cystic fibrosis or alpha(1)-antitrypsin deficiency. ..
  5. Guffei A, Lichtensztejn Z, Gonçalves Dos Santos Silva A, Louis S, Caporali A, Mai S. c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells. Neoplasia. 2007;9:578-88 pubmed
    ..Our findings are relevant to the understanding of nuclear chromosome remodeling during the initiation of genomic instability and tumorigenesis. ..
  6. Corbett C, Elias M, Simpson L, Yuan X, Cassan R, Ballegeer E, et al. High-throughput homogeneous immunoassay readily identifies monoclonal antibody to serovariant clostridial neurotoxins. J Immunol Methods. 2007;328:128-38 pubmed
    ..In summary, FMAT provides a reliable method for the screening of mAbs against C. botulinum neurotoxins. ..
  7. Joyee A, Qiu H, Fan Y, Wang S, Yang X. Natural killer T cells are critical for dendritic cells to induce immunity in Chlamydial pneumonia. Am J Respir Crit Care Med. 2008;178:745-56 pubmed publisher
    ..Our results provide direct evidence of the critical role of NKT activation in the functional modulation of DC for the development of protective immunity in a clinically relevant respiratory infection. ..
  8. Poritsanos N, Wong D, Vrontakis M, Mizuno T. Regulation of hepatic PPARgamma2 and lipogenic gene expression by melanocortin. Biochem Biophys Res Commun. 2008;376:384-8 pubmed publisher
    ..These findings suggest that reduced central melanocortin signaling increases hepatic lipid deposition by stimulating hepatic lipogenic gene expression at least partly through the activation of SREBP-1c and PPARgamma2. ..
  9. Liu D, Kebaier C, Pakpour N, Capul A, Beverley S, Scott P, et al. Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions. Infect Immun. 2009;77:3272-83 pubmed publisher
    ..Thus, Leishmania PGs influence host early immune response by modulating DC functions in a way that inhibits antigen presentation and promotes early IL-4 response, and their absence may impact the balance between Th1 and Th2 responses. ..
  10. Drobic B, Perez Cadahia B, Yu J, Kung S, Davie J. Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex. Nucleic Acids Res. 2010;38:3196-208 pubmed publisher
    ..The recruited SWI/SNF remodels nucleosomes at the promoter of IE genes enabling the binding of transcription factors like JUN and the onset of transcription. ..
  11. Jackson A, Kammouni W, Zherebitskaya E, Fernyhough P. Role of oxidative stress in rabies virus infection of adult mouse dorsal root ganglion neurons. J Virol. 2010;84:4697-705 pubmed publisher
    ..Oxidative stress may be important in vivo in rabies and may explain previous observations of the degeneration of neuronal processes. ..
  12. Hou S, Pauls S, Liu P, Marshall A. The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain Fc?RI-induced calcium flux and granule release. Mol Immunol. 2010;48:89-97 pubmed publisher
    ..Together our results identify Bam32 as a novel regulator of mast cell activation, potentially functioning in membrane-proximal integration of positive and negative signaling pathways. ..
  13. Gao X, Gigoux M, Yang J, Leconte J, Yang X, Suh W. Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling. PLoS ONE. 2012;7:e52657 pubmed publisher
  14. Huang H, Rajkumar K, Murphy L. Reduced fecundity in insulin-like growth factor-binding protein-1 transgenic mice. Biol Reprod. 1997;56:284-9 pubmed
    ..Furthermore, expression of the transgene in neither the blastocyst nor the maternal tissues had any significant negative effect on implantation or fetal wastage. ..
  15. Rideout T, Harding S, Mackay D, AbuMweis S, Jones P. High basal fractional cholesterol synthesis is associated with nonresponse of plasma LDL cholesterol to plant sterol therapy. Am J Clin Nutr. 2010;92:41-6 pubmed publisher
    ..4-fold of control, P = 0.00). The results suggest that subjects with high basal cholesterol synthesis are less responsive to PS treatment than are subjects with low basal cholesterol synthesis. ..
  16. Al Alwan M, Hou S, Zhang T, Makondo K, Marshall A. Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells. J Immunol. 2010;184:6961-9 pubmed publisher
    ..Together, these results indicate that Bam32 serves to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for Ag presentation function. ..
