Genomes and Genes
Experts and Doctors on amino acid sequence in Edmonton, Alberta, Canada
Locale: Edmonton, Alberta, Canada
Topic: amino acid sequence
Publications201 found, 100 shown here
- Page W, Kwon E, Cornish A, Tindale A. The csbX gene of Azotobacter vinelandii encodes an MFS efflux pump required for catecholate siderophore export. FEMS Microbiol Lett. 2003;228:211-6 pubmed..CsbX was most important for the export of the high affinity chelator protochelin with the majority of the catecholates released by csbX mutants being the protochelin intermediates azotochelin and aminochelin...
- Schellenberg M, Edwards R, Ritchie D, Kent O, Golas M, Stark H, et al. Crystal structure of a core spliceosomal protein interface. Proc Natl Acad Sci U S A. 2006;103:1266-71 pubmed..SF3b155 presents a noncanonical surface for RNA recognition at the heart of the mammalian spliceosome. ..
- Scott P, Dodd C, Bergmann E, Sheehan J, Bishop P. Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans. J Biol Chem. 2006;281:13324-32 pubmed..This implies novel interrelated functions for the parallel beta sheet faces of these leucine-rich repeat proteoglycans, including dimerization and stabilization of protein folding. ..
- Lu J, Edwards R, Wong J, Manchak J, Scott P, Frost L, et al. Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM. EMBO J. 2006;25:2930-9 pubmed publisher..Comparison of TraM to its Glu88 mutants predicted to stabilize the helical structure suggests that the protonated state is the active form for binding TraD in conjugation...
- Chow A, Cena J, El Yazbi A, Crawford B, Holt A, Cho W, et al. Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J Mol Cell Cardiol. 2007;42:896-901 pubmed..These data suggest that Cav-1 plays a role in regulating MMP-2 activity. Cav-1 may thus be a novel mechanism to regulate MMP-2 activity in the heart. ..
- Lin E, Sikand A, Wickware J, Hao Y, Derda R. Peptide microarray patterning for controlling and monitoring cell growth. Acta Biomater. 2016;34:53-59 pubmed publisher..As DNA printers are broadly available in academic institutions, we foresee rapid adaptation of this approach by academic researchers. ..
- Barber D, Sanders E, Aebersold R, Schneider W. The receptor for yolk lipoprotein deposition in the chicken oocyte. J Biol Chem. 1991;266:18761-70 pubmed..These studies establish that a cell-specific receptor mediates the endocytosis of VTG and VLDL into growing chicken oocytes and thus possibly plays a key role in control of oocyte growth. ..
- Hoffmann E, Shi Q, Floroff M, Mickle D, Wu T, Olley P, et al. Molecular cloning and complete nucleotide sequence of a human ventricular myosin light chain 1. Nucleic Acids Res. 1988;16:2353 pubmed
- Huang K, Strynadka N, Bernard V, Peanasky R, James M. The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure. 1994;2:679-89 pubmed..These inhibitors share 30-40% sequence identity with one another, but have virtually no sequence identity with members of any of the other families of serine proteinase inhibitors...
- Worobo R, Henkel T, Sailer M, Roy K, Vederas J, Stiles M. Characteristics and genetic determinant of a hydrophobic peptide bacteriocin, carnobacteriocin A, produced by Carnobacterium piscicola LV17A. Microbiology. 1994;140 ( Pt 3):517-26 pubmed..Carnobacteriocin A2 has a similar structure except that Met 52 is oxidized to a sulphoxide, whereas A1 appears to be a mixture of peptides derived proteolytically from A3 or A2. ..
- Upton C, Schiff L, Rice S, Dowdeswell T, Yang X, McFadden G. A poxvirus protein with a RING finger motif binds zinc and localizes in virus factories. J Virol. 1994;68:4186-95 pubmed..The truncated protein of vaccinia virus strain WR failed to localize in this manner but instead was observed throughout the cytoplasm...
