Genomes and Genes
Experts and Doctors on carrier proteins in Clayton, Victoria, Australia
Locale: Clayton, Victoria, Australia
Topic: carrier proteins
- Tsukamoto T, Gearhart M, Spike C, Huelgas Morales G, Mews M, Boag P, et al. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Genetics. 2017;206:2007-2039 pubmed publisher..Upon their synthesis, SPN-4 and MEG-1 assemble into LIN-41 RNPs prior to their functions in the embryo. This study defines a translational repression-to-activation switch as a key element of cytoplasmic maturation. ..
- Alcock F, Webb C, Dolezal P, Hewitt V, Shingu Vasquez M, Likic V, et al. A small Tim homohexamer in the relict mitochondrion of Cryptosporidium. Mol Biol Evol. 2012;29:113-22 pubmed publisher..We show that the atypical CpTimS exists as a relatively unstable homohexamer, shedding light both on the early evolution of the small Tim protein family and on small Tim hexamer formation in contemporary eukaryotes...
- Al Hasani K, Navarro Garcia F, Huerta J, Sakellaris H, Adler B. The immunogenic SigA enterotoxin of Shigella flexneri 2a binds to HEp-2 cells and induces fodrin redistribution in intoxicated epithelial cells. PLoS ONE. 2009;4:e8223 pubmed publisher..We have also demonstrated that SigA is cytopathic for HEp-2 cells and plays a role in the intestinal fluid accumulation associated with S. flexneri infections...
- Davidson K, Jamshidi P, Daly R, Hearn M, Pera M, Dottori M. Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells. Mol Cell Neurosci. 2007;36:408-15 pubmed..These findings demonstrate a requirement of Wnt signaling for maintenance, proliferation, and survival of NP when cultured in neurosphere conditions. ..
- Fenner J, Starr R, Cornish A, Zhang J, Metcalf D, Schreiber R, et al. Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol. 2006;7:33-9 pubmed..Thus, SOCS1 is an important in vivo inhibitor of type I interferon signaling and contributes to balancing its beneficial antiviral versus detrimental proinflammatory effects on innate immunity. ..
- Hewitt K, Pratis K, Jones M, Simpson E. Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse. Endocrinology. 2004;145:1842-8 pubmed
- Pompolo S, Pereira A, Scott C, Fujiyma F, Clarke I. Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter-2. J Comp Neurol. 2003;465:136-44 pubmed..We conclude that E-responsive glutamatergic neurons arising from the brainstem, the BnST, and ARC/VMH provide input to the POA and may be involved in the regulation of GnRH secretion. ..
- Buxton P, Zhang X, Walsh B, Sriratana A, Schenberg I, Manickam E, et al. Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. Biochem J. 2003;375:433-40 pubmed..An important implication of our results is that Snapin is likely to perform a general role in SNARE-mediated vesicle fusion events in non-neuronal cells in addition to its participation in Ca2+-regulated neurosecretion. ..
- Martinez G, Mishina Y, Bertram J. BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies. Int J Dev Biol. 2002;46:525-33 pubmed..Noggin did not alter metanephric development in vitro, but did block the effect of BMP4. The experiments described in this study have shown that BMP4 has distinct roles from BMP2 in metanephric development...
- Parish C, Finkelstein D, Drago J, Borrelli E, Horne M. The role of dopamine receptors in regulating the size of axonal arbors. J Neurosci. 2001;21:5147-57 pubmed..These results suggest that individual dopaminergic axons in D2(-/-) mice have reached maximal arbor size. We conclude that the D2 receptor may play a role in modulating the extent of the terminal arbor of SNpc neurons. ..
- Bateson M, Devenish R, Nagley P, Prescott M. Single copies of subunits d, oligomycin-sensitivity conferring protein, and b are present in the Saccharomyces cerevisiae mitochondrial ATP synthase. J Biol Chem. 1999;274:7462-6 pubmed..As only the Hex6-tagged subunit was recovered from such purifications, we demonstrate that the stoichiometry of subunits d, OSCP, and b in yeast is 1 in each case. ..
- Sloan J, McMurry L, Lyras D, Levy S, Rood J. The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants. Mol Microbiol. 1994;11:403-15 pubmed..It is proposed that tetB(P) evolved from the conjugative transfer into C. perfringens of a tet(M)-like gene from another bacterium...
- Verity K, Fuller P. Isolation of a rat amiloride-binding protein cDNA clone: tissue distribution and regulation of expression. Am J Physiol. 1994;266:C1505-12 pubmed..The distribution of rat ABP is not as would be predicted for an aldosterone-induced gene and is thus unlikely to be a component of the amiloride-sensitive electrogenic sodium channel...
- Rouch D, Cram D, DiBerardino D, Littlejohn T, Skurray R. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. Mol Microbiol. 1990;4:2051-62 pubmed..The last common ancestor of the qacA and related tet (tetracycline resistance) lineages is inferred to have been repressor controlled, as occurs for modern tet determinants from Gram-negative, but not those from Gram-positive, bacteria...
- Stinear T, Seemann T, Harrison P, Jenkin G, Davies J, Johnson P, et al. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res. 2008;18:729-41 pubmed publisher..tuberculosis. The work described herein provides a foundation for using M. marinum to better understand the determinants of pathogenesis of tuberculosis...
- Dolezal P, Aili M, Tong J, Jiang J, Marobbio C, Marobbio C, et al. Legionella pneumophila secretes a mitochondrial carrier protein during infection. PLoS Pathog. 2012;8:e1002459 pubmed publisher..A hidden Markov model revealed further MCF proteins in the intracellular pathogens, Legionella longbeachae and Neorickettsia sennetsu, thereby challenging the notion that MCF proteins exist exclusively in eukaryotic organisms...
- Nasr N, Alshehri A, Wright T, Shahid M, Heiner B, Harman A, et al. Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages. J Virol. 2017;91: pubmed publisher..These antiviral ISGs may contribute to persistent infection in macrophages and to the establishment of viral reservoirs in vivo. ..