Experts and Doctors on micrornas in Brisbane, Queensland, Australia


Locale: Brisbane, Queensland, Australia
Topic: micrornas

Top Publications

  1. Luong H, Nyholt D, Painter J, Chapman B, Kennedy S, Treloar S, et al. No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosis. Hum Reprod. 2012;27:3616-21 pubmed publisher
    ..The research was funded by grants from the Australian National Health and Medical Research Council and Wellcome Trust. None of the authors has competing interests for the study. ..
  2. Vinod M, Chennamsetty I, Colin S, Belloy L, De Paoli F, Schaider H, et al. miR-206 controls LXR? expression and promotes LXR-mediated cholesterol efflux in macrophages. Biochim Biophys Acta. 2014;1841:827-35 pubmed publisher
    ..We therefore propose a feed-back loop between miR-206 and LXR? that might be part of an LXR auto-regulatory mechanism to fine tune LXR activity. ..
  3. Hussain M, Asgari S. MicroRNA-like viral small RNA from Dengue virus 2 autoregulates its replication in mosquito cells. Proc Natl Acad Sci U S A. 2014;111:2746-51 pubmed publisher
    ..The results revealed that DENV is able to encode functional vsRNAs, and one of those, which resembles miRNAs, specifically targets a viral gene, opening an avenue for possible utilization of the small RNA to limit DENV replication. ..
  4. Chen J, Jiang C, Jin L, Zhang X. Regulation of PD-L1: a novel role of pro-survival signalling in cancer. Ann Oncol. 2016;27:409-16 pubmed publisher
    ..Clinically, it could increase treatment efficacy of targeted therapy by choosing those molecules that control both PD-L1 expression and cell proliferation. ..
  5. de Rie D, Abugessaisa I, Alam T, Arner E, Arner P, Ashoor H, et al. An integrated expression atlas of miRNAs and their promoters in human and mouse. Nat Biotechnol. 2017;35:872-878 pubmed publisher
    ..We thus provide a broad atlas of miRNA expression and promoters in primary mammalian cells, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions. ..
  6. Gu W, An J, Ye P, Zhao K, Antonsson A. Prediction of conserved microRNAs from skin and mucosal human papillomaviruses. Arch Virol. 2011;156:1161-71 pubmed publisher
    ..Potential gene targets of the predicted miRNA that may aid HPV in infection and pathogenesis were also analysed. ..
  7. Monsanto Hearne V, Asad S, Asgari S, Johnson K. Drosophila microRNA modulates viral replication by targeting a homologue of mammalian cJun. J Gen Virol. 2017;98:1904-1912 pubmed publisher
    ..These results highlight the role of miRNA in regulating the transcription factor gene dJun and uncover a previously unrecognized mechanism by which dJun is regulated during host-virus interaction. ..
  8. Osei Amo S, Hussain M, O Neill S, Asgari S. Wolbachia-induced aae-miR-12 miRNA negatively regulates the expression of MCT1 and MCM6 genes in Wolbachia-infected mosquito cell line. PLoS ONE. 2012;7:e50049 pubmed publisher
    ..Our study has identified two target genes of aae-miR-12, a differentially expressed mosquito miRNA in Wolbachia-infected cells, and determined that the miRNA affects Wolbachia density in the host cells. ..
  9. Hussain M, Walker T, O Neill S, Asgari S. Blood meal induced microRNA regulates development and immune associated genes in the Dengue mosquito vector, Aedes aegypti. Insect Biochem Mol Biol. 2013;43:146-52 pubmed publisher
    ..In addition, we demonstrate that aae-miR-375 enhances Dengue virus serotype 2 (DENV-2) infection in an Ae. aegypti cell line. ..

