Genomes and Genes
Experts and Doctors on amino acid sequence in Clayton, Victoria, Australia
Locale: Clayton, Victoria, Australia
Topic: amino acid sequence
Publications118 found, 100 shown here
- O Bryan M, Sebire K, Meinhardt A, Edgar K, Keah H, Hearn M, et al. Tpx-1 is a component of the outer dense fibers and acrosome of rat spermatozoa. Mol Reprod Dev. 2001;58:116-25 pubmed..As such, tpx-1 may have functional significance in the processes of sperm head development and tail function. ..
- Sim H, Rimmer K, Kelly S, Ludbrook L, Clayton A, Harley V. Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal. Mol Endocrinol. 2005;19:1884-92 pubmed..CaM recognition could underlie XY sex reversal. Given that the CaM-binding region of SRY is well-conserved among high mobility group box proteins, CaM-dependent nuclear import may underlie additional disease states. ..
- Udawela M, Christopoulos G, Morfis M, Christopoulos A, Ye S, Tilakaratne N, et al. A critical role for the short intracellular C terminus in receptor activity-modifying protein function. Mol Pharmacol. 2006;70:1750-60 pubmed..Thus, this study reveals important functionality of the RAMP C-terminal domain and identifies key differences in the role of the RAMP C terminus for CTR versus CLR-based receptors. ..
- Papakonstantinou T, Harris S, Fredericks D, Harrison C, Wallace E, Hearn M. Synthesis, purification and bioactivity of recombinant human activin A expressed in the yeast Pichia pastoris. Protein Expr Purif. 2009;64:131-8 pubmed publisher..These results document an approach of considerable potential for the simple, large-scale expression and purification of this important human growth factor for use in diagnostic and therapeutic purposes. ..
- Quinn J, Tam S, Sims N, Saleh H, McGregor N, Poulton I, et al. Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function. FASEB J. 2010;24:275-85 pubmed publisher..These results show that AMPK is required to maintain normal bone density, but not through bone cell differentiation, and does not mediate powerful osteolytic effects of AICA-riboside. ..
- Lieu K, Marsh G, Wang L, Netter H. The non-pathogenic Henipavirus Cedar paramyxovirus phosphoprotein has a compromised ability to target STAT1 and STAT2. Antiviral Res. 2015;124:69-76 pubmed publisher..These results strongly suggest that the ability of CedPV to counteract the IFN/STAT response is compromised compared to HeV. ..
- Yang Z, deVeer M, Gardiner E, Devenish R, Handley C, Underwood J, et al. Rabbit polymorphonuclear neutrophils form 35S-labeled S-sulfo-calgranulin C when incubated with inorganic [35S]sulfate. J Biol Chem. 1996;271:19802-9 pubmed..The specific radioactivity of calgranulin C from the neutrophil culture medium was 50-fold greater than that of the calgranulin C within the cells, suggesting that S-sulfation of calgranulin C might be associated with its secretion. ..
- Elliott R, Betzner A, Huttner E, Oakes M, Tucker W, Gerentes D, et al. AINTEGUMENTA, an APETALA2-like gene of Arabidopsis with pleiotropic roles in ovule development and floral organ growth. Plant Cell. 1996;8:155-68 pubmed..The expression pattern of ANT in floral and vegetative tissues indicates that it is involved not only in the initiation of integuments but also in the initiation and early growth of all primorida except roots. ..
- Ruffolo C, Adler B. Cloning, sequencing, expression, and protective capacity of the oma87 gene encoding the Pasteurella multocida 87-kilodalton outer membrane antigen. Infect Immun. 1996;64:3161-7 pubmed..Specific Oma87 antiserum protected mice against homologous, lethal P. multocida challenge. These results suggest that Oma87 is a protective outer membrane antigen of P. multocida. ..
- Topolska A, Lidgett A, Truman D, Fujioka H, Coppel R. Characterization of a membrane-associated rhoptry protein of Plasmodium falciparum. J Biol Chem. 2004;279:4648-56 pubmed..The p60 RAMA form is discharged from the rhoptries of free merozoites and binds to the red blood cell membrane by its most C-terminal region. In early ring stages RAMA is found in association with the parasitophorous vacuole. ..
