Experts and Doctors on gene expression profiling in Burnaby, British Columbia, Canada


Locale: Burnaby, British Columbia, Canada
Topic: gene expression profiling

Top Publications

  1. Wenzel C, Hester Q, Mattsson J. Identification of genes expressed in vascular tissues using NPA-induced vascular overgrowth in Arabidopsis. Plant Cell Physiol. 2008;49:457-68 pubmed publisher
    ..This study provides empirical evidence of the efficiency of the approach and describes for the first time the in situ expression patterns of the majority of the assessed genes. ..
  2. Blacque O, Perens E, Boroevich K, Inglis P, Li C, Warner A, et al. Functional genomics of the cilium, a sensory organelle. Curr Biol. 2005;15:935-41 pubmed
    ..7a. Together, our findings help define a ciliary transcriptome and suggest that DYF-13, an evolutionarily conserved protein, is a novel core IFT component required for cilia function. ..
  3. Shin H, Hirst M, Bainbridge M, Magrini V, Mardis E, Moerman D, et al. Transcriptome analysis for Caenorhabditis elegans based on novel expressed sequence tags. BMC Biol. 2008;6:30 pubmed publisher
    ..This study provides a more complete C. elegans transcriptome profile and, furthermore, gives insight into the evolutionary and biological complexity of this organism. ..
  4. Tarailo Graovac M, Wang J, Chu J, Tu D, Baillie D, Chen N. Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans. BMC Cell Biol. 2010;11:71 pubmed publisher
    ..Importantly, our research provides the first evidence that postembryonic cell division is more sensitive to SAC loss, in particular MDF-2 loss, than embryonic cell division. ..
  5. Holloway D, Lopes F, da Fontoura Costa L, Traven├žolo B, Golyandina N, Usevich K, et al. Gene expression noise in spatial patterning: hunchback promoter structure affects noise amplitude and distribution in Drosophila segmentation. PLoS Comput Biol. 2011;7:e1001069 pubmed publisher
    ..g. multiple regulatory sites, cooperativity, self-feedback), the current results contribute to the general understanding of the reproducibility and determinacy of spatial patterning in early development. ..
  6. Quinn N, McGowan C, Cooper G, Koop B, Davidson W. Identification of genes associated with heat tolerance in Arctic charr exposed to acute thermal stress. Physiol Genomics. 2011;43:685-96 pubmed publisher
    ..Our results highlight the importance of using more than one approach to identify candidate genes, particularly when examining a complicated trait such as UTT in a highly complex genome for which there is no reference genome. ..
  7. Quinn N, McGowan C, Cooper G, Koop B, Davidson W. Ribosomal genes and heat shock proteins as putative markers for chronic, sublethal heat stress in Arctic charr: applications for aquaculture and wild fish. Physiol Genomics. 2011;43:1056-64 pubmed publisher
    ..We suggest that these are candidate gene targets for the future development of genetic markers for broodstock development or for monitoring temperature stress and recovery in wild or cultured conditions. ..
  8. Ursic Bedoya R, Buchhop J, Joy J, Durvasula R, Lowenberger C. Prolixicin: a novel antimicrobial peptide isolated from Rhodnius prolixus with differential activity against bacteria and Trypanosoma cruzi. Insect Mol Biol. 2011;20:775-86 pubmed publisher
    ..No significant toxicity was demonstrated against Trypanosoma cruzi, the human parasite transmitted by R. prolixus...
  9. Uyar B, Chu J, Vergara I, Chua S, Jones M, Wong T, et al. RNA-seq analysis of the C. briggsae transcriptome. Genome Res. 2012;22:1567-80 pubmed publisher
    ..briggsae reference genome that can be readily corrected. The revised C. briggsae genome annotation represents a solid platform for comparative genomics analysis and evolutionary studies of Caenorhabditis species. ..

More Information


  1. Foster A, Hall D, Mortimer L, Abercromby S, Gries R, Gries G, et al. Identification of genes in Thuja plicata foliar terpenoid defenses. Plant Physiol. 2013;161:1993-2004 pubmed publisher
    ..Taken together, this approach generated both general resources and detailed functional characterization in the identification of genes of foliar terpenoid biosynthesis in T. plicata...
  2. Steimel A, Suh J, Hussainkhel A, Deheshi S, Grants J, Zapf R, et al. The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation. Dev Biol. 2013;377:385-98 pubmed publisher
    ..This suggests that the CDK8 module specifically represses the SAX-3/ROBO pathway to ensure proper commissure navigation...
  3. Conesa A, Madrigal P, Tarazona S, Gomez Cabrero D, Cervera A, McPherson A, et al. A survey of best practices for RNA-seq data analysis. Genome Biol. 2016;17:13 pubmed publisher
    ..We discuss the analysis of small RNAs and the integration of RNA-seq with other functional genomics techniques. Finally, we discuss the outlook for novel technologies that are changing the state of the art in transcriptomics. ..