Experts and Doctors on signal transduction in Leuven, Flanders, Belgium

Summary

Locale: Leuven, Flanders, Belgium
Topic: signal transduction

Top Publications

  1. Bossuyt W, Kazanjian A, De Geest N, Van Kelst S, De Hertogh G, Geboes K, et al. Atonal homolog 1 is a tumor suppressor gene. PLoS Biol. 2009;7:e39 pubmed publisher
    ..Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation. ..
  2. Loges S, Schmidt T, Carmeliet P. "Antimyeloangiogenic" therapy for cancer by inhibiting PlGF. Clin Cancer Res. 2009;15:3648-53 pubmed publisher
    ..Because of these promising results, a humanized alphaPlGF antibody (TB403) is currently evaluated in different phase I clinical trials in cancer patients. ..
  3. Peeters K, Loyen S, Van Kerckhoven S, Stoffels K, Hoylaerts M, Van Geet C, et al. Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis. Br J Haematol. 2010;151:54-61 pubmed publisher
    ..g. immune thrombocytopenia purpura, or need to be produced de novo, e.g. after irradiation and BMT. ..
  4. Kauskot A, Di Michele M, Loyen S, Freson K, Verhamme P, Hoylaerts M. A novel mechanism of sustained platelet ?IIb?3 activation via PEAR1. Blood. 2012;119:4056-65 pubmed publisher
    ..This study is the first demonstration of a functional role for PEAR1 in platelet activation, underpinning the observed association between PEAR1 and platelet function in genome-wide association studies. ..
  5. Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats K, Laird A, et al. EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med. 2012;18:1418-22 pubmed
    ..This suggests that Epha4 generically modulates the vulnerability of (motor) neurons to axonal degeneration and may represent a new target for therapeutic intervention. ..
  6. Verschooten L, Barrette K, Van Kelst S, Rubio Romero N, Proby C, De Vos R, et al. Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. PLoS ONE. 2012;7:e48264 pubmed publisher
    ..Hence, Luteolin might be a promising agent for the treatment of cutaneous SCC. ..
  7. Arsenault J, Nelissen K, Jarraya B, Vanduffel W. Dopaminergic reward signals selectively decrease fMRI activity in primate visual cortex. Neuron. 2013;77:1174-86 pubmed publisher
    ..This cue-selective negative reward signal offers a mechanism for selectively gating sensory cortical plasticity. ..
  8. Kauskot A, Vandenbriele C, Louwette S, Gijsbers R, Tousseyn T, Freson K, et al. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. Blood. 2013;121:5208-17 pubmed publisher
    ..In summary, this is the first demonstration that PEAR1 influences the PI3K/PTEN pathway, a critical determinant of Akt phosphorylation, itself controlling megakaryopoiesis and thrombopoiesis. ..
  9. Pierson W, Cauwe B, Policheni A, Schlenner S, Franckaert D, Berges J, et al. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3? regulatory T cells. Nat Immunol. 2013;14:959-65 pubmed publisher
    ..Together, these data define the active processes by which Treg cells maintain homeostasis via critical survival pathways. ..

More Information

Publications122 found, 100 shown here

  1. De Rechter S, Decuypere J, Ivanova E, van den Heuvel L, De Smedt H, Levtchenko E, et al. Autophagy in renal diseases. Pediatr Nephrol. 2016;31:737-52 pubmed publisher
    ..In this review, we provide an overview of the role of autophagy in kidney physiology and kidney diseases. ..
  2. Peacock H, Caolo V, Jones E. Arteriovenous malformations in hereditary haemorrhagic telangiectasia: looking beyond ALK1-NOTCH interactions. Cardiovasc Res. 2016;109:196-203 pubmed publisher
    ..A nuanced understanding of the precise molecular mechanisms underlying idiopathic and HHT-associated arteriovenous malformations will allow for development of targeted treatments for these lesions. ..
  3. Van Hoof C, Janssens V, De Baere I, de Winde J, Winderickx J, Dumortier F, et al. The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle. J Mol Biol. 2000;302:103-20 pubmed
    ..In addition, both PP2A and ypa1Delta mutants show similar aberrant bud morphology. This would support the notion that YPA1 may act as a positive regulator of PP2A in vivo. ..
