Experts and Doctors on mitochondrial proteins in Melbourne, Victoria, Australia


Locale: Melbourne, Victoria, Australia
Topic: mitochondrial proteins

Top Publications

  1. Wyckelsma V, Levinger I, McKenna M, Formosa L, Ryan M, Petersen A, et al. Preservation of skeletal muscle mitochondrial content in older adults: relationship between mitochondria, fibre type and high-intensity exercise training. J Physiol. 2017;595:3345-3359 pubmed publisher
    ..These findings reveal (i) a similar amount of mitochondria in muscle from young and healthy older adults and (ii) a robust increase of mitochondrial content following 12 weeks of HIT exercise in older adults. ..
  2. Elgass K, Pakay J, Ryan M, Palmer C. Recent advances into the understanding of mitochondrial fission. Biochim Biophys Acta. 2013;1833:150-61 pubmed publisher
    ..This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology. ..
  3. Coffey V, Jemiolo B, Edge J, Garnham A, Trappe S, Hawley J. Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1441-51 pubmed publisher
    ..Accordingly, we suggest that sprint-activities are isolated from resistance training and that adequate recovery time is considered within periodized training plans that incorporate these divergent exercise modes. ..
  4. Tucker E, Mimaki M, Compton A, McKenzie M, Ryan M, Thorburn D. Next-generation sequencing in molecular diagnosis: NUBPL mutations highlight the challenges of variant detection and interpretation. Hum Mutat. 2012;33:411-8 pubmed publisher
    ..It is important that locus-specific databases contain accurate information on pathogenic variation. NGS data, therefore, require rigorous experimental follow-up to confirm mutation pathogenicity. ..
  5. Johnston A, Hoogenraad J, Dougan D, Truscott K, Yano M, Mori M, et al. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem. 2002;277:42197-204 pubmed
    ..These results indicate that the levels of Tom22 within mitochondria dictate the assembly of TOM complexes and hence may regulate its biogenesis. ..
  6. Dolezal P, Dagley M, Kono M, Wolynec P, Liki V, Foo J, et al. The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica. PLoS Pathog. 2010;6:e1000812 pubmed publisher
  7. Koutsopoulos O, Laine D, Osellame L, Chudakov D, Parton R, Frazier A, et al. Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. Biochim Biophys Acta. 2010;1803:564-74 pubmed publisher
    ..We conclude that the human Miltons are important mediators of the mitochondrial trafficking machinery. ..
  8. Palmer C, Osellame L, Stojanovski D, Ryan M. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Cell Signal. 2011;23:1534-45 pubmed publisher
    ..This review focuses on our current understanding of the mitochondrial morphology machinery in cell homeostasis, apoptosis and neurodegeneration, and the post translational modifications that regulate these processes. ..
  9. Tan A, Sourris K, Harcourt B, Thallas Bonke V, Penfold S, Andrikopoulos S, et al. Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. Am J Physiol Renal Physiol. 2010;298:F763-70 pubmed publisher
    ..In the present study, diverse approaches to block the AGE-RAGE axis had disparate effects on DN, which has potential clinical implications for the way this axis should be targeted in humans. ..

