Experts and Doctors on molecular sequence data in Melbourne, Victoria, Australia


Locale: Melbourne, Victoria, Australia
Topic: molecular sequence data

Top Publications

  1. Qian H, Pipolo L, Thomas W. Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization. Mol Endocrinol. 2001;15:1706-19 pubmed
  2. Caminschi I, Lucas K, O Keeffe M, Hochrein H, Laabi Y, Brodnicki T, et al. Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells. Mol Immunol. 2001;38:365-73 pubmed
    ..CIRE shares 57% identity with human DC-SIGN, a molecule that has been shown to be the ligand of ICAM-3 and that is also a receptor that binds HIV and facilitates trans-infection of T cells. ..
  3. Marti M, Good R, Rug M, Knuepfer E, Cowman A. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science. 2004;306:1930-3 pubmed
    ..The conservation of this signal across Plasmodium species has implications for the development of new antimalarials. ..
  4. Bathgate R, Lin F, Hanson N, Otvos L, Guidolin A, Giannakis C, et al. Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry. 2006;45:1043-53 pubmed
    ..Thus, H3 relaxin is able to interact with the relaxin receptor LGR7 both in vitro and in vivo. ..
  5. Sadler A, Williams B. Structure and function of the protein kinase R. Curr Top Microbiol Immunol. 2007;316:253-92 pubmed
    ..Finally, PKR plays a role in normal cell differentiation in platelet-derived growth factor signalling and in osteoblast-mediated calcification. ..
  6. Conlan B, Gillon A, Craik D, Anderson M. Circular proteins and mechanisms of cyclization. Biopolymers. 2010;94:573-83 pubmed publisher
    ..These proteases cleave an amide bond and form an acyl enzyme intermediate before nucleophilic attack by the amine group of the N-terminal residue to form a peptide bond, resulting in a cyclic peptide. ..
  7. Bernoux M, Ve T, Williams S, Warren C, Hatters D, Valkov E, et al. Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host Microbe. 2011;9:200-211 pubmed publisher
    ..Analysis of the structure combined with site-directed mutagenesis suggests that self-association is a requirement for immune signaling and reveals distinct surface regions involved in self-association, signaling, and autoregulation...
  8. Jastrzebski K, Hannan K, House C, Hung S, Pearson R, Hannan R. A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth. Cell Signal. 2011;23:1338-47 pubmed publisher
    ..Consistent with this domain being involved in folding substrate interactions, we found that phosphorylation of serine 260 modulates chaperonin folding activity. ..
  9. Reeder J, Wapling J, Mueller I, Siba P, Barry A. Population genetic analysis of the Plasmodium falciparum 6-cys protein Pf38 in Papua New Guinea reveals domain-specific balancing selection. Malar J. 2011;10:126 pubmed publisher
    ..The findings have implications for future population genetic studies on vaccine candidates, showing that the biological context must also be considered as a framework for analysis. ..

More Information

Publications103 found, 100 shown here

  1. Manji S, Miller K, Williams L, Dahl H. Identification of three novel hearing loss mouse strains with mutations in the Tmc1 gene. Am J Pathol. 2012;180:1560-9 pubmed publisher
    ..These three allelic mutants provide valuable models for studying nonsyndromic recessive sensorineural hearing loss (DFNB7/11) in humans. ..
  2. Tikoo A, Roh V, Montgomery K, Ivetac I, Waring P, Pelzer R, et al. Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ER?-positive tumors. PLoS ONE. 2012;7:e36924 pubmed publisher
  3. Lo J, Jamsai D, O Connor A, Borg C, Clark B, Whisstock J, et al. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8:e1002969 pubmed publisher
    ..Our data demonstrate a novel function for the RABL protein family, an essential role for RABL2 in male fertility and a previously uncharacterised mechanism for protein delivery to the flagellum. ..
  4. Bernhard O, Greening D, Barnes T, Ji H, Simpson R. Detection of cadherin-17 in human colon cancer LIM1215 cell secretome and tumour xenograft-derived interstitial fluid and plasma. Biochim Biophys Acta. 2013;1834:2372-9 pubmed publisher
    ..In this study, we report for the first time that the presence of full-length cadherin-17 in exosomes released into the CM. This article is part of a Special Issue entitled: An Updated Secretome. ..
