Experts and Doctors on hyaluronoglucosaminidase in Namur, Wallonia, Belgium
Locale: Namur, Wallonia, Belgium
Jadin L, Wu X, Ding H, Frost G, Onclinx C, Triggs Raine B, et al
. Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?. FASEB J. 2008;22:4316-26 pubmed publisher
..In addition, the viability of HYAL2-deficient mice raises the possibility that a similar defect, defining a new MPS disorder, exists in humans. ..
Duterme C, Mertens Strijthagen J, Tammi M, Flamion B. Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions. J Biol Chem. 2009;284:33495-508 pubmed publisher
..These effects may be relevant to the purported in vivo tumor-suppressive activity of Hyal2...
Gasingirwa M, Thirion J, Mertens Strijthagen J, Wattiaux de Coninck S, Flamion B, Wattiaux R, et al
. Endocytosis of hyaluronidase-1 by the liver. Biochem J. 2010;430:305-13 pubmed publisher
..Although its degradation half-time is short, Hyal-1 could exert its activity due to a constant supply of active molecules from the blood. ..
Andre B, Duterme C, Van Moer K, Mertens Strijthagen J, Jadot M, Flamion B. Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase. Biochem Biophys Res Commun. 2011;411:175-9 pubmed publisher
Declèves A, Caron N, Voisin V, Legrand A, Bouby N, Kultti A, et al
. Synthesis and fragmentation of hyaluronan in renal ischaemia. Nephrol Dial Transplant. 2012;27:3771-81 pubmed publisher
..The current data open the door to timed pharmacological interventions blocking the production of HA fragments. ..
Boonen M, Puissant E, Gilis F, Flamion B, Jadot M. Mouse liver lysosomes contain enzymatically active processed forms of Hyal-1. Biochem Biophys Res Commun. 2014;446:1155-60 pubmed publisher
..The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase activity in the mouse liver, confirming that Hyal-1 is a key actor of HA catabolism in this organ. ..