- Halls M, Bond C, Sudo S, Kumagai J, Ferraro T, Layfield S, et al. Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8). J Pharmacol Exp Ther. 2005;313:677-87 pubmed..Evidence obtained in this study supports a two-stage binding model of receptor activation: binding to the primary site allows a conformational change and interaction with the low-affinity transmembrane site. ..
- Gras S, Chen Z, Miles J, Liu Y, Bell M, Sullivan L, et al. Allelic polymorphism in the T cell receptor and its impact on immune responses. J Exp Med. 2010;207:1555-67 pubmed publisher..Thus, polymorphism in the TCR loci may contribute toward variability in immune responses and the outcome of infection. ..
- Piantavigna S, McCubbin G, Boehnke S, Graham B, Spiccia L, Martin L. A mechanistic investigation of cell-penetrating Tat peptides with supported lipid membranes. Biochim Biophys Acta. 2011;1808:1811-7 pubmed publisher..These results suggest that both electrostatic and hydrophobic interactions, as well as peptide geometry, determine the antimicrobial activity of Tat. This should guide the development of more potent Tat antibiotics. ..
- Simpson C, Stanton P, Walton K, Chan K, Ritter L, Gilchrist R, et al. Activation of latent human GDF9 by a single residue change (Gly 391 Arg) in the mature domain. Endocrinology. 2012;153:1301-10 pubmed publisher..This important species difference in the activation status of GDF9 may contribute to the variation observed in follicular development, ovulation rate, and fecundity between mammals. ..
- Woon A, Tohidpour A, Alonso H, Saijo Hamano Y, Kwok T, Roujeinikova A. Conformational analysis of isolated domains of Helicobacter pylori CagA. PLoS ONE. 2013;8:e79367 pubmed publisher..Taken together, these results provide a deeper understanding of the physicochemical properties of CagA that underpin its complex cellular and oncogenic functions. ..
- Khandokar Y, Srivastava P, Sarker S, Swarbrick C, Aragao D, Cowieson N, et al. Structural and Functional Characterization of the PaaI Thioesterase from Streptococcus pneumoniae Reveals a Dual Specificity for Phenylacetyl-CoA and Medium-chain Fatty Acyl-CoAs and a Novel CoA-induced Fit Mechanism. J Biol Chem. 2016;291:1866-76 pubmed publisher
- Revill P, Davidson A, Wright P. The nucleotide sequence and genome organization of mushroom bacilliform virus: a single-stranded RNA virus of Agaricus bisporus (Lange) Imbach. Virology. 1994;202:904-11 pubmed publisher..The putative RNA-dependent RNA polymerase and the coat protein display homology with corresponding proteins encoded by certain plant viruses, particularly luteoviruses and carmoviruses...
- Ghildyal R, Ho A, Wagstaff K, Dias M, Barton C, Jans P, et al. Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. Biochemistry. 2005;44:12887-95 pubmed
- Duncan R, Mohlin F, Taleski D, Coetzer T, Huntington J, Payne R, et al. Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. J Immunol. 2012;189:2365-73 pubmed publisher..We present a molecular model for the interaction between C1s and C4 that provides support for the above data and poses questions for future research into this aspect of complement activation. ..
- Zhang C, Sriratana A, Minamikawa T, Nagley P. Photosensitisation properties of mitochondrially localised green fluorescent protein. Biochem Biophys Res Commun. 1998;242:390-5 pubmed..Thus, GFP5 can be used in the development of an organelle-specific photosensitiser since it can be targeted to different subcellular locations by protein engineering of the signal sequences. ..
- Sharma L, Melis E, Hickey M, Clyne C, Erlich J, Khachigian L, et al. The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia. Am J Pathol. 2004;165:331-40 pubmed..These results indicate that deletion of the cytoplasmic domain of TF impairs the recruitment and activation of leukocytes and increases survival following endotoxin challenge. ..
- Gao W, Chua K, Davies J, Newton H, Seemann T, Harrison P, et al. Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection. PLoS Pathog. 2010;6:e1000944 pubmed publisher..These results reinforce the exquisite adaptability of S. aureus and show how subtle molecular changes cause major alterations in bacterial behaviour, as well as highlighting potential weaknesses of current antibiotic treatment regimens...
