Experts and Doctors on neurons in Burnaby, British Columbia, Canada

Summary

Locale: Burnaby, British Columbia, Canada
Topic: neurons

Top Publications

  1. Nicholson R, Liao C, Zheng J, David L, Coyne L, Errington A, et al. Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. Brain Res. 2003;978:194-204 pubmed
    ..This mechanism has potential to depress synaptic transmission in brain by damping neuronal capacity to support action potentials and reducing evoked release of both excitatory and inhibitory transmitters. ..
  2. Fan Y, Esmail M, Ansley S, Blacque O, Boroevich K, Ross A, et al. Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Nat Genet. 2004;36:989-93 pubmed
    ..These findings implicate a small GTP-binding protein in ciliary transport and the pathogenesis of a pleiotropic disorder. ..
  3. Blacque O, Perens E, Boroevich K, Inglis P, Li C, Warner A, et al. Functional genomics of the cilium, a sensory organelle. Curr Biol. 2005;15:935-41 pubmed
    ..7a. Together, our findings help define a ciliary transcriptome and suggest that DYF-13, an evolutionarily conserved protein, is a novel core IFT component required for cilia function. ..
  4. Shan X, Hu J, Cayabyab F, Krieger C. Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis. Neuroscience. 2005;134:833-46 pubmed
  5. Duan Y, Zheng J, Law V, Nicholson R. Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain. Eur J Pharmacol. 2006;530:9-14 pubmed
    ..We conclude that the 20(S)protopanaxadiol and the less potent inhibitor Rh(2) destabilize BTX-B-activated sodium channels through non-covalent allosteric modification of neurotoxin binding site 2. ..
  6. Mah A, Armstrong K, Chew D, Chu J, Tu D, Johnsen R, et al. Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6. J Biol Chem. 2007;282:28074-86 pubmed
    ..These parallels in transcriptional control between Brn1 and CEH-6 suggest that C. elegans may well be an appropriate model for determining gene-regulatory networks in the developing vertebrate kidney. ..
  7. Palsson E. A cAMP signaling model explains the benefit of maintaining two forms of phosphodiesterase in Dictyostelium. Biophys J. 2009;97:2388-98 pubmed publisher
  8. Decker H, Lo K, Unger S, Ferreira S, Silverman M. Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons. J Neurosci. 2010;30:9166-71 pubmed publisher
    ..Results demonstrate that AbetaOs negatively impact axonal transport by a mechanism that is initiated by NMDARs and mediated by GSK-3beta and establish a new connection between toxic Abeta oligomers and AD pathology. ..
  9. Lo K, Kuzmin A, Unger S, Petersen J, Silverman M. KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons. Neurosci Lett. 2011;491:168-73 pubmed publisher
    ..Taken together, these data support a primary role for KIF1A in the anterograde transport of DCVs in mammalian neurons, and also provide evidence that KIF1A remains associated with DCVs during retrograde DCV transport. ..
  10. Chu J, Tarailo Graovac M, Zhang D, Wang J, Uyar B, Tu D, et al. Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans. Nucleic Acids Res. 2012;40:53-64 pubmed publisher
    ..Our identification of genes with multiple X-box motifs will also improve our understanding of RFX/DAF-19-mediated regulation in C. elegans and in other organisms including humans. ..