More Information


  1. Glazov E, McWilliam S, Barris W, Dalrymple B. Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals. Mol Biol Evol. 2008;25:939-48 pubmed publisher
    ..Overrepresentation of genes involved in regulation of neurogenesis among predicted miRNAs targets indicates an important role of the mir-379/mir-656 cluster in this biological process in the placental mammals. ..
  2. Boyle G, Woods S, Bonazzi V, Stark M, Hacker E, Aoude L, et al. Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell Melanoma Res. 2011;24:525-37 pubmed publisher
    ..We propose a model for the apparent non-overlapping expression levels of BRN2 and MITF in melanoma, mediated by miR-211 expression. ..
  3. Ragan C, Zuker M, Ragan M. Quantitative prediction of miRNA-mRNA interaction based on equilibrium concentrations. PLoS Comput Biol. 2011;7:e1001090 pubmed publisher
    ..Our approach offers a more-quantitative understanding of post-translational regulation in different cell types, tissues, and developmental conditions. ..
  4. Bhatia S, Monkman J, Toh A, Nagaraj S, Thompson E. Targeting epithelial-mesenchymal plasticity in cancer: clinical and preclinical advances in therapy and monitoring. Biochem J. 2017;474:3269-3306 pubmed publisher
  5. Saldaña M, Etebari K, Hart C, Widen S, Wood T, Thangamani S, et al. Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes. PLoS Negl Trop Dis. 2017;11:e0005760 pubmed publisher
    ..This study expands our understanding of ZIKV-vector interactions and provides potential avenues to be further investigated to target ZIKV in the mosquito host. ..
  6. Truong G, Guanzon D, Kinhal V, Elfeky O, Lai A, Longo S, et al. Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells - Liquid biopsies for monitoring complications of pregnancy. PLoS ONE. 2017;12:e0174514 pubmed publisher
  7. An J, Lai J, Lehman M, Nelson C. miRDeep*: an integrated application tool for miRNA identification from RNA sequencing data. Nucleic Acids Res. 2013;41:727-37 pubmed publisher
    ..Further, we show that miRDeep* outperformed existing miRNA prediction tools using our LNCaP and other small RNAseq datasets. miRDeep* is freely available online at ..
  8. Luu H, Lin H, Sørensen K, Ogunwobi O, Kumar N, Chornokur G, et al. miRNAs associated with prostate cancer risk and progression. BMC Urol. 2017;17:18 pubmed publisher
    ..Nevertheless, the findings from previous studies suggest miRNAs may play an important role in the risk and progression of prostate cancer as promising biomarkers. ..
  9. Bracken C, Li X, Wright J, Lawrence D, Pillman K, Salmanidis M, et al. Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. EMBO J. 2014;33:2040-56 pubmed publisher
  10. Jayachandran B, Hussain M, Asgari S. An insect trypsin-like serine protease as a target of microRNA: utilization of microRNA mimics and inhibitors by oral feeding. Insect Biochem Mol Biol. 2013;43:398-406 pubmed publisher
    ..This is the first study which shows the potential of utilization of miRNA mimics and inhibitors in pest control by targeting specific insect genes. ..
  11. Davidson M, Larsen J, Yang I, Hayward N, Clarke B, Duhig E, et al. MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS ONE. 2010;5:e12560 pubmed publisher
  12. Wainwright E, Jorgensen J, Kim Y, Truong V, Bagheri Fam S, Davidson T, et al. SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation. Biol Reprod. 2013;89:34 pubmed publisher
    ..Our findings indicate that expression of the conserved gonad microRNA, miR-202-5p/3p, is downstream of the testis-determining factor SOX9, suggesting an early role in testis development. ..
  13. Rakoczy J, Fernandez Valverde S, Glazov E, Wainwright E, Sato T, Takada S, et al. MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biol Reprod. 2013;88:143 pubmed publisher
  14. Brewster B, Rossiello F, French J, Edwards S, Wong M, Wronski A, et al. Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. Hum Mutat. 2012;33:1665-75 pubmed publisher
    ..0007) in 3'UTR reporter activity when coexpressed with the predicted targeting miRNA, miR-103. This is the most comprehensive identification and analysis of BRCA1 3'UTR variants published to date. ..
  15. Ragan C, Mowry B, Bauer D. Hybridization-based reconstruction of small non-coding RNA transcripts from deep sequencing data. Nucleic Acids Res. 2012;40:7633-43 pubmed publisher
    ..This feature makes it the first method particularly suitable for the prediction of both known and novel piRNAs. ..
  16. Bonazzi V, Stark M, Hayward N. MicroRNA regulation of melanoma progression. Melanoma Res. 2012;22:101-13 pubmed publisher
    ..On the basis of the current literature, we present a network of miRNA interactions involved in melanoma progression. Some of these key miRNAs may have utility as diagnostic markers or in targeted treatments...
  17. Hussain M, Torres S, Schnettler E, Funk A, Grundhoff A, Pijlman G, et al. West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells. Nucleic Acids Res. 2012;40:2210-23 pubmed publisher