Experts and Doctors on kinetochores in Edmonton, Alberta, Canada

Summary

Locale: Edmonton, Alberta, Canada
Topic: kinetochores

Top Publications

  1. Famulski J, Vos L, Sun X, Chan G. Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. J Cell Biol. 2008;180:507-20 pubmed publisher
    ..Moreover, we find that stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest. ..
  2. Iouk T, Kerscher O, Scott R, Basrai M, Wozniak R. The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J Cell Biol. 2002;159:807-19 pubmed
    ..Furthermore, we show that the association of Mad1p with the NPC is not passive and that it plays a role in nuclear transport. ..
  3. Chan G, Yen T. The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. Prog Cell Cycle Res. 2003;5:431-9 pubmed
    ..A single unattached kinetochore is proposed to amplify the "wait anaphase" signal through a kinase cascade involving checkpoint kinases such as hBubR1, hBub1 and Mps1. ..
  4. Scott R, Lusk C, Dilworth D, Aitchison J, Wozniak R. Interactions between Mad1p and the nuclear transport machinery in the yeast Saccharomyces cerevisiae. Mol Biol Cell. 2005;16:4362-74 pubmed
    ..Our further analysis also showed that only the C terminus of Mad1p is required for SAC function and that the NPC, through Nup53p, may act to regulate the duration of the SAC response. ..
  5. Famulski J, Chan G. Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores. Curr Biol. 2007;17:2143-9 pubmed
    ..We therefore conclude that Aurora B kinase activity is required for the accumulation of tension-sensitive mitotic-checkpoint components, such as hZW10 and hROD, in order to maintain mitotic-checkpoint arrest. ..
  6. Scott R, Cairo L, Van de Vosse D, Wozniak R. The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast. J Cell Biol. 2009;184:21-9 pubmed publisher
    ..These results reveal an important function for Xpo1p in mediating intranuclear transport events and identify a signaling pathway between kinetochores and NPCs. ..
  7. Cairo L, Ptak C, Wozniak R. Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p. Mol Cell. 2013;49:109-20 pubmed publisher
    ..We propose that a distinct branch of the SAC exists in which Mad1p senses unattached kinetochores and, by altering NPC transport activity, regulates the nuclear environment of the spindle. ..
  8. Cairo L, Wozniak R. The Nuclear Transport Factor Kap121 Is Required for Stability of the Dam1 Complex and Mitotic Kinetochore Bi-orientation. Cell Rep. 2016;14:2440-50 pubmed publisher
    ..We propose that Kap121 stabilizes the Dam1 complex and participates in escorting it to spindle MTs. ..
  9. Vos L, Famulski J, Chan G. hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain. Biochem J. 2011;436:157-68 pubmed publisher
    ..The two domains are at opposite ends of the protein as expected for a protein that bridges the inner and outer kinetochore. ..

Detail Information

Publications9

  1. Famulski J, Vos L, Sun X, Chan G. Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. J Cell Biol. 2008;180:507-20 pubmed publisher
    ..Moreover, we find that stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest. ..
  2. Iouk T, Kerscher O, Scott R, Basrai M, Wozniak R. The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J Cell Biol. 2002;159:807-19 pubmed
    ..Furthermore, we show that the association of Mad1p with the NPC is not passive and that it plays a role in nuclear transport. ..
  3. Chan G, Yen T. The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. Prog Cell Cycle Res. 2003;5:431-9 pubmed
    ..A single unattached kinetochore is proposed to amplify the "wait anaphase" signal through a kinase cascade involving checkpoint kinases such as hBubR1, hBub1 and Mps1. ..
  4. Scott R, Lusk C, Dilworth D, Aitchison J, Wozniak R. Interactions between Mad1p and the nuclear transport machinery in the yeast Saccharomyces cerevisiae. Mol Biol Cell. 2005;16:4362-74 pubmed
    ..Our further analysis also showed that only the C terminus of Mad1p is required for SAC function and that the NPC, through Nup53p, may act to regulate the duration of the SAC response. ..
  5. Famulski J, Chan G. Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores. Curr Biol. 2007;17:2143-9 pubmed
    ..We therefore conclude that Aurora B kinase activity is required for the accumulation of tension-sensitive mitotic-checkpoint components, such as hZW10 and hROD, in order to maintain mitotic-checkpoint arrest. ..
  6. Scott R, Cairo L, Van de Vosse D, Wozniak R. The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast. J Cell Biol. 2009;184:21-9 pubmed publisher
    ..These results reveal an important function for Xpo1p in mediating intranuclear transport events and identify a signaling pathway between kinetochores and NPCs. ..
  7. Cairo L, Ptak C, Wozniak R. Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p. Mol Cell. 2013;49:109-20 pubmed publisher
    ..We propose that a distinct branch of the SAC exists in which Mad1p senses unattached kinetochores and, by altering NPC transport activity, regulates the nuclear environment of the spindle. ..
  8. Cairo L, Wozniak R. The Nuclear Transport Factor Kap121 Is Required for Stability of the Dam1 Complex and Mitotic Kinetochore Bi-orientation. Cell Rep. 2016;14:2440-50 pubmed publisher
    ..We propose that Kap121 stabilizes the Dam1 complex and participates in escorting it to spindle MTs. ..
  9. Vos L, Famulski J, Chan G. hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain. Biochem J. 2011;436:157-68 pubmed publisher
    ..The two domains are at opposite ends of the protein as expected for a protein that bridges the inner and outer kinetochore. ..