Experts and Doctors on immunoprecipitation in Brussels, Brussels Capital, Belgium
Locale: Brussels, Brussels Capital, Belgium
Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, et al
. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005;24:336-46 pubmed
..Furthermore, these findings suggest that targeting of DNA methyltransferases by transcription factors is a wide and general mechanism for the generation of specific DNA methylation patterns within a cell. ..
Journe F, Durbecq V, Chaboteaux C, Rouas G, Laurent G, Nonclercq D, et al
. Association between farnesoid X receptor expression and cell proliferation in estrogen receptor-positive luminal-like breast cancer from postmenopausal patients. Breast Cancer Res Treat. 2009;115:523-35 pubmed publisher
..These results suggest that ER-positive breast tumors could be stimulated to proliferate via a crosstalk between FXR and ER, particularly in a state of estrogen deprivation (menopause, aromatase inhibitors). ..
Bockstaele L, Bisteau X, Paternot S, Roger P. Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation. Mol Cell Biol. 2009;29:4188-200 pubmed publisher
..Moreover, they provide a new model of a potentially oncogenic activating mutation of a CDK. ..
Azizieh R, Orduz D, Van Bogaert P, Bouschet T, Rodriguez W, Schiffmann S, et al
. Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons. Mol Neurobiol. 2011;44:111-21 pubmed publisher
..Our data link progressive myoclonic epilepsy to an inherited defect of the neuron plasma membrane's resting potential in the brain. ..
Starkel P, Saeger C, Leclercq I, Horsmans Y. Role of signal transducer and activator of transcription 3 in liver fibrosis progression in chronic hepatitis C-infected patients. Lab Invest. 2007;87:173-81 pubmed
..The decrease in Stat3 activity correlated with reduced hepatocytes proliferation and a positive antiapoptotic balance in infiltrating inflammatory cells that are known mediators of cell damage in HCV. ..
Kalai M, Suin V, Festjens N, Meeus A, Bernis A, Wang X, et al
. The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation. Cell Death Differ. 2007;14:1050-9 pubmed
..PKR-ND facilitates the interaction of PKR-KD with full-length PKR and thus the activation of the kinase and amplifies the translation inhibitory signal. ..
Van den Bossche J, Bogaert P, van Hengel J, Guerin C, Berx G, Movahedi K, et al
. Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes. Blood. 2009;114:4664-74 pubmed publisher
..This study identifies the E-cadherin/catenin complex as a discriminative, partly polyamine-regulated feature of IL-4/IL-13-exposed alternatively activated macrophages that contributes to homotypic and heterotypic cellular interactions. ..
Leroy K, Ando K, Héraud C, Yilmaz Z, Authelet M, Boeynaems J, et al
. Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. J Alzheimers Dis. 2010;19:705-19 pubmed publisher
Rorive S, Lopez X, Maris C, Trepant A, Sauvage S, Sadeghi N, et al
. TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas. Mod Pathol. 2010;23:1418-28 pubmed publisher
..It identifies TIMP-4 and CD63 as markers of the astrocytic phenotype in patients with gliomas. In addition, this work highlights the contribution of high TIMP-4/CD63 co-expression to the adverse outcomes of patients with glioblastomas. ..