Experts and Doctors on mice in South Brisbane, Queensland, Australia


Locale: South Brisbane, Queensland, Australia
Topic: mice

Top Publications

  1. Winkler I, Pettit A, Raggatt L, Jacobsen R, Forristal C, Barbier V, et al. Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia. 2012;26:1594-601 pubmed publisher
  2. Levesque J, Winkler I. 38th Annual Meeting of the International Society of Experimental Hematology. Expert Rev Hematol. 2009;2:645-7 pubmed publisher
    ..Owing to the large number of keynote speakers, this report focuses on the most novel, unpublished data presented during the meeting. ..
  3. McGuckin M, Eri R, Das I, Lourie R, Florin T. ER stress and the unfolded protein response in intestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2010;298:G820-32 pubmed publisher
    ..Evidence is reviewed from mouse models and human inflammatory bowel diseases that ties ER stress and activation of the UPR with intestinal inflammation, and possible therapeutic approaches to ameliorate ER stress are discussed. ..
  4. Barbier V, Winkler I, Wadley R, Levesque J. Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo. Methods Mol Biol. 2012;844:45-63 pubmed publisher
    ..This technique enables prospective isolation of HSCs based on the in vivo perfusion of the niches in which they reside. ..
  5. Wilson J, Cullup H, Lourie R, Sheng Y, Palkova A, Radford K, et al. Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. J Exp Med. 2009;206:387-98 pubmed publisher
    ..Antibodies that target activated DC are a promising new therapeutic approach to the control of GVHD. ..
  6. Winkler I, Barbier V, Wadley R, Zannettino A, Williams S, Levesque J. Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood. 2010;116:375-85 pubmed publisher
    ..This technique enables prospective isolation of serially reconstituting HSCs distinct from other less potent HSCs of the same phenotype, based on the in vivo niche in which they reside. ..
  7. Thakur S, Ward M, Popat A, Flemming N, Parat M, Barnett N, et al. Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina. PLoS ONE. 2017;12:e0178305 pubmed publisher
    ..The results of this study pave the way towards better understanding mechanisms underlying cellular responsiveness to ultrasound-triggered drug delivery in future ex vivo and in vivo models of the posterior eye. ..
  8. Kato M, Khan S, d Aniello E, McDonald K, Hart D. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. J Immunol. 2007;179:6052-63 pubmed
    ..These data suggest that hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration and thus may become a target for therapeutic manipulation. ..
  9. Winkler I, Sims N, Pettit A, Barbier V, Nowlan B, Helwani F, et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood. 2010;116:4815-28 pubmed publisher
    ..Together, these results establish that bone marrow macrophages are pivotal to maintain the endosteal HSC niche and that the loss of such macrophages leads to the egress of HSCs into the blood. ..