  17. Kim E, Mizuno T. Xenin delays gastric emptying rate and activates the brainstem in mice. Neurosci Lett. 2010;481:59-63 pubmed publisher
    ..These findings support the hypothesis that xenin-induced anorexia is at least partly due to delayed gastric emptying and the activation of the NTS cells. ..
  18. Bassett C, McCullough R, Edel A, Patenaude A, Lavallée R, Pierce G. The ?-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat. Am J Physiol Heart Circ Physiol. 2011;301:H2220-6 pubmed publisher
    ..Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA. ..
  19. Liao C, Rak M, Lund J, Unger M, Platt E, Albensi B, et al. Synchrotron FTIR reveals lipid around and within amyloid plaques in transgenic mice and Alzheimer's disease brain. Analyst. 2013;138:3991-7 pubmed publisher
    ..Remarkable compositional similarities in early stage plaques suggest similar routes to plaque formation, regardless of genetic predisposition or mammalian origin. ..
  20. Murphy L, Barron D. The IGFs and their binding proteins in murine development. Mol Reprod Dev. 1993;35:376-81 pubmed
    ..We have started to develop transgenic mice lines overexpressing IGFBPs to attempt to address the role of these binding proteins in fetal development. ..
  21. Krahn M, Anderson J. Anabolic steroid treatment increases myofiber damage in mdx mouse muscular dystrophy. J Neurol Sci. 1994;125:138-46 pubmed
    ..Results show that mdx dystrophy is worsened by anabolic steroid treatment, possibly by altered influences on muscle use patterns and muscle precursor fusion, and is not accompanied by an increase in fiber size. ..
  22. Yang X, HayGlass K, Brunham R. Different roles are played by alpha beta and gamma delta T cells in acquired immunity to Chlamydia trachomatis pulmonary infection. Immunology. 1998;94:469-75 pubmed
  23. Del Bigio M, Hosain S, Altumbabic M. Localization of urokinase-type plasminogen activator, its receptor, and inhibitors in mouse forebrain during postnatal development. Int J Dev Neurosci. 1999;17:387-99 pubmed
  24. Marshall A, Krahn A, Ma K, Duronio V, Hou S. TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Mol Cell Biol. 2002;22:5479-91 pubmed
    ..We postulate that the TAPPs function to orchestrate cellular responses during the sustained phase of signaling. ..
  25. Aukema H, Adolphe J, Mishra S, Jiang J, Cuozzo F, Ogborn M. Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease. FASEB J. 2003;17:298-300 pubmed
    ..The altered levels of these eicosanoid-regulating enzymes has implications for the use of NSAIDS and specific COX inhibitors in individuals with this disorder. ..
  26. Han X, Fan Y, Wang S, Yang J, Bilenki L, Qiu H, et al. Dendritic cells from Chlamydia-infected mice show altered Toll-like receptor expression and play a crucial role in inhibition of allergic responses to ovalbumin. Eur J Immunol. 2004;34:981-9 pubmed
    ..The data demonstrate a critical role played by DC in infection-mediated inhibition of allergic responses. ..
  27. Garbutt M, Liebscher R, Wahl Jensen V, Jones S, Möller P, Wagner R, et al. Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses. J Virol. 2004;78:5458-65 pubmed
    ..Our data suggest that the recombinant VSV can be used to study the role of the viral glycoproteins in virus replication, immune response, and pathogenesis...
  28. Gui Y, Silha J, Murphy L. Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse. Obes Res. 2004;12:1481-91 pubmed
    ..The gender differences in adipokine mRNA expression and plasma levels were not ablated by castration and seem to be dependent on other factors in addition to gonadal steroids. ..
  29. Archer J, Vargas C, Anderson J. Persistent and improved functional gain in mdx dystrophic mice after treatment with L-arginine and deflazacort. FASEB J. 2006;20:738-40 pubmed
    ..Results suggest a potential new treatment option for improving the quality of life for boys with DMD...
  30. Silha J, Sheppard P, Mishra S, Gui Y, Schwartz J, Dodd J, et al. Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms. Endocrinology. 2006;147:2112-21 pubmed
    ..After 15 wk of age, a marked reduction in tumor growth was apparent in LPB-Tag/PGKmBP-3 mice, indicating that the IGF-independent effects of IGFBP-3 may be important in inhibiting tumor progression. ..