Detail Information

Publications15

  1. Nicholson R, Liao C, Zheng J, David L, Coyne L, Errington A, et al. Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. Brain Res. 2003;978:194-204 pubmed
    ..This mechanism has potential to depress synaptic transmission in brain by damping neuronal capacity to support action potentials and reducing evoked release of both excitatory and inhibitory transmitters. ..
  2. Fan Y, Esmail M, Ansley S, Blacque O, Boroevich K, Ross A, et al. Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Nat Genet. 2004;36:989-93 pubmed
    ..These findings implicate a small GTP-binding protein in ciliary transport and the pathogenesis of a pleiotropic disorder. ..
  3. Blacque O, Perens E, Boroevich K, Inglis P, Li C, Warner A, et al. Functional genomics of the cilium, a sensory organelle. Curr Biol. 2005;15:935-41 pubmed
    ..7a. Together, our findings help define a ciliary transcriptome and suggest that DYF-13, an evolutionarily conserved protein, is a novel core IFT component required for cilia function. ..
  4. Shan X, Hu J, Cayabyab F, Krieger C. Increased phospho-adducin immunoreactivity in a murine model of amyotrophic lateral sclerosis. Neuroscience. 2005;134:833-46 pubmed
  5. Duan Y, Zheng J, Law V, Nicholson R. Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain. Eur J Pharmacol. 2006;530:9-14 pubmed
    ..We conclude that the 20(S)protopanaxadiol and the less potent inhibitor Rh(2) destabilize BTX-B-activated sodium channels through non-covalent allosteric modification of neurotoxin binding site 2. ..
  6. Mah A, Armstrong K, Chew D, Chu J, Tu D, Johnsen R, et al. Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6. J Biol Chem. 2007;282:28074-86 pubmed
    ..These parallels in transcriptional control between Brn1 and CEH-6 suggest that C. elegans may well be an appropriate model for determining gene-regulatory networks in the developing vertebrate kidney. ..
  7. Palsson E. A cAMP signaling model explains the benefit of maintaining two forms of phosphodiesterase in Dictyostelium. Biophys J. 2009;97:2388-98 pubmed publisher
  8. Decker H, Lo K, Unger S, Ferreira S, Silverman M. Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons. J Neurosci. 2010;30:9166-71 pubmed publisher
    ..Results demonstrate that AbetaOs negatively impact axonal transport by a mechanism that is initiated by NMDARs and mediated by GSK-3beta and establish a new connection between toxic Abeta oligomers and AD pathology. ..
  9. Lo K, Kuzmin A, Unger S, Petersen J, Silverman M. KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons. Neurosci Lett. 2011;491:168-73 pubmed publisher
    ..Taken together, these data support a primary role for KIF1A in the anterograde transport of DCVs in mammalian neurons, and also provide evidence that KIF1A remains associated with DCVs during retrograde DCV transport. ..
  10. Chu J, Tarailo Graovac M, Zhang D, Wang J, Uyar B, Tu D, et al. Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans. Nucleic Acids Res. 2012;40:53-64 pubmed publisher
    ..Our identification of genes with multiple X-box motifs will also improve our understanding of RFX/DAF-19-mediated regulation in C. elegans and in other organisms including humans. ..
  11. Yuzwa S, Shan X, Macauley M, Clark T, Skorobogatko Y, Vosseller K, et al. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol. 2012;8:393-9 pubmed publisher
    ..These results also suggest O-GlcNAcase as a potential therapeutic target that could hinder progression of Alzheimer's disease. ..
  12. Unsoeld T, Park J, Hutter H. Discoidin domain receptors guide axons along longitudinal tracts in C. elegans. Dev Biol. 2013;374:142-52 pubmed publisher
    ..Our results provide the first insight on discoidin domain receptor function in invertebrates and establish a novel role for discoidin domain receptors in axon navigation and axon tract formation. ..
  13. Frédéric M, Lundin V, Whiteside M, Cueva J, Tu D, Kang S, et al. Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis. PLoS Genet. 2013;9:e1003804 pubmed publisher
  14. Iworima D, Pasqualotto B, Rintoul G. Kif5 regulates mitochondrial movement, morphology, function and neuronal survival. Mol Cell Neurosci. 2016;72:22-33 pubmed publisher
    ..Moreover, our studies demonstrate an interesting interplay between the regulation of mitochondrial motility and morphology. ..
  15. Huang J, Vanoye C, Cutts A, Goldberg Y, Dib Hajj S, Cohen C, et al. Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability. J Clin Invest. 2017;127:2805-2814 pubmed publisher