Experts and Doctors on saccharomyces cerevisiae proteins in Salzburg, Austria
Locale: Salzburg, Austria
Topic: saccharomyces cerevisiae proteins
Kaser A, Bogengruber E, Hallegger M, Doppler E, Lepperdinger G, Jantsch M, et al
. Brix from xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. Biol Chem. 2001;382:1637-47 pubmed
..Depletion of Brx1 p in a conditional yeast mutant leads to defects in rRNA processing, and a block in the assembly of large ribosomal subunits. ..
Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kössler S, Klinger H, et al
. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging (Albany NY). 2009;1:622-36 pubmed
..AFO1/MRPL25 function establishes a new connection between mitochondria, metabolism and aging. ..
Klinger H, Rinnerthaler M, Lam Y, Laun P, Heeren G, Klocker A, et al
. Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells. Exp Gerontol. 2010;45:533-42 pubmed publisher
..As the aconitase remains mitochondrial during aging and cell division, our findings could indicate discrimination between active and no longer active mitochondria during the process. ..
Lettner T, Zeidler U, Gimona M, Hauser M, Breitenbach M, Bito A. Candida albicans AGE3, the ortholog of the S. cerevisiae ARF-GAP-encoding gene GCS1, is required for hyphal growth and drug resistance. PLoS ONE. 2010;5:e11993 pubmed publisher
..albicans and essential for detoxification of azole drugs which are routinely used for antifungal therapy. Thus, it represents a promising antifungal drug target. ..
Rinnerthaler M, Buttner S, Laun P, Heeren G, Felder T, Klinger H, et al
. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Proc Natl Acad Sci U S A. 2012;109:8658-63 pubmed publisher
..Several independent lines of evidence point to regulation of the actin cytoskeleton by reactive oxygen species (ROS) produced by Yno1p. ..