More Information


  1. Lazarou M, Smith S, Thorburn D, Ryan M, McKenzie M. Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria. FEBS J. 2009;276:6701-13 pubmed publisher
    ..We conclude that newly imported nuclear DNA-encoded subunits can integrate into the complex IV holoenzyme and supercomplex forms by associating with pre-existing subunits and intermediate assembly complexes. ..
  2. El Osta A, Brasacchio D, Yao D, Pocai A, Jones P, Roeder R, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med. 2008;205:2409-17 pubmed publisher
  3. McKenzie M, Liolitsa D, Akinshina N, Campanella M, Sisodiya S, Hargreaves I, et al. Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption. J Biol Chem. 2007;282:36845-52 pubmed
    ..These data suggest that in response to impaired respiration due to the mtDNA mutation, mitochondria consume ATP to maintain Deltapsim, representing a potential pathophysiological mechanism in human mitochondrial disease. ..
  4. Latouche C, Heywood S, Henry S, Ziemann M, Lazarus R, El Osta A, et al. Maternal overnutrition programs changes in the expression of skeletal muscle genes that are associated with insulin resistance and defects of oxidative phosphorylation in adult male rat offspring. J Nutr. 2014;144:237-44 pubmed publisher
    ..These data indicate that maternal overnutrition, even in the absence of prepregnancy obesity, can promote metabolic dysregulation and predispose offspring to type 2 diabetes. ..
  5. Richter V, Palmer C, Osellame L, Singh A, Elgass K, Stroud D, et al. Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. J Cell Biol. 2014;204:477-86 pubmed publisher
    ..MiD51 foci are also dependent on the presence of Drp1, and after scission they are distributed to daughter organelles, supporting the involvement of MiD51 in the fission apparatus...
  6. Heinz E, Lithgow T. Back to basics: a revealing secondary reduction of the mitochondrial protein import pathway in diverse intracellular parasites. Biochim Biophys Acta. 2013;1833:295-303 pubmed publisher
    ..This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids...
  7. Sheeran F, Pepe S. Mitochondrial Bioenergetics and Dysfunction in Failing Heart. Adv Exp Med Biol. 2017;982:65-80 pubmed publisher
  8. Palmer C, Osellame L, Laine D, Koutsopoulos O, Frazier A, Ryan M. MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep. 2011;12:565-73 pubmed publisher
    ..Overexpression of MiD49/51 seems to sequester Drp1 from functioning at mitochondria and cause fused tubules to associate with actin. Thus, MiD49/51 are new mediators of mitochondrial division affecting Drp1 action at mitochondria. ..
  9. Baker M, Webb C, Stroud D, Palmer C, Frazier A, Guiard B, et al. Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import. Mol Biol Cell. 2009;20:769-79 pubmed publisher
    ..We conclude that Tim9 plays an important functional role that includes facilitating the initial steps in translocating precursor substrates into the intermembrane space. ..
  10. Dunning C, McKenzie M, Sugiana C, Lazarou M, Silke J, Connelly A, et al. Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease. EMBO J. 2007;26:3227-37 pubmed
    ..Our results indicate that CIA30 is a crucial component in the early assembly of complex I and mutations in its gene can cause mitochondrial disease. ..
  11. Uren R, Dewson G, Bonzon C, Lithgow T, Newmeyer D, Kluck R. Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes. J Biol Chem. 2005;280:2266-74 pubmed
  12. Stojanovski D, Koutsopoulos O, Okamoto K, Ryan M. Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J Cell Sci. 2004;117:1201-10 pubmed
    ..These results indicate that the levels of hFis1 at the mitochondrial surface influences mitochondrial fission events and hence overall mitochondrial morphology within the cell. ..
  13. Gentle I, Gabriel K, Beech P, Waller R, Lithgow T. The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria. J Cell Biol. 2004;164:19-24 pubmed
  14. Hewitt V, Alcock F, Lithgow T. Minor modifications and major adaptations: the evolution of molecular machines driving mitochondrial protein import. Biochim Biophys Acta. 2011;1808:947-54 pubmed publisher
    ..This article is part of a Special Issue entitled Protein translocation across or insertion into membranes. ..
  15. Truscott K, Lowth B, Strack P, Dougan D. Diverse functions of mitochondrial AAA+ proteins: protein activation, disaggregation, and degradation. Biochem Cell Biol. 2010;88:97-108 pubmed publisher
    ..In this review, we describe the current status of knowledge regarding the known mitochondrial AAA+ proteins and their role in this organelle. ..
  16. Van Bergen N, Crowston J, Kearns L, Staffieri S, Hewitt A, Cohn A, et al. Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with OPA1-linked autosomal dominant optic atrophy. PLoS ONE. 2011;6:e21347 pubmed publisher
    ..Identification of genetic variants that enable this response may provide novel therapeutic insights into OXPHOS compensation for preventing vision loss in optic neuropathies. ..
  17. Fang L, Moore X, Gao X, Dart A, Lim Y, Du X. Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo. Life Sci. 2007;80:2154-60 pubmed
    ..Further study is required to examine the causal relationship between Mfn2 and cardiac hypertrophy. ..
  18. Humphries A, Streimann I, Stojanovski D, Johnston A, Yano M, Hoogenraad N, et al. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005;280:11535-43 pubmed
    ..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies. ..
  19. Bazzocco S, Dopeso H, Cartón García F, Macaya I, Andretta E, Chionh F, et al. Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. Clin Cancer Res. 2015;21:3695-704 pubmed publisher
    ..We have characterized at the transcriptomic level the differences between colorectal cancer cells that vary in their growth rates, and identified novel candidate chemotherapeutic targets for the treatment of colorectal cancer. ..