Experts and Doctors on biliary tract neoplasms in Salzburg, Austria
Locale: Salzburg, Austria
Topic: biliary tract neoplasms
Wachter J, Neureiter D, Alinger B, Pichler M, Fuereder J, Oberdanner C, et al
. Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells. Int J Biol Sci. 2012;8:15-29 pubmed
..Further in vivo investigation of these drugs as well as of new Wnt inhibitors may provide a promising approach for targeted therapy of this difficult-to-treat tumour. ..
Mayr C, Wagner A, Loeffelberger M, Brückner D, Jakab M, Berr F, et al
. The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells. Oncotarget. 2016;7:745-58 pubmed publisher
..In addition, PTC-209 reduced sphere formation and, in a cell line-dependent manner, aldehyde dehydrogease-1 positive cells. We conclude that PTC-209 might be a promising drug for future in vitro and in vivo studies in BTC. ..
Kiesslich T, Alinger B, Wolkersdörfer G, Ocker M, Neureiter D, Berr F. Active Wnt signalling is associated with low differentiation and high proliferation in human biliary tract cancer in vitro and in vivo and is sensitive to pharmacological inhibition. Int J Oncol. 2010;36:49-58 pubmed
..Further investigation of the mechanism(s) of Wnt pathway activation and its inhibition may provide new molecular treatment strategies for biliary tract cancer...
Kiesslich T, Neureiter D, Wolkersdörfer G, Plaetzer K, Berr F. Advances in photodynamic therapy for the treatment of hilar biliary tract cancer. Future Oncol. 2010;6:1925-36 pubmed publisher
..This article summarizes the recent advances in preclinical and clinical experience of PDT for hBTC, including experimental in vitro and in vivo studies, clinical studies and an overview of the ongoing clinical trials...