Experts and Doctors on chick embryo in Melbourne, Victoria, Australia


Locale: Melbourne, Victoria, Australia
Topic: chick embryo

Top Publications

  1. Lambeth L, Cummins D, Doran T, Sinclair A, Smith C. Overexpression of aromatase alone is sufficient for ovarian development in genetically male chicken embryos. PLoS ONE. 2013;8:e68362 pubmed publisher
  2. Smith C, Katz M, Sinclair A. DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos. Biol Reprod. 2003;68:560-70 pubmed
    ..Higher levels of DMRT1 expression during testis differentiation therefore do not simply reflect a gene dosage difference between the two sexes but imply active involvement in male development. ..
  3. Foletta V, Moussi N, Sarmiere P, Bamburg J, Bernard O. LIM kinase 1, a key regulator of actin dynamics, is widely expressed in embryonic and adult tissues. Exp Cell Res. 2004;294:392-405 pubmed
    ..The rat monoclonal LIMK1 antibody recognizes proteins of similar size in cell and tissue extracts from numerous species. Thus, LIMK1 is a widely expressed protein that exists as several isoforms. ..
  4. Smith C, McClive P, Hudson Q, Sinclair A. Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling. Dev Biol. 2005;284:337-50 pubmed
    ..Taken together, these studies indicate that a key cellular event in gonadal sex differentiation is conserved among higher vertebrates, that it involves PDGF signalling, and that in mammals is an indirect effect of Sry expression. ..
  5. Wong J, Farlie P, Holbert S, Lockhart P, Thomas P. Polyalanine expansion mutations in the X-linked hypopituitarism gene SOX3 result in aggresome formation and impaired transactivation. Front Biosci. 2007;12:2085-95 pubmed
    ..These data suggest that deregulation of SOX3 target genes and inappropriate canonical Wnt signaling in central nervous system (CNS) progenitors may also contribute to dysfunction of the hypothalamic-pituitary axis in XH patients...
  6. Smith C, Roeszler K, Ohnesorg T, Cummins D, Farlie P, Doran T, et al. The avian Z-linked gene DMRT1 is required for male sex determination in the chicken. Nature. 2009;461:267-71 pubmed publisher
    ..These results indicate that DMRT1 is required for testis determination in the chicken. Our data support the Z dosage hypothesis for avian sex determination. ..
  7. Smith C, Clifford V, Western P, Wilcox S, Bell K, Sinclair A. Cloning and expression of a DAX1 homologue in the chicken embryo. J Mol Endocrinol. 2000;24:23-32 pubmed
    ..Expression increased in both sexes during gonadogenesis, but was higher in females than in males. This is the first description of a DAX1 homologue in a non-mammalian vertebrate. ..
  8. Mangum J, Farlie P, Hubbard M. Proteomic profiling of facial development in chick embryos. Proteomics. 2005;5:2542-50 pubmed
    ..A broader value of extending these approaches to facial development in other species and to other areas in embryology can be anticipated. ..
  9. Guarnaccia T, Carolan L, Maurer Stroh S, Lee R, Job E, Reading P, et al. Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model. PLoS Pathog. 2013;9:e1003354 pubmed publisher
    ..Furthermore, the potential changes in receptor binding properties that accompany antigenic changes highlight the importance of routine characterization of clinical samples in human A(H1N1)pdm09 influenza surveillance. ..

More Information


  1. Lambeth L, Ayers K, Cutting A, Doran T, Sinclair A, Smith C. Anti-Müllerian Hormone Is Required for Chicken Embryonic Urogenital System Growth but Not Sexual Differentiation. Biol Reprod. 2015;93:138 pubmed publisher
    ..These data suggest that although AMH does not directly contribute to testicular or ovarian differentiation, it is required in a sex-independent manner for proper cell proliferation and urogenital system growth. ..