Experts and Doctors on human t lymphotropic virus 1 in Gembloux, Wallonia, Belgium

Summary

Locale: Gembloux, Wallonia, Belgium
Topic: human t lymphotropic virus 1

Top Publications

  1. Twizere J, Kruys V, Lef bvre L, Vanderplasschen A, Collete D, Debacq C, et al. Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. J Natl Cancer Inst. 2003;95:1846-59 pubmed
    ..This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis...
  2. Bouzar A, Willems L. How HTLV-1 may subvert miRNAs for persistence and transformation. Retrovirology. 2008;5:101 pubmed publisher
    ..The pathways modulated by these described miRNAs are critically involved in apoptosis, proliferation and innate immune response...
  3. Lefebvre L, Vanderplasschen A, Ciminale V, Heremans H, Dangoisse O, Jauniaux J, et al. Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. J Virol. 2002;76:1400-14 pubmed
    ..Identification of FPPS as a molecular partner for p13(II) and G4 accessory proteins opens new prospects for treatment of retrovirus-induced leukemia...
  4. Gatot J, Callebaut I, Van Lint C, Demonte D, Kerkhofs P, Portetelle D, et al. Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo. J Virol. 2002;76:7956-67 pubmed
  5. Twizere J, Lefebvre L, Collete D, Debacq C, Urbain P, Heremans H, et al. The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity. J Biol Chem. 2005;280:29804-11 pubmed
    ..And interestingly, MSX2 also interacts with and inhibits the transactivation function of the related Tax1 protein encoded by the Human T-cell leukemia virus type 1 (HTLV-1)...
  6. Gillet N, Florins A, Boxus M, Burteau C, Nigro A, Vandermeers F, et al. Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology. 2007;4:18 pubmed
    ..Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far...
  7. Boxus M, Twizere J, Legros S, Dewulf J, Kettmann R, Willems L. The HTLV-1 Tax interactome. Retrovirology. 2008;5:76 pubmed publisher
    ..In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far...
  8. Boxus M, Willems L. Mechanisms of HTLV-1 persistence and transformation. Br J Cancer. 2009;101:1497-501 pubmed publisher
    ..HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development...