- Kong A, Speed C, O Malley C, Layton M, Meehan T, Loveland K, et al. Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. J Biol Chem. 2000;275:24052-64 pubmed..We propose that the novel 5-phosphatase hydrolyzes phosphatidylinositol 3,4, 5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby may regulate Golgi-vesicular trafficking. ..
- Xu Y, Ramsland P, Davies J, Scealy M, Nandakumar K, Holmdahl R, et al. Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry. Mol Immunol. 2004;41:411-9 pubmed
- Doughty S, Ruffolo C, Adler B. The type 4 fimbrial subunit gene of pasteurella multocida. Vet Microbiol. 2000;72:79-90 pubmed..The ptfA gene was amplified and sequenced from several P. multocida strains. Comparison of these sequences revealed variation within the type 4 subunit gene of P. multocida. ..
- Law R, Smooker P, Irving J, Piedrafita D, Ponting R, Kennedy N, et al. Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection. Infect Immun. 2003;71:6921-32 pubmed..hepatica. The kinetics of the response to cathepsin B and cathepsin L after infection of sheep and rats confirm the temporal expression of these proteins during the life cycle of the parasite. ..
- Kasimiotis H, Myers M, Argentaro A, Mertin S, Fida S, Ferraro T, et al. Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets. Diabetes. 2000;49:555-61 pubmed
- O Bryan M, Loveland K, Herszfeld D, McFarlane J, Hearn M, de Kretser D. Identification of a rat testis-specific gene encoding a potential rat outer dense fibre protein. Mol Reprod Dev. 1998;50:313-22 pubmed
- Bowden M, Drummond A, Salamonsen L, Findlay J, Nie G. Evolutionary conservation of mammalian HTRA3 and its developmental regulation in the rat ovary. J Exp Zool B Mol Dev Evol. 2009;312:701-13 pubmed publisher..The luteinizing granulosa cells of the corpus luteum expressed the highest levels of Htra3. Collectively, these results suggest an important role for Htra3 in ovarian development, granulosa cell differentiation and luteinization. ..
- Culshaw A, Ladell K, Gras S, McLaren J, Miners K, Farenc C, et al. Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nat Immunol. 2017;18:1228-1237 pubmed publisher..Collectively, these data reveal an innate-like mode of epitope recognition with potential implications for the outcome of sequential exposure to heterologous DENVs. ..
- Witchell T, Coutts S, Bulach D, Adler B. Differential expression of the Bhmp39 major outer membrane proteins of Brachyspira hyodysenteriae. Infect Immun. 2006;74:3271-6 pubmed..Northern blot analysis across predicted Rho-independent terminators demonstrated that the genes of the bhmp39efgh locus result in monocistronic transcripts. ..
- Smith R, Spithill T, Pike R, Meeusen E, Piedrafita D. Fasciola hepatica and Fasciola gigantica: cloning and characterisation of 70 kDa heat-shock proteins reveals variation in HSP70 gene expression between parasite species recovered from sheep. Exp Parasitol. 2008;118:536-42 pubmed publisher..hepatica. These results suggest that hosts refractory to F. gigantica are associated with higher HSP70 expression by this parasite and that HSP70 expression may represent a biochemical marker of the stress response of F. gigantica...
- Broughton S, Petersen J, Theodossis A, Scally S, Loh K, Thompson A, et al. Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease. Immunity. 2012;37:611-21 pubmed publisher..Accordingly, biased TCR usage is an important factor in the pathogenesis of DQ8-mediated celiac disease. ..
- Lieu K, Shim E, Wang J, Lokareddy R, Tao T, Cingolani G, et al. The p53-induced factor Ei24 inhibits nuclear import through an importin ?-binding-like domain. J Cell Biol. 2014;205:301-12 pubmed publisher..Thus, Ei24 can bind specifically to IMP?1 and IMP?2 to impede their normal role in nuclear import, shedding new light on the cellular functions of Ei24 and its tumor suppressor role. ..
- Deuis J, Dekan Z, Inserra M, Lee T, Aguilar M, Craik D, et al. Development of a ?O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J Biol Chem. 2016;291:11829-42 pubmed publisher..This analogue had increased potency at NaV1.8 and was analgesic in the mouse formalin assay. ..
