Genomes and Genes
Experts and Doctors on mice in Brisbane, Queensland, Australia
Locale: Brisbane, Queensland, Australia
Publications453 found, 100 shown here
- Matusica D, Alfonsi F, Turner B, Butler T, Shepheard S, Rogers M, et al. Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment. J Cell Sci. 2016;129:517-30 pubmed publisher..We conclude that the c29 peptide facilitates BDNF-dependent survival of motor neurons in vitro and in vivo. ..
- St John J, Clarris H, McKeown S, Royal S, Key B. Sorting and convergence of primary olfactory axons are independent of the olfactory bulb. J Comp Neurol. 2003;464:131-40 pubmed..Olfactory axon behaviour in these models demonstrates that sorting and convergence of axons are independent of the target, which instead provides distinct topographic cues for guidance. ..
- McGlinn E, van Bueren K, Fiorenza S, Mo R, Poh A, Forrest A, et al. Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev. 2005;122:1218-33 pubmed..Our data have also revealed that perturbation of early patterning events within the Gli3(Xt/Xt) limb culminates in a specific delay of anterior chondrogenesis which is subsequently realised as extra digits. ..
- Ford P, Gemmell E, Timms P, Chan A, Preston F, Seymour G. Anti-P. gingivalis response correlates with atherosclerosis. J Dent Res. 2007;86:35-40 pubmed..hHSP60 was detected in lesions, and in P. gingivalis-immunized mice, lesion development was correlated with anti-GroEL antibody levels, supporting the involvement of molecular mimicry between GroEL and hHSP60. ..
- Clark D, Lobigs M, Lee E, Howard M, Clark K, Blitvich B, et al. In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein. J Gen Virol. 2007;88:1175-83 pubmed publisher..The inability to detect dimeric NS1 in supernatant or cell monolayers of cultures productively infected with mutant virus also suggests that dimerization of the protein may not be essential for virus replication...
- Alayan J, Gemmell E, Ford P, Hamlet S, Bird P, Ivanovski S, et al. The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model. Oral Microbiol Immunol. 2007;22:304-12 pubmed..Interestingly, serum-specific antibodies suggested a strong T helper type 2 response. The results of our study indicate an important role for IL-12 in a primary P. gingivalis subcutaneous challenge. ..
- Ovchinnikov D, van Zuylen W, DeBats C, Alexander K, Kellie S, Hume D. Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. J Leukoc Biol. 2008;83:430-3 pubmed..The new mouse line provides a useful tool for overexpression of transgenes in cells of the myeloid lineage, while simultaneously labeling them by ECFP expression. ..
- Mercer T, Qureshi I, Gokhan S, Dinger M, Li G, Mattick J, et al. Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. BMC Neurosci. 2010;11:14 pubmed publisher..These observations explicitly link ncRNA dynamics to neural stem cell fate decisions, specification and epigenetic reprogramming and may have important implications for understanding and treating neuropsychiatric diseases. ..
- Ashman R, Vijayan D, Wells C. IL-12 and related cytokines: function and regulatory implications in Candida albicans infection. Clin Dev Immunol. 2011;2011:686597 pubmed publisher..This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them. ..
- Day B, Stringer B, Al Ejeh F, Ting M, Wilson J, Ensbey K, et al. EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. Cancer Cell. 2013;23:238-48 pubmed publisher..These results identify EphA3 as a functional, targetable receptor in GBM. ..
- Hargrave M, James K, Yamada T, Koopman P. Sox14 maps to mouse chromosome 9 and shows no mutations in the neurological mouse mutants ducky and tippy. Mamm Genome. 2000;11:231-3 pubmed
- Himes S, Tagoh H, Goonetilleke N, Sasmono T, Oceandy D, Clark R, et al. A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J Leukoc Biol. 2001;70:812-20 pubmed..Removal of FIRE abolished reporter gene expression, revealing a suppressive activity in the remaining intronic sequences. Hence, FIRE is shown to be a key regulatory element in the fms gene. ..
- Pantaleon M, Jericho H, Rabnott G, Kaye P. The role of insulin-like growth factor II and its receptor in mouse preimplantation development. Reprod Fertil Dev. 2003;15:37-45 pubmed..These responses indicate that the IGF-II/M6P receptor is functional and likely to participate in such a regulatory circuit. The functional role of IGF-II and its receptor is discussed with reference to regulation of early development. ..
- Jeanes A, Wilhelm D, Wilson M, Bowles J, McClive P, Sinclair A, et al. Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis. Reproduction. 2005;130:509-16 pubmed..Although not strictly specific for PM cells, these markers are likely to be useful in studying the biology of early PM cells in the fetal testis...