- Wu X, Roy K. Complete nucleotide sequence of a linear plasmid from Streptomyces clavuligerus and characterization of its RNA transcripts. J Bacteriol. 1993;175:37-52 pubmed
- Dibrov E, Robinson K, Lemire B. The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain. J Biol Chem. 1997;272:9175-81 pubmed..We conclude that the COQ5 gene encodes the mitochondria-localized 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase of the yeast ubiquinone biosynthetic pathway. ..
- Hobman T, Lemon H, Jewell K. Characterization of an endoplasmic reticulum retention signal in the rubella virus E1 glycoprotein. J Virol. 1997;71:7670-80 pubmed..Accordingly, assembly of E2 and E1 would mask the signal, thereby allowing transport of the heterodimer from the ER. ..
- Cummings M, Ling H, Armstrong G, Brunton J, Read R. Modeling the carbohydrate-binding specificity of pig edema toxin. Biochemistry. 1998;37:1789-99 pubmed..This model is consistent with a wide variety of mutation and binding data and clearly shows the importance of the terminal GalNAc residue of Gb4, as well as that of the two mutated residues of GT3, to the intermolecular interaction...
- Ritzel M, Yao S, Ng A, Mackey J, Cass C, Young J. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol. 1998;15:203-11 pubmed..hCNT2 is, therefore potentially involved in both the intestinal absorption and renal handling of purine nucleosides (including adenosine), uridine and purine nucleoside drugs. The gene encoding hCNT2 was mapped to chromosome 15q15. ..
- Ritzel M, Ng A, Yao S, Graham K, Loewen S, Smith K, et al. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J Biol Chem. 2001;276:2914-27 pubmed..The hCNT3 gene mapped to chromosome 9q22.2 and included an upstream phorbol myristate acetate response element. ..
- Vizeacoumar F, Torres Guzman J, Bouard D, Aitchison J, Rachubinski R. Pex30p, Pex31p, and Pex32p form a family of peroxisomal integral membrane proteins regulating peroxisome size and number in Saccharomyces cerevisiae. Mol Biol Cell. 2004;15:665-77 pubmed..Our data suggest a role for Ylr324p, Ygr004p, and Ybr168p--now designated Pex30p, Pex31p, and Pex32p, respectively--together with Pex28p and Pex29p in controlling peroxisome size and proliferation in Saccharomyces cerevisiae. ..
- Jensen S, Wong A, Griffin A, Barton B. Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene. Antimicrob Agents Chemother. 2004;48:514-20 pubmed..clavuligerus when they were grown on starch asparagine or soy medium. However, double mutants with defects in both pah1 and pah2 were defective in the production of both clavulanic acid and all of the 5S clavam metabolites. ..
- Li Q, Manolescu A, Ritzel M, Yao S, Slugoski M, Young J, et al. Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. Am J Physiol Gastrointest Liver Physiol. 2004;287:G236-42 pubmed..Comparison between these proteins may provide key information as to the structural determinants for the recognition of fructose as a substrate. ..
- Lee M, Edwards R, Thede G, Glover J. Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail. J Biol Chem. 2005;280:32053-6 pubmed
- Zhang J, Tackaberry T, Ritzel M, Raborn T, Barron G, Baldwin S, et al. Cysteine-accessibility analysis of transmembrane domains 11-13 of human concentrative nucleoside transporter 3. Biochem J. 2006;394:389-98 pubmed
- Moon D, Veniamin S, Parks Dely J, Magor K. The MHC of the duck (Anas platyrhynchos) contains five differentially expressed class I genes. J Immunol. 2005;175:6702-12 pubmed..The limitation to one expressed MHC class I gene may have functional consequences for the ability of ducks to eliminate viral pathogens, such as influenza...
- Siloto R, Madhavji M, Wiehler W, Burton T, Boora P, Laroche A, et al. An N-terminal fragment of mouse DGAT1 binds different acyl-CoAs with varying affinity. Biochem Biophys Res Commun. 2008;373:350-4 pubmed publisher..The acyl-CoA-binding site in mammalian DGAT1 could represent a potential target for therapeutic interventions for disorders such as type-2 diabetes and obesity. ..
