Genomes and Genes
Experts and Doctors on molecular sequence data in Brisbane, Queensland, Australia
Locale: Brisbane, Queensland, Australia
Topic: molecular sequence data
Publications177 found, 100 shown here
- Mason M, Botella J. Isolation of a novel G-protein gamma-subunit from Arabidopsis thaliana and its interaction with Gbeta. Biochim Biophys Acta. 2001;1520:147-53 pubmed..The isolation of a second gamma-subunit from A. thaliana indicates that plant G-proteins, like their mammalian counterparts, may form different heterotrimer combinations that presumably regulate multiple signal transduction pathways. ..
- Wang Y, McWilliam S, Barendse W, Kata S, Womack J, Moore S, et al. Mapping of 12 bovine ribosomal protein genes using a bovine radiation hybrid panel. Anim Genet. 2001;32:269-73 pubmed..The 12 ribosomal protein genes mapped in this study are spread over 10 chromosomes, including the X chromosome. The locations show conservation of comparative map position in cattle and human. ..
- Leo N, Barker S. Intragenomic variation in ITS2 rDNA in the louse of humans, Pediculus humanus: ITS2 is not a suitable marker for population studies in this species. Insect Mol Biol. 2002;11:651-7 pubmed..A phylogenetic tree of 15 different ITS2 sequences showed that the sequences from individual lice were not monophyletic. We conclude that the ITS2 is not a useful marker of populations for Pediculus humanus. ..
- Adams D, Smith A, Schroeder C, Yasuda T, Lewis R. Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. J Biol Chem. 2003;278:4057-62 pubmed..Bosey, G. M., Snutch, T. P., and Zamponi, G. W. (2001) J. Biol. Chem. 276, 15728-15735), it is likely that the calcium channel in preganglionic nerve terminals targeted by CVID is a N-type (Ca(v)2.2) calcium channel variant. ..
- Loffler K, Zarkower D, Koopman P. Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development. Endocrinology. 2003;144:3237-43 pubmed..Further, our results suggest that FOXL2 is a highly conserved early regulator of vertebrate ovarian development...
- Yang I, Hafner G, Revill P, Dale J, Harding R. Sequence diversity of South Pacific isolates of Taro bacilliform virus and the development of a PCR-based diagnostic test. Arch Virol. 2003;148:1957-68 pubmed..The possibility that this may represent either an integrated sequence or the genome of an additional badnavirus infecting taro is discussed...
- Turner M, Hafner L, Walsh T, Giffard P. Identification and characterization of the novel LysM domain-containing surface protein Sep from Lactobacillus fermentum BR11 and its use as a peptide fusion partner in Lactobacillus and Lactococcus. Appl Environ Microbiol. 2004;70:3673-80 pubmed..rhamnosus a fragment of human E-cadherin, which contains the receptor region for Listeria monocytogenes. This study demonstrates that Sep has potential for heterologous protein expression and export in lactic acid bacteria. ..
- Landsberg M, Moran Jones K, Smith R. Molecular recognition of an RNA trafficking element by heterogeneous nuclear ribonucleoprotein A2. Biochemistry. 2006;45:3943-51 pubmed
- Cooper B, Key B, Carter A, Angel N, Hart D, Kato M. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. J Biol Chem. 2006;281:22471-84 pubmed publisher..These data suggest that AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release...
- Miller T, Cribb T. Coevolution of Retrovarium n. gen. (Digenea: Cryptogonimidae) in Lutjanidae and Haemulidae (Perciformes) in the Indo-West Pacific. Int J Parasitol. 2007;37:1023-45 pubmed..Overall, Retrovarium appears to have had an exceptionally patchy radiation, failing to infect many taxa, infecting species with no readily discernible pattern, and radiating dramatically within one species. ..