- Eisen D, Saul A, Fryauff D, Reeder J, Coppel R. Alterations in Plasmodium falciparum genotypes during sequential infections suggest the presence of strain specific immunity. Am J Trop Med Hyg. 2002;67:8-16 pubmed..This strain was predominant at the first time point but had disappeared at the fourth time point. This significant change in malaria genotypes could be due to strain-specific immunity developing in this population. ..
- Van Lierop B, Robinson S, Kompella S, Belgi A, McArthur J, Hung A, et al. Dicarba ?-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem Biol. 2013;8:1815-21 pubmed publisher..1 peptide retains activity at the ?9?10 nAChR subtype. These singularly acting analogues will enable the elucidation of the biological target responsible for the peptide's potent analgesic activity. ..
- Kuusisto H, Wagstaff K, Alvisi G, Jans D. The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module. Int J Cancer. 2008;123:2965-9 pubmed publisher..Thus, the C-terminus of VP3 represents a unique tumor cell-enhanced nuclear targeting module with potential application in tumor cell-specific drug delivery...
- O Donnell L, Rhodes D, Smith S, Merriner D, Clark B, Borg C, et al. An essential role for katanin p80 and microtubule severing in male gamete production. PLoS Genet. 2012;8:e1002698 pubmed publisher..Collectively these data demonstrate that katanin p80 serves an essential and evolutionarily conserved role in several aspects of male germ cell development...
- Figeac N, Serralbo O, Marcelle C, Zammit P. ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. Dev Biol. 2014;386:135-51 pubmed publisher..These observations demonstrate a conserved function of Ebp1 in the regulation of embryonic muscle progenitors and adult muscle stem cells, which likely operates independently of ErbB3 signaling. ..
- Unkles S, Heck I, Appleyard M, Kinghorn J. Eukaryotic molybdopterin synthase. Biochemical and molecular studies of Aspergillus nidulans cnxG and cnxH mutants. J Biol Chem. 1999;274:19286-93 pubmed..In contrast, molybdopterin synthase homologues are absent in the yeast Saccharomyces cerevisiae. Precursor Z and molybdopterin are undetectable in this organism nor do there appear to be homologues of molybdoenzymes. ..
- Mackay I, Whittingham S, Fida S, Myers M, Ikuno N, Gershwin M, et al. The peculiar autoimmunity of primary biliary cirrhosis. Immunol Rev. 2000;174:226-37 pubmed
- Luck S, Turner S, Rajakumar K, Adler B, Sakellaris H. Excision of the Shigella resistance locus pathogenicity island in Shigella flexneri is stimulated by a member of a new subgroup of recombination directionality factors. J Bacteriol. 2004;186:5551-4 pubmed..Sequence analysis suggests that Rox belongs to a new subfamily of recombination directionality factors, which includes proteins from P4, enterohemorrhagic Escherichia coli, and Yersinia pestis. ..
- Fulcher A, Ahmed C, Noon Song E, Kwan R, Subramaniam P, Johnson H, et al. Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic. FEBS Lett. 2008;582:1569-74 pubmed publisher..This has important implications for IFNgamma's anti-viral action, and the potential use of the IFNgamma mimetic in antiviral therapies. ..
- Rouch D, Messerotti L, Loo L, Jackson C, Skurray R. Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257. Mol Microbiol. 1989;3:161-75 pubmed..5' to dfrA is a thymidylate synthetase gene, designated thyE...
- Verity K, Fuller P. Isolation of a rat amiloride-binding protein cDNA clone: tissue distribution and regulation of expression. Am J Physiol. 1994;266:C1505-12 pubmed..The distribution of rat ABP is not as would be predicted for an aldosterone-induced gene and is thus unlikely to be a component of the amiloride-sensitive electrogenic sodium channel...
- Boysen R, Erdmann V, Hearn M. Systematic, computer-assisted optimisation of the isolation of Thermus thermophilus 50S ribosomal proteins by reversed-phase high-performance liquid chromatography. J Biochem Biophys Methods. 1998;37:69-89 pubmed
- Nie G, Li Y, Wang J, Minoura H, Findlay J, Salamonsen L. Complex regulation of calcium-binding protein D9k (calbindin-D(9k)) in the mouse uterus during early pregnancy and at the site of embryo implantation. Biol Reprod. 2000;62:27-36 pubmed..5. In situ hybridization localized this mRNA predominantly in the luminal epithelium of the pregnant uterus. The complex regulation of calbindin-D(9k) in mouse uterus suggests an important role for this protein during pregnancy. ..