- Tompkins Macdonald G, Gallin W, Sakarya O, Degnan B, Leys S, Boland L. Expression of a poriferan potassium channel: insights into the evolution of ion channels in metazoans. J Exp Biol. 2009;212:761-7 pubmed publisher..We present an original analysis of sponge ion channel physiology and an examination of the phylogenetic relationships of this channel with other cloned Kir channels. ..
- Leung C, Kellogg E, Kuhnert A, Hänel F, Baker D, Glover J. Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIbeta binding protein 1. Protein Sci. 2010;19:162-7 pubmed publisher..We further provide insight into poly(ADP-ribose) binding and sites of potential modification by PARP-1. ..
- Na H, Acharjee S, Jones G, Vivithanaporn P, Noorbakhsh F, McFarlane N, et al. Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence. Retrovirology. 2011;8:44 pubmed publisher..05). These observations underscored the potent neuropathogenic properties of Vpr but also indicated viral diversity modulates innate neuroimmunity and neurodegeneration. ..
- Lohans C, Vederas J. Structural characterization of thioether-bridged bacteriocins. J Antibiot (Tokyo). 2014;67:23-30 pubmed publisher..Despite their differences in structure, similar strategies have proved useful to study the structures of both lantibiotics and sactibiotics. ..
- Robinson K, von Kieckebusch Gück A, Lemire B. Isolation and characterization of a Saccharomyces cerevisiae mutant disrupted for the succinate dehydrogenase flavoprotein subunit. J Biol Chem. 1991;266:21347-50 pubmed..Disruption of the flavoprotein subunit gene results in the simultaneous loss of both the iron-sulfur and the flavoprotein subunits from mitochondrial membranes. ..
- Kaul R, Roy K, Wenman W. Cloning, expression, and primary structure of a Chlamydia trachomatis binding protein. J Bacteriol. 1987;169:5152-6 pubmed..Polyclonal antibodies to the recombinant protein exhibited neutralizing activity. ..
- Rochet J, Bridger W. Identification of glutamate 344 as the catalytic residue in the active site of pig heart CoA transferase. Protein Sci. 1994;3:975-81 pubmed..This information should prove useful to future mutagenesis work aimed at better understanding the active-site structure and catalytic mechanism of CoA transferase. ..
- Weiner J, Bilous P, Shaw G, Lubitz S, Frost L, Thomas G, et al. A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins. Cell. 1998;93:93-101 pubmed..MttA, B, and C are members of a large family of related sequences extending from archaebacteria to higher eukaryotes. ..
- Bernstein N, Cherney M, Loetscher H, Ridley R, James M. Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum. Nat Struct Biol. 1999;6:32-7 pubmed..Disruption of key salt bridges at low pH may be important in activation. ..
- Li M, Spyracopoulos L, Sykes B. Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C. Biochemistry. 1999;38:8289-98 pubmed..Thus the mechanistic differences between the regulation of cardiac and skeletal muscle contraction can be understood in terms of different thermodynamics and kinetics equilibria between essentially the same structure states. ..
- Stone S, Vance J. Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. J Biol Chem. 2000;275:34534-40 pubmed..These data leave open the question of which enzyme imparts PSS activity to the ER and suggest that a third isoform of PSS might be located in the ER. ..
- McKenna S, Moraes T, Pastushok L, Ptak C, Xiao W, Spyracopoulos L, et al. An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2.Ubc13. The structural basis for lysine 63 chain catalysis. J Biol Chem. 2003;278:13151-8 pubmed..Using these NMR-derived constraints and an unbiased docking approach, we have assembled the four components of this catalytic complex into a three-dimensional model that agrees well with its catalytic function. ..
- Prenner E, Kiricsi M, Jelokhani Niaraki M, Lewis R, Hodges R, McElhaney R. Structure-activity relationships of diastereomeric lysine ring size analogs of the antimicrobial peptide gramicidin S: mechanism of action and discrimination between bacterial and animal cell membranes. J Biol Chem. 2005;280:2002-11 pubmed..These results were rationalized by considering how the physiochemical properties of these GS14 analogs are likely to be reflected in their partitioning into lipid bilayer membranes. ..