- Collins B, Norwood S, Kerr M, Mahony D, Seaman M, Teasdale R, et al. Structure of Vps26B and mapping of its interaction with the retromer protein complex. Traffic. 2008;9:366-79 pubmed
- Smythe L, Adler B, Hartskeerl R, Galloway R, Turenne C, Levett P. Classification of Leptospira genomospecies 1, 3, 4 and 5 as Leptospira alstonii sp. nov., Leptospira vanthielii sp. nov., Leptospira terpstrae sp. nov. and Leptospira yanagawae sp. nov., respectively. Int J Syst Evol Microbiol. 2013;63:1859-62 pubmed publisher..yanagawae Sao Paulo(T) (?=?ATCC 700523(T)) as the type strains. The type strains are also available from the culture collections of the WHO Collaborating Centres in Amsterdam, The Netherlands, and Brisbane, Australia...
- Lee Y, Cui C, Chow E, Pue N, Lonhienne T, Wang J, et al. Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. J Med Chem. 2013;56:210-9 pubmed publisher..For the sulfonylureas tested there was a strong correlation between inhibitory activity toward C. albicans AHAS and fungicidal activity, supporting the hypothesis that AHAS is the target for their inhibitory activity within the cell. ..
- King G, Chanson A, McCallum E, Ohme Takagi M, Byriel K, Hill J, et al. The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface. J Biol Chem. 2013;288:3198-207 pubmed publisher..The triple mutant R249E/R289E/R296E was almost completely incapable of DNA binding in vitro. Thus, we have revealed that although VRN1 is sequence-nonspecific in DNA binding, it has a defined DNA-binding surface. ..
- Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Nat Genet. 1996;14:474-8 pubmed..We identify the peptide WMHHNMDLI derived from the UTY protein as an H-Y epitope, H-YDb. Our data formally demonstrate that H-Y antigen is the product of more than one gene on the Y chromosome. ..
- Soo H, Handley J, Maugeri M, Burns P, Smith G, Dale J, et al. Molecular characterization of Fiji disease fijivirus genome segment 9. J Gen Virol. 1998;79 ( Pt 12):3155-61 pubmed..These results indicate that FDV S9 ORF 1 encodes a major structural protein, while ORF 2 probably encodes a non-structural protein. ..
- Seib K, Peak I, Jennings M. Phase variable restriction-modification systems in Moraxella catarrhalis. FEMS Immunol Med Microbiol. 2002;32:159-65 pubmed..We suggest that the phase variable nature of these R-M systems indicates that they have an important role in the biology of M. catarrhalis. ..
- Vickers C, Xue G, Gresshoff P. A novel cis-acting element, ESP, contributes to high-level endosperm-specific expression in an oat globulin promoter. Plant Mol Biol. 2006;62:195-214 pubmed
- Schroder K, Lichtinger M, Irvine K, Brion K, Trieu A, Ross I, et al. PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. J Leukoc Biol. 2007;81:1577-90 pubmed..This study therefore characterizes the regulation of mouse Tlr9 expression and defines a molecular mechanism by which IFN-gamma amplifies mouse macrophage responses to CpG DNA. ..
- Totsika M, Wells T, Beloin C, Valle J, Allsopp L, King N, et al. Molecular characterization of the EhaG and UpaG trimeric autotransporter proteins from pathogenic Escherichia coli. Appl Environ Microbiol. 2012;78:2179-89 pubmed publisher..Thus, while the EhaG and UpaG TAAs contain some conserved binding and regulatory features, they also possess important differences that correlate with the distinct pathogenic lifestyles of EHEC and UPEC. ..
- Guddat L, Bardwell J, Zander T, Martin J. The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding. Protein Sci. 1997;6:1148-56 pubmed..The active-site disulfide and all three surrounding uncharged surface features of DsbA could, in principle, participate in the binding or stabilization of peptide. ..
- Wu L, Birch R. Characterization of the highly efficient sucrose isomerase from Pantoea dispersa UQ68J and cloning of the sucrose isomerase gene. Appl Environ Microbiol. 2005;71:1581-90 pubmed..They may favor the production of isomaltulose as an inhibitor of competing microbes in high-sucrose environments, and they are likely to be highly beneficial for industrial production of isomaltulose...
