Experts and Doctors on excitatory amino acid antagonists in Vancouver, British Columbia, Canada


Locale: Vancouver, British Columbia, Canada
Topic: excitatory amino acid antagonists

Top Publications

  1. Dalton G, Wu D, Wang Y, Floresco S, Phillips A. NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear. Neuropharmacology. 2012;62:797-806 pubmed publisher
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'. ..
  2. Gazerani P, Dong X, Wang M, Kumar U, Cairns B. Sensitization of rat facial cutaneous mechanoreceptors by activation of peripheral N-methyl-d-aspartate receptors. Brain Res. 2010;1319:70-82 pubmed publisher
    ..Subcutaneous injection of glutamate mechanically sensitizes rat facial cutaneous mechanoreceptors through activation of peripheral NMDA receptors. Peripheral NMDA receptor antagonists may be considered for craniofacial pain. ..
  3. Dong X, Mann M, Kumar U, Svensson P, Arendt Nielsen L, Hu J, et al. Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity. Neuroscience. 2007;146:822-32 pubmed
  4. Curry K, Pajouhesh H. Pharmacological profile of the isomers of the GluR-specific agonist ATPA. Can J Physiol Pharmacol. 1998;76:690-2 pubmed
  5. Milnerwood A, Kaufman A, Sepers M, Gladding C, Zhang L, Wang L, et al. Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice. Neurobiol Dis. 2012;48:40-51 pubmed publisher
  6. Dong X, Mann M, Sessle B, Arendt Nielsen L, Svensson P, Cairns B. Sensitivity of rat temporalis muscle afferent fibers to peripheral N-methyl-D-aspartate receptor activation. Neuroscience. 2006;141:939-45 pubmed
    ..These results suggest that unlike masseter afferent fibers, temporalis afferent fibers are relatively insensitive to peripheral N-methyl-D-aspartate receptor activation. ..
  7. Dong X, Svensson P, Cairns B. The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism. Pain. 2009;147:36-45 pubmed publisher
    ..This property may contribute to the analgesic effect of topical diclofenac when used for muscle pain. ..
  8. Floresco S, Tse M, Ghods Sharifi S. Dopaminergic and glutamatergic regulation of effort- and delay-based decision making. Neuropsychopharmacology. 2008;33:1966-79 pubmed
    ..Furthermore, they suggest that dopamine and NMDA receptors make dissociable contributions to these different types of cost-benefit analyses. ..
  9. Butts K, Phillips A. Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. Int J Neuropsychopharmacol. 2013;16:1799-807 pubmed publisher
    ..Taken together, our data indicate that glucocorticoids act locally within the mPFC to modulate mesocortical DA efflux by potentiation of glutamatergic drive onto DA neurons in the VTA. ..

More Information


  1. Barr A, Fish K, Markou A. The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice. Neuropharmacology. 2007;52:1114-23 pubmed
    ..These findings have relevance to a range of neuropsychiatric disorders that involve sensorimotor gating deficits, including schizophrenia. ..
  2. Liu L, Wong T, Pozza M, Lingenhoehl K, Wang Y, Sheng M, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science. 2004;304:1021-4 pubmed
    ..These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity. ..
  3. Krebs C, Fernandes H, Sheldon C, Raymond L, Baimbridge K. Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. J Neurosci. 2003;23:3364-72 pubmed
    ..Control astrocytes were not responsive to NMDA but responded to glutamate. An understanding of the role of astrocytes that express functional NMDA receptors in response to ischemia may guide development of novel stroke therapies. ..
  4. Harrison T, Ayling O, Murphy T. Distinct cortical circuit mechanisms for complex forelimb movement and motor map topography. Neuron. 2012;74:397-409 pubmed publisher
    ..Our data suggest that the topography of movement maps arises from their segregated output projections, whereas complex movements evoked by prolonged stimulation require intracortical synaptic transmission...
  5. Shaw C, Bains J. Synergistic versus antagonistic actions of glutamate and glutathione: the role of excitotoxicity and oxidative stress in neuronal disease. Cell Mol Biol (Noisy-le-grand). 2002;48:127-36 pubmed
    ..Only once such molecules have been identified, can we begin to design appropriate pharmaceutical strategies to prevent or halt the progression of the age-related neurological diseases. ..
  6. Chen S, Mohajerani M, Xie Y, Murphy T. Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex. J Neurosci. 2012;32:13510-9 pubmed
  7. Puil E, El Beheiry H. Anaesthetic suppression of transmitter actions in neocortex. Br J Pharmacol. 1990;101:61-6 pubmed
  8. Kumar U. Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicity. J Mol Neurosci. 2008;35:345-54 pubmed publisher
    ..Taken together, these results provide first evidence that the presence of SST is a unique feature for the selective sparing of medium sized aspiny interneurons in excitotoxicity. ..
  9. Metzler M, Gan L, Mazarei G, Graham R, Liu L, Bissada N, et al. Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A. J Neurosci. 2010;30:14318-29 pubmed publisher
  10. Xu W, Tse Y, Dobie F, Baudry M, Craig A, Wong T, et al. Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression. J Neurosci. 2013;33:5867-5877 pubmed publisher
    ..In addition, this study indicates that biotinylation of vesicular transporters in live cultured neurons is a valuable tool for studying presynaptic function. ..