- Salvador Recatala V, Gallin W, Abbruzzese J, Ruben P, Spencer A. A potassium channel (Kv4) cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit. J Exp Biol. 2006;209:731-47 pubmed..In summary, our results suggest that modulation of Kv4 channels by KChIP subunits is an ancient mechanism for modulating electrical excitability. ..
- Lukowski C, Ritzel R, Waskiewicz A. Expression of two insm1-like genes in the developing zebrafish nervous system. Gene Expr Patterns. 2006;6:711-8 pubmed..The expression data along with functional characterization of invertebrate homologues suggest a conserved pathway involving the EIN transcription factors in early neurogenesis. ..
- Vilas G, Corvi M, Plummer G, Seime A, Lambkin G, Berthiaume L. Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. Proc Natl Acad Sci U S A. 2006;103:6542-7 pubmed..Posttranslational myristoylation of caspase-cleaved proteins involved in cytoskeletal dynamics (e.g., PAK2, actin, and gelsolin) might be part of a unique series of mechanisms involved in the regulation of the later events of apoptosis. ..
- Chow R, Olesen J, Onyskiw C, Baksh S. Mitotic regulation of CDK4 by the serine/threonine phosphatase, calcineurin. Biochem Biophys Res Commun. 2007;363:506-12 pubmed..Our data suggest that calcineurin may regulate the kinase activity of CDK4 in a cell cycle-dependent manner and may be an important component of the negative regulation of CDK4. ..
- Gammon D, Evans D. The 3'-to-5' exonuclease activity of vaccinia virus DNA polymerase is essential and plays a role in promoting virus genetic recombination. J Virol. 2009;83:4236-50 pubmed publisher..The 3'-to-5' exonuclease activity appears to be an essential virus function, and our results suggest that this might be because poxviruses use it to promote genetic exchange. ..
- Oladiran A, Belosevic M. Trypanosoma carassii calreticulin binds host complement component C1q and inhibits classical complement pathway-mediated lysis. Dev Comp Immunol. 2010;34:396-405 pubmed publisher..Our findings suggest that CRT may be used by the parasite to inhibit hosts' classical complement pathway. ..
- Ibraheem A, Yap H, Ding Y, Campbell R. A bacteria colony-based screen for optimal linker combinations in genetically encoded biosensors. BMC Biotechnol. 2011;11:105 pubmed publisher..3 × improved relative to that of the initially constructed biosensor (29%). ..
- Campbell S, Edwards R, Leung C, Neculai D, Hodge C, Dhe Paganon S, et al. Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. J Biol Chem. 2012;287:23900-10 pubmed publisher..These findings support the hypothesis that RNF8 is responsible for the initiation of Lys-63-linked ubiquitylation in the DNA damage response, which is subsequently amplified by RNF168. ..
- Gorski P, Glaves J, Vangheluwe P, Young H. Sarco(endo)plasmic reticulum calcium ATPase (SERCA) inhibition by sarcolipin is encoded in its luminal tail. J Biol Chem. 2013;288:8456-67 pubmed publisher..Based on our results, we propose that the C-terminal tail of SLN is a distinct, essential domain in the regulation of SERCA and that the functional properties of the SLN tail can be transferred to PLN. ..
- Zhang I, Cui Y, Amiri A, Ding Y, Campbell R, Maysinger D. Pharmacological inhibition of lipid droplet formation enhances the effectiveness of curcumin in glioblastoma. Eur J Pharm Biopharm. 2016;100:66-76 pubmed publisher..Together, our results suggest that the inhibition of lipid droplet accumulation is an effective way to enhance the chemotherapeutic effect of curcumin against glioblastoma multiforme. ..
- Stone S, Vance J. Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Biochem J. 1999;342 ( Pt 1):57-64 pubmed..In addition, mRNAs encoding the two synthases are differentially expressed in several murine tissues, supporting the idea that PSS1 and PSS2 might perform unique functions. ..
