Experts and Doctors on cytoplasm in Melbourne, Victoria, Australia


Locale: Melbourne, Victoria, Australia
Topic: cytoplasm

Top Publications

  1. Ramdzan Y, Polling S, Chia C, Ng I, Ormsby A, Croft N, et al. Tracking protein aggregation and mislocalization in cells with flow cytometry. Nat Methods. 2012;9:467-70 pubmed publisher
    ..Combining PulSA with tetracysteine-based oligomer sensors in a cell model of Huntington's disease enabled further separation of cells enriched with monomers, oligomers and inclusion bodies. ..
  2. Gilberger T, Thompson J, Reed M, Good R, Cowman A. The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking. J Cell Biol. 2003;162:317-27 pubmed
    ..These results show that the parasite uses the same components of its cellular machinery for invasion regardless of the host cell type and invasive form. ..
  3. Dutka T, Lamboley C, McKenna M, Murphy R, Lamb G. Effects of carnosine on contractile apparatus Ca²? sensitivity and sarcoplasmic reticulum Ca²? release in human skeletal muscle fibers. J Appl Physiol (1985). 2012;112:728-36 pubmed publisher
  4. Hagemeyer C, von zur Muhlen C, Von Elverfeldt D, Peter K. Single-chain antibodies as diagnostic tools and therapeutic agents. Thromb Haemost. 2009;101:1012-9 pubmed
  5. Adisa A, Albano F, Reeder J, Foley M, Tilley L. Evidence for a role for a Plasmodium falciparum homologue of Sec31p in the export of proteins to the surface of malaria parasite-infected erythrocytes. J Cell Sci. 2001;114:3377-86 pubmed
    ..These data support the suggestion that the malaria parasite establishes a vesicle-mediated trafficking pathway outside the boundaries of its own plasma membrane - a novel paradigm in eukaryotic biology. ..
  6. Nguyen N, Kozer Gorevich N, Gliddon B, Smolka A, Clayton A, Gleeson P, et al. Independent trafficking of the KCNQ1 K+ channel and H+-K+-ATPase in gastric parietal cells from mice. Am J Physiol Gastrointest Liver Physiol. 2013;304:G157-66 pubmed publisher
    ..In addition, these studies indicate that acid secretion is regulated by independent trafficking of KCNQ1 and H(+)-K(+)-ATPase. ..
  7. Traven A, Lo T, Lithgow T, Heierhorst J. The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. PLoS ONE. 2010;5:e10651 pubmed publisher
    ..The Pop2-independent roles for Puf5 could involve spatial control of gene expression, a proposition supported by our data indicating that the active form of Puf5 is localised to cytoplasmic foci. ..
  8. Ghildyal R, Ho A, Dias M, Soegiyono L, Bardin P, Tran K, et al. The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism. J Virol. 2009;83:5353-62 pubmed publisher
    ..Together, our data suggest that Crm1-dependent nuclear export of M is central to RSV infection, representing the first report of such a mechanism for a paramyxovirus M protein and with important implications for related paramyxoviruses. ..
  9. Marti M, Good R, Rug M, Knuepfer E, Cowman A. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science. 2004;306:1930-3 pubmed
    ..The conservation of this signal across Plasmodium species has implications for the development of new antimalarials. ..

More Information


  1. Browne K, Johnstone R, Jans D, Trapani J. Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis. J Biol Chem. 2000;275:39262-6 pubmed
    ..Thus, filamin is a functionally important substrate for granzyme B, as its cleavage may account at least partly for caspase-independent cell death mediated by the granzyme. ..
  2. Murphy R, Lamb G. Endogenous calpain-3 activation is primarily governed by small increases in resting cytoplasmic [Ca2+] and is not dependent on stretch. J Biol Chem. 2009;284:7811-9 pubmed publisher
  3. Li D, Jans D, Bardin P, Meanger J, Mills J, Ghildyal R. Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein. J Virol. 2008;82:8863-70 pubmed publisher
    ..The interaction of M2-1 with M and, in particular, the N-terminal region of M may represent a target for novel antivirals that block the association of M with nucleocapsids, thereby inhibiting virus assembly...
  4. Derby M, van Vliet C, Brown D, Luke M, Lu L, Hong W, et al. Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. J Cell Sci. 2004;117:5865-74 pubmed
  5. Davis A, Perugini M, Smith B, Stewart J, Ilg T, Hodder A, et al. Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana. J Biol Chem. 2004;279:12462-8 pubmed publisher
    ..Our studies provide insight into the structure of a novel target for the development of anti-Leishmania drugs...
  6. Williams R, Senior P, Van Stekelenburg L, Layton J, Smith P, Dziadek M. Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation. Biochim Biophys Acta. 2002;1596:131-7 pubmed
    ..These studies provide the first evidence for an extracellular localisation of a SAM domain within any protein, and the first example of a SAM domain modified by N-linked glycosylation. ..
  7. Giam M, Mintern J, Rautureau G, Hinds M, Strasser A, Bouillet P. Detection of Bcl-2 family member Bcl-G in mouse tissues using new monoclonal antibodies. Cell Death Dis. 2012;3:e378 pubmed publisher
    ..The Bcl-G monoclonal antibodies represent new tools for studying this protein, using a variety of techniques, including immunoprecipitation and flow cytometry. ..
  8. Rani V, McCullough M, Chandu A. Assessment of laminin-5 in oral dysplasia and squamous cell carcinoma. J Oral Maxillofac Surg. 2013;71:1873-9 pubmed publisher
    ..The aims of this study were to assess the expression of laminin-5 (?2 chain) using cyclin D1 and Ki-67 in hyperplastic oral mucosal lesions, oral dysplasia, and squamous cell carcinoma (SCC)...
  9. Bullen H, Tonkin C, O Donnell R, Tham W, Papenfuss A, Gould S, et al. A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role. J Biol Chem. 2009;284:25353-63 pubmed publisher
    ..Hence, these proteins are strong candidates for an IMC-anchoring role, either directly or indirectly tethering the motor to the cytoskeleton. ..