  5. Morley G, Callaghan J, Rose J, Toh B, Gleeson P, van Driel I. The mouse gastric H,K-ATPase beta subunit. Gene structure and co-ordinate expression with the alpha subunit during ontogeny. J Biol Chem. 1992;267:1165-74 pubmed
    ..Co-ordinate expression of the two subunit genes suggest that the regulatory mechanisms will be similar and that the beta subunit may be required for localization and function of the catalytic alpha subunit. ..
  6. Albiston A, Obeyesekere V, Smith R, Krozowski Z. Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol. 1994;105:R11-7 pubmed
    ..These data suggest that 11 beta HSD2 plays an important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids. ..
  7. Holloway A, Della N, Fletcher C, Largespada D, Copeland N, Jenkins N, et al. Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia. Genomics. 1997;41:160-8 pubmed
    ..By comparing the complexity of the Siah genes in these two mammalian species we have gained further insight into which members of this murine multigene family are likely to be functional. ..
  8. Krien M, Bugg S, Palatsides M, Asouline G, Morimyo M, O Connell M. A NIMA homologue promotes chromatin condensation in fission yeast. J Cell Sci. 1998;111 ( Pt 7):967-76 pubmed
    ..These data indicate that NIMA-related kinases may be a general feature of the cell cycle and chromatin organisation at mitosis. ..
  9. Whitley J, Moore C, Giraud A, Shulkes A. Molecular cloning, genomic organization and selective expression of bombesin receptor subtype 3 in the sheep hypothalamus and pituitary. J Mol Endocrinol. 1999;23:107-16 pubmed
    ..Cloning of the ovine BRS-3 gene will permit a detailed functional analysis of this receptor in the sheep and its role in the mediation of action of uterine GRP. ..
  10. Albano F, Berman A, La Greca N, Hibbs A, Wickham M, Foley M, et al. A homologue of Sar1p localises to a novel trafficking pathway in malaria-infected erythrocytes. Eur J Cell Biol. 1999;78:453-62 pubmed
    ..This provides the first evidence that the malaria parasite is capable of elaborating components of the classical vesicle-mediated trafficking machinery outside the boundaries of its own plasma membrane. ..
  11. Harley V, Layfield S, Mitchell C, Forwood J, John A, Briggs L, et al. Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. Proc Natl Acad Sci U S A. 2003;100:7045-50 pubmed
    ..This study documents cases of human disease being explained, at a molecular level, by the impaired ability of a protein to accumulate in the nucleus. ..
  12. Rollman E, Turner S, Kedzierska K, Kent S. Anti-SIV cytolytic molecules in pigtail macaques. AIDS Res Hum Retroviruses. 2008;24:1127-31 pubmed publisher
    ..We also successfully studied the release of perforin and granzyme B from deregulating SIV-specific CD8 T cells by flow cytometry. These sequences and tools enable further study of the cytolytic control of SIV in pigtail macaques. ..
  13. Kelleher M, Bacic A, Handman E. Identification of a macrophage-binding determinant on lipophosphoglycan from Leishmania major promastigotes. Proc Natl Acad Sci U S A. 1992;89:6-10 pubmed
    ..3, suggesting that P5b is a site of L. major LPG that is recognized by macrophage receptor(s) and is an important determinant in the attachment of promastigotes to host macrophages and initiation of infection. ..
  14. Dorow D, Devereux L, Dietzsch E, De Kretser T. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. Eur J Biochem. 1993;213:701-10 pubmed
    ..mRNA from MLK1 has been found to be expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. The MLK1 gene has been mapped to human chromosome 14q24.3-31. ..
  15. Li S, Parish R. Isolation of two novel myb-like genes from Arabidopsis and studies on the DNA-binding properties of their products. Plant J. 1995;8:963-72 pubmed
    ..Thus the binding pattern of the chimeric Myb protein is similar to that of the Atmyb6. This result suggests that the last 20 amino acids in the R3 repeat of Atmyb6 play a major role in DNA-binding. ..
  16. Kjer Nielsen L, Teasdale R, van Vliet C, Gleeson P. A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. Curr Biol. 1999;9:385-8 pubmed
    ..Thus, we have identified a family of coiled-coil proteins that share a domain shown to be sufficient for the localisation of peripheral membrane proteins to the Golgi apparatus. ..