- Darnell G, Schroder W, Gardner J, Harrich D, Yu H, Medcalf R, et al. SerpinB2 is an inducible host factor involved in enhancing HIV-1 transcription and replication. J Biol Chem. 2006;281:31348-58 pubmed..This is the first report associating HIV-1 replication with SerpinB2 expression and illustrates that SerpinB2 is a potentially important inducible host factor that significantly promotes HIV-1 replication. ..
- van der Horst A, Khanna K. The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. Cancer Res. 2009;69:6651-9 pubmed publisher..These data are the first evidence that Pin1 regulates cytokinesis and may provide a mechanistic explanation as to how pathologic levels of Pin1 can stimulate tumorigenesis. ..
- Moldrich R, Pannek K, Hoch R, Rubenstein J, Kurniawan N, Richards L. Comparative mouse brain tractography of diffusion magnetic resonance imaging. Neuroimage. 2010;51:1027-36 pubmed publisher..In conclusion, probabilistic tractography can elucidate the phenotypes of mice with neurodegenerative or neurodevelopmental disorders in a quantitative manner. ..
- Windus L, Chehrehasa F, Lineburg K, Claxton C, Mackay Sim A, Key B, et al. Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth. Cell Mol Life Sci. 2011;68:3233-47 pubmed publisher..These results demonstrate that the migration of OECs strongly regulates the motility of axons and that stimulation of OEC motility enhances axon extension and growth cone activity...
- Town L, McGlinn E, Davidson T, Browne C, Chawengsaksophak K, Koopman P, et al. Tmem26 is dynamically expressed during palate and limb development but is not required for embryonic survival. PLoS ONE. 2011;6:e25228 pubmed publisher..However, ubiquitous inactivation of Tmem26 led to no overt phenotype in the resulting embryos or adult mice, suggesting that TMEM26 function is dispensable for embryonic survival...
- Chen K, Richards A, Ariffin J, Ross I, Sweet M, Kellie S, et al. The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. Acta Crystallogr D Biol Crystallogr. 2012;68:637-48 pubmed publisher..Although predicted to have a signal peptide, it is shown that Fam96a is cytoplasmic. The data reveal that eukaryotic DUF59 proteins share intriguing characteristics with amyloidogenic proteins. ..
- O Meara C, Armitage C, Harvie M, Timms P, Lycke N, Beagley K. Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology. PLoS ONE. 2013;8:e61962 pubmed publisher..This identifies a disconnection between the control of infection and the development of pathology, which may influence the design of future vaccines. ..
- Kim R, Pinkerton J, Essilfie A, Robertson A, Baines K, Brown A, et al. Role for NLRP3 Inflammasome-mediated, IL-1?-Dependent Responses in Severe, Steroid-Resistant Asthma. Am J Respir Crit Care Med. 2017;196:283-297 pubmed publisher..Neutrophil depletion suppressed IL-1?-induced steroid-resistant airway hyperresponsiveness. NLRP3 inflammasome responses drive experimental severe, steroid-resistant asthma and are potential therapeutic targets in this disease. ..
- Tisay K, St John J, Key B. Expression of specific glycoconjugates in both primary and secondary olfactory pathways in BALB/C mice. J Comp Neurol. 2002;443:213-25 pubmed..These results suggest that glycoconjugates recognized by DBA may have a specific role in the formation and maintenance of neural connections within a select functional pathway in the brain. ..
- Zhong J, Rist M, Cooper L, Smith C, Khanna R. Induction of pluripotent protective immunity following immunisation with a chimeric vaccine against human cytomegalovirus. PLoS ONE. 2008;3:e3256 pubmed publisher..These studies demonstrate that the adenovirus chimeric HCMV vaccine provides an excellent platform for reconstituting protective immunity to prevent HCMV diseases in different clinical settings. ..
- Nasreen M, Waldie T, Dixon C, Steptoe R. Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses. Eur J Immunol. 2010;40:2016-25 pubmed publisher..This finding is important in understanding how to effectively apply immunotherapy to ongoing T-cell-mediated autoimmune and inflammatory diseases. ..
- Zhong J, Khanna R. Delineating the role of CD4+ T cells in the activation of human cytomegalovirus-specific immune responses following immunization with Ad-gBCMVpoly vaccine: implications for vaccination of immunocompromised individuals. J Gen Virol. 2010;91:2994-3001 pubmed publisher..These results highlight the importance of monitoring CD4(+) T-cell numbers before vaccination for the successful implementation of a CMV vaccine in an immunocompromised setting...