  31. Parkinson F, Ferguson J, Zamzow C, Xiong W. Gene expression for enzymes and transporters involved in regulating adenosine and inosine levels in rat forebrain neurons, astrocytes and C6 glioma cells. J Neurosci Res. 2006;84:801-8 pubmed
    ..Thus, cell type differences in adenosine formation and release are primarily a function of differences in expression of purinergic enzymes and transporters. ..
  32. Carlin K, Brownstone R. Rapid pH and PO2 changes in the tissue recording chamber during stoppage of a gas-equilibrated perfusate: effects on calcium currents in ventral horn neurons. Eur J Neurosci. 2006;24:1353-8 pubmed
  33. Medina S, Hatherall A, Parchaliuk D, Robertson C, Booth S. Quantitative reverse-transcription polymerase chain reaction analysis of Alzheimer's-associated genes in mouse scrapie. J Toxicol Environ Health A. 2009;72:1075-82 pubmed publisher
  34. Sofronescu A, Detillieux K, Cattini P. FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart. Cardiovasc Res. 2010;87:102-10 pubmed publisher
    ..Finally, TATA1 and the proximal NF-kappaB element are conserved in the human genome and responsive to IsP. The mouse and human Fgf-16 gene is a target for NF-kappaB activation in the postnatal heart. ..
  35. Vora P, Mina R, Namaka M, Frost E. A novel transcriptional regulator of myelin gene expression: implications for neurodevelopmental disorders. Neuroreport. 2010;21:917-21 pubmed publisher
    ..Our findings show a potential role for myelin in the pathophysiology of methyl-CpG-binding protein 2 mutation-associated disorders. ..
  36. Gao X, Zhao L, Wang S, Yang J, Yang X. Enhanced inducible costimulator ligand (ICOS-L) expression on dendritic cells in interleukin-10 deficiency and its impact on T-cell subsets in respiratory tract infection. Mol Med. 2013;19:346-56 pubmed publisher
    ..The data suggest that ICOS-L expression on DC may be negatively regulated by IL-10 and that ICOS-L expression on DC in the presence or absence of IL-10 costimulation may promote Treg or Th17 response, without significant impact on Th1. ..
  37. Zhao R, Ren S, Moghadasain M, Rempel J, Shen G. Involvement of fibrinolytic regulators in adhesion of monocytes to vascular endothelial cells induced by glycated LDL and to aorta from diabetic mice. J Leukoc Biol. 2014;95:941-9 pubmed publisher
  38. Lin L, Metherel A, Jones P, Bazinet R. Fatty acid amide hydrolase (FAAH) regulates hypercapnia/ischemia-induced increases in n-acylethanolamines in mouse brain. J Neurochem. 2017;142:662-671 pubmed publisher
    ..Our study demonstrates that FAAH is necessary for CO2 - induced increases in OEA and AEA but not DHEA. Targeting brain FAAH could impair the production of NAEs in response to brain injuries. ..
  39. Cann K, Hicks G. Absence of an immediate G1/S checkpoint in primary MEFs following gamma-irradiation identifies a novel checkpoint switch. Cell Cycle. 2006;5:1823-30 pubmed
  40. Huebner K, Jassal D, Halevy O, Pines M, Anderson J. Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone. Am J Physiol Heart Circ Physiol. 2008;294:H1550-61 pubmed publisher
    ..Marked improvements in vital-organ functions implicate Halo as a strong candidate drug to reduce morbidity and mortality in Duchenne muscular dystrophy. ..
  41. Jin Y, Pasumarthi K, Bock M, Lytras A, Kardami E, Cattini P. Cloning and expression of fibroblast growth factor receptor-1 isoforms in the mouse heart: evidence for isoform switching during heart development. J Mol Cell Cardiol. 1994;26:1449-59 pubmed
  42. Rajkumar K, Dheen S, Murphy L. Hyperglycemia and impaired glucose tolerance in IGF binding protein-1 transgenic mice. Am J Physiol. 1996;270:E565-71 pubmed
    ..The glucose response to subcutaneous insulin was similar in transgenic and wild-type mice. These data demonstrate that constitutive overexpression of IGFBP-1 results in impaired glucose tolerance with normal insulin sensitivity. ..
