Experts and Doctors on electron transport complex ii in Edmonton, Alberta, Canada
Locale: Edmonton, Alberta, Canada
Topic: electron transport complex ii
- Szeto S, Reinke S, Oyedotun K, Sykes B, Lemire B. Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes. J Biol Chem. 2012;287:22509-20 pubmed publisher..Surprisingly, the Sdh3p subunit can form SDH isoenzymes with Sdh4p or with Shh4p as well as be a subunit of the TIM22 mitochondrial protein import complex. ..
- Dibrov E, Fu S, Lemire B. The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). J Biol Chem. 1998;273:32042-8 pubmed..Tcm62p forms a complex containing at least three SDH subunits. We propose that Tcm62p functions as a chaperone in the assembly of yeast SDH. ..
- Oyedotun K, Lemire B. The Saccharomyces cerevisiae succinate-ubiquinone reductase contains a stoichiometric amount of cytochrome b562. FEBS Lett. 1999;442:203-7 pubmed..92+/-0.11. The cytochrome is not detectable in mitochondria isolated from SDH3 and SDH4 deletion strains. These observations strongly support our conclusion that cytochrome b562 is a component of the yeast SDH. ..
- Tran Q, Rothery R, Maklashina E, Cecchini G, Weiner J. The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b. J Biol Chem. 2006;281:32310-7 pubmed..Overall, these results demonstrate the importance of a functional, semiquinone-stabilizing Q(P) site for the observation of rapid succinate-dependent heme reduction. ..
- Silkin Y, Oyedotun K, Lemire B. The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase. Biochim Biophys Acta. 2007;1767:143-50 pubmed..Our results support a role for Tyr-89 in the protonation of ubiquinone and argue that the generation of reactive oxygen species is not causative of tumor formation. ..