  17. Caminschi I, Lucas K, O Keeffe M, Hochrein H, Laabi Y, Kontgen F, et al. Molecular cloning of F4/80-like-receptor, a seven-span membrane protein expressed differentially by dendritic cell and monocyte-macrophage subpopulations. J Immunol. 2001;167:3570-6 pubmed
    ..It is expressed by blood monocytes and by some tissue macrophages, but not by most macrophage cell lines or by lymphoid cells. FIRE is a useful marker of myeloid cells with a DC developmental potential. ..
  18. Adisa A, Albano F, Reeder J, Foley M, Tilley L. Evidence for a role for a Plasmodium falciparum homologue of Sec31p in the export of proteins to the surface of malaria parasite-infected erythrocytes. J Cell Sci. 2001;114:3377-86 pubmed
    ..These data support the suggestion that the malaria parasite establishes a vesicle-mediated trafficking pathway outside the boundaries of its own plasma membrane - a novel paradigm in eukaryotic biology. ..
  19. Quinn L, Herr A, McGarry T, Richardson H. The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis. Genes Dev. 2001;15:2741-54 pubmed
    ..In a partially female-sterile Dm geminin mutant, excessive DNA amplification in the ovarian follicle cells is observed. Our data suggest roles for Dm Geminin in limiting DNA replication, in anaphase and in neural differentiation. ..
  20. Betteridge T, Yang J, Pittard A, Praszkier J. Interaction of the initiator protein of an IncB plasmid with its origin of DNA replication. J Bacteriol. 2003;185:2210-8 pubmed
    ..Changing the spacing between box 1 and the other three boxes affected binding of RepA in vitro and origin activity in vivo, indicating that the RepA molecules bound to ori(B) interact with one another. ..
  21. Ma S, Bonaventure P, Ferraro T, Shen P, Burazin T, Bathgate R, et al. Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat. Neuroscience. 2007;144:165-90 pubmed
  22. Figueiredo A, Moore K, Mak J, Sluis Cremer N, de Béthune M, Tachedjian G. Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol. PLoS Pathog. 2006;2:e119 pubmed
    ..Furthermore, these drugs can serve as useful probes to further understand processes involved in HIV-1 particle assembly and maturation. ..
  23. Hu Y, Yu H, Pask A, O Brien D, Shaw G, Renfree M. A-kinase anchoring protein 4 has a conserved role in mammalian spermatogenesis. Reproduction. 2009;137:645-53 pubmed publisher
    ..This is consistent with its expression in other mammals. Thus, AKAP4 appears to have a conserved role in spermatogenesis for at least the last 166 million years of mammalian evolution...
  24. Anwari K, Poggio S, Perry A, Gatsos X, Ramarathinam S, Williamson N, et al. A modular BAM complex in the outer membrane of the alpha-proteobacterium Caulobacter crescentus. PLoS ONE. 2010;5:e8619 pubmed publisher
    ..We suggest the modular design of the BAM complex facilitates access to substrates from the protein translocase in the inner membrane. ..
  25. Alexander M, Wheatley A, Center R, Purcell D. Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor. Nucleic Acids Res. 2010;38:3041-53 pubmed publisher
    ..Thus, transcriptional coupling of U1 snRNA binding to the SD may licence the polymerase for transcription through the intron. ..
  26. Gartlan K, Belz G, Tarrant J, Minigo G, Katsara M, Sheng K, et al. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J Immunol. 2010;185:3158-66 pubmed publisher
    ..Therefore, in the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37(-/-) or Tssc6(-/-) mice, demonstrating a complementary role for these two molecules in cellular immunity...
  27. Song J, Matthews A, Reboul C, Kaiserman D, Pike R, Bird P, et al. Predicting serpin/protease interactions. Methods Enzymol. 2011;501:237-73 pubmed publisher
    ..The method described here could also be applied to other proteases for more generalized substrate specificity analysis and substrate discovery. ..
  28. Jegaskanda S, Reece J, De Rose R, Stambas J, Sullivan L, Brooks A, et al. Comparison of influenza and SIV specific CD8 T cell responses in macaques. PLoS ONE. 2012;7:e32431 pubmed publisher
    ..Our results suggest that strategies to maintain a more functional CD8(+) T-cell response, profile may assist in controlling HIV disease. ..
  29. Yu H, Lindsay J, Feng Z, Frankenberg S, Hu Y, Carone D, et al. Evolution of coding and non-coding genes in HOX clusters of a marsupial. BMC Genomics. 2012;13:251 pubmed publisher
    ..The sequencing of the kangaroo genome provides an opportunity to use comparative analyses to compare the HOX clusters of a mammal with a distinct body plan to those of other mammals...