  43. Xu W, Murphy L. Cloning of the mouse Pax4 gene promoter and identification of a pancreatic beta cell specific enhancer. Mol Cell Endocrinol. 2000;170:79-89 pubmed
    ..2 and GATA-1,-2 binding sites. Site-directed mutagenesis indicated that both of these regions were necessary for beta-cell specific enhancer activity. ..
  44. Vila B, Jaradat Z, Marquardt R, Frohlich A. Effect of T-2 toxin on in vivo lipid peroxidation and vitamin E status in mice. Food Chem Toxicol. 2002;40:479-86 pubmed
    ..Plasma alpha-tocopherol levels decreased as soon as 6 h after the toxin challenge, while MDA did not increase until there was a severe depletion of vitamin E. These changes were accompanied by decrease in weight of spleen and thymus. ..
  45. Chadee D, Peltier C, Davie J. Histone H1(S)-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts. Oncogene. 2002;21:8397-403 pubmed
    ..The chromatin remodelling actions of these modified histones may result in aberrant gene expression. ..
  46. Booth S, Bowman C, Baumgartner R, Sorensen G, Robertson C, Coulthart M, et al. Identification of central nervous system genes involved in the host response to the scrapie agent during preclinical and clinical infection. J Gen Virol. 2004;85:3459-71 pubmed
    ..This cluster included four transcripts representing haematopoietic system-related genes, which suggests that the haematopoietic system is involved in the disease process from an early stage. ..
  47. Webb M, Emberley E, Lizardo M, Alowami S, Qing G, Alfia ar A, et al. Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis. BMC Cancer. 2005;5:17 pubmed
  48. Le T, Du G, Fonseca M, Zhou Q, Wigle J, Eisenstat D. Dlx homeobox genes promote cortical interneuron migration from the basal forebrain by direct repression of the semaphorin receptor neuropilin-2. J Biol Chem. 2007;282:19071-81 pubmed
    ..As well, our results support the hypothesis that down-regulation of Neuropilin-2 expression may facilitate tangential interneuron migration from the basal forebrain. ..
  49. Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze Osthoff K, et al. Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol. 2009;29:1235-48 pubmed publisher
    ..Thus, our results not only decipher the pathway of apoptin-induced cell death but also provide mechanistic insights for the selective killing of tumor cells. ..
  50. Parkinson F, Xiong W, Zamzow C, Chestley T, Mizuno T, Duckworth M. Transgenic expression of human equilibrative nucleoside transporter 1 in mouse neurons. J Neurochem. 2009;109:562-72 pubmed publisher
    ..Instead, hENT1 expression affects dynamic changes in endogenous adenosine levels, as revealed by altered behavioral responses to drugs that affect adenosine receptor signalling. ..
  51. Safronetz D, Hegde N, Ebihara H, Denton M, Kobinger G, St Jeor S, et al. Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus. J Virol. 2009;83:7285-95 pubmed publisher
    ..These observations set the stage for a more detailed characterization of the types of immunity required to protect humans from hantavirus infections. ..
  52. Akude E, Zherebitskaya E, Roy Chowdhury S, Girling K, Fernyhough P. 4-Hydroxy-2-nonenal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy. Neurotox Res. 2010;17:28-38 pubmed publisher
  53. Poritsanos N, Mizuno T, Lautatzis M, Vrontakis M. Chronic increase of circulating galanin levels induces obesity and marked alterations in lipid metabolism similar to metabolic syndrome. Int J Obes (Lond). 2009;33:1381-9 pubmed publisher
    ..The obese phenotype in the GAL-Tg mice is related to the reduced energy expenditure and insulin resistance. These findings support the hypothesis that increased circulating GAL levels contribute to the development of metabolic syndrome. ..
  54. Dai Y, Carlin K, Li Z, McMahon D, Brownstone R, Jordan L. Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice. J Neurophysiol. 2009;102:3365-83 pubmed publisher
    ..The actions of 5-HT and ACh on these neurons provide insights into the neuronal properties modulated by these transmitters for generation of locomotion. ..