- Foster S, Porrello E, Purdue B, Chan H, Voigt A, Frenzel S, et al. Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS ONE. 2013;8:e64579 pubmed publisher..The discovery of taste GPCRs in the heart opens an exciting new field of cardiac research. We predict that these taste receptors may function as nutrient sensors in the heart. ..
- Chen N, Lu Z, Land M, Ayres R, Crane D. Peroxisomal membrane protein PMP68 of mouse liver: cloning of a cDNA encompassing the nucleotide binding fold and epitope mapping of monoclonal antibodies to the expressed protein. Arch Biochem Biophys. 1995;321:526-30 pubmed..These antibodies are expected to be useful in the elucidation of the biological function of this putative membrane transporter...
- Hamilton B, Hurbungs M, Jones A, Lewis R. Multiple ciguatoxins present in Indian Ocean reef fish. Toxicon. 2002;40:1347-53 pubmed..The ratio of CTX-1 and -2 varied depending on the fish extract being analysed. These results suggest that I-CTX-1 and -2 may arise from separate dinoflagellate precursors that may be oxidatively biotransformed to I-CTX-3 and -4 in fish. ..
- Sasmono R, Oceandy D, Pollard J, Tong W, Pavli P, Wainwright B, et al. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood. 2003;101:1155-63 pubmed..We have therefore defined the elements required to generate myeloid- and trophoblast-specific transgenes as well as a model system for the study of mononuclear phagocyte development and function. ..
- St John J, Key B. Heterogeneity in olfactory neurons in mouse revealed by differential expression of glycoconjugates. Histochem J. 2002;34:281-9 pubmed..The conserved expression of these carbohydrates across species suggests they play an important role in the functional organization of this region of the nervous system. ..
- Flight S, Johnson L, Du Q, Warner R, Trabi M, Gaffney P, et al. Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss. Br J Haematol. 2009;145:207-11 pubmed publisher..Based on these data, textilinin-1 merits further investigation as a therapeutic alternative to aprotinin. ..
- Burke M, McGarvey L, McSorley H, Bielefeldt Ohmann H, McManus D, Gobert G. Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung. Mol Immunol. 2011;49:191-200 pubmed publisher..These findings contribute to our understanding of host-parasite interactions associated with schistosome and, especially, S. japonicum infection, and may aid the future design of novel vaccines that target the lung stage schistosomulum...
- Unni D, Piper M, Moldrich R, Gobius I, Liu S, Fothergill T, et al. Multiple Slits regulate the development of midline glial populations and the corpus callosum. Dev Biol. 2012;365:36-49 pubmed publisher..Finally, our data also indicate that some of the roles of Slit proteins at the midline may be independent of Robo signalling, suggestive of additional receptors regulating Slit signalling during development. ..
- Chiang I, Fritzsche M, Pichol Thievend C, Neal A, Holmes K, Lagendijk A, et al. SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development. 2017;144:2629-2639 pubmed publisher..These findings position SoxF transcription factors directly upstream of Notch receptor expression during the acquisition of arterial identity in vertebrates. ..
- Falconar A, Young P. Immunoaffinity purification of native dimer forms of the flavivirus non-structural glycoprotein, NS1. J Virol Methods. 1990;30:323-32 pubmed..In moderately sized virus growth experiments, greater than 1 mg quantities of purified NS1 were obtained...
- Little M, Holmes G, Walsh P. WT1: what has the last decade told us?. Bioessays. 1999;21:191-202 pubmed..Finally, further research into the role of WT1 in haematopoiesis will improve our understanding of WT1 in leukaemia. ..
- Abu Bakar A, Satarug S, Marks G, Lang M, Moore M. Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2. Toxicol Lett. 2004;148:199-210 pubmed..Upregulation of CYP2A5 by cadmium in the Nrf2 +/+ mice but not in the Nrf2-/- mice indicates a role for this transcription factor in the regulation...
- Hodge D, Coghill E, Keys J, Maguire T, Hartmann B, McDowall A, et al. A global role for EKLF in definitive and primitive erythropoiesis. Blood. 2006;107:3359-70 pubmed..In short, EKLF regulates global erythroid gene expression that is critical for the development of primitive and definitive red cells. ..
- Antonsson A, Payne E, Hengst K, McMillan N. The human papillomavirus type 16 E7 protein binds human interferon regulatory factor-9 via a novel PEST domain required for transformation. J Interferon Cytokine Res. 2006;26:455-61 pubmed..Our work suggests E7-IRF-9 interaction is important for the transforming ability of HPV-16 E7 and that HPV-16 E7 may interact with other IRF proteins that have IAD domains. ..