  4. Claeys I, Simonet G, Poels J, Van Loy T, Vercammen L, De Loof A, et al. Insulin-related peptides and their conserved signal transduction pathway. Peptides. 2002;23:807-16 pubmed
  5. Stoffels K, Overbergh L, Giulietti A, Verlinden L, Bouillon R, Mathieu C. Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. J Bone Miner Res. 2006;21:37-47 pubmed
    ..Combined activation of the JAK-STAT, p38 MAPK, and NF-kappaB pathways is necessary, with C/EBPbeta most probably being the essential transcription factor controlling immune-mediated transcription. ..
  6. Laleman W, Van Landeghem L, Severi T, Vander Elst I, Zeegers M, Bisschops R, et al. Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine. Am J Physiol Gastrointest Liver Physiol. 2007;292:G556-64 pubmed
  7. Hellings P, Kasran A, Bullens D, Overbergh L, Mathieu C, Heremans H, et al. IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling. J Immunol. 2006;177:5138-44 pubmed
  8. Boesmans W, Owsianik G, Tack J, Voets T, Vanden Berghe P. TRP channels in neurogastroenterology: opportunities for therapeutic intervention. Br J Pharmacol. 2011;162:18-37 pubmed publisher
    ..However, their role in gastrointestinal pathophysiology first needs to be further elucidated. ..
  9. Philips T, Robberecht W. Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. Lancet Neurol. 2011;10:253-63 pubmed publisher
    ..An improved understanding of the biological processes that cause neuroinflammation will help to define its medical importance and to identify the therapeutic potential of interfering with this reaction...
  10. Beets I, Janssen T, Meelkop E, Temmerman L, Suetens N, Rademakers S, et al. Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans. Science. 2012;338:543-5 pubmed publisher
    ..elegans. Our study suggests that vasopressin and oxytocin neuropeptides have ancient roles in modulating sensory processing in neural circuits that underlie behavioral plasticity...
  11. Martens K, Bottelbergs A, Peeters A, Jacobs F, Espeel M, Carmeliet P, et al. Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone. Mol Genet Metab. 2012;107:735-47 pubmed publisher
    ..We conclude that peroxisomal metabolism is necessary to maintain the adrenergic tone in mice, which in turn determines metabolic homeostasis. ..
  12. Gonnissen A, Isebaert S, Haustermans K. Hedgehog signaling in prostate cancer and its therapeutic implication. Int J Mol Sci. 2013;14:13979-4007 pubmed publisher
    ..In this review, we will highlight the role of Hh signaling in the development and progression of prostate cancer and summarize the different therapeutic applications of Hedgehog inhibition. ..
  13. Badisco L, Huybrechts J, Simonet G, Verlinden H, Marchal E, Huybrechts R, et al. Transcriptome analysis of the desert locust central nervous system: production and annotation of a Schistocerca gregaria EST database. PLoS ONE. 2011;6:e17274 pubmed publisher
    ..However, molecular studies in locusts are hampered by the fact that genome/transcriptome sequence information available for this branch of insects is still limited...
  14. Sarnelli G, Vanden Berghe P, Raeymaekers P, Janssens J, Tack J. Inhibitory effects of galanin on evoked [Ca2+]i responses in cultured myenteric neurons. Am J Physiol Gastrointest Liver Physiol. 2004;286:G1009-14 pubmed
    ..Finally, the inhibitory effect of galanin on electrical stimulation, but not on DMPP- and carbachol-induced responses, suggests that, at least for the cholinergic component, galanin acts at the presynaptic level. ..
  15. Hendrickx N, Dewaele M, Buytaert E, Marsboom G, Janssens S, Van Boven M, et al. Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy. Biochem Biophys Res Commun. 2005;337:928-35 pubmed
  16. Masuyama R, Stockmans I, Torrekens S, Van Looveren R, Maes C, Carmeliet P, et al. Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest. 2006;116:3150-9 pubmed
    ..Taken together, our findings provide evidence that VDR signaling in chondrocytes is required for timely osteoclast formation during bone development and for the endocrine action of bone in phosphate homeostasis. ..
  17. Voordeckers K, De Maeyer D, van der Zande E, Vinces M, Meert W, Cloots L, et al. Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology. Mol Microbiol. 2012;86:225-39 pubmed publisher
    ..Together, our results provide a first comprehensive look at the complex genetic network that underlies the diversity in the morphologies of yeast colonies. ..