  55. Upadhaya R, Mizunoya W, Anderson J. Detecting multiple proteins by Western blotting using same-species primary antibodies, precomplexed serum, and hydrogen peroxide. Anal Biochem. 2011;419:342-4 pubmed publisher
    ..Both methods will be valuable in specific detection of multiple proteins by Western blotting, and will save time, valuable samples, and reagents. ..
  56. Rahimi Balaei M, Jiao X, Ashtari N, Afsharinezhad P, Ghavami S, Marzban H. Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse. Int J Mol Sci. 2016;17: pubmed publisher
  57. Bassett C, Rodriguez Leyva D, Pierce G. Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed. Appl Physiol Nutr Metab. 2009;34:965-74 pubmed publisher
    ..Dietary flaxseed may also protect against ischemic heart disease by improving vascular relaxation responses and by inhibiting the incidence of ventricular fibrillation. ..
  58. Cabral T, Berhane Y, Schmidt L, Tracz D, Hole K, Leith M, et al. Development and characterization of neutralizing monoclonal antibodies against the pandemic H1N1 virus (2009). J Virol Methods. 2012;183:25-33 pubmed publisher
    ..The developed MAbs have demonstrated utility as immunodiagnostic and research reagents, and their neutralizing capabilities also hold potential for designing antiviral drugs against pandemic influenza. ..
  59. Anderson J, Liu L, Kardami E. The effects of hyperthyroidism on muscular dystrophy in the mdx mouse: greater dystrophy in cardiac and soleus muscle. Muscle Nerve. 1994;17:64-73 pubmed
  60. Wang C, Entwistle J, Hou G, Li Q, Turley E. The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains. Gene. 1996;174:299-306 pubmed
    ..The overall homology between the overlapping region of human and mouse RHAMM v4 cDNA clone is 85%, but the HA binding motif (B[X7]B), shown to be critical for the signaling capability of this receptor, is 100% conserved. ..
  61. Kuschak T, Kuschak B, Smith G, Wright J, Mai S. Isolation of extrachromosomal elements by histone immunoprecipitation. Biotechniques. 2001;30:1064-8, 1070-2 pubmed
    ..We demonstrate the enrichment of immunoprecipitated DHFR-containing extrachromosomal DNA molecules. ..
  62. Flick R, Flick K, Feldmann H, Elgh F. Reverse genetics for crimean-congo hemorrhagic fever virus. J Virol. 2003;77:5997-6006 pubmed
  63. Hermann L, Coombs K. Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment. J Virol. 2004;78:6171-9 pubmed
  64. Yang M, Clavijo A, Li M, Hole K, Holland H, Wang H, et al. Identification of a major antibody binding epitope in the non-structural protein 3D of foot-and-mouth disease virus in cattle and the development of a monoclonal antibody with diagnostic applications. J Immunol Methods. 2007;321:174-81 pubmed
    ..The approach described here provides a useful tool for specific mAb production in the development of new diagnostic tests. ..
  65. Dunn K, He S, Wark L, Delcuve G, Sun J, Yu Chen H, et al. Increased genomic instability and altered chromosomal protein phosphorylation timing in HRAS-transformed mouse fibroblasts. Genes Chromosomes Cancer. 2009;48:397-409 pubmed publisher
    ..Together our results demonstrate the increased genomic instability and alterations in the epigenetic program in HRAS-transformed cells. ..
  66. On N, Savant S, TOEWS M, Miller D. Rapid and reversible enhancement of blood-brain barrier permeability using lysophosphatidic acid. J Cereb Blood Flow Metab. 2013;33:1944-54 pubmed publisher
    ..The administration of LPA also resulted in 20-fold enhancement of radiolabeled methotrexate in the brain. These studies indicate that administration of LPA in combination with therapeutic agents may increase drug delivery to the brain. ..
  67. Boese A, Saba R, Campbell K, Majer A, Medina S, Burton L, et al. MicroRNA abundance is altered in synaptoneurosomes during prion disease. Mol Cell Neurosci. 2016;71:13-24 pubmed publisher
    ..These included almost all members of the related miR-200 family (miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-141-3p, and miR-429-3p) and the 182 cluster (miR-182-5p and miR-183-5p). ..
  68. Moseti D, Regassa A, Kim W. Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules. Int J Mol Sci. 2016;17: pubmed publisher
    ..In this review, we address the process of adipogenic differentiation, key transcription factors and proteins involved, adipogenic regulators and potential anti-adipogenic bioactive molecules. ..