  30. Miao Y, Eckhardt B, Cao Y, Pasqualini R, Argani P, Arap W, et al. Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78. Clin Cancer Res. 2013;19:2107-16 pubmed publisher
    ..The significance to patients with advanced breast cancer of a therapy that can reduce established metastatic disease should not be underestimated. ..
  31. Trist H, Tan P, Wines B, Ramsland P, Orlowski E, Stubbs J, et al. Polymorphisms and interspecies differences of the activating and inhibitory Fc?RII of Macaca nemestrina influence the binding of human IgG subclasses. J Immunol. 2014;192:792-803 pubmed publisher
    ..These marked interspecies differences in IgG binding between human and macaque FcRs and polymorphisms within species have implications for preclinical evaluation of Abs and vaccines in macaques. ..
  32. McCaffrey K, Boo I, Tewierek K, Edmunds M, Poumbourios P, Drummer H. Role of conserved cysteine residues in hepatitis C virus glycoprotein e2 folding and function. J Virol. 2012;86:3961-74 pubmed publisher
    ..Furthermore, the yield of total monomeric E2 increased to 70% in M+C597A. These studies reveal the contribution of each cysteine residue and the nine disulfide pairs to E2 structure and function...
  33. Bickle Q, Coppel R. A fourth family of the Plasmodium falciparum S-antigen. Mol Biochem Parasitol. 1992;56:141-50 pubmed
    ..This pattern of sequence variation differs considerably from that found for MSA-1 and MSA-2, the only other diverse proteins of P. falciparum for which sequence information is available. ..
  34. Prakash A, Denny W, Gourdie T, Valu K, Woodgate P, Wakelin L. DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustards. Biochemistry. 1990;29:9799-807 pubmed
    ..Relationships between the DNA alkylation patterns of these compounds and their biological activities are discussed. ..
  35. Matzaris M, O Malley C, Badger A, Speed C, Bird P, Mitchell C. Distinct membrane and cytosolic forms of inositol polyphosphate 5-phosphatase II. Efficient membrane localization requires two discrete domains. J Biol Chem. 1998;273:8256-67 pubmed
    ..This allows differential distribution of the 5-phosphatase II activity between the membrane and cytosol of the cell and thereby may regulate enzyme access to phosphoinositide-derived signaling molecules. ..
  36. Moritz R, Ritter G, Catimel B, Cohen L, Welt S, Old L, et al. Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium. J Chromatogr A. 1998;798:91-101 pubmed
    ..This amino acid sequence information has facilitated the cloning and subsequent sequencing of a cDNA for the A33 antigen which demonstrates that it is a novel human cell surface molecule of the immunoglobulin superfamily. ..
  37. Zhou J, Ng A, Tymms M, Jermiin L, Seth A, Thomas R, et al. A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. Oncogene. 1998;17:2719-32 pubmed
    ..Our data suggest that ELF5 may play roles in mammary, lung, prostate and/or kidney function, and possibly also in tumorigenesis. ..
  38. Kamarinos M, McGill J, Lynch M, Dahl H. Identification of a novel COCH mutation, I109N, highlights the similar clinical features observed in DFNA9 families. Hum Mutat. 2001;17:351 pubmed
    ..The remarkable clinical uniformity observed between DFNA9 families is intriguing especially in light of the great phenotypic variability observed with some of the other hearing loss genes. Hum Mutat 117:351, 2001. ..
  39. Churchill M, Sterjovski J, Gray L, Cowley D, Chatfield C, Learmont J, et al. Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia. J Infect Dis. 2004;190:2181-6 pubmed
    ..Thus, nef/LTR-deleted HIV-1 strains may undergo compartmentalized evolution in long-term survivors and cause neurologic disease. ..
  40. Likic V, Perry A, Hulett J, Derby M, Traven A, Waller R, et al. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. J Mol Biol. 2005;347:81-93 pubmed
    ..No Tom20-related protein was found in genome sequence data from plants or protozoans, suggesting the receptor Tom20 evolved after the split of animals and fungi from the main lineage of eukaryotes. ..
  41. Bird C, Sun J, Ung K, Karambalis D, Whisstock J, Trapani J, et al. Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol. 2005;25:7854-67 pubmed
    ..In this electrostatic "exchange-adsorption" model, cs1 and cs2 participate in binding of GrB to the cell surface, thereby promoting its uptake and eventual release into the cytoplasm. ..