  18. Janssen T, Husson S, Lindemans M, Mertens I, Rademakers S, Ver Donck K, et al. Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans. J Biol Chem. 2008;283:15241-9 pubmed publisher
    ..Our findings strengthen the hypothesis that the PDF signaling system, which imposes the circadian clock rhythm on behavior in Drosophila, has been functionally conserved throughout the protostomian evolutionary lineage. ..
  19. Liston A, Papadopoulou A, Danso Abeam D, Dooley J. MicroRNA-29 in the adaptive immune system: setting the threshold. Cell Mol Life Sci. 2012;69:3533-41 pubmed publisher
    ..These results identify the miR-29 family as potent immune modulators which have already been exploited through the evolution of a viral mimic and could potentially be exploited further for therapeutic intervention. ..
  20. Floris G, Wozniak A, Sciot R, Li H, Friedman L, Van Looy T, et al. A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal. Clin Cancer Res. 2013;19:620-30 pubmed publisher
    ..Notably, after treatment withdrawal, tumor regression was sustained in tumors exposed to GDC+IMA, which was not observed under imatinib. Assessment of PTEN status may represent a useful predictive biomarker for patient selection. ..
  21. Soldano A, Okray Z, Janovská P, Tmejová K, Reynaud E, Claeys A, et al. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. PLoS Biol. 2013;11:e1001562 pubmed publisher
    ..Taken together our data suggest that APPL is the first example of a modulator of the Wnt-PCP pathway specifically required for axon outgrowth. ..
  22. Rice G, del Toro Duany Y, Jenkinson E, Forte G, Anderson B, Ariaudo G, et al. Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling. Nat Genet. 2014;46:503-509 pubmed publisher
    ..Our results demonstrate that aberrant sensing of nucleic acids can cause immune upregulation. ..
  23. Darras V. Endocrine disrupting polyhalogenated organic pollutants interfere with thyroid hormone signalling in the developing brain. Cerebellum. 2008;7:26-37 pubmed publisher
    ..The fact that persistent organohalogens can amplify the neurotoxic effects of other environmental pollutants, such as heavy metals, further increases their risk for human and animal neurodevelopment. ..
  24. Dzwonek J, Preobrazhenska O, Cazzola S, Conidi A, Schellens A, Van Dinther M, et al. Smad3 is a key nonredundant mediator of transforming growth factor beta signaling in Nme mouse mammary epithelial cells. Mol Cancer Res. 2009;7:1342-53 pubmed publisher
    ..Our results identify Smad3 as a key factor to trigger TGFbeta-regulated events and ascribe tumor suppressor as well as oncogenic activities to this protein. ..
  25. Lieben L, Masuyama R, Torrekens S, Van Looveren R, Schrooten J, Baatsen P, et al. Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest. 2012;122:1803-15 pubmed publisher
  26. Langouche L, Pals K, Denef C. Structure-activity relationship and signal transduction of gamma-MSH peptides in GH3 cells: further evidence for a new melanocortin receptor. Peptides. 2002;23:1077-86 pubmed
    ..We conclude that the putative novel gamma-MSH receptor in GH3 cells is a GPCR, but with structure-activity and signal transduction features different from those of the classical MCRs. ..
  27. Li X, Tjwa M, Moons L, Fons P, Noel A, Ny A, et al. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest. 2005;115:118-27 pubmed
    ..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases. ..
  28. Bellon E, Luyten F, Tylzanowski P. delta-EF1 is a negative regulator of Ihh in the developing growth plate. J Cell Biol. 2009;187:685-99 pubmed publisher
    ..In summary, we have identified delta-EF1 as an in vivo negative regulator of Ihh expression in the growth plate. ..
  29. Roosen L, Boesmans W, Dondeyne M, Depoortere I, Tack J, Vanden Berghe P. Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity. J Physiol. 2012;590:4321-33 pubmed publisher
  30. Vermeire S. Towards a novel molecular classification of IBD. Dig Dis. 2012;30:425-7 pubmed publisher
    ..Only then could the value of molecular markers to predict the speed of progression be fully explored in prospective studies. ..
  31. Baeke F, Gysemans C, Korf H, Mathieu C. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol. 2010;25:1597-606 pubmed publisher
    ..In this review, specific attention is given to the effects of 1,25(OH)(2)D(3) on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function. ..
