Experts and Doctors on intracellular signaling peptides and proteins in Clayton, Victoria, Australia


Locale: Clayton, Victoria, Australia
Topic: intracellular signaling peptides and proteins

Top Publications

  1. Chen C, Xu R. The in vitro regulation of growth hormone secretion by orexins. Endocrine. 2003;22:57-66 pubmed
    ..It is therefore suggested that orexins may play an important role in regulating GHRH-stimulated GH secretion through an increase in the L-type Ca2+ current and the PKC-mediated signaling pathways in ovine somatotropes. ..
  2. McGrath M, Cottle D, Nguyen M, Dyson J, Coghill I, Robinson P, et al. Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. J Biol Chem. 2006;281:7666-83 pubmed
    ..This study identified FHL1 as a novel regulator of myosin-binding protein C activity and indicates a role for FHL1 in sarcomere assembly. ..
  3. Cowling B, McGrath M, Nguyen M, Cottle D, Kee A, Brown S, et al. Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy. J Cell Biol. 2008;183:1033-48 pubmed publisher
    ..NFATc1 also colocalizes with mutant FHL1 to reducing bodies in RBM-afflicted skeletal muscle. Therefore, via NFATc1 signaling regulation, FHL1 appears to modulate muscle mass and strength enhancement. ..
  4. Brown S, McGrath M, Ooms L, Gurung R, Maimone M, Mitchell C. Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nu. J Biol Chem. 1999;274:27083-91 pubmed
    ..Collectively, these results suggest distinct roles for SLIM1 and SLIMMER in focal adhesions and nuclear-cytoplasmic communication. ..
  5. Ivetac I, Munday A, Kisseleva M, Zhang X, Luff S, Tiganis T, et al. The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell. 2005;16:2218-33 pubmed
    ..The 4-phosphatase therefore both generates and terminates phosphoinositide 3-kinase signals at distinct subcellular locations. ..
  6. Hansen T, Smith D, Nagley P. Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c. Cell Death Differ. 2006;13:1181-90 pubmed
  7. Farnworth P, Wang Y, Leembruggen P, Ooi G, Harrison C, Robertson D, et al. Rodent adrenocortical cells display high affinity binding sites and proteins for inhibin A, and express components required for autocrine signalling by activins and bone morphogenetic proteins. J Endocrinol. 2006;188:451-65 pubmed
  8. Udawela M, Christopoulos G, Tilakaratne N, Christopoulos A, Albiston A, Sexton P. Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors. Mol Pharmacol. 2006;69:1984-9 pubmed
  9. Udawela M, Christopoulos G, Morfis M, Christopoulos A, Ye S, Tilakaratne N, et al. A critical role for the short intracellular C terminus in receptor activity-modifying protein function. Mol Pharmacol. 2006;70:1750-60 pubmed
    ..Thus, this study reveals important functionality of the RAMP C-terminal domain and identifies key differences in the role of the RAMP C terminus for CTR versus CLR-based receptors. ..

More Information


  1. Morfis M, Tilakaratne N, Furness S, Christopoulos G, Werry T, Christopoulos A, et al. Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology. 2008;149:5423-31 pubmed publisher
    ..These data demonstrate that RAMP-complexed receptors have a different signaling profile to CTRs expressed in the absence of RAMPs, and this is likely due to direct effects of the RAMP on G protein-coupling efficiency. ..
  2. Qi Y, Oldfield B, Clarke I. Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction. J Neuroendocrinol. 2009;21:690-7 pubmed publisher
    ..We conclude that RFRP-3 neurones project to hypothalamic regions and cells involved in regulation of energy balance and reproduction in the ovine brain...
  3. Cottle D, McGrath M, Wilding B, Cowling B, Kane J, D Arcy C, et al. SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis. J Biol Chem. 2009;284:26964-77 pubmed publisher
    ..In skeletal muscle sections from the mdx mouse model of Duchenne muscular dystrophy, SLIMMER and Siva-1 co-localized in the nucleus of apoptotic myofibers. Therefore, SLIMMER may protect skeletal muscle from apoptosis. ..
  4. Martin K, Corlett A, Dubach D, Mustafa T, Coleman H, Parkington H, et al. Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory. Hum Mol Genet. 2012;21:3025-41 pubmed publisher
    ..Our data strongly suggest that RCAN1 plays an important role in normal brain development and function and its up-regulation likely contributes to the neural deficits associated with DS. ..
  5. Ng H, Smith D, Nagley P. Application of flow cytometry to determine differential redistribution of cytochrome c and Smac/DIABLO from mitochondria during cell death signaling. PLoS ONE. 2012;7:e42298 pubmed publisher
    ..Moreover, differential redistribution of cyt c and Smac occurs under various conditions, thereby reflecting constraints on availability of these proteins to exit mitochondria after permeabilization of the outer membrane. ..