  42. Dunning C, McKenzie M, Sugiana C, Lazarou M, Silke J, Connelly A, et al. Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease. EMBO J. 2007;26:3227-37 pubmed
    ..Our results indicate that CIA30 is a crucial component in the early assembly of complex I and mutations in its gene can cause mitochondrial disease. ..
  43. Li J, Halgamuge S, Kells C, Tang S. Gene function prediction based on genomic context clustering and discriminative learning: an application to bacteriophages. BMC Bioinformatics. 2007;8 Suppl 4:S6 pubmed
    ..Although our experimental focus is on bacteriophages, the method may be extended to other microbial genomes as they share a number of similar characteristics with phage genomes such as gene order conservation. ..
  44. Sgrò C, Milton C, Jensen L, Frydenberg J, Loeschcke V, Batterham P, et al. Nucleotide diversity in the Hsp90 gene in natural populations of Drosophila melanogaster from Australia. Insect Mol Biol. 2008;17:685-97 pubmed publisher
    ..These results are discussed within the context of Hsp90 variation being involved in thermotolerance as well as the expression of genetic and phenotypic variability. ..
  45. Dunse K, Stevens J, Lay F, Gaspar Y, Heath R, Anderson M. Coexpression of potato type I and II proteinase inhibitors gives cotton plants protection against insect damage in the field. Proc Natl Acad Sci U S A. 2010;107:15011-5 pubmed publisher
    ..Better crop protection thus is achieved using combinations of inhibitors in which one class of proteinase inhibitor is used to match the genetic capacity of an insect to adapt to a second class of proteinase inhibitor. ..
  46. Harper M, St Michael F, Vinogradov E, John M, Boyce J, Adler B, et al. Characterization of the lipopolysaccharide from Pasteurella multocida Heddleston serovar 9: identification of a proposed bi-functional dTDP-3-acetamido-3,6-dideoxy-?-D-glucose biosynthesis enzyme. Glycobiology. 2012;22:332-44 pubmed publisher
  47. Mantri N, Olarte A, Li C, Xue C, Pang E. Fingerprinting the Asterid species using subtracted diversity array reveals novel species-specific sequences. PLoS ONE. 2012;7:e34873 pubmed publisher
    ..In addition, this method allowed detection of several new loci that can be explored to solve existing discrepancies in phylogenetics and fingerprinting of plants. ..
  48. Stroud D, Formosa L, Wijeyeratne X, Nguyen T, Ryan M. Gene knockout using transcription activator-like effector nucleases (TALENs) reveals that human NDUFA9 protein is essential for stabilizing the junction between membrane and matrix arms of complex I. J Biol Chem. 2013;288:1685-90 pubmed publisher
    ..We conclude that NDUFA9 is involved in stabilizing the junction between membrane and matrix arms of complex I, a late assembly step critical for complex I biogenesis and activity. ..
  49. Albiston A, Herington A. Cloning and characterization of the growth hormone-dependent insulin-like growth factor binding protein (IGFBP-3) in the rat. Biochem Biophys Res Commun. 1990;166:892-7 pubmed
  50. Erlich R, Gleeson P, Campbell P, Dietzsch E, Toh B. Molecular characterization of trans-Golgi p230. A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. J Biol Chem. 1996;271:8328-37 pubmed
    ..This is the first report of a cytosolic Golgi protein containing a granin motif. The structural characteristics of p230 indicate that it may play a role in vesicular transport from the trans-Golgi. ..
  51. Robb L, Hartley L, Wang C, Harvey R, Begley C. musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle. Mech Dev. 1998;76:197-201 pubmed
    ..While all skeletal muscles expressed the gene, only a subset of myocytes within each muscle were positive, indicating molecular heterogeneity within fetal muscle. ..
  52. Smith C, Clifford V, Western P, Wilcox S, Bell K, Sinclair A. Cloning and expression of a DAX1 homologue in the chicken embryo. J Mol Endocrinol. 2000;24:23-32 pubmed
    ..Expression increased in both sexes during gonadogenesis, but was higher in females than in males. This is the first description of a DAX1 homologue in a non-mammalian vertebrate. ..