  32. Brems H, Legius E. Legius syndrome, an Update. Molecular pathology of mutations in SPRED1. Keio J Med. 2013;62:107-12 pubmed
    ..Recently, specific binding between neurofibromin and SPRED1 was demonstrated. SPRED1 seems to play an important role in recruiting neurofibromin to the plasma membrane. ..
  33. Beets K, Huylebroeck D, Moya I, Umans L, Zwijsen A. Robustness in angiogenesis: notch and BMP shaping waves. Trends Genet. 2013;29:140-9 pubmed publisher
    ..Deeper knowledge about the coregulation of vessel plasticity in different vascular beds may result in refinement of anti-angiogenesis and vessel normalization therapies. ..
  34. Brusselmans K, Bono F, Collen D, Herbert J, Carmeliet P, Dewerchin M. A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. J Biol Chem. 2005;280:3493-9 pubmed
    ..Thus, VEGF plays a critical role in survival of ES cells during prolonged hypoxia. ..
  35. Lories R, Derese I, Luyten F. Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis. J Clin Invest. 2005;115:1571-9 pubmed
    ..Our data suggest that BMP signaling is an attractive therapeutic target for interfering with structural changes in spondyloarthropathy either as an alternative or complementary approach to current antiinflammatory treatments. ..
  36. Thathiah A, De Strooper B. G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. Sci Signal. 2009;2:re8 pubmed publisher
  37. De Schutter T, Andrei G, Topalis D, Naesens L, Snoeck R. Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage. BMC Med Genomics. 2013;6:18 pubmed publisher
    ..Our findings underline the therapeutic potential of CDV for HPV-associated malignancies as well as other neoplasias. ..
  38. Schutyser E, Struyf S, Menten P, Lenaerts J, Conings R, Put W, et al. Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. J Immunol. 2000;165:4470-7 pubmed
    ..It is concluded that in addition to its role in homeostatic trafficking of leukocytes, LARC/MIP-3alpha can function as an inflammatory chemokine during host defense. ..
  39. De Keersmaecker K, Versele M, Cools J, Superti Furga G, Hantschel O. Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases. Leukemia. 2008;22:2208-16 pubmed publisher
  40. Lories R, Luyten F. Osteoimmunology: Wnt antagonists: for better or worse?. Nat Rev Rheumatol. 2009;5:420-1 pubmed publisher
    ..Molecules involved in developmental signaling pathways have emerged as therapeutic targets for various rheumatic diseases. New research sheds light on the consequences of interfering with these processes. ..
  41. Janssen T, Lindemans M, Meelkop E, Temmerman L, Schoofs L. Coevolution of neuropeptidergic signaling systems: from worm to man. Ann N Y Acad Sci. 2010;1200:1-14 pubmed publisher
    ..Our data indicate that these four neuropeptide signaling systems have been well conserved during the course of evolution and that they were already well established prior to the divergence of protostomes and deuterostomes. ..
  42. Maes C, Carmeliet G, Schipani E. Hypoxia-driven pathways in bone development, regeneration and disease. Nat Rev Rheumatol. 2012;8:358-66 pubmed publisher
    ..The study of these models expands our understanding of the cell autonomous, paracrine and autocrine effects that mediate the homeostatic responses downstream of HIFs and VEGF. ..
  43. Ramon M, Ruelens P, Li Y, Sheen J, Geuten K, Rolland F. The hybrid four-CBS-domain KIN?? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1. Plant J. 2013;75:11-25 pubmed publisher
  44. Pils D, Bachmayr Heyda A, Auer K, Svoboda M, Auner V, Hager G, et al. Cyclin E1 (CCNE1) as independent positive prognostic factor in advanced stage serous ovarian cancer patients - a study of the OVCAD consortium. Eur J Cancer. 2014;50:99-110 pubmed publisher
  45. Carmeliet P, Lampugnani M, Moons L, Breviario F, Compernolle V, Bono F, et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999;98:147-57 pubmed
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival. ..
  46. Vandamme D, Landuyt B, Luyten W, Schoofs L. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 2012;280:22-35 pubmed publisher
    ..Recent insights even indicate for a role of these peptides in cancer. This review provides a comprehensive summary of the most recent and relevant insights concerning the human cathelicidin LL-37. ..
  47. Day F, Ruth K, Thompson D, Lunetta K, Pervjakova N, Chasman D, et al. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet. 2015;47:1294-1303 pubmed publisher
    ..Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms. ..