- Stothard P, Hansen D, Pilgrim D. Evolution of the PP2C family in Caenorhabditis: rapid divergence of the sex-determining protein FEM-2. J Mol Evol. 2002;54:267-82 pubmed..fem-2 (RNAi) in C. elegans and C. briggsae caused germ-line feminization, but had no noticeable effect in CB5161. Thus the function of fem-2 in CB5161 remains uncertain. ..
- Rothery R, Workun G, Weiner J. The prokaryotic complex iron-sulfur molybdoenzyme family. Biochim Biophys Acta. 2008;1778:1897-929 pubmed..We have used genome sequence data to establish that there is a bias against the presence of soluble periplasmic molybdoenzymes in bacteria lacking an outer membrane...
- Fujinaga M, James M. Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution. J Mol Biol. 1987;195:373-96 pubmed..The differences in the structures of the two enzymes are concentrated in several loop regions; these structural differences are probably responsible for the differences in their reactivities and specificities. ..
- Allaire M, Chernaia M, Malcolm B, James M. Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases. Nature. 1994;369:72-6 pubmed..The 3C cleavage specificity for glutamine residues is defined primarily by His 191. The overall structure suggests that an intermolecular (trans) cleavage releases 3C and that there is an active proteinase in the polyprotein. ..
- Chernaia M, Malcolm B, Allaire M, James M. Hepatitis A virus 3C proteinase: some properties, crystallization and preliminary crystallographic characterization. J Mol Biol. 1993;234:890-3 pubmed..The crystals belong to the hexagonal space group P6(1)22 (or its enantiomorph, P6(5)22) with unit cell dimensions a = b = 65.2 A, c = 246.1 A and diffract X-rays to 2.3 A resolution. ..
- Penfold S, Simon J, Frost L. Regulation of the expression of the traM gene of the F sex factor of Escherichia coli. Mol Microbiol. 1996;20:549-58 pubmed..Thus, a control circuit has been established whereby traM is negatively regulated by the FinOP fertility inhibition system through its repression of TraJ expression, which adversely affects transcription of the traY gene. ..
- Silver E, Elliott J, Kane K. Alternatively spliced Ly-49D and H transcripts are found in IL-2-activated NK cells. Immunogenetics. 1996;44:478-82 pubmed
- Ge Z, Taylor D. Sequencing, expression, and genetic characterization of the Helicobacter pylori ftsH gene encoding a protein homologous to members of a novel putative ATPase family. J Bacteriol. 1996;178:6151-7 pubmed..coli ftsH operon on the chromosome was not significantly affected by overproduction of H. pylori FtsH itself. This result suggests that the abnormal growth of cells results from interaction between H. pylori FtsH and E. coli FtsH. ..
- Ebinu J, Bottorff D, Chan E, Stang S, Dunn R, Stone J. RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. Science. 1998;280:1082-6 pubmed..RasGRP is expressed in the nervous system, where it may couple changes in DAG and possibly calcium concentrations to Ras activation. ..
- Liu M, Taylor D. Characterization of gram-positive tellurite resistance encoded by the Streptococcus pneumoniae tehB gene. FEMS Microbiol Lett. 1999;174:385-92 pubmed..The results in this study showed that the S. pneumoniae tehB alone not only conferred on E. coli high level resistance to tellurite, but also caused filamentous morphology in E. coli. ..
- Everett H, Barry M, Lee S, Sun X, Graham K, Stone J, et al. M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes. J Exp Med. 2000;191:1487-98 pubmed..We suggest that apoptosis of tissue macrophages represents an important antiviral defense, and that the inhibition of apoptosis by viral proteins can be directed in a cell-specific fashion. ..
- Silver E, Gong D, Hazes B, Kane K. Ly-49W, an activating receptor of nonobese diabetic mice with close homology to the inhibitory receptor Ly-49G, recognizes H-2D(k) and H-2D(d). J Immunol. 2001;166:2333-41 pubmed..Ly-49W is the first activating Ly-49 receptor demonstrated to recognize an H-2(k) class I product. Ly-49G and Ly-49W represent a new pair of NK receptors with very similar ligand-binding domains, but opposite signaling functions. ..