  53. Dep M, Mendz G, Trend M, Coloe P, Fry B, Korolik V. Differentiation between Campylobacter hyoilei and Campylobater coli using genotypic and phenotypic analyses. Int J Syst Evol Microbiol. 2001;51:819-26 pubmed publisher
    ..Both the genetic and phenotypic data indicate that C. hyoilei is a unique Campylobacter species...
  54. Thompson J, Triglia T, Reed M, Cowman A. A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes. Mol Microbiol. 2001;41:47-58 pubmed
    ..These results suggest that EBA140 may be involved in merozoite invasion using a sialic acid-dependent receptor on human erythrocytes. ..
  55. Bouillet P, Purton J, Godfrey D, Zhang L, Coultas L, Puthalakath H, et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature. 2002;415:922-6 pubmed
    ..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection. ..
  56. Delorenzi M, Sexton A, Shams Eldin H, Schwarz R, Speed T, Schofield L. Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum. Infect Immun. 2002;70:4510-22 pubmed
    ..The biosynthetic pathway of the malaria parasite GPI offers potential targets for drug development and may be useful for studying parasite cell biology and the molecular basis for the pathophysiology of parasitic diseases. ..
  57. Nandurkar H, Layton M, Laporte J, Selan C, Corcoran L, Caldwell K, et al. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A. 2003;100:8660-5 pubmed
    ..Collectively these studies indicate 3-PAP functions as an "adapter" for myotubularin, regulating myotubularin intracellular location and thereby altering the phenotype resulting from myotubularin overexpression. ..
  58. Mangum J, Farlie P, Hubbard M. Proteomic profiling of facial development in chick embryos. Proteomics. 2005;5:2542-50 pubmed
    ..A broader value of extending these approaches to facial development in other species and to other areas in embryology can be anticipated. ..
  59. Yarovaya N, Schot R, Fodero L, McMahon M, Mahoney A, Williams R, et al. Sialin, an anion transporter defective in sialic acid storage diseases, shows highly variable expression in adult mouse brain, and is developmentally regulated. Neurobiol Dis. 2005;19:351-65 pubmed
    ..We discuss the possible role of sialin in normal development and in SASD pathogenesis, as a framework for further investigation of its function in these contexts...
  60. Churchill M, Rhodes D, Learmont J, Sullivan J, Wesselingh S, Cooke I, et al. Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source. J Virol. 2006;80:1047-52 pubmed
    ..The in vivo pathogenicity of attenuated HIV-1 is therefore dictated by viral and/or host factors other than those that impose a unidirectional selection pressure on the nef/LTR region of the HIV-1 genome. ..
  61. Bokko P, Francione L, Bandala Sanchez E, Ahmed A, Annesley S, Huang X, et al. Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Mol Biol Cell. 2007;18:1874-86 pubmed
    ..The results show that diverse cytopathologies in Dictyostelium mitochondrial disease are caused by chronic AMPK signaling not by insufficient ATP. ..
  62. Gatsos X, Perry A, Anwari K, Dolezal P, Wolynec P, Likic V, et al. Protein secretion and outer membrane assembly in Alphaproteobacteria. FEMS Microbiol Rev. 2008;32:995-1009 pubmed publisher
  63. Veith P, O Brien Simpson N, Tan Y, Djatmiko D, Dashper S, Reynolds E. Outer membrane proteome and antigens of Tannerella forsythia. J Proteome Res. 2009;8:4279-92 pubmed publisher
    ..The major OmpA-like protein was found to be TF1331. Uniquely, it was found to exist as a homodimer held together by up to three disulfide bridges as demonstrated by MS/MS of a tryptic peptide derived from unreduced TF1331. ..
  64. Calatayud N, Pask A, Shaw G, Richings N, Osborn S, Renfree M. Ontogeny of the oestrogen receptors ESR1 and ESR2 during gonadal development in the tammar wallaby, Macropus eugenii. Reproduction. 2010;139:599-611 pubmed publisher
    ..The receptors can respond to exogenous estrogen at this early stage and are capable of transducing signals in the early mammalian gonad. However, the selective forces that maintained conserved ER expression in this tissue remain unknown...
  65. Sadowski M, Suryadinata R, Lai X, Heierhorst J, Sarcevic B. Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34. Mol Cell Biol. 2010;30:2316-29 pubmed publisher
  66. Cashin K, Roche M, Sterjovski J, Ellett A, Gray L, Cunningham A, et al. Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages. J Virol. 2011;85:10699-709 pubmed publisher
    ..Together, the results of our study provide novel insights into alternative mechanisms of Env-coreceptor engagement that are associated with efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages. ..