More Information


  1. Hasnain S, Tauro S, Das I, Tong H, Chen A, Jeffery P, et al. IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology. 2013;144:357-368.e9 pubmed publisher
    ..However, it is not clear how immune factors affect ER stress and therefore disease symptoms...
  2. Dawson P, Rakoczy J, Simmons D. Placental, renal, and ileal sulfate transporter gene expression in mouse gestation. Biol Reprod. 2012;87:43 pubmed publisher
  3. Bowling F. Pyridoxine supply in human development. Semin Cell Dev Biol. 2011;22:611-8 pubmed publisher
    ..Pyridoxine potentiates vitamin A teratogenicity and an excess leads to peripheral nerve cell degeneration. The key role of vitamin B(6) in the developing human is in metabolism, especially of the neurotransmitters. ..
  4. Eri R, Adams R, Tran T, Tong H, Das I, Roche D, et al. An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol. 2011;4:354-64 pubmed publisher
    ..Thus, the Winnie primary epithelial defect results in complex multicytokine-mediated colitis involving both innate and adaptive immune components with a prominent IL-23/T(H)17 response, similar to that of human ulcerative colitis. ..
  5. Williams S, Munster D, Quin R, Gotley D, McGuckin M. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Biochem Biophys Res Commun. 1999;261:83-9 pubmed
    ..The new finding that MUC3 encodes a transmembrane molecule presents a new paradigm for the structure of this mucin and the manner in which it may function. ..
  6. Linden S, Sheng Y, Every A, Miles K, Skoog E, Florin T, et al. MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog. 2009;5:e1000617 pubmed publisher
    ..pylori infected mice. Thus, MUC1 protects the epithelium from non-MUC1 binding bacteria by inhibiting adhesion to the cell surface by steric hindrance, and from MUC1-binding bacteria by acting as a releasable decoy. ..
  7. McAuley J, Linden S, Png C, King R, Pennington H, Gendler S, et al. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest. 2007;117:2313-24 pubmed
  8. Winkler I, Hendy J, Coughlin P, Horvath A, Levesque J. Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med. 2005;201:1077-88 pubmed
    ..These data suggest an unexpected role for serpina1 and serpina3 in regulating the bone marrow hematopoietic microenvironment as well as influencing the migratory behavior of hematopoietic precursors. ..
  9. Clark G, Fitzpatrick S, Kuo B, Modra C, Jamriska L, Hart D. CMRF-35A, CMRF-35H: potential new CD. J Biol Regul Homeost Agents. 2002;16:233-5 pubmed
  10. Wykes M, MacDonald K, Tran M, Quin R, Xing P, Gendler S, et al. MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. J Leukoc Biol. 2002;72:692-701 pubmed
    ..The function of CD227 on DC and T cells requires further elucidation. ..
  11. Ju X, Clark G, Hart D. Review of human DC subtypes. Methods Mol Biol. 2010;595:3-20 pubmed publisher
    ..We also hope to clarify the differences in nomenclature between the human and mouse models that have arisen by way of the different experimental models. ..
  12. Linden S, Florin T, McGuckin M. Mucin dynamics in intestinal bacterial infection. PLoS ONE. 2008;3:e3952 pubmed publisher
    ..coli. Mucin glycoproteins are the main component of the first barrier that bacteria encounter in the intestinal tract...
  13. Sheng Y, Lourie R, Linden S, Jeffery P, Roche D, Tran T, et al. The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut. 2011;60:1661-70 pubmed publisher
  14. Heazlewood C, Cook M, Eri R, Price G, Tauro S, Taupin D, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008;5:e54 pubmed publisher
  15. Sheng Y, Hasnain S, Png C, McGuckin M, Linden S. Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo. Methods Mol Biol. 2012;842:297-312 pubmed publisher
  16. Levesque J, Winkler I, Hendy J, Williams B, Helwani F, Barbier V, et al. Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow. Stem Cells. 2007;25:1954-65 pubmed
    ..Disclosure of potential conflicts of interest is found at the end of this article. ..
  17. Winkler I, Barbier V, Nowlan B, Jacobsen R, Forristal C, Patton J, et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med. 2012;18:1651-7 pubmed publisher
    ..As bone marrow suppression is a severe side effect of high-dose chemotherapy, transient blockade of E-selectin is potentially a promising treatment for the protection of HSCs during chemotherapy or irradiation. ..
  18. Forristal C, Winkler I, Nowlan B, Barbier V, Walkinshaw G, Levesque J. Pharmacologic stabilization of HIF-1? increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood. 2013;121:759-69 pubmed publisher
    ..HIF-1? protein stabilization increases HSC quiescence in vivo. HIF-1? protein stabilization increases HSC resistance to irradiation and accelerates recovery. ..
  19. Sanchez W, McGee S, Connor T, Mottram B, Wilkinson A, Whitehead J, et al. Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib. Br J Cancer. 2013;108:1624-33 pubmed publisher
    ..Myeloma cells display aerobic glycolysis and DCA may complement clinically used MM therapies to inhibit disease progression. ..
  20. Das I, Png C, Oancea I, Hasnain S, Lourie R, Proctor M, et al. Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med. 2013;210:1201-16 pubmed publisher
    ..In IBD, glucocorticoids are likely to ameliorate ER stress by promoting correct folding of secreted proteins and enhancing removal of misfolded proteins from the ER. ..