- Wiradjaja F, Ooms L, Whisstock J, McColl B, Helfenbaum L, Sambrook J, et al. The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: regulation of secretion from the endoplasmic reticulum. J Biol Chem. 2001;276:7643-53 pubmed..We propose that Inp54p plays a role in regulating secretion, possibly by modulating the levels of phosphatidylinositol (4,5)-bisphosphate on the cytoplasmic surface of the endoplasmic reticulum membrane. ..
- Harley V, Clarkson M, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev. 2003;24:466-87 pubmed..Many genes, however, remain unidentified, because in the majority of cases of XY females and in all cases of XX males lacking SRY, the mutated gene is unknown. ..
- Clements C, Reid H, Beddoe T, Tynan F, Perugini M, Johns T, et al. The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. Proc Natl Acad Sci U S A. 2003;100:11059-64 pubmed..The structure of this key autoantigen suggests a relationship between the dimeric form of MOG within the myelin sheath and a breakdown of immunological tolerance to MOG that is observed in multiple sclerosis. ..
- Rogerson F, Yao Y, Elsass R, Dimopoulos N, Smith B, Fuller P. A critical region in the mineralocorticoid receptor for aldosterone binding and activation by cortisol: evidence for a common mechanism governing ligand binding specificity in steroid hormone receptors. Mol Endocrinol. 2007;21:817-28 pubmed
- Lea Smith D, Pyke J, Tull D, McConville M, Coppel R, Crellin P. The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem. 2007;282:11000-8 pubmed
- Gantier M, Irving A, Kaparakis Liaskos M, Xu D, Evans V, Cameron P, et al. Genetic modulation of TLR8 response following bacterial phagocytosis. Hum Mutat. 2010;31:1069-79 pubmed publisher..Thus, TLR8 sensing can be activated following bacterial phagocytosis, and rs3764880 may play a role in the modulation of TLR8-dependent microbicidal response of infected macrophages. ..
- Cram D, Loh S, Cheah K, Skurray R. Sequence and conservation of genes at the distal end of the transfer region on plasmids F and R6-5. Gene. 1991;104:85-90 pubmed..The conservation of traX sequences suggests a functional importance for that gene and/or its product. ..
- Ham L, Firth N, Skurray R. Nucleotide sequence of the F plasmid transfer gene, traH: identification of a new gene and a promoter within the transfer operon. Gene. 1989;75:157-65 pubmed..Transcription of trbF and traH from P trbF may well serve to complement transcription from the major tra operon promoter PY located some 16 kb upstream of these genes. ..
- Rajakumar K, Jost B, Sasakawa C, Okada N, Yoshikawa M, Adler B. Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence. J Bacteriol. 1994;176:2362-73 pubmed..However, N1308 was capable of inducing deposition of F-actin, which accumulated in a peribacterial fashion with only slight, if any, unipolar accumulation of the cytoskeletal protein. ..
- Sloan J, McMurry L, Lyras D, Levy S, Rood J. The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants. Mol Microbiol. 1994;11:403-15 pubmed..It is proposed that tetB(P) evolved from the conjugative transfer into C. perfringens of a tet(M)-like gene from another bacterium...
- Evans B, Papaioannou M, Hamilton S, Summers R. Alternative splicing generates two isoforms of the beta3-adrenoceptor which are differentially expressed in mouse tissues. Br J Pharmacol. 1999;127:1525-31 pubmed..Beta3b-AR mRNA is differentially expressed in mouse tissues, with levels relative to beta3a-AR mRNA highest in hypothalamus, cortex and white adipose tissue, and lower in ileum smooth muscle and brown adipose tissue. ..
- Quinsey N, Whisstock J, Le Bonniec B, Louvain V, Bottomley S, Pike R. Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide. J Biol Chem. 2002;277:15971-8 pubmed
- Nie G, Li Y, Minoura H, Batten L, Ooi G, Findlay J, et al. A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Mol Hum Reprod. 2003;9:279-90 pubmed..Based on PRSP protein domain structure and its unique expression during pregnancy, we propose that PRSP plays an important role in the formation/function of the placenta. ..