  67. Smyth R, Schlub T, Grimm A, Waugh C, Ellenberg P, Chopra A, et al. Identifying recombination hot spots in the HIV-1 genome. J Virol. 2014;88:2891-902 pubmed publisher
    ..The strength and location of these recombination hot and cold spots can be used to improve models of viral dynamics and evolution, which will be useful for the design of robust antiretroviral therapies. ..
  68. Huang L, Vanstone M, Hartley T, Osmond M, Barrowman N, Allanson J, et al. Mandibulofacial Dysostosis with Microcephaly: Mutation and Database Update. Hum Mutat. 2016;37:148-54 pubmed publisher
    ..All reported EFTUD2 mutations can be found in the EFTUD2 mutation database ( ..
  69. Ramus S, Forrest S, Cotton R. Illegitimate transcription of phenylalanine hydroxylase for detection of mutations in patients with phenylketonuria. Hum Mutat. 1992;1:154-8 pubmed
    ..Illegitimate transcription was successful for studying splicing defects and it was found that the previously described mutation which changes G to A at the 5' donor site of intron 7 causes exon 7 to be spliced out. ..
  70. Warren R, Ebert D, Mitchell A, Barter P. Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels. J Lipid Res. 1991;32:1333-9 pubmed
    ..1.00 +/- 0.01, n = 5, P = 0.0001). Thus, low hepatic lipase activity in the rabbit is associated with low mRNA levels, suggesting that the observed species difference in activity is due to differences in the level of mRNA. ..
  71. Hansen L, Brown G, Kirby D, Dahl H. Characterization of the mutations in three patients with pyruvate dehydrogenase E1 alpha deficiency. J Inherit Metab Dis. 1991;14:140-51 pubmed
    ..The other has a base change, resulting in an Arg to His substitution. All three mutations are located near the carboxyl terminus of the subunit. ..
  72. Callaghan J, Tan S, Khan M, Curran K, Campbell W, Smolka A, et al. Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase beta-subunit. Am J Physiol. 1995;268:F363-74 pubmed
  73. Rubio J, Cowman A. Plasmodium falciparum: the pfmdr2 protein is not overexpressed in chloroquine-resistant isolates of the malaria parasite. Exp Parasitol. 1994;79:137-47 pubmed
    ..These results support the evidence that pfmdr2 is not involved in the chloroquine resistance phenotype. ..
  74. Ismaili J, Antica M, Wu L. CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells. Eur J Immunol. 1996;26:731-7 pubmed
    ..Although they have initiated synthesis of some recombination-associated enzymes, full commitment to the T lineage and TCR gene rearrangement is a later event. ..
  75. Biben C, Hatzistavrou T, Harvey R. Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech Dev. 1998;73:125-7 pubmed
    ..Expression was also seen at opposite poles of the developing heart from E8-8.5 in posterior myocardial progenitors, then sinus venosa and dorsal pericardium, and from E9.5 in outflow tract myocardium. ..
  76. Walsh P, Bursac D, Law Y, Cyr D, Lithgow T. The J-protein family: modulating protein assembly, disassembly and translocation. EMBO Rep. 2004;5:567-71 pubmed
    ..We suggest that J-like proteins might function to regulate the activity of bona fide J proteins during protein translocation, assembly and disassembly. ..
  77. Smith C, McClive P, Sinclair A. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Dev Dyn. 2005;233:188-93 pubmed
    ..In the developing testis, its expression profile suggests that Alex2 has a role in specification or development of the interstitial cell lineage. ..
  78. Churchill M, Chiavaroli L, Wesselingh S, Gorry P. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus. Retrovirology. 2007;4:43 pubmed
    ..In addition, attenuated rev alleles may contribute to viral attenuation and long-term survival of HIV-1 infection in a subset of SBBC members. ..
  79. Waterhouse N, Trapani J. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007;28:373-5 pubmed
  80. Woollard D, Haqshenas G, Dong X, Pratt B, Kent S, Gowans E. Virus-specific T-cell immunity correlates with control of GB virus B infection in marmosets. J Virol. 2008;82:3054-60 pubmed
    ..These results indicate that virus-specific T-cell responses are detectable in the liver and blood of GBV-B-infected marmosets and that the clearance of GBV-B is associated with the appearance of these responses...