- Tyagi R, Duquerroy S, Navaza J, Guddat L, Duggleby R. The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. Protein Sci. 2005;14:3089-100 pubmed..This contrasts with P. aeruginosa KARI, which forms a dodecamer, and spinach KARI, a dimer. In the E. coli KARI tetramer, a novel subunit-to-subunit interacting surface is formed by a symmetrical pair of bulbous protrusions. ..
- Barry G, Le G, Fairlie D. Agonists and antagonists of protease activated receptors (PARs). Curr Med Chem. 2006;13:243-65 pubmed
- Glazov E, Pheasant M, Nahkuri S, Mattick J. Evidence for control of splicing by alternative RNA secondary structures in Dipteran homothorax pre-mRNA. RNA Biol. 2006;3:36-9 pubmed
- Gruber C, Cemazar M, Clark R, Horibe T, Renda R, Anderson M, et al. A novel plant protein-disulfide isomerase involved in the oxidative folding of cystine knot defense proteins. J Biol Chem. 2007;282:20435-46 pubmed..The nucleotide sequence(s) reported in this paper have been submitted to the GenBank/EBI Data Bank with accession number(s) 911777...
- Robin G, Chappell K, Stoermer M, Hu S, Young P, Fairlie D, et al. Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation. J Mol Biol. 2009;385:1568-77 pubmed publisher..Analysis of other West Nile virus NS3 protease structures and related serine proteases supports this hypothesis, suggesting that the common catalytic mechanism involves an induced-fit mechanism. ..
- Ambrose R, Lander G, Maaty W, Bothner B, Johnson J, Johnson K. Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase. J Gen Virol. 2009;90:2191-200 pubmed publisher..Taken together, this indicates that DAV is highly divergent from previously described viruses...
- Becherel O, Jakob B, Cherry A, Gueven N, Fusser M, Kijas A, et al. CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res. 2010;38:1489-503 pubmed publisher..These results indicate that aprataxin is involved not only in single strand break repair but also in the processing of a subset of double strand breaks presumably through its interaction with MDC1. ..
- Kaas Q, Westermann J, Craik D. Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon. 2010;55:1491-509 pubmed publisher..The study identifies gaps in current knowledge of conopeptides and points to potential directions for future research. ..
- Tallack M, Whitington T, Yuen W, Wainwright E, Keys J, Gardiner B, et al. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res. 2010;20:1052-63 pubmed publisher..Additionally, we suggest new mechanisms for KLF1 cooperation with other transcription factors, in particular the erythroid transcription factor GATA1, to maintain homeostasis in the erythroid compartment...
- Harrison R, Ruiz Gómez G, Hill T, Chow S, Shepherd N, Lohman R, et al. Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice. J Med Chem. 2010;53:8400-8 pubmed publisher..Such helix-constrained peptides may be valuable physiological probes and therapeutics for treating some forms of pain. ..
- Gardner L, Mills D, Wiegand A, Leavesley D, Elizur A. Spatial analysis of biomineralization associated gene expression from the mantle organ of the pearl oyster Pinctada maxima. BMC Genomics. 2011;12:455 pubmed publisher..The development of PmaxArray 1.0, and the spatial map of its ESTs expression in the mantle has begun characterizing the molecular mechanisms linking the organics and inorganics of the molluscan shell. ..
- Jennings M, Virji M, Evans D, Foster V, Srikhanta Y, Steeghs L, et al. Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis. Mol Microbiol. 1998;29:975-84 pubmed
- Le T, Blair D, McManus D. Complete DNA sequence and gene organization of the mitochondrial genome of the liverfluke, Fasciola hepatica L. (Platyhelminthes; Trematoda). Parasitology. 2001;123:609-21 pubmed..Transfer RNA genes range in length from 58 to 70 nt, their products producing characteristic 'clover leaf' structures, except for tRNA(S(UNC)) and tRNA(S(AGN)) lacking the DHU arm. ..
