Experts and Doctors on cattle in Gembloux, Wallonia, Belgium


Locale: Gembloux, Wallonia, Belgium
Topic: cattle

Top Publications

  1. Gatot J, Callebaut I, Van Lint C, Demonte D, Kerkhofs P, Portetelle D, et al. Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo. J Virol. 2002;76:7956-67 pubmed
  2. Marbaix H, Budinger D, Dieu M, Fumière O, Gillard N, Delahaut P, et al. Identification of Proteins and Peptide Biomarkers for Detecting Banned Processed Animal Proteins (PAPs) in Meat and Bone Meal by Mass Spectrometry. J Agric Food Chem. 2016;64:2405-14 pubmed publisher
  3. Florins A, de Brogniez A, Elemans M, Bouzar A, François C, Reichert M, et al. Viral expression directs the fate of B cells in bovine leukemia virus-infected sheep. J Virol. 2012;86:621-4 pubmed publisher
    ..Furthermore, cyclosporine treatment of these animals indicated that an efficient immune response is required to control virus-expressing cells...
  4. Colinet F, Vanderick S, Charloteaux B, Eggen A, Gengler N, Renaville B, et al. Genomic location of the bovine growth hormone secretagogue receptor (GHSR) gene and investigation of genetic polymorphism. Anim Biotechnol. 2009;20:28-33 pubmed publisher
    ..These variations are located in the extracellular N-terminal end, the exoloop 2, and the cytoloop 3 of the receptor, respectively. ..
  5. Florins A, Boxus M, Vandermeers F, Verlaeten O, Bouzar A, Defoiche J, et al. Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease. Vet Immunol Immunopathol. 2008;125:1-7 pubmed publisher
    ..Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression...
  6. Twizere J, Kruys V, Lef bvre L, Vanderplasschen A, Collete D, Debacq C, et al. Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. J Natl Cancer Inst. 2003;95:1846-59 pubmed
    ..This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis...
  7. Willems L, Kettmann R, Chen G, Portetelle D, Burny A, Derse D. A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat. J Virol. 1992;66:766-72 pubmed
    ..These data suggest that the cyclic AMP pathway plays a role in the regulation of viral expression in BLV-infected animals...
  8. Debacq C, Asquith B, Kerkhofs P, Portetelle D, Burny A, Kettmann R, et al. Increased cell proliferation, but not reduced cell death, induces lymphocytosis in bovine leukemia virus-infected sheep. Proc Natl Acad Sci U S A. 2002;99:10048-53 pubmed
    ..The imbalance created by the net increase in proliferation in the absence of compensating cell death reveals a complex mechanism of feedback regulation controlling homeostasis in the blood compartment...
  9. Lefebvre L, Vanderplasschen A, Ciminale V, Heremans H, Dangoisse O, Jauniaux J, et al. Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase. J Virol. 2002;76:1400-14 pubmed
    ..Identification of FPPS as a molecular partner for p13(II) and G4 accessory proteins opens new prospects for treatment of retrovirus-induced leukemia...

More Information


  1. Dequiedt F, Willems L, Burny A, Kettmann R. Nucleotide sequence of the bovine P53 tumor-suppressor cDNA. DNA Seq. 1995;5:261-4 pubmed
    ..Furthermore, the homology is not equally distributed along the molecule since the highest divergence is located within the exon 4. The bovine p53 shares 93% and 91% homology with the ovine p53 at the DNA and protein level respectively. ..
  2. Yu Q, Reichert M, Brousseau T, Cleuter Y, Burny A, Kettmann R. Sequence of bovine CD5. Nucleic Acids Res. 1990;18:5296 pubmed
  3. Merezak C, Pierreux C, Adam E, Lemaigre F, Rousseau G, Calomme C, et al. Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latency. J Virol. 2001;75:6977-88 pubmed
    ..These observations, which were obtained in an animal model for HTLV-1, are of interest for oncovirus-induced pathogenesis in humans...
  4. Debacq C, Sanchez Alcaraz M, Mortreux F, Kerkhofs P, Kettmann R, Willems L. Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants. Retrovirology. 2004;1:31 pubmed
    ..In order to better understand the mechanisms associated with this period, we aimed at analyzing simultaneously three parameters: B-lymphocytosis, cell proliferation and viral replication...
  5. Florins A, Gillet N, Asquith B, Boxus M, Burteau C, Twizere J, et al. Cell dynamics and immune response to BLV infection: a unifying model. Front Biosci. 2007;12:1520-31 pubmed
    ..As conclusion, we propose a hypothetical model unifying all these mechanisms...
  6. Gillet N, Florins A, Boxus M, Burteau C, Nigro A, Vandermeers F, et al. Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology. 2007;4:18 pubmed
    ..Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far...
  7. Willems L, Kettmann R, Chen G, Portetelle D, Burny A, Derse D. Nucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA. DNA Seq. 1991;1:415-7 pubmed
    ..The deduced amino acid sequence revealed that CREB2 contains a leucine zipper structure (residue 295 to 316), a basic amino acid domain (residue 268 to 291) and several potential phosphorylation sites. ..
  8. Sneyers M, Kettmann R, Massart S, Renaville R, Burny A, Portetelle D. Cloning and characterization of a cDNA encoding the bovine insulin-like growth factor binding protein 1 (bIGFBP-1). DNA Seq. 1991;1:407-8 pubmed
    ..This communication reports the complete amino acid sequence (263 amino acids) for the insulin-like growth factor binding protein 1 in the bovine (bIGFBP-1). It is 70% homologous with the equivalent IGFBP-1 in human and rat. ..
  9. Bastin C, Soyeurt H, Gengler N. Genetic parameters of milk production traits and fatty acid contents in milk for Holstein cows in parity 1-3. J Anim Breed Genet. 2013;130:118-27 pubmed publisher
  10. Sneyers M, Kettmann R, Massart S, Renaville R, Burny A, Portetelle D. Cloning and characterization of a cDNA encoding the beta-subunit of the bovine insulin-like growth factor-1 receptor. DNA Seq. 1991;1:405-6 pubmed
    ..This communication reports the sequence of the beta-subunit of the insulin-like growth factor-1 receptor. It shares 91.1% homology at the nucleotide level and 97.7% at the amino acid level with the equivalent human receptor subunit. ..