  69. Amiri S, Haj Mirzaian A, Amini Khoei H, Momeny M, Shirzadian A, Rahimi Balaei M, et al. NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice. Brain Res Bull. 2016;121:158-68 pubmed publisher
  70. McIntosh L, Pernitsky A, Anderson J. The effects of altered metabolism (hypothyroidism) on muscle repair in the mdx dystrophic mouse. Muscle Nerve. 1994;17:444-53 pubmed
    ..This may be due to the larger pool of muscle precursors in mdx than control muscle, and a possible impairment of precursor cell proliferation or fusion during myotube formation. ..
  71. Modric T, Silha J, Shi Z, Gui Y, Suwanichkul A, Durham S, et al. Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice. Endocrinology. 2001;142:1958-67 pubmed
    ..Our data indicate that overexpression of IGFBP-3 is associated with modest intrauterine and postnatal growth retardation despite elevated circulating IGF-I levels. ..
  72. Gibson E, Henson E, Villanueva J, Gibson S. MEK kinase 1 induces mitochondrial permeability transition leading to apoptosis independent of cytochrome c release. J Biol Chem. 2002;277:10573-80 pubmed
    ..Overall, this suggests that cleaved MEKK1 leads to permeability transition contributing to MEKK1-induced apoptosis independent of cytochrome c release from the mitochondria. ..
  73. Sontag D, Cattini P. Cloning and bacterial expression of postnatal mouse heart FGF-16. Mol Cell Biochem. 2003;242:65-70 pubmed
    ..3 kDa was detected. The generation of cardiac mFGF-16 cDNA and a purified FGF-16 protein preparation are seen as important tools in the further characterization of FGF-16 expression and function in the mammalian heart. ..
  74. Mendez I, She Y, Ens W, Coombs K. Digestion pattern of reovirus outer capsid protein sigma3 determined by mass spectrometry. Virology. 2003;311:289-304 pubmed
    ..4, but treatment of virions with pepsin at pH 3.0 released different sigma3 peptides, suggesting acid-induced conformational changes in this outer capsid protein. These studies also revealed that the N-terminus of sigma3 is acetylated...
  75. McLachlan E, White T, Ugonabo C, Olson C, Nagy J, Valdimarsson G. Zebrafish Cx35: cloning and characterization of a gap junction gene highly expressed in the retina. J Neurosci Res. 2003;73:753-64 pubmed
    ..A similar pattern was seen in the 4 and 5 dpf retina, but no labeling was detected in the retina of earlier embryos. ..
  76. Bilenki L, Wang S, Yang J, Fan Y, Joyee A, Yang X. NK T cell activation promotes Chlamydia trachomatis infection in vivo. J Immunol. 2005;175:3197-206 pubmed
    ..These data provide in vivo evidence for the involvement of NKT in a bacterial pathogenesis and its role in promoting Th2 responses during infection...
  77. Wozniak A, Anderson J. Nitric oxide-dependence of satellite stem cell activation and quiescence on normal skeletal muscle fibers. Dev Dyn. 2007;236:240-50 pubmed
    ..Results have important implications for designing new therapies that target the role of exercise in health, aging, and disease. ..
  78. Salins P, He Y, Olson K, Glazner G, Kashour T, Amara F. TGF-beta1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis. Neurosci Lett. 2008;430:81-6 pubmed
    ..Since Abeta(1-42)-induced TGF-beta1, we suggest that TGF-beta1 may amplify Abeta(1-42)-mediated neurodegeneration in AD via Smad7 and beta-catenin interaction and nuclear localization. ..
  79. Ghavami S, Asoodeh A, Klonisch T, Halayko A, Kadkhoda K, Kroczak T, et al. Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. J Cell Mol Med. 2008;12:1005-22 pubmed publisher
    ..Autophagosomes have been detected upon Brevinin-2R treatment. Our results show that Brevinin-2R activates the lysosomalmitochondrial death pathway, and involves autophagy-like cell death. ..