  81. Sheng K, Kalkanidis M, Pouniotis D, Wright M, Pietersz G, Apostolopoulos V. The adjuvanticity of a mannosylated antigen reveals TLR4 functionality essential for subset specialization and functional maturation of mouse dendritic cells. J Immunol. 2008;181:2455-64 pubmed
    ..Optimal functionality of DC subsets in Ag presentation necessitates concomitant TLR signaling critical for efficient Ag localization and processing. ..
  82. Miller K, Williams L, Rose E, Kuiper M, Dahl H, Manji S. Inner ear morphology is perturbed in two novel mouse models of recessive deafness. PLoS ONE. 2012;7:e51284 pubmed publisher
  83. Cashin K, Jakobsen M, Sterjovski J, Roche M, Ellett A, Flynn J, et al. Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection. Retrovirology. 2013;10:98 pubmed publisher
  84. Lin P, Lu C, Shen B, Lee G, Bowman J, Arteaga Vazquez M, et al. Identification of miRNAs and Their Targets in the Liverwort Marchantia polymorpha by Integrating RNA-Seq and Degradome Analyses. Plant Cell Physiol. 2016;57:339-58 pubmed publisher
    ..1 to autoregulate MpPPR_66 (LW9825) mRNA. This study provides a foundation for further investigations of the RNA-mediated silencing mechanism in M. polymorpha as well as of the evolution of this gene silencing pathway in embryophytes. ..
  85. Dorow D, Devereux L, Tu G, Price G, Nicholl J, Sutherland G, et al. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. Eur J Biochem. 1995;234:492-500 pubmed
    ..8 kb that was expressed at highest levels in RNA from brain and skeletal muscle. The 3454-bp cDNA was also used for fluorescence in situ hybridisation to localise the MLK2 gene to human chromosome 19 q13.2. ..
  86. Heath J, White S, Johnstone C, Catimel B, Simpson R, Moritz R, et al. The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. Proc Natl Acad Sci U S A. 1997;94:469-74 pubmed
    ..These data indicate that the A33 antigen is a novel cell surface receptor or cell adhesion molecule in the immunoglobulin superfamily. ..
  87. Li S, Higginson T, Parish R. A novel MYB-related gene from Arabidopsis thaliana expressed in developing anthers. Plant Cell Physiol. 1999;40:343-7 pubmed
    ..Plants transgenic for chimeric AtMYB103 promoter/GUS genes expressed the enzyme in early anthers. In situ hybridization of flower sections showed a high level of AtMYB103 mRNA in the tapetum and middle layer of developing anthers. ..
  88. Harvey S, Sheedy D, Cuddihy A, O Connell M. Coordination of DNA damage responses via the Smc5/Smc6 complex. Mol Cell Biol. 2004;24:662-74 pubmed
    ..The Smc5/6 complex is fundamental to genome integrity and may function with the condensin and cohesin complexes in a coordinated manner. ..
  89. Gillon A, Saska I, Jennings C, Guarino R, Craik D, Anderson M. Biosynthesis of circular proteins in plants. Plant J. 2008;53:505-15 pubmed
    ..We propose that there are two processing pathways in planta: one to produce the mature cyclotide and the other to produce linear variants that ultimately cannot be cyclized...
  90. Gray L, Sterjovski J, Ramsland P, Churchill M, Gorry P. Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues. Retrovirology. 2011;8:42 pubmed publisher
    ..Furthermore, we now provide new evidence that these CD4bs alterations augment the ability of gp120 to interact with CD4 by increasing the exposure of the CD4bs. ..
  91. Al Tamimi M, Arthur J, Gardiner E, Andrews R. Focusing on plasma glycoprotein VI. Thromb Haemost. 2012;107:648-55 pubmed publisher
    ..Here, we describe some of the critical mechanisms for generating soluble GPVI from platelets, and future avenues for exploiting this unique platelet-specific receptor for diagnosis and/or disease prevention. ..
  92. Ng S, Palombo E, Bhave M. The heavy metal tolerant soil bacterium Achromobacter sp. AO22 contains a unique copper homeostasis locus and two mer operons. J Microbiol Biotechnol. 2012;22:742-53 pubmed
    ..Achromobacter sp. strain AO22 is thus an ideal candidate for understanding copper homeostasis mechanisms and exploiting them for copper biosensor or biosorption systems...