  48. Bolander J, Ji W, Geris L, Bloemen V, Chai Y, Schrooten J, et al. The combined mechanism of bone morphogenetic protein- and calcium phosphate-induced skeletal tissue formation by human periosteum derived cells. Eur Cell Mater. 2016;31:11-25 pubmed
    ..This study presents further evidence for the potential of BMP-technology in the development of clinically relevant cell-based constructs for bone regenerative strategies. ..
  49. Masuyama R, Vriens J, Voets T, Karashima Y, Owsianik G, Vennekens R, et al. TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab. 2008;8:257-65 pubmed publisher
  50. Spee B, Carpino G, Schotanus B, Katoonizadeh A, Vander Borght S, Gaudio E, et al. Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut. 2010;59:247-57 pubmed publisher
    ..These pathways can be targeted in future therapies. ..
  51. Hoeben A, Martin D, Clement P, Cools J, Gutkind J. Role of GRB2-associated binder 1 in epidermal growth factor receptor-induced signaling in head and neck squamous cell carcinoma. Int J Cancer. 2013;132:1042-50 pubmed publisher
    ..These findings support the emerging notion that reducing GAB1 function may sensitize HNSCC to EGFR inhibitors, hence representing a new therapeutic target HNSCC treatment in combination with EGFR targeting agents. ..
  52. Garg A, Martin S, Golab J, Agostinis P. Danger signalling during cancer cell death: origins, plasticity and regulation. Cell Death Differ. 2014;21:26-38 pubmed publisher
  53. Sodero A, Weissmann C, Ledesma M, Dotti C. Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro. Neurobiol Aging. 2011;32:1043-53 pubmed publisher
    ..The current studies highlight excitatory neurotransmission as 1 of the mechanisms involved in cholesterol loss during aging...
  54. Dillen S, Zels S, Verlinden H, Spit J, Van Wielendaele P, Vanden Broeck J. Functional characterization of the short neuropeptide F receptor in the desert locust, Schistocerca gregaria. PLoS ONE. 2013;8:e53604 pubmed publisher
    ..This is the first comprehensive study in which a clearly negative correlation is described between the sNPF signalling pathway and feeding, prompting a reconsideration of the diverse roles of sNPFs in the physiology of insects. ..
  55. Casazza A, Laoui D, Wenes M, Rizzolio S, Bassani N, Mambretti M, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell. 2013;24:695-709 pubmed publisher
    ..This study shows that TAMs' heterogeneity depends on their localization, which is tightly controlled by Sema3A/Nrp1 signaling. ..
  56. Clements J, Hens K, Francis C, Schellens A, Callaerts P. Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons. Proc Natl Acad Sci U S A. 2008;105:16183-8 pubmed publisher
    ..We propose that Eyeless has an evolutionarily conserved role in IPCs with remarkable similarities to the role of vertebrate Pax6 in beta cells of the pancreas. ..
  57. Lodewyckx L, Lories R. WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician?. Curr Rheumatol Rep. 2009;11:23-30 pubmed
    ..This review focuses on recent studies in human genetics and animal models and highlights the potential clinical relevance of this rapidly evolving field of research. ..
  58. Poels J, Spasic M, Callaerts P, Norga K. Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy. Bioessays. 2009;31:944-52 pubmed publisher
    ..Additionally, recent views on the role of AMPK in autophagy, an important catabolic process that is also involved in neurodegeneration and cancer, will be highlighted. ..
  59. Gembarska A, Luciani F, Fedele C, Russell E, Dewaele M, Villar S, et al. MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med. 2012;18:1239-47 pubmed publisher
    ..Our results identify MDM4 as a key determinant of impaired p53 function in human melanoma and designate MDM4 as a promising target for antimelanoma combination therapy. ..
  60. Ivanova E, Arcolino F, Elmonem M, Rastaldi M, Giardino L, Cornelissen E, et al. Cystinosin deficiency causes podocyte damage and loss associated with increased cell motility. Kidney Int. 2016;89:1037-1048 pubmed publisher
    ..Thus, our study extends the list of genetic disorders causing podocyte damage and provides the evidence of altered cell signaling cascades resulting in impaired cell adhesion and enhanced cell motility in cystinosis. ..
  61. Autiero M, Waltenberger J, Communi D, Kranz A, Moons L, Lambrechts D, et al. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med. 2003;9:936-43 pubmed
  62. Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, et al. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009;324:639-42 pubmed publisher
    ..The Aph1B complex contributes to total gamma-secretase activity in the human brain, and thus specific targeting of Aph1B-containing gamma-secretase complexes may help generate less toxic therapies for Alzheimer's disease. ..