- Olver S, Apte S, Baz A, Kienzle N. The duplicitous effects of interleukin 4 on tumour immunity: how can the same cytokine improve or impair control of tumour growth?. Tissue Antigens. 2007;69:293-8 pubmed..Thus, the search for factors that improve or weaken the effectiveness of tumour-specific T cells has to be continued to improve modern approaches of immunotherapy against cancer. ..
- Darnell G, Schroder W, Antalis T, Lambley E, Major L, Gardner J, et al. Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein. J Biol Chem. 2007;282:37492-500 pubmed publisher..Calpain, thus, emerges as a central player in E7-mediated degradation of Rb and represents a potential new drug target for the treatment of HPV-associated lesions...
- Kuphal S, Martyn A, Pedley J, Crowther L, Bonazzi V, Parsons P, et al. H-cadherin expression reduces invasion of malignant melanoma. Pigment Cell Melanoma Res. 2009;22:296-306 pubmed publisher..Our study presents for the first time the down-regulation of H-cadherin in malignant melanomas and its possible functional relevance in maintenance healthy skin architecture. ..
- Zhou F, Frazer I, Leggatt G. Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis. Exp Dermatol. 2009;18:1053-9 pubmed publisher..These results suggest that primary KCs will be susceptible to CTL-mediated apoptosis when endogenous KC antigens are targeted during immunotherapy. ..
- Combes A, Spiller C, Harley V, Sinclair A, Dunwoodie S, Wilhelm D, et al. Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation. Int J Dev Biol. 2010;54:683-9 pubmed publisher..These data suggest a novel role for SF1 in promoting ovarian development in addition to its roles in testis differentiation. ..
- Mercer T, Wilhelm D, Dinger M, Soldà G, Korbie D, Glazov E, et al. Expression of distinct RNAs from 3' untranslated regions. Nucleic Acids Res. 2011;39:2393-403 pubmed publisher..Our findings suggest novel functions for 3'UTRs, as well as caution in the use of 3'UTR sequence probes to analyze gene expression. ..
- Lee I, Chow E, Morrow C, Djordjevic J, Fraser J. Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans. Genetics. 2011;188:309-23 pubmed publisher..A murine inhalation model of cryptococcosis revealed that the gat1? mutant is slightly more virulent than wild type, indicating that Gat1 plays a complex regulatory role during infection...
- Chawengsaksophak K, Svingen T, Ng E, Epp T, Spiller C, Clark C, et al. Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biol Reprod. 2012;86:1-12 pubmed publisher..Our results indicate multiple roles for Wnt5a during mammalian reproductive development and help to clarify further the etiology of Robinow syndrome (OMIM 268310), a disease previously linked to the WNT5A pathway. ..
- Fernández Rojo M, Restall C, Ferguson C, Martel N, Martin S, Bosch M, et al. Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration. Hepatology. 2012;55:1574-84 pubmed publisher..Our data demonstrate that lack of CAV1 alters hepatocyte energy metabolism homeostasis under physiological and pathological conditions. ..
- Sumanadasa S, Goodman C, Lucke A, Skinner Adams T, Sahama I, Haque A, et al. Antimalarial activity of the anticancer histone deacetylase inhibitor SB939. Antimicrob Agents Chemother. 2012;56:3849-56 pubmed publisher..These results identify SB939 as a potent new antimalarial HDAC inhibitor and underscore the potential of investigating next-generation anticancer HDAC inhibitors as prospective new drug leads for treatment of malaria. ..
- You H, McManus D, Hu W, Smout M, Brindley P, Gobert G. Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII. PLoS Pathog. 2013;9:e1003254 pubmed publisher..Together, these studies comprehensively charted transcriptional changes upon exposure to praziquantel and, notably, identified CamKII as potentially central to the, as yet undefined, mode of action of praziquantel. ..
- Pennisi D, Gardner J, Chambers D, Hosking B, Peters J, Muscat G, et al. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet. 2000;24:434-7 pubmed..Our observations implicate mutations in Sox18 as the underlying cause of the Ra phenotype, and identify Sox18 as a critical gene for cardiovascular and hair follicle formation. ..
- Olive C, Clair T, Yarwood P, Good M. Protection of mice from group A streptococcal infection by intranasal immunisation with a peptide vaccine that contains a conserved M protein B cell epitope and lacks a T cell autoepitope. Vaccine. 2002;20:2816-25 pubmed..These data indicate that immunity to GAS infection can be evoked by intranasal immunisation with a GAS M protein C-region peptide vaccine that contains a protective B cell epitope and lacks a T cell autoepitope. ..