- Girjes A, Keriakous D, Cockerill G, Hayward I, Campbell G, Campbell J. Cloning of a differentially expressed tropomyosin isoform from cultured rabbit aortic smooth muscle cells. Int J Biochem Cell Biol. 2002;34:505-15 pubmed..Since this TM-beta gene was the only gene strongly enough expressed in SMC changing phenotype to be observed by the subtractive hybridisation screen, it likely plays a significant role in this process. ..
- Bateson M, Lines R, Revill P, Chaleeprom W, Ha C, Gibbs A, et al. On the evolution and molecular epidemiology of the potyvirus Papaya ringspot virus. J Gen Virol. 2002;83:2575-85 pubmed
- McManus D, Zhang L, Castrodale L, Le T, Pearson M, Blair D. Short report: molecular genetic characterization of an unusually severe case of hydatid disease in Alaska caused by the cervid strain of Echinococcus granulosus. Am J Trop Med Hyg. 2002;67:296-8 pubmed
- Dong Y, Kaushal A, Brattsand M, Nicklin J, Clements J. Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. Clin Cancer Res. 2003;9:1710-20 pubmed..However, additional clinical studies assessing serum levels of these putative biomarkers are required to confirm their usefulness in the diagnosis and/or monitoring of these tumors. ..
- Janssen B, Schirra H, Lay F, Anderson M, Craik D. Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds. Biochemistry. 2003;42:8214-22 pubmed..Comparison of its structure with those of classic, four-disulfide defensins has allowed us to identify a previously unrecognized hydrogen bond network that is integral to structure stabilization in the family. ..
- Colgrave M, Craik D. Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot. Biochemistry. 2004;43:5965-75 pubmed..In general, the reduced peptides were significantly more susceptible to chemical or enzymatic breakdown than the oxidized species. ..
- Horvath A, Olive C, Karpati L, Sun H, Good M, Toth I. Toward the development of a synthetic group a streptococcal vaccine of high purity and broad protective coverage. J Med Chem. 2004;47:4100-4 pubmed..The LCP construct, however, elicited excellent antibody responses to all three epitopes without the need for any additional adjuvant or carrier. We have synthesized the LCP synthetic vaccine system with good reproducibility. ..
- Ha C, Coombs S, Revill P, Harding R, Vu M, Dale J. Corchorus yellow vein virus, a New World geminivirus from the Old World. J Gen Virol. 2006;87:997-1003 pubmed publisher..Evidence is provided that CoYVV is probably indigenous to the region and may be the remnant of a previous population of New World begomoviruses in the Old World...
- Pasay C, Walton S, Fischer K, Holt D, McCarthy J. PCR-based assay to survey for knockdown resistance to pyrethroid acaricides in human scabies mites (Sarcoptes scabiei var hominis). Am J Trop Med Hyg. 2006;74:649-57 pubmed..This will facilitate early detection and monitoring of pyrethroid resistance in scabies mite populations under drug selection pressure...
- St Pierre L, Birrell G, Earl S, Wallis T, Gorman J, de Jersey J, et al. Diversity of toxic components from the venom of the evolutionarily distinct black whip snake, Demansia vestigiata. J Proteome Res. 2007;6:3093-107 pubmed..The results of this study have important implications not only for the further characterization of venom from whip snakes, but also for our understanding of the evolutionary relationship of Australian snake species. ..
- Blanchfield J, Gallagher O, Cros C, Lewis R, Alewood P, Toth I. Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochem Biophys Res Commun. 2007;361:97-102 pubmed..Neither peptide crossed the blood-brain barrier to any significant extent. This is the first study of the in vivo biodistribution of an alpha-conotoxin after oral administration. ..
