Experts and Doctors on hypothalamus in Vancouver, British Columbia, Canada

Summary

Locale: Vancouver, British Columbia, Canada
Topic: hypothalamus

Top Publications

  1. Kumar U. Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus. J Comp Neurol. 2007;504:185-205 pubmed
    ..Taken together, these data suggest that SSTRs may interact with NADPH-d and TH to exert a physiological role in concert within the hypothalamus. ..
  2. Soma K, Sinchak K, Lakhter A, Schlinger B, Micevych P. Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus. Endocrinology. 2005;146:4386-90 pubmed
    ..These data support the hypothesis that PROG is a neurosteroid, produced locally in the hypothalamus from cholesterol, which functions in the estrogen positive-feedback mechanism driving the LH surge. ..
  3. Prentice L, d Anglemont de Tassigny X, McKinney S, Ruiz de Algara T, Yap D, Turashvili G, et al. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. BMC Genomics. 2011;12:209 pubmed publisher
    ..Taken together, global transcriptional profiling shows that loss of GPR54 and kisspeptin are not fully equivalent in the mouse hypothalamus. ..
  4. Karunakaran S, Manji A, Yan C, Wu Z, Clee S. Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake. Physiol Genomics. 2013;45:191-9 pubmed publisher
    ..These studies show that the Moo1 obesity QTL affects food intake, likely through a novel mechanism, and indicate that modulation of the underlying pathway may not only ameliorate obesity but also its clinical consequences. ..
  5. Chan E, Nasir J, Gutekunst C, Coleman S, Maclean A, Maas A, et al. Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Hum Mol Genet. 2002;11:945-59 pubmed
    ..HAP-1 is particularly enriched in the hypothalamus, which is well documented to regulate feeding behavior. Our results demonstrate that HAP-1 plays an essential role in regulating postnatal feeding. ..
  6. Sohn C, Lam R. Update on the biology of seasonal affective disorder. CNS Spectr. 2005;10:635-46; quiz 1-14 pubmed
  7. Kumar U. Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain. J Mol Neurosci. 2012;48:684-95 pubmed
    ..In conclusion, the changes in hypothalamus of ApoD(-/-) mice may indicate potential role of ApoD in regulation of endocrine functions of somatostatin in a receptor-dependent manner. ..

Detail Information

Publications7

  1. Kumar U. Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus. J Comp Neurol. 2007;504:185-205 pubmed
    ..Taken together, these data suggest that SSTRs may interact with NADPH-d and TH to exert a physiological role in concert within the hypothalamus. ..
  2. Soma K, Sinchak K, Lakhter A, Schlinger B, Micevych P. Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus. Endocrinology. 2005;146:4386-90 pubmed
    ..These data support the hypothesis that PROG is a neurosteroid, produced locally in the hypothalamus from cholesterol, which functions in the estrogen positive-feedback mechanism driving the LH surge. ..
  3. Prentice L, d Anglemont de Tassigny X, McKinney S, Ruiz de Algara T, Yap D, Turashvili G, et al. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. BMC Genomics. 2011;12:209 pubmed publisher
    ..Taken together, global transcriptional profiling shows that loss of GPR54 and kisspeptin are not fully equivalent in the mouse hypothalamus. ..
  4. Karunakaran S, Manji A, Yan C, Wu Z, Clee S. Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake. Physiol Genomics. 2013;45:191-9 pubmed publisher
    ..These studies show that the Moo1 obesity QTL affects food intake, likely through a novel mechanism, and indicate that modulation of the underlying pathway may not only ameliorate obesity but also its clinical consequences. ..
  5. Chan E, Nasir J, Gutekunst C, Coleman S, Maclean A, Maas A, et al. Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Hum Mol Genet. 2002;11:945-59 pubmed
    ..HAP-1 is particularly enriched in the hypothalamus, which is well documented to regulate feeding behavior. Our results demonstrate that HAP-1 plays an essential role in regulating postnatal feeding. ..
  6. Sohn C, Lam R. Update on the biology of seasonal affective disorder. CNS Spectr. 2005;10:635-46; quiz 1-14 pubmed
  7. Kumar U. Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain. J Mol Neurosci. 2012;48:684-95 pubmed
    ..In conclusion, the changes in hypothalamus of ApoD(-/-) mice may indicate potential role of ApoD in regulation of endocrine functions of somatostatin in a receptor-dependent manner. ..