  80. Li X, Kamasawa N, Ciolofan C, Olson C, Lu S, Davidson K, et al. Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1. J Neurosci. 2008;28:9769-89 pubmed publisher
    ..These data document that in Cx45-expressing neurons of IPL, Cx45 is almost always accompanied by Cx36, forming "bihomotypic" gap junctions, with Cx45 structurally coupling to Cx45 and Cx36 coupling to Cx36. ..
  81. Jassal D, Han S, Hans C, Sharma A, Fang T, Ahmadie R, et al. Utility of tissue Doppler and strain rate imaging in the early detection of trastuzumab and anthracycline mediated cardiomyopathy. J Am Soc Echocardiogr. 2009;22:418-24 pubmed publisher
    ..DTI can detect early LV dysfunction prior to alterations in conventional echocardiographic indices and predicts early mortality in mice receiving doxorubicin plus trastuzumab. ..
  82. Okwor I, Muleme H, Jia P, Uzonna J. Altered proinflammatory cytokine production and enhanced resistance to Trypanosoma congolense infection in lymphotoxin beta-deficient mice. J Infect Dis. 2009;200:361-9 pubmed publisher
    ..These results suggest that LTbeta plays critical role in regulating the outcome of T. congolense infection in mice. ..
  83. Nistor A, Bowden G, Blanchard A, Myal Y. Influence of mouse prolactin-inducible protein in saliva on the aggregation of oral bacteria. Oral Microbiol Immunol. 2009;24:510-3 pubmed publisher
  84. Tran J, Mahmood S, Carlyle J, Kung S. Altering the specificity of NK:target cell interactions by genetic manipulation of NK receptor expression on primary mouse NK cells. Vaccine. 2010;28:3767-72 pubmed publisher
    ..This study demonstrated the utility of lentiviral vectors as a means to stably manipulate the target cell specificity of primary NK cells. ..
  85. Ahmadie R, Santiago J, Walker J, Fang T, Le K, Zhao Z, et al. A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload. J Nutr. 2010;140:1438-44 pubmed publisher
    ..A HLD potentiates LV dysfunction in NOS3(-/-) mice in a chronic pressure overload state. ..
  86. Mehedi M, Falzarano D, Seebach J, Hu X, Carpenter M, Schnittler H, et al. A new Ebola virus nonstructural glycoprotein expressed through RNA editing. J Virol. 2011;85:5406-14 pubmed publisher
    ..While ssGP appears to share similar structural properties with sGP, it does not appear to have the same anti-inflammatory function on endothelial cells as sGP...
  87. Lafarge S, Johnston J, Gibson S, Marshall A. Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway. Leuk Res. 2014;38:109-15 pubmed publisher
    ..Altogether, our results indicate that targeting the PI3K pathway can reverse protective CLL-microenvironment interactions in both ZAP-70 positive and negative CLL despite their differences in cytokine responsiveness. ..
  88. Deffie A, Bosman D, Goldenberg G. Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells. Cancer Res. 1989;49:6879-82 pubmed
    ..6-kilobase mRNA. The unique 5.5-kilobase mRNA in resistant cells may represent a shortened transcript of the mutated topoisomerase II allele. ..
  89. Myal Y, Iwasiow B, Yarmill A, Shiu R. A new member of the hormonally regulated rodent submaxillary gland glycoprotein gene family: cDNA cloning and tissue specific expression. Mol Cell Endocrinol. 1996;120:133-8 pubmed
  90. Kong J, Anderson J. Dystrophin is required for organizing large acetylcholine receptor aggregates. Brain Res. 1999;839:298-304 pubmed
    ..Our results suggest dystrophin is involved in organizing small AChR clusters into large AChR aggregates during muscle regeneration, although it is not required for initiating the original AChR clustering activity. ..
  91. Wang S, Fan Y, Brunham R, Yang X. IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection. Eur J Immunol. 1999;29:3782-92 pubmed
    ..Moreover, the data suggest that the IFN-gamma KO mouse is a useful model system for studying chlamydial pathogenesis. ..
  92. Yang X, Fan Y, Wang S, Han X, Yang J, Bilenki L, et al. Mycobacterial infection inhibits established allergic inflammatory responses via alteration of cytokine production and vascular cell adhesion molecule-1 expression. Immunology. 2002;105:336-43 pubmed
    ..These findings suggest that intracellular bacterial infection can inhibit established allergic responses via alteration of local cytokine production and the expression of adhesion molecules. ..