Experts and Doctors on nuclear proteins in Clayton, Victoria, Australia


Locale: Clayton, Victoria, Australia
Topic: nuclear proteins

Top Publications

  1. Hatzistavrou T, Micallef S, Ng E, Vadolas J, Stanley E, Elefanty A. ErythRED, a hESC line enabling identification of erythroid cells. Nat Methods. 2009;6:659-62 pubmed publisher
    ..We describe a genetically modified hESC line, ErythRED, in which expression of RFP, controlled by regulatory sequences from the human beta-globin locus control region, is restricted to maturing erythroid cells...
  2. Pleuger C, Fietz D, Hartmann K, Schuppe H, Weidner W, Kliesch S, et al. Expression of ciliated bronchial epithelium 1 during human spermatogenesis. Fertil Steril. 2017;108:47-54 pubmed publisher
    ..The absence of CBE1 in spermatozoa suggests that CBE1 is important for the spermatid development but not for the maintenance of mature spermatozoa as a component of the flagellum. ..
  3. Chang F, McGhie J, Chan F, Tang M, Anderson M, Mann J, et al. PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells. Nucleic Acids Res. 2013;41:4447-58 pubmed publisher
    ..Our study demonstrates that PML bodies act as epigenetic regulators by serving as platforms for the assembly of the telomeric chromatin to ensure a faithful inheritance of epigenetic information at the telomere. ..
  4. Goulburn A, Alden D, Davis R, Micallef S, Ng E, Yu Q, et al. A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives. Stem Cells. 2011;29:462-73 pubmed publisher
    ..These studies highlight the diversity of cell types that can be generated from human NKX2.1(+) progenitors and demonstrate the utility of NKX2.1(GFP/w) hESCs for investigating human forebrain development and neuronal differentiation. ..
  5. Smith D, Cossins L, Hatzinisiriou I, Haber M, Nagley P. Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines. BMC Cancer. 2008;8:259 pubmed publisher
    ..Our results suggest preferential use of glycolysis for energy production and MYCN expression may be independent markers of neuroblastoma malignancy in vitro if not in vivo. ..
  6. Sim H, Rimmer K, Kelly S, Ludbrook L, Clayton A, Harley V. Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal. Mol Endocrinol. 2005;19:1884-92 pubmed
    ..CaM recognition could underlie XY sex reversal. Given that the CaM-binding region of SRY is well-conserved among high mobility group box proteins, CaM-dependent nuclear import may underlie additional disease states. ..
  7. Harley V, Clarkson M, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev. 2003;24:466-87 pubmed
    ..Many genes, however, remain unidentified, because in the majority of cases of XY females and in all cases of XX males lacking SRY, the mutated gene is unknown. ..
  8. Fida S, Myers M, Whittingham S, Rowley M, Ozaki S, Mackay I. Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases. J Autoimmun. 2002;19:251-7 pubmed
    ..Anti-SOX13 in PBC may occur merely as an immune response to products of damage to parenchymal tissue, or may be illustrative of a general proclivity of transcriptional regulatory proteins to elicit autoimmune responses. ..
  9. Elliott R, Betzner A, Huttner E, Oakes M, Tucker W, Gerentes D, et al. AINTEGUMENTA, an APETALA2-like gene of Arabidopsis with pleiotropic roles in ovule development and floral organ growth. Plant Cell. 1996;8:155-68 pubmed
    ..The expression pattern of ANT in floral and vegetative tissues indicates that it is involved not only in the initiation of integuments but also in the initiation and early growth of all primorida except roots. ..

More Information


  1. Western P, Ralli R, Wakeling S, Lo C, Van Den Bergen J, Miles D, et al. Mitotic arrest in teratoma susceptible fetal male germ cells. PLoS ONE. 2011;6:e20736 pubmed publisher
    ..Further understanding of fetal male germ cell differentiation promises to provide insight into disorders of the testis and germ cell lineage, such as testis tumour formation and infertility. ..
  2. Young J, Major A, Miyamoto Y, Loveland K, Jans D. Distinct effects of importin ?2 and ?4 on Oct3/4 localization and expression in mouse embryonic stem cells. FASEB J. 2011;25:3958-65 pubmed publisher
    ..These findings implicate IMP?2 and IMP?4 in specific but distinct roles in the fate choice between pluripotency and commitment to differentiation. ..
  3. Ly Huynh J, Lieu K, Major A, Whiley P, Holt J, Loveland K, et al. Importin alpha2-interacting proteins with nuclear roles during mammalian spermatogenesis. Biol Reprod. 2011;85:1191-202 pubmed publisher
  4. Xu D, Wilson T, Chan D, De Luca E, Zhou J, Hertzog P, et al. Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J. 2002;21:4081-93 pubmed
  5. Davies R, Wagstaff K, McLaughlin E, Loveland K, Jans D. The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins. Biochim Biophys Acta. 2013;1833:3436-3444 pubmed publisher
    ..These results imply for the first time that BRAP2 may have an important role in modulating subcellular localization during testicular development. ..
  6. Figeac N, Serralbo O, Marcelle C, Zammit P. ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. Dev Biol. 2014;386:135-51 pubmed publisher
    ..These observations demonstrate a conserved function of Ebp1 in the regulation of embryonic muscle progenitors and adult muscle stem cells, which likely operates independently of ErbB3 signaling. ..
  7. Lieu K, Shim E, Wang J, Lokareddy R, Tao T, Cingolani G, et al. The p53-induced factor Ei24 inhibits nuclear import through an importin ?-binding-like domain. J Cell Biol. 2014;205:301-12 pubmed publisher
    ..Thus, Ei24 can bind specifically to IMP?1 and IMP?2 to impede their normal role in nuclear import, shedding new light on the cellular functions of Ei24 and its tumor suppressor role. ..
  8. Nie G, Li Y, Batten L, Griffiths B, Wang J, Findlay J, et al. Uterine expression of alternatively spliced mRNAs of mouse splicing factor SC35 during early pregnancy. Mol Hum Reprod. 2000;6:1131-9 pubmed
    ..These results demonstrate, for the first time, that an essential splicing factor is regulated in a complex manner during implantation in the mouse uterus. Hence, its correct regulation could be important for the success of pregnancy. ..
  9. Ghildyal R, Ho A, Wagstaff K, Dias M, Barton C, Jans P, et al. Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. Biochemistry. 2005;44:12887-95 pubmed
  10. Ellisdon A, Thomas B, Bottomley S. The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step. J Biol Chem. 2006;281:16888-96 pubmed
    ..However, the presence of a pathological length polyglutamine tract introduces an additional step resulting in formation of a highly stable amyloid-like aggregate. ..