- Bialasiewicz S, Whiley D, Lambert S, Wang D, Nissen M, Sloots T. A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children. J Clin Virol. 2007;40:15-8 pubmed..Recently, Allander and co-workers reported the discovery of a new human polyomavirus, KI virus, in respiratory secretions from patients with acute respiratory tract infection (ARTI)...
- Goh S, Mabbett A, Welch J, Hall S, McEwan A. Molecular ecology of a facultative swine waste lagoon. Lett Appl Microbiol. 2009;48:486-92 pubmed publisher..This study provides the first molecular evidence for the existence of a sulfur cycle which is linked to phototrophic sulfide oxidation by purple bacteria and organotrophic sulfate-reduction by SRB. ..
- Ogg C, Patel B. Fervidicella metallireducens gen. nov., sp. nov., a thermophilic, anaerobic bacterium from geothermal waters. Int J Syst Evol Microbiol. 2010;60:1394-400 pubmed publisher..nov., sp. nov. is proposed; the type strain is AeB(T) (=JCM 15555(T)=KCTC 5667(T)). ..
- Tang Y, Gao X, Rosa B, Abubucker S, Hallsworth Pepin K, Martin J, et al. Genome of the human hookworm Necator americanus. Nat Genet. 2014;46:261-269 pubmed publisher..This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases. ..
- Robles Espinoza C, Harland M, Ramsay A, Aoude L, Quesada V, Ding Z, et al. POT1 loss-of-function variants predispose to familial melanoma. Nat Genet. 2014;46:478-481 pubmed publisher..These findings suggest that POT1 variants predispose to melanoma formation via a direct effect on telomeres. ..
- St Pierre L, Flight S, Masci P, Hanchard K, Lewis R, Alewood P, et al. Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids. Biochimie. 2006;88:1923-31 pubmed..The data presented in this study represent a significant resource for understanding the role of various natriuretic peptides isoforms during the envenomation process by Australian elapid snakes...
- Loughnan M, Nicke A, Lawrence N, Lewis R. Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry. 2009;48:3717-29 pubmed publisher..mustelinus venom. The discovery of the precursors and several novel conotoxins from different species defines this large conotoxin family and expands our understanding of sequence diversification mechanisms in Conus species. ..
- Bowles J, Cooper L, Berkman J, Koopman P. Sry requires a CAG repeat domain for male sex determination in Mus musculus. Nat Genet. 1999;22:405-8 pubmed..We conclude that the glutamine-rich repeat domain of the mouse Sry protein has an essential role in sex determination in vivo, and that Sry may act via a fundamentally different biochemical mechanism in mice compared with other mammals. ..
- Revill P, Trinh X, Dale J, Harding R. Taro vein chlorosis virus: characterization and variability of a new nucleorhabdovirus. J Gen Virol. 2005;86:491-9 pubmed..4 %. Within the N gene, maximum variability among 15 isolates at the nucleotide level was 19.3 %. The high level of TaVCV variability observed suggested that the introduction of TaVCV to the Pacific Islands was not a recent occurrence. ..
- Ireland D, Wang C, Wilson J, Gustafson K, Craik D. Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90:51-60 pubmed
- Miyahara A, Hirani T, Oakes M, Kereszt A, Kobe B, Djordjevic M, et al. Soybean nodule autoregulation receptor kinase phosphorylates two kinase-associated protein phosphatases in vitro. J Biol Chem. 2008;283:25381-91 pubmed publisher..Autophosphorylated NARK kinase domain was, in turn, dephosphorylated by both KAPP1 and KAPP2. Our results suggest a model for signal transduction involving NARK in the control of nodule development...
- Imelfort M, Edwards D. De novo sequencing of plant genomes using second-generation technologies. Brief Bioinform. 2009;10:609-18 pubmed publisher..In this review, we compare the current approaches for second-generation genome sequencing, explore the future direction of this technology and the implications for plant genome research. ..