- Visser F, Vickers M, Ng A, Baldwin S, Young J, Cass C. Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole. J Biol Chem. 2002;277:395-401 pubmed..These data established that mutation of residue 33 (Met versus Ile) of hENT1 and hENT2 altered the dilazep and dipyridamole sensitivities in both proteins, suggesting that a common region of inhibitor interaction has been identified. ..
- Boraston A, Nurizzo D, Notenboom V, Ducros V, Rose D, Kilburn D, et al. Differential oligosaccharide recognition by evolutionarily-related beta-1,4 and beta-1,3 glucan-binding modules. J Mol Biol. 2002;319:1143-56 pubmed publisher..Thermodynamics interpreted in the light of structural information highlights the differential role of water in the interaction of these CBMs with their respective oligosaccharide ligands...
- Ginsberg J, Labedz T, Brindley D. Phosphorylation of heat shock protein-90 by TSH in FRTL-5 thyroid cells. Thyroid. 2006;16:737-42 pubmed..In summary, we have demonstrated that TSH action stimulates the phosphorylation of hsp-90 in FRTL-5 thyroid cells. Abnormalities of hsp-90 phosphorylation may be a mediator in the development of thyroid disease. ..
- Kandasamy A, Schulz R. Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts. Cardiovasc Res. 2009;83:698-706 pubmed publisher..Glycogen synthase kinase (GSK)-3beta is dysregulated during oxidative stress and is susceptible to proteolytic cleavage. Here we determined whether GSK-3beta is a MMP-2 substrate as a result of oxidative stress...
- Liu H, Boudreau M, Zheng J, Whittal R, Austin P, Roskelley C, et al. Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity. J Am Chem Soc. 2010;132:1486-7 pubmed publisher..Compounds 4 and 6 demonstrated potent bioactivity comparable to that of the parent peptides. ..
- Carlson H, Cotton D, Campbell R. Circularly permuted monomeric red fluorescent proteins with new termini in the beta-sheet. Protein Sci. 2010;19:1490-9 pubmed publisher..These new variants may ultimately prove useful for the creation of single FP-based Ca(2+) biosensors. ..
- Gao Z, Poon H, Li L, Li X, Palmesino E, Glubrecht D, et al. Splice-mediated motif switching regulates disabled-1 phosphorylation and SH2 domain interactions. Mol Cell Biol. 2012;32:2794-808 pubmed publisher..We propose that coordinated expression of specific Dab1 isoforms in different populations of cells in the developing brain contributes to precise neuronal migration by modulating the activity of subsets of Dab1 downstream effectors. ..
- Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi C, Ren H, et al. LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol. 2012;422:556-574 pubmed publisher..Data from this work provide a first glimpse into a hitherto neglected molecular biology that ties PrP to its LZT cousins and suggest that manganese or zinc starvation may contribute to the etiology of prion disease in mice. ..
- Fliegel L, Sardet C, Pouyssegur J, Barr A. Identification of the protein and cDNA of the cardiac Na+/H+ exchanger. FEBS Lett. 1991;279:25-9 pubmed..The antibodies reacted with a sarcolemma protein of 50 kDa and with a protein of 70 kDa. The results show that the rabbit myocardium does possess a Na+/H+ exchanger protein homologous to the known human Na+/H+ exchanger. ..
- Cherney L, Cherney M, Garen C, Lu G, James M. Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis. J Mol Biol. 2008;384:1330-40 pubmed publisher..This structure shows that, in the absence of arginine, the ArgR trimer can bind three ARG box half-sites. It also reveals the structure of the whole MtbArgR molecule itself containing both N-terminal and C-terminal domains. ..
- Wolodko W, Fraser M, James M, Bridger W. The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution. J Biol Chem. 1994;269:10883-90 pubmed..A short segment of the beta-subunit from one alpha beta-dimer is in close proximity to the CoA-binding site of the other alpha beta-dimer, providing a possible rationale for the overall tetrameric structure. ..
