Experts and Doctors on catalysis in Ontario, Canada


Locale: Ontario, Canada
Topic: catalysis

Top Publications

  1. Sun W, Shahinas D, Bonvin J, Hou W, Kimber M, Turnbull J, et al. The crystal structure of Aquifex aeolicus prephenate dehydrogenase reveals the mode of tyrosine inhibition. J Biol Chem. 2009;284:13223-32 pubmed publisher
    ..aeolicus prephenate dehydrogenase. The identification of a tyrosine-insensitive mutant provides a novel avenue for designing an unregulated enzyme for application in metabolic engineering. ..
  2. Gouliaras C, Lee D, Chan L, Taylor M. Regioselective activation of glycosyl acceptors by a diarylborinic acid-derived catalyst. J Am Chem Soc. 2011;133:13926-9 pubmed publisher
    ..Catalyst control presents a new means of generating defined glycosidic linkages from unprotected or minimally protected carbohydrate feedstocks. ..
  3. Paradis F, Zhu H, Krell P, Phillips J, Forsberg C. The xynC gene from Fibrobacter succinogenes S85 codes for a xylanase with two similar catalytic domains. J Bacteriol. 1993;175:7666-72 pubmed
    ..flavefaciens and N. patriciarum. So far, these features are not shared broadly with bacteria from other environments and may indicate specific selection for this domain structure in the highly competitive environment of the rumen...
  4. Grinberg L, O Brien P, Hrkal Z. The effects of heme-binding proteins on the peroxidative and catalatic activities of hemin. Free Radic Biol Med. 1999;27:214-9 pubmed
    ..It is thought that by complexing heme, the Hx and Alb can prevent the toxic effects of extracellular heme in blood plasma. ..
  5. Saridakis V, Christendat D, Kimber M, Dharamsi A, Edwards A, Pai E. Insights into ligand binding and catalysis of a central step in NAD+ synthesis: structures of Methanobacterium thermoautotrophicum NMN adenylyltransferase complexes. J Biol Chem. 2001;276:7225-32 pubmed publisher
    ..In addition, the role of the conserved (16)HXGH(19) active site motif in catalysis was probed by mutagenic, enzymatic and crystallographic techniques, including the characterization of an NMN(+)/SO4(2-) complex of mutant H19A NMNATase...
  6. Saridakis V, Pai E. Mutational, structural, and kinetic studies of the ATP-binding site of Methanobacterium thermoautotrophicum nicotinamide mononucleotide adenylyltransferase. J Biol Chem. 2003;278:34356-63 pubmed publisher
    ..3%, respectively, of WT NMNATase activity indicating that His-19 is a key catalytic group. Surprisingly, this H19A mutant displayed a novel and distinct mode of NAD+ binding when co-crystallized in the presence of NAD+ and SO42-...
  7. Shah N, Kuntz D, Rose D. Comparison of kifunensine and 1-deoxymannojirimycin binding to class I and II alpha-mannosidases demonstrates different saccharide distortions in inverting and retaining catalytic mechanisms. Biochemistry. 2003;42:13812-6 pubmed
    ..Thus, these two alpha-mannosidase classes distort these inhibitors in distinct manners. This is likely indicative of the binding characteristics of the two different catalytic mechanisms of these enzymes. ..
  8. Bradshaw M, Barril C, Clark A, Prenzler P, Scollary G. Ascorbic acid: a review of its chemistry and reactivity in relation to a wine environment. Crit Rev Food Sci Nutr. 2011;51:479-98 pubmed publisher
    ..Limitations in existing knowledge, especially regarding the crossover between the antioxidant and pro-oxidant roles of ascorbic acid, are identified. ..
  9. Hinek A, Pshezhetsky A, von Itzstein M, Starcher B. Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly. J Biol Chem. 2006;281:3698-710 pubmed
    ..In turn, the exposed galactosugars interact with the galectin domain of EBP, thereby inducing the release of transported tropoelastin molecules and facilitating their subsequent assembly into elastic fibers. ..

More Information


  1. Kim A, Rylett R, Shilton B. Substrate binding and catalytic mechanism of human choline acetyltransferase. Biochemistry. 2006;45:14621-31 pubmed
    ..Interactions between this surface loop and CoA may function to lower the KM for CoA and could be important for phosphorylation-dependent regulation of ChAT activity. ..
  2. Davis B, Khumtaveeporn K, Bott R, Jones J. Altering the specificity of subtilisin Bacillus lentus through the introduction of positive charge at single amino acid sites. Bioorg Med Chem. 1999;7:2303-11 pubmed
  3. Yu B, Howell P. Intragenic complementation and the structure and function of argininosuccinate lyase. Cell Mol Life Sci. 2000;57:1637-51 pubmed
    ..This review describes the structure and function of ASL and its homologue delta crystallin, the genetic defects associated with argininosuccinic aciduria and current theories regarding complementation in this protein. ..
  4. Maguire J, Collins R. Effects of cobalt hexammine on folding and self-cleavage of the Neurospora VS ribozyme. J Mol Biol. 2001;309:45-56 pubmed
    ..In contrast, at sub-saturating concentrations of Mg2+, Co(NH3)6(3+) increases the rate of Mg2+-induced self-cleavage, indicating that Co(NH3)6(3+) contributes to the functionally relevant folding of the VS ribozyme. ..
  5. Nazi I, Wright G. Catalytic mechanism of fungal homoserine transacetylase. Biochemistry. 2005;44:13560-6 pubmed
    ..These results form the basis of future exploitation of this enzyme as an antimicrobial target. ..
  6. Baker P, Carere J, Seah S. Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI. Biochemistry. 2011;50:3559-69 pubmed publisher
    ..In H20A and H20S variants, pH profiles show the dependence of enzyme activity on hydroxide concentration. On the basis of these results, a catalytic mechanism is proposed...
  7. Jiang L, Nie G, Zhu R, Wang J, Chen J, Mao Y, et al. Efficient degradation of chlorobenzene in a non-thermal plasma catalytic reactor supported on CeO2/HZSM-5 catalysts. J Environ Sci (China). 2017;55:266-273 pubmed publisher