  63. Jurisch Yaksi N, Rose A, Lu H, Raemaekers T, Munck S, Baatsen P, et al. Rer1p maintains ciliary length and signaling by regulating ?-secretase activity and Foxj1a levels. J Cell Biol. 2013;200:709-20 pubmed publisher
    ..We further demonstrate that Rer1p depletion reduced ciliary length and function by increasing ?-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression. ..
  64. Moelants E, Mortier A, Van Damme J, Proost P. Regulation of TNF-? with a focus on rheumatoid arthritis. Immunol Cell Biol. 2013;91:393-401 pubmed publisher
    ..Owing to the important role of TNF-? in RA, the TNF-?-producing cells and the dynamics of its expression, the direct and indirect action of this cytokine and possible biological therapy for RA are described. ..
  65. Proost P, Schutyser E, Menten P, Struyf S, Wuyts A, Opdenakker G, et al. Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties. Blood. 2001;98:3554-61 pubmed
    ..These data demonstrate a negative feedback regulation by CD26/DPP IV in CXCR3-mediated chemotaxis without affecting the angiostatic potential of the CXCR3 ligands IP-10 and Mig. ..
  66. Meelkop E, Temmerman L, Janssen T, Suetens N, Beets I, Van Rompay L, et al. PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying. Mol Cell Endocrinol. 2012;361:232-40 pubmed publisher
    ..We also show that egg-laying patterns of pdf-1 and pdf-2 mutants are affected, but not those of pdfr-1 mutants, pointing to a novel role for the PDF-system in the regulation of egg-laying...
  67. Marine J. Spotlight on the role of COP1 in tumorigenesis. Nat Rev Cancer. 2012;12:455-64 pubmed publisher
    ..These findings add to our growing appreciation of the roles for E3 ligases in cancer. ..
  68. Gonnissen A, Isebaert S, McKee C, Muschel R, Haustermans K. The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..Although the interaction between metformin and Hh signaling seems to be promising from a therapeutic point of view in vitro, more research is needed when implementing this combination strategy in vivo. ..
  69. Proost P, Menten P, Struyf S, Schutyser E, De Meester I, Van Damme J. Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist. Blood. 2000;96:1674-80 pubmed
    ..Blood. 2000;96:1674-1680) ..
  70. Hartmann D, De Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, et al. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002;11:2615-24 pubmed
    ..Thus, the observed variability, together with recent reports on tissue-specific expression patterns of ADAMs 9, 10 and 17, points to the existence of tissue-specific 'teams' of different proteases exerting alpha-secretase activity. ..
  71. Vermeiren J, Ceuppens J, Van Ghelue M, Witters P, Bullens D, Mages H, et al. Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity. J Immunol. 2004;172:5371-8 pubmed
    ..Thus, a subtype of regulatory T cells in human blood can be activated in the absence of costimulatory signals from CD40, CD80, and CD86, and they can be identified by expression of ICOS after activation. ..
  72. D hondt C, Ponsaerts R, Srinivas S, Vereecke J, Himpens B. Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions. Invest Ophthalmol Vis Sci. 2007;48:120-33 pubmed
    ..This study was undertaken to investigate the effect of thrombin on gap junctional (GJIC) and paracrine (PIC) intercellular communication in cultured bovine corneal endothelial cells (BCECs)...
  73. Aerts S, Vilain S, Hu S, Tranchevent L, Barriot R, Yan J, et al. Integrating computational biology and forward genetics in Drosophila. PLoS Genet. 2009;5:e1000351 pubmed publisher
    ..A systems genetics approach that combines the power of computational predictions with in vivo genetic screens strongly enhances the process of gene function and gene-gene association discovery. ..
  74. Rubio Texeira M, Van Zeebroeck G, Voordeckers K, Thevelein J. Saccharomyces cerevisiae plasma membrane nutrient sensors and their role in PKA signaling. FEMS Yeast Res. 2010;10:134-49 pubmed publisher
  75. Feng Y, Gordts S, Chen F, Hu Y, Van Craeyveld E, Jacobs F, et al. Topical HDL administration reduces vein graft atherosclerosis in apo E deficient mice. Atherosclerosis. 2011;214:271-8 pubmed publisher
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