Experts and Doctors on saccharomyces cerevisiae in Clayton, Victoria, Australia


Locale: Clayton, Victoria, Australia
Topic: saccharomyces cerevisiae

Top Publications

  1. Prescott M, Bush N, Nagley P, Devenish R. Properties of yeast cells depleted of the OSCP subunit of mitochondrial ATP synthase by regulated expression of the ATP5 gene. Biochem Mol Biol Int. 1994;34:789-99 pubmed
    ..Thus, OSCP plays a role in the assembly as well as function of the enzyme complex. ..
  2. Papakonstantinou T, Law R, Nesbitt W, Nagley P, Devenish R. Molecular genetic analysis of the central hydrophobic domain of subunit 8 of yeast mitochondrial ATP synthase. Curr Genet. 1996;30:12-8 pubmed
  3. Bateson M, Devenish R, Nagley P, Prescott M. Single copies of subunits d, oligomycin-sensitivity conferring protein, and b are present in the Saccharomyces cerevisiae mitochondrial ATP synthase. J Biol Chem. 1999;274:7462-6 pubmed
    ..As only the Hex6-tagged subunit was recovered from such purifications, we demonstrate that the stoichiometry of subunits d, OSCP, and b in yeast is 1 in each case. ..
  4. Ellis T, Lukins H, Nagley P, Corner B. Suppression of a nuclear aep2 mutation in Saccharomyces cerevisiae by a base substitution in the 5'-untranslated region of the mitochondrial oli1 gene encoding subunit 9 of ATP synthase. Genetics. 1999;151:1353-63 pubmed
    ..In the present study, direct RNA-protein interactions are likely to form the basis of suppression. ..
  5. Wiradjaja F, Ooms L, Whisstock J, McColl B, Helfenbaum L, Sambrook J, et al. The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: regulation of secretion from the endoplasmic reticulum. J Biol Chem. 2001;276:7643-53 pubmed
    ..We propose that Inp54p plays a role in regulating secretion, possibly by modulating the levels of phosphatidylinositol (4,5)-bisphosphate on the cytoplasmic surface of the endoplasmic reticulum membrane. ..
  6. Beddoe T, Bushell S, Perugini M, Lithgow T, Mulhern T, Bottomley S, et al. A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway. J Biol Chem. 2004;279:46448-54 pubmed
    ..The data suggest that the malleability of the monomeric Tom70 receptor is an important factor in mitochondrial import. ..
  7. Wiradjaja F, Ooms L, Tahirovic S, Kuhne E, Devenish R, Munn A, et al. Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-bisphosphate on vacuole membranes and vacuolar fusion defects. J Biol Chem. 2007;282:16295-307 pubmed
  8. Bursac D, Lithgow T. Jid1 is a J-protein functioning in the mitochondrial matrix, unable to directly participate in endoplasmic reticulum associated protein degradation. FEBS Lett. 2009;583:2954-8 pubmed publisher
    ..The location of Jid1 within mitochondria makes it unavailable to participate directly in the regulation of ERAD. ..
  9. Lithgow T, Schneider A. Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes. Philos Trans R Soc Lond B Biol Sci. 2010;365:799-817 pubmed publisher
    ..We discuss how the processes of protein import and tRNA import relate to each other in an evolutionary context. ..

More Information


  1. Shingu Vazquez M, Traven A. Mitochondria and fungal pathogenesis: drug tolerance, virulence, and potential for antifungal therapy. Eukaryot Cell. 2011;10:1376-83 pubmed publisher
    ..We discuss how the contrasting effects of mitochondrial dysfunction on fungal drug tolerance and virulence could be explained and the potential for targeting mitochondrial factors for future antifungal drug development. ..
  2. Dolezal P, Aili M, Tong J, Jiang J, Marobbio C, Marobbio C, et al. Legionella pneumophila secretes a mitochondrial carrier protein during infection. PLoS Pathog. 2012;8:e1002459 pubmed publisher
    ..A hidden Markov model revealed further MCF proteins in the intracellular pathogens, Legionella longbeachae and Neorickettsia sennetsu, thereby challenging the notion that MCF proteins exist exclusively in eukaryotic organisms...
  3. Uwamahoro N, Qu Y, Jelicic B, Lo T, Beaurepaire C, Bantun F, et al. The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression. PLoS Genet. 2012;8:e1002613 pubmed publisher
    ..cerevisiae and are activators of the ALS genes in C. albicans. This suggests that Mediator subunits regulate adhesion in a distinct manner between these two distantly related fungal species. ..
  4. Traven A, Jänicke A, Harrison P, Swaminathan A, Seemann T, Beilharz T. Transcriptional profiling of a yeast colony provides new insight into the heterogeneity of multicellular fungal communities. PLoS ONE. 2012;7:e46243 pubmed publisher
  5. Mayorga J, Camacho Villasana Y, Shingú Vázquez M, García Villegas R, Zamudio Ochoa A, García Guerrero A, et al. A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria. J Biol Chem. 2016;291:9343-55 pubmed publisher
    ..Pet54 may play a role in Mss51 hemylation/conformational change necessary for translational activity. Moreover, Pet54 physically interacts with the COX1 mRNA, and this binding was independent of the presence of Mss51. ..
  6. Finnegan P, Ellis T, Nagley P, Lukins H. The mature AEP2 gene product of Saccharomyces cerevisiae, required for the expression of subunit 9 of ATP synthase, is a 58 kDa mitochondrial protein. FEBS Lett. 1995;368:505-8 pubmed
    ..Cell-free translation of AEP2 produces a 64 kDa polypeptide (consistent with the AEP2 sequence) which is imported into mitochondria and processed to a 58 kDa product by the removal of a presequence of about 50 amino acids. ..