Experts and Doctors on somatostatin in Vancouver, British Columbia, Canada

Summary

Locale: Vancouver, British Columbia, Canada
Topic: somatostatin

Top Publications

  1. Campos R, Buchan A, Meloche R, Pederson R, Kwok Y, Coy D. Gastrin secretion from human antral G cells in culture. Gastroenterology. 1990;99:36-44 pubmed
    ..Furthermore, the adenylate cyclase and phosphatidyl inositide second messenger systems seem to be intracellular mediators of gastrin secretion from human antral G cells. ..
  2. Kumar U. Cross-talk and modulation of signaling between somatostatin and growth factor receptors. Endocrine. 2011;40:168-80 pubmed publisher
    ..Furthermore, functional consequences of such an interaction in modulation of signaling pathways linked to pathological conditions specifically in cancer are discussed. ..
  3. Yip L, Kwok Y. Role of adenosine A2A receptor in the regulation of gastric somatostatin release. J Pharmacol Exp Ther. 2004;309:804-15 pubmed
    ..The lowest level was detected in the mucosa. In conclusion, adenosine may act on A(2A) receptors to augment SLI release and consequently control gastric acid secretion. ..
  4. Breitkopf T, Lo B, Leung G, Wang E, Yu M, Carr N, et al. Somatostatin expression in human hair follicles and its potential role in immune privilege. J Invest Dermatol. 2013;133:1722-30 pubmed publisher
    ..Addition of SST antagonists to PBMCs cocultured with allogeneic HF cells increased IFN? secretion. The data identify SST as a secretory factor potentially contributing to the HF IP repertoire. ..
  5. Kumar U, Grant M. Somatostatin and somatostatin receptors. Results Probl Cell Differ. 2010;50:137-84 pubmed publisher
  6. Kumar U. Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicity. J Mol Neurosci. 2008;35:345-54 pubmed publisher
    ..Taken together, these results provide first evidence that the presence of SST is a unique feature for the selective sparing of medium sized aspiny interneurons in excitotoxicity. ..
  7. Fujita Y, Asadi A, Yang G, Kwok Y, Kieffer T. Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut. Am J Physiol Gastrointest Liver Physiol. 2010;298:G608-14 pubmed publisher
    ..Amidated GIP(1-30) and GIP(1-42) have comparable potency at stimulating somatostatin release in the perfused mouse stomach. Therefore, GIP(1-30) represents a naturally occurring, biologically active form of GIP. ..
  8. Somvanshi R, War S, Chaudhari N, Qiu X, Kumar U. Receptor specific crosstalk and modulation of signaling upon heterodimerization between ?1-adrenergic receptor and somatostatin receptor-5. Cell Signal. 2011;23:794-811 pubmed publisher
    ..Taken together, the functional consequences of results described here might have relevance in the cardiovascular system where SSTR and AR subtypes play important roles. ..
  9. Kharmate G, Rajput P, Watt H, Somvanshi R, Chaudhari N, Qiu X, et al. Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling. Biochim Biophys Acta. 2011;1813:1172-89 pubmed publisher
    ..We propose that the activation of SSTR and blockade of EGFR might serve novel therapeutic approach in inhibition of tumor proliferation. ..

More Information

Publications14

  1. Kumar U. Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain. J Mol Neurosci. 2012;48:684-95 pubmed
    ..In conclusion, the changes in hypothalamus of ApoD(-/-) mice may indicate potential role of ApoD in regulation of endocrine functions of somatostatin in a receptor-dependent manner. ..
  2. Somvanshi R, Zou S, Qiu X, Kumar U. Somatostatin receptor-2 negatively regulates ?-adrenergic receptor mediated Ca(2+) dependent signaling pathways in H9c2 cells. Biochim Biophys Acta. 2014;1843:735-45 pubmed publisher
    ..Taken together, the results described here provide direct evidence in support of cardiac protective role of SSTR2 via modulation of Ca(2+) associated signaling pathways attributed to cardiac hypertrophy. ..
  3. Kumar U. Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus. J Comp Neurol. 2007;504:185-205 pubmed
    ..Taken together, these data suggest that SSTRs may interact with NADPH-d and TH to exert a physiological role in concert within the hypothalamus. ..
  4. Rajput P, Billova S, Patel S, Kharmate G, Somvanshi R, Kumar U. Expression of somatostatin and somatostatin receptor subtypes in Apolipoprotein D (ApoD) knockout mouse brain: An immunohistochemical analysis. J Chem Neuroanat. 2009;38:20-33 pubmed publisher
    ..Taken together, our results describe receptor and region specific changes in SST and SSTR subtypes expression in ApoD(-/-) mice brain, which may be linked to specific neurological disorders. ..
  5. Rajput P, Kharmate G, Kumar U. Colocalization of somatostatin receptors with DARPP-32 in cortex and striatum of rat brain. J Mol Neurosci. 2012;48:696-705 pubmed
    ..Taken together, these results provide the first evidence that the SSTR-positive neurons lacking colocalization with DARPP-32 might be spared in excitotoxicity. ..