- Li S, Wang Q, Wang Y, Chen X, Wang Z. PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration. Mol Endocrinol. 2009;23:901-13 pubmed publisher..We conclude that PLC-gamma1 and Rac1 coregulate EGF-induced cell cytoskeleton remodeling and cell migration by a direct functional interaction. ..
- Chen X, Truksa M, Snyder C, El Mezawy A, Shah S, Weselake R. Three homologous genes encoding sn-glycerol-3-phosphate acyltransferase 4 exhibit different expression patterns and functional divergence in Brassica napus. Plant Physiol. 2011;155:851-65 pubmed publisher..Our results revealed that the BnGPAT4 homologs have evolved into functionally divergent forms and play important roles in cutin synthesis and stomatal development. ..
- Wang G, Kuriki T, Roy K, Kaneda T. The primary structure of branched-chain alpha-oxo acid dehydrogenase from Bacillus subtilis and its similarity to other alpha-oxo acid dehydrogenases. Eur J Biochem. 1993;213:1091-9 pubmed..This organization is identical to that of the 2-oxoglutarate dehydrogenase in B. subtilis. ..
- Ryan D, Lin T, Brownie E, Bridger W, Wolodko W. Mutually exclusive splicing generates two distinct isoforms of pig heart succinyl-CoA synthetase. J Biol Chem. 1997;272:21151-9 pubmed..The production of the PHalpha108 message involves the use of a non-canonical splice site pair, AT-AA. Finally, we provide evidence for tissue specific regulation in the splicing of the PHalpha108 message. ..
- Manolea F, Chun J, Chen D, Clarke I, Summerfeldt N, Dacks J, et al. Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors. Mol Biol Cell. 2010;21:1836-49 pubmed publisher..These results suggest that Arf3 plays a unique function at the TGN that likely involves recruitment by a specific receptor. ..
- Eitzen G, Szilard R, Rachubinski R. Enlarged peroxisomes are present in oleic acid-grown Yarrowia lipolytica overexpressing the PEX16 gene encoding an intraperoxisomal peripheral membrane peroxin. J Cell Biol. 1997;137:1265-78 pubmed..lipolytica leads to the appearance of a small number of enlarged peroxisomes, which contain the normal complement of peroxisomal proteins at levels approaching those of wild-type peroxisomes...
- Zelyas N, Tahlan K, Jensen S. Use of the native flp gene to generate in-frame unmarked mutations in Streptomyces spp. Gene. 2009;443:48-54 pubmed publisher..clavuligerus, and RedJ was demonstrated to be important for optimal undecylprodigiosin biosynthesis in S. coelicolor but traces of the antibiotic were still produced in a DeltaredJ mutant. ..
- Oladiran A, Belosevic M. Trypanosoma carassii hsp70 increases expression of inflammatory cytokines and chemokines in macrophages of the goldfish (Carassius auratus L.). Dev Comp Immunol. 2009;33:1128-36 pubmed publisher..Parasite hsp70 also up-regulated the expression inducible nitric oxide synthase (iNOS) isoforms A and B and induced a strong nitric oxide response of goldfish macrophages. ..
- Skene Arnold T, Luu H, Uhrig R, De Wever V, Nimick M, Maynes J, et al. Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins. Biochem J. 2013;449:649-59 pubmed publisher..Overall, we provide the first direct evidence for PP-1c binding via its C-terminus to an SH3 protein domain. ..
- Barber M, Aldridge J, Webster R, Magor K. Association of RIG-I with innate immunity of ducks to influenza. Proc Natl Acad Sci U S A. 2010;107:5913-8 pubmed publisher..Finding this natural disease resistance gene in ducks opens the possibility of increasing influenza resistance through creation of a transgenic chicken. ..
- Stone S, Cui Z, Vance J. Cloning and expression of mouse liver phosphatidylserine synthase-1 cDNA. Overexpression in rat hepatoma cells inhibits the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis. J Biol Chem. 1998;273:7293-302 pubmed..These data suggest that (i) cellular levels of PtdSer and PtdEtn are tightly controlled, and (ii) the metabolism of PtdSer and PtdEtn is coordinately regulated to maintain phospholipid homeostasis. ..