- Hardy M, Owczarek C, Jermiin L, Ejdeback M, Hertzog P. Characterization of the type I interferon locus and identification of novel genes. Genomics. 2004;84:331-45 pubmed..These studies represent the first detailed annotation of the mouse type I IFN locus, and the products of these novel genes may have important functions in reproduction and host defense. ..
- Thumma B, Nolan M, Evans R, Moran G. Polymorphisms in cinnamoyl CoA reductase (CCR) are associated with variation in microfibril angle in Eucalyptus spp. Genetics. 2005;171:1257-65 pubmed..This study demonstrates that LD mapping can be used to identify alleles associated with wood quality traits in natural populations of trees...
- Halls M, van der Westhuizen E, Bathgate R, Summers R. Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways. Br J Pharmacol. 2007;150:677-91 pubmed..Studies of the distribution and function of RXFP3 suggest that it is a potential target for anti-anxiety and anti-obesity drugs. ..
- Lai Z, Lew R, Yarski M, Mu F, Andrews R, Smith A. The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2. Endocrinology. 2009;150:2376-81 pubmed publisher..In summary, we have demonstrated that calmodulin is able to bind ACE2 and suggest that the ACE2 ectodomain shedding and/or sheddase(s) activation regulated by calmodulin is independent from the phorbol ester-induced shedding. ..
- Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A. The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway. J Hepatol. 2011;55:762-9 pubmed publisher..These finding suggest the mechanism as to how HBeAg evades innate immune responses contributing to the pathogenesis of chronic hepatitis B infection and the establishment of viral persistence...
- Harrison C, Selemidis S, Guida E, King P, Sobey C, Drummond G. NOX2?: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages. PLoS ONE. 2012;7:e48326 pubmed publisher..The discovery of Nox2? paves the way for future examination of its role in physiological and pathological processes. ..
- Berry R, Ng N, Saunders P, Vivian J, Lin J, Deuss F, et al. Targeting of a natural killer cell receptor family by a viral immunoevasin. Nat Immunol. 2013;14:699-705 pubmed publisher..Furthermore, ligation of m157 to Ly49H or Ly49C resulted in intracellular signaling. Accordingly, m157 has evolved to 'tackle the legs' of a family of NK cell receptors. ..
- King A, Bartpho T, Sermswan R, Bulach D, Eshghi A, Picardeau M, et al. Leptospiral outer membrane protein LipL41 is not essential for acute leptospirosis but requires a small chaperone protein, lep, for stable expression. Infect Immun. 2013;81:2768-76 pubmed publisher..The roles of LipL41 and Lep in the pathogenesis of Leptospira interrogans were investigated; surprisingly, neither of these two unique proteins was essential for acute leptospirosis...
- Kaiserman D, Stewart S, Plasman K, Gevaert K, Van Damme P, Bird P. Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A. J Biol Chem. 2014;289:9408-17 pubmed publisher..The identification of an intracellular inhibitor specific for mGzmA only indicates that a lineage-specific increase in GzmA cytotoxic potential has driven cognate inhibitor evolution...
- Firth N, Skurray R. Characterization of the F plasmid bifunctional conjugation gene, traG. Mol Gen Genet. 1992;232:145-53 pubmed..TraGp* is located in the periplasm and has been shown to possess sequences required for aggregate stabilization. The detection of TraGp* raises the possibility that the two functions of traG are carried out by separate products. ..
- Littlejohn T, DiBerardino D, Messerotti L, Spiers S, Skurray R. Structure and evolution of a family of genes encoding antiseptic and disinfectant resistance in Staphylococcus aureus. Gene. 1991;101:59-66 pubmed..The entire sequence of the 2.4-kb plasmid pSK89 (which contains qacC) was determined, and is compared with other plasmids from Gram + bacteria...
