Experts and Doctors on cell proliferation in Salzburg, Austria


Locale: Salzburg, Austria
Topic: cell proliferation

Top Publications

  1. Mayr C, Wagner A, Loeffelberger M, Brückner D, Jakab M, Berr F, et al. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells. Oncotarget. 2016;7:745-58 pubmed publisher
    ..In addition, PTC-209 reduced sphere formation and, in a cell line-dependent manner, aldehyde dehydrogease-1 positive cells. We conclude that PTC-209 might be a promising drug for future in vitro and in vivo studies in BTC. ..
  2. Hofbauer S, Krenn P, Ganghammer S, Asslaber D, Pichler U, Oberascher K, et al. Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells. Blood. 2014;123:2181-8 pubmed publisher
    ..Collectively, our data suggest a dynamic regulation of Rac1 function in the CLL microenvironment. Rac inhibition could be of clinical use by selectively interfering with CLL cell proliferation and chemoresistance. ..
  3. Kandasamy M, Couillard Despres S, Raber K, Stephan M, Lehner B, Winner B, et al. Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. J Neuropathol Exp Neurol. 2010;69:717-28 pubmed publisher
    ..Thus, TGF-beta1 signaling seems to be a crucial modulator of neurogenesis in Huntington disease and may represent a target for future therapy. ..
  4. Steinbacher P, Haslett J, Six M, Gollmann H, Sänger A, Stoiber W. Phases of myogenic cell activation and possible role of dermomyotome cells in teleost muscle formation. Dev Dyn. 2006;235:3132-43 pubmed
    ..These findings are discussed in relation to their implications for the generality of vertebrate developmental patterns. ..
  5. Bauer J, Lang R, Jakab M, Kofler B. Galanin family of peptides in skin function. Cell Mol Life Sci. 2008;65:1820-5 pubmed publisher
    ..We discuss these data in light of the role of the galanin peptide family in inflammation and cell proliferation. ..
  6. Neureiter D, Zopf S, Leu T, Dietze O, Hauser Kronberger C, Hahn E, et al. Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models. Scand J Gastroenterol. 2007;42:103-16 pubmed
    ..These compounds may therefore be suitable as adjunctive therapeutic agents in the treatment of pancreatic cancer. ..
  7. Gruber W, Hutzinger M, Elmer D, Parigger T, Sternberg C, Cegielkowski L, et al. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance. Oncotarget. 2016;7:7134-48 pubmed publisher
    ..The results support the use of DYRK1B antagonists for the treatment of HH/GLI-associated cancers where SMO inhibitors fail to demonstrate therapeutic efficacy. ..
  8. Schmidt S, Jakab M, Jav S, Streif D, Pitschmann A, Zehl M, et al. Extracts from Leonurus sibiricus L. increase insulin secretion and proliferation of rat INS-1E insulinoma cells. J Ethnopharmacol. 2013;150:85-94 pubmed publisher
    ..enhance insulin secretion and/or foster cell proliferation may provide possible explanations for the underlying therapeutic principles in the empirical use of LS-containing formulations in DM and DM-related disorders as applied in TMM. ..
  9. Laner Plamberger S, Kaser A, Paulischta M, Hauser Kronberger C, Eichberger T, Frischauf A. Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes. Oncogene. 2009;28:1639-51 pubmed publisher
    ..These results suggest a novel connection between HH/GLI pathway activity and JUN, which may contribute to the oncogenic activity of HH/GLI signaling in skin. ..

More Information


  1. Traweger A, Lehner C, Farkas A, Krizbai I, Tempfer H, Klement E, et al. Nuclear Zonula occludens-2 alters gene expression and junctional stability in epithelial and endothelial cells. Differentiation. 2008;76:99-106 pubmed
  2. Stoecklinger A, Grieshuber I, Scheiblhofer S, Weiss R, Ritter U, Kissenpfennig A, et al. Epidermal langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization. J Immunol. 2007;179:886-93 pubmed
    ..Together, our data show that gene gun immunization is capable of inducing humoral and cell-mediated immune reactions independently of LC. ..
  3. Steinbacher P, Haslett J, Obermayer A, Marschallinger J, Bauer H, Sänger A, et al. MyoD and Myogenin expression during myogenic phases in brown trout: a precocious onset of mosaic hyperplasia is a prerequisite for fast somatic growth. Dev Dyn. 2007;236:1106-14 pubmed
    ..Furthermore, we suggest that Pax7 is expressed in myogenic progenitor cells that account for second- and third-phase myogenesis. These findings are discussed in relation to teleost myotome development and to teleost growth strategies. ..
  4. Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kössler S, Klinger H, et al. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging (Albany NY). 2009;1:622-36 pubmed
    ..AFO1/MRPL25 function establishes a new connection between mitochondria, metabolism and aging. ..
  5. Kiesslich T, Alinger B, Wolkersdörfer G, Ocker M, Neureiter D, Berr F. Active Wnt signalling is associated with low differentiation and high proliferation in human biliary tract cancer in vitro and in vivo and is sensitive to pharmacological inhibition. Int J Oncol. 2010;36:49-58 pubmed
    ..Further investigation of the mechanism(s) of Wnt pathway activation and its inhibition may provide new molecular treatment strategies for biliary tract cancer...
  6. Merkel O, Hamacher F, Laimer D, Sifft E, Trajanoski Z, Scheideler M, et al. Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma. Proc Natl Acad Sci U S A. 2010;107:16228-33 pubmed publisher
    ..In addition to future therapeutical and diagnostic applications, it will be of interest to study the physiological implications and prognostic value of the identified miRNA profiles. ..
  7. Wallner M, Hauser M, Himly M, Zaborsky N, Mutschlechner S, Harrer A, et al. Reshaping the Bet v 1 fold modulates T(H) polarization. J Allergy Clin Immunol. 2011;127:1571-8.e9 pubmed publisher
    ..We observed that the fold alteration led to a modified crosstalk with dendritic cells and a shift of the immune response polarization toward a mixed T(H)1/T(H)2 cytokine production. ..
  8. Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S, et al. Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. Cell Physiol Biochem. 2012;29:75-86 pubmed publisher
    ..We conclude that under standard cell culture conditions the AMPK modulators AICAR and compound C, but not metformin, stimulate insulin secretion by AMPK-independent mechanisms. ..