- Clark G, Green B, Hart D. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. Tissue Antigens. 2000;55:101-9 pubmed..Furthermore, this gene has been mapped to chromosome 17 and thus is not linked to the known human ITIM containing genes which map to human chromosome 19 or the recently characterized molecule, NKp44, localized to human chromosome 6. ..
- Wang X, Rothnagel J. Post-transcriptional regulation of the gli1 oncogene by the expression of alternative 5' untranslated regions. J Biol Chem. 2001;276:1311-6 pubmed
- Lewis R, Schroeder C, Ekberg J, Nielsen K, Loughnan M, Thomas L, et al. Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Mol Pharmacol. 2007;71:676-85 pubmed..TIIIA and analogs provide new biochemical probes as well as insights into the structure-activity of mu-conotoxins. ..
- Bastiani M, Liu L, Hill M, Jedrychowski M, Nixon S, Lo H, et al. MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. J Cell Biol. 2009;185:1259-73 pubmed publisher..Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein. ..
- Delaney S, Rich D, Thomson S, Hargrave M, Lovelock P, Welsh M, et al. Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. Nat Genet. 1993;4:426-31 pubmed
- Frazer D, Vulpe C, McKie A, Wilkins S, Trinder D, Cleghorn G, et al. Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Am J Physiol Gastrointest Liver Physiol. 2001;281:G931-9 pubmed..The high sequence conservation between rat and mouse hephaestin is consistent with this protein playing a central role in intestinal iron absorption, although its precise function remains to be determined...
- Matamoros M, Clemente M, Sato S, Asamizu E, Tabata S, Ramos J, et al. Molecular analysis of the pathway for the synthesis of thiol tripeptides in the model legume Lotus japonicus. Mol Plant Microbe Interact. 2003;16:1039-46 pubmed publisher..This strongly suggests an important role of GSH in the rhizobia-legume symbiosis...
- Richards A, Stephens T, Charlton H, Jones A, Macdonald G, Prins J, et al. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications. Mol Endocrinol. 2006;20:1673-87 pubmed..Collectively, these data suggest that adiponectin multimer composition is affected by changes in PTM in response to physiological factors. ..
- Lee N, Baker J, Bell D, McCarthy J, Cheng Q. Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detecting rapid diagnostic tests. J Clin Microbiol. 2006;44:4547-9 pubmed..vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity. ..
- Abankwa D, Gorfe A, Inder K, Hancock J. Ras membrane orientation and nanodomain localization generate isoform diversity. Proc Natl Acad Sci U S A. 2010;107:1130-5 pubmed publisher..Finally, we show that G-domain orientation and nanoclustering synergize to generate Ras isoform specificity with respect to effector interactions. ..
- Beck L, Markovich D. The mouse Na(+)-sulfate cotransporter gene Nas1. Cloning, tissue distribution, gene structure, chromosomal assignment, and transcriptional regulation by vitamin D. J Biol Chem. 2000;275:11880-90 pubmed..It also provides the basis for a detailed analysis of Nas1 gene regulation and the tools required for assessing Nas1 role in sulfate homeostasis using targeted gene manipulation in mice. ..
- Pang S, Duggleby R, Guddat L. Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors. J Mol Biol. 2002;317:249-62 pubmed..The conformation of FAD and its position in the active site are defined. The structure of AHAS provides a starting point for the rational design of new herbicides. ..
- King G, Stöckli J, Hu S, Winnen B, Duprez W, Meoli C, et al. Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. J Biol Chem. 2012;287:40996-1006 pubmed publisher..Isothermal titration calorimetry data reveal the interaction between APPL2 and Rab31 has a K(d) of 140 nM. Together with other biophysical data, we conclude the stoichiometry of the complex is 2:2. ..
- Fernando G, Stenzel D, Tindle R, Merza M, Morein B, Frazer I. Peptide polymerisation facilitates incorporation into ISCOMs and increases antigen-specific IgG2a production. Vaccine. 1995;13:1460-7 pubmed..These data indicate that polymerised peptides could be incorporated into ISCOMs to form efficient immunogens which may elicit a Th1 type response. ..