- Byrne M, Gillespie M, Skurray R. Molecular analysis of a gentamicin resistance transposonlike element on plasmids isolated from North American Staphylococcus aureus strains. Antimicrob Agents Chemother. 1990;34:2106-13 pubmed..These elements flank determinants for resistance to the aminoglycosides neomycin and paromomycin and to ethidium bromide and quaternary ammonium compounds, as well as the region involved in conjugative plasmid transfer. ..
- Fyfe J, Davies J. Nucleotide sequence and expression in Escherichia coli of the recA gene of Neisseria gonorrhoeae. Gene. 1990;93:151-6 pubmed..The product of this gene can act as a recombinase in Escherichia coli, but does so with a decreased efficiency, probably because of the formation of mixed multimers with the equivalent E. coli protein...
- Papakonstantinou T, Law R, Nesbitt W, Nagley P, Devenish R. Molecular genetic analysis of the central hydrophobic domain of subunit 8 of yeast mitochondrial ATP synthase. Curr Genet. 1996;30:12-8 pubmed
- Fairlie W, Stanton P, Hearn M. The disulphide bond structure of thyroid-stimulating hormone beta-subunit. Biochem J. 1996;314 ( Pt 2):449-55 pubmed
- Rood J. Virulence genes of Clostridium perfringens. Annu Rev Microbiol. 1998;52:333-60 pubmed..The production of many of the extracellular toxins is regulated at the transcriptional level by the products of the virR and virS genes, which together comprise a two-component signal transduction system...
- Dyson J, O Malley C, Becanovic J, Munday A, Berndt M, Coghill I, et al. The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. J Cell Biol. 2001;155:1065-79 pubmed..Collectively these studies demonstrate that filamin-dependent SHIP-2 localization critically regulates phosphatidylinositol 3 kinase signaling to the actin cytoskeleton. ..
- Ghildyal R, Li D, Peroulis I, Shields B, Bardin P, Teng M, et al. Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. J Gen Virol. 2005;86:1879-84 pubmed publisher..Data from co-expression in cells and a cell-free binding assay showed that the N-terminal aa 2-6 of G play a key role in G-M interaction, with serine at position 2 and aspartate at position 6 playing key roles...
- Vivian J, Riedmaier P, Ge H, Le Nours J, Sansom F, Wilce M, et al. Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDases. Structure. 2010;18:228-38 pubmed publisher..Collectively, these findings provide insight into the mechanism of this enzyme and highlight its role in host-pathogen interactions. ..
- Walton K, Makanji Y, Chen J, Wilce M, Chan K, Robertson D, et al. Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex. J Biol Chem. 2010;285:17029-37 pubmed publisher..Significantly, genetic mutations in LAP (e.g. R218H) that cause the rare bone disorder Camurati-Engelmann disease disrupted dimerization and reduced the stability of the latent TGF-beta1 complex. ..
- Heng S, Paule S, Hardman B, Li Y, Singh H, Rainczuk A, et al. Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. Endocrinology. 2010;151:3909-17 pubmed publisher..This study thus demonstrates for the first time that the proteolytic activation and thus bioavailability of BMP2 is controlled by PC6. ..
- de Jong A, Cheng T, Huang S, Gras S, Birkinshaw R, Kasmar A, et al. CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. Nat Immunol. 2014;15:177-85 pubmed publisher..Oily autoantigens naturally coat the surface of the skin; thus, this points to a previously unknown mechanism of barrier immunity. ..
- Rouch D, Cram D, DiBerardino D, Littlejohn T, Skurray R. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. Mol Microbiol. 1990;4:2051-62 pubmed..The last common ancestor of the qacA and related tet (tetracycline resistance) lineages is inferred to have been repressor controlled, as occurs for modern tet determinants from Gram-negative, but not those from Gram-positive, bacteria...
- Byrne M, Rouch D, Skurray R. Nucleotide sequence analysis of IS256 from the Staphylococcus aureus gentamicin-tobramycin-kanamycin-resistance transposon Tn4001. Gene. 1989;81:361-7 pubmed..J. Gen. Microbiol. 133 (1987) 3039-3052], completes the entire sequence of Tn4001, which totals 4566 bp. ..
- Lyristis M, Bryant A, Sloan J, Awad M, Nisbet I, Stevens D, et al. Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens. Mol Microbiol. 1994;12:761-77 pubmed..A model that described the regulation of extracellular toxin production in C. perfringens was constructed...