Experts and Doctors on immunologic memory in Melbourne, Victoria, Australia

Summary

Locale: Melbourne, Victoria, Australia
Topic: immunologic memory

Top Publications

  1. Mackay L, Stock A, Ma J, Jones C, Kent S, Mueller S, et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc Natl Acad Sci U S A. 2012;109:7037-42 pubmed publisher
    ..The results demonstrate that peripheral T(RM) cells can be generated and survive in the absence of local antigen presentation and provide a powerful means of achieving immune protection against peripheral infection. ..
  2. Belz G, Wilson N, Kupresanin F, Mount A, Smith C. Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation. Adv Exp Med Biol. 2007;590:31-42 pubmed
  3. Grant E, Quiñones Parra S, Clemens E, Kedzierska K. Human influenza viruses and CD8(+) T cell responses. Curr Opin Virol. 2016;16:132-142 pubmed publisher
    ..We also review the importance of CD8(+) T cell immunity in individuals highly susceptible to severe influenza infection, including those hospitalised with influenza, the elderly and Indigenous populations. ..
  4. Wakim L, Gebhardt T, Heath W, Carbone F. Cutting edge: local recall responses by memory T cells newly recruited to peripheral nonlymphoid tissues. J Immunol. 2008;181:5837-41 pubmed
    ..Thus, expansion represents a means of local Ag-specific enrichment of T cells recruited from a circulating memory pool of mixed specificities. ..
  5. Belz G, Kallies A. Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination. Curr Opin Immunol. 2010;22:279-85 pubmed publisher
    ..This review focuses on the recent progress in our understanding of the molecular wiring of this differentiation process. ..
  6. Belz G, Wilson N, Smith C, Mount A, Carbone F, Heath W. Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin. Eur J Immunol. 2006;36:327-35 pubmed
    ..As Langerhans cells are radioresistant, unlike other DC populations, these studies also demonstrate that the radiosensitive DC responsible for secondary expansion of HSV-specific memory are not Langerhans cells. ..
  7. Bedoui S, Davey G, Lew A, Heath W. Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process. Immunol Cell Biol. 2009;87:255-9 pubmed publisher
  8. Kupresanin F, Chow J, Mount A, Smith C, Stevenson P, Belz G. Dendritic cells present lytic antigens and maintain function throughout persistent gamma-herpesvirus infection. J Immunol. 2007;179:7506-13 pubmed
    ..Our results support that, during persistent viral infection, continual presentation of lytic Ags by DC leads to T cell activation critical for maintaining CD8(+) T cells capable of limiting persistent viral infection. ..
  9. Vujanic A, Snibson K, Wee J, Edwards S, Pearse M, Scheerlinck J, et al. Long-term antibody and immune memory response induced by pulmonary delivery of the influenza Iscomatrix vaccine. Clin Vaccine Immunol. 2012;19:79-83 pubmed publisher
    ..Pulmonary delivery of an influenza Iscomatrix vaccine induces a long-lived influenza virus-specific antibody and memory response of suitable length for annual vaccination against influenza. ..

More Information

Publications25

  1. Guillonneau C, Mintern J, Hubert F, Hurt A, Besra G, Porcelli S, et al. Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity. Proc Natl Acad Sci U S A. 2009;106:3330-5 pubmed publisher
  2. Shann F. Heterologous immunity and the nonspecific effects of vaccines: a major medical advance?. Pediatr Infect Dis J. 2004;23:555-8 pubmed
  3. Belz G, Zhang L, Lay M, Kupresanin F, Davenport M. Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell. Proc Natl Acad Sci U S A. 2007;104:6341-6 pubmed
    ..The ability of the memory T cells to remove antigen-presenting cells provides a negative-feedback loop to directly limit the duration of antigen presentation in vivo. ..
  4. Smith C, Wilson N, Waithman J, Villadangos J, Carbone F, Heath W, et al. Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity. Nat Immunol. 2004;5:1143-8 pubmed
    ..In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing. ..
  5. Belz G, Bedoui S, Kupresanin F, Carbone F, Heath W. Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells. Nat Immunol. 2007;8:1060-6 pubmed
  6. Masson F, Minnich M, Olshansky M, Bilic I, Mount A, Kallies A, et al. Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation. J Immunol. 2013;190:4585-94 pubmed publisher
    ..Our findings reveal that the Id2/E2A axis orchestrates T cell differentiation through the induction or repression of downstream transcription factors essential for effector and memory T cell differentiation. ..
  7. Gugasyan R, Horat E, Kinkel S, Ross F, Grigoriadis G, Gray D, et al. The NF-?B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. EMBO J. 2012;31:692-706 pubmed publisher
    ..These findings indicate that NF-?B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics. ..
  8. White J, Cross E, Kedl R. Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them. Nat Rev Immunol. 2017;17:391-400 pubmed publisher
    ..Furthermore, we suggest a unifying model for the categorization of antigen-inexperienced memory-phenotype CD8+ T cells...
  9. Dwyer K, Hanidziar D, Putheti P, Hill P, Pommey S, McRae J, et al. Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype. Am J Transplant. 2010;10:2410-20 pubmed publisher
  10. Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron P, Lewin S. CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood. 2007;110:4161-4 pubmed
    ..CCR7 ligands facilitate efficient entry of HIV-1 into resting CD4(+) T cells. These studies demonstrate a unique action of the chemokines CCL19 and CCL21 and provide a novel model with which to study HIV-1 latency in vitro. ..
  11. Gebhardt T, Whitney P, Zaid A, Mackay L, Brooks A, Heath W, et al. Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature. 2011;477:216-9 pubmed publisher
    ..Overall, these results identify a complexity in memory T-cell migration, illuminating previously unappreciated differences between the CD4(+) and CD8(+) subsets. ..
  12. Westwood J, Darcy P, Guru P, Sharkey J, Pegram H, Amos S, et al. Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice. J Transl Med. 2010;8:42 pubmed publisher
    ..The use of combination immunotherapy stimulating multiple facets of immunity and including cytokine support for T cells can induce effective anti-tumor responses against orthotopic and metastatic tumors. ..
  13. Gebhardt T, Mueller S, Heath W, Carbone F. Peripheral tissue surveillance and residency by memory T cells. Trends Immunol. 2013;34:27-32 pubmed publisher
  14. Wakim L, Gupta N, Mintern J, Villadangos J. Enhanced survival of lung tissue-resident memory CD8? T cells during infection with influenza virus due to selective expression of IFITM3. Nat Immunol. 2013;14:238-45 pubmed publisher
    ..Thus, lung T(RM) cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures. ..
  15. Belz G, Masson F. Interleukin-2 tickles T cell memory. Immunity. 2010;32:7-9 pubmed publisher
    ..In this issue of Immunity, Pipkin et al. (2010) and Kalia et al. (2010) link differential interleukin-2 signaling and inflammation with the transcriptional events leading to the development of effector and memory cells. ..
  16. Fischer S, Bouillet P, O Donnell K, Light A, Tarlinton D, Strasser A. Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells. Blood. 2007;110:3978-84 pubmed
    ..We have identified for the first time the physiologic mechanisms for killing low-affinity antibody-expressing B cells in an immune response and have shown this to be dependent on the BH3-only protein Bim. ..