- Schreiber R, Pavenstadt H, Greger R, Kunzelmann K. Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator. FEBS Lett. 2000;475:291-5 pubmed..The interaction requires stimulation of wild type CFTR by cAMP and an intact first nucleotide binding domain as demonstrated for other CFTR-protein interactions. ..
- McQualter R, Burns P, Smith G, Dale J, Harding R. Molecular analysis of Fiji disease virus genome segments 5, 6, 8 and 10. Arch Virol. 2004;149:713-21 pubmed publisher..Based on sequence similarities, it is predicted that FDV S8 encodes a minor core protein, while FDV S10 encodes an outer capsid protein. The evolutionary relationships of FDV to other reoviruses are discussed...
- Ireland D, Colgrave M, Nguyencong P, Daly N, Craik D. Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteins. J Mol Biol. 2006;357:1522-35 pubmed..Enzymatic stability assays on violacin A indicate that despite an increase in the flexibility of the structure relative to cyclic counterparts, the cystine knot preserves the overall stability of the molecule...
- Herrera Valencia V, Dugdale B, Harding R, Dale J. An iterated sequence in the genome of Banana bunchy top virus is essential for efficient replication. J Gen Virol. 2006;87:3409-12 pubmed..Mutation of the F1 and R iterons caused a 42 and 62 % reduction in DNA-N replication, respectively, whereas mutation of the F2 and combined F1F2 iteron virtually abolished DNA-N replication...
- Purnell M, Stewart G, Botella J. Cloning and characterisation of a glutamate dehydrogenase cDNA from tomato (Lycopersicon esculentum L.). Gene. 1997;186:249-54 pubmed..Comparison of cloned plant GDH proteins reveals a high degree of homology throughout the sequence except for a very specific, highly divergent region. ..
- Semmler A, Whitchurch C, Leech A, Mattick J. Identification of a novel gene, fimV, involved in twitching motility in Pseudomonas aeruginosa. Microbiology. 2000;146 ( Pt 6):1321-32 pubmed..It is suggested that FimV may be involved in remodelling of the peptidoglycan layer to enable assembly of the type IV fimbrial structure and machinery. ..
- Kanso S, Patel B. Phenylobacterium lituiforme sp. nov., a moderately thermophilic bacterium from a subsurface aquifer, and emended description of the genus Phenylobacterium. Int J Syst Evol Microbiol. 2004;54:2141-6 pubmed..nov. in the order Caulobacterales, subclass alpha-Proteobacteria, class Proteobacteria. The type strain is FaiI3(T) (=ATCC BAA-294(T)=DSM 14363(T))...
- Ullah M, Ve T, Mangan M, Alaidarous M, Sweet M, Mansell A, et al. The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins. Acta Crystallogr D Biol Crystallogr. 2013;69:2420-30 pubmed publisher..These findings thus identify opportunities for the selective targeting of TLR3- and TLR4-mediated inflammation. ..
- Hobbs M, Mattick J. Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes. Mol Microbiol. 1993;10:233-43 pubmed..The diverse studies summarized in this review are providing insight into an extensive infrastructural system which appears to be utilized in the formation of a variety of cell surface-associated complexes. ..
- Rae F, Hooper J, Nicol D, Clements J. Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. Mol Carcinog. 2001;32:44-53 pubmed..The upregulation of this gene in several solid tumors indicated that it may play an important role in tumorigenesis. ..
- Maguire D, Shah J, McCabe M. Assaying ATP synthase rotor activity. Adv Exp Med Biol. 2006;578:67-72 pubmed
- Dunn T, Mynett Johnson L, Wright E, Hosking B, Koopman P, Muscat G. Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. Gene. 1995;161:223-5 pubmed..We have determined the full cDNA sequence of Sox-18 which encodes a protein of 378 aa. Sox-18 mRNA transcripts were restricted to heart, lung and skeletal muscle in the adult mouse. ..