- Liu X, Xu Y, Hardy L, Khammanivong V, Zhao W, Fernando G, et al. IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host. J Immunol. 2003;171:4765-72 pubmed..Induction of virus- or tumor Ag-specific CD8 effector T cells in the partially Ag-primed host may thus be facilitated by local neutralization of IL-10. ..
- Jeffery P, Duncan R, Yeh A, Jaskolski R, Hammond D, Herington A, et al. Expression of the ghrelin axis in the mouse: an exon 4-deleted mouse proghrelin variant encodes a novel C terminal peptide. Endocrinology. 2005;146:432-40 pubmed..Exon 4-deleted proghrelin, a novel mouse proghrelin isoform with a unique C-terminal peptide sequence, is also widely expressed in the mouse and thus may possess biological activity in these tissues. ..
- Burne T, McGrath J, Eyles D, Mackay Sim A. Behavioural characterization of vitamin D receptor knockout mice. Behav Brain Res. 2005;157:299-308 pubmed..Therefore, it appears that VDR -/- mice have muscular and motor impairments that significantly affects locomotor behaviour but seemingly no impairments in cognition as indicated by exploration, working memory or anxiety. ..
- Pinzon Charry A, McPhun V, Kienzle V, Hirunpetcharat C, Engwerda C, McCarthy J, et al. Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice. J Clin Invest. 2010;120:2967-78 pubmed publisher..If applicable to humans, this approach should facilitate the generation of robust, cross-reactive T cell responses against malaria as well as antigen availability for vaccine manufacture. ..
- Tallack M, Perkins A. KLF1 directly coordinates almost all aspects of terminal erythroid differentiation. IUBMB Life. 2010;62:886-90 pubmed publisher..The full extent of KLF1 target genes have provided new insights into erythropoiesis, and have established that KLF1 controls almost all aspects of erythroid cell development and maturation. ..
- Francois M, Short K, Secker G, Combes A, Schwarz Q, Davidson T, et al. Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol. 2012;364:89-98 pubmed publisher..Our data support a new model for lymphatic vascular patterning and morphogenesis, as a basis for identifying the molecular cues governing these processes...
- Bailey T, Machanick P. Inferring direct DNA binding from ChIP-seq. Nucleic Acids Res. 2012;40:e128 pubmed..CentriMo is now part of the MEME Suite software package available at http://meme.nbcr.net. All data and output files presented here are available at: http://research.imb.uq.edu.au/t.bailey/sd/Bailey2011a. ..
- Reeves P, Rudraraju R, Wong F, Hamilton Williams E, Steptoe R. Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice. Eur J Immunol. 2017;47:1550-1561 pubmed publisher..This shift from T-cell priming to T-cell tolerance exemplifies the tolerogenic capacity of autoantigen expression by APC and the capacity to overcome genetic tolerance defects...
- Rehli M, den Elzen N, Cassady A, Ostrowski M, Hume D. Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics. 1999;56:111-20 pubmed..Evolutionary aspects and implications for structure-function relationships are discussed. ..
- Koopman P. Sry and Sox9: mammalian testis-determining genes. Cell Mol Life Sci. 1999;55:839-56 pubmed
- Hosking B, Wang S, Chen S, Penning S, Koopman P, Muscat G. SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun. 2001;287:493-500 pubmed..These results suggest that MEF2C and SOX18 may be important partners directing the transcriptional regulation of vascular development. ..
- Schepers G, Wilson M, Wilhelm D, Koopman P. SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J Biol Chem. 2003;278:28101-8 pubmed
- Ellis T, Smyth I, Riley E, Bowles J, Adolphe C, Rothnagel J, et al. Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis. Dev Biol. 2003;263:203-15 pubmed..Through a comparison with other mouse models, the characteristics of the HK1-Shh transgenic mice suggest that the precise timing and site of Shh expression are key in dictating the resultant skin and tumour phenotype. ..
- La Linn M, Eble J, Lübken C, Slade R, Heino J, Davies J, et al. An arthritogenic alphavirus uses the alpha1beta1 integrin collagen receptor. Virology. 2005;336:229-39 pubmed..We speculate that two highly conserved regions within the cell-receptor binding domain of E2 mimic collagen and provide access to cellular collagen-binding receptors. ..
- Woodruff A, Sah P. Networks of parvalbumin-positive interneurons in the basolateral amygdala. J Neurosci. 2007;27:553-63 pubmed..We propose that these properties allow networks of parvalbumin-expressing neurons to perform an array of information-processing tasks within the BLA. ..
- Alayan J, Ivanovski S, Farah C. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res. 2007;42:97-103 pubmed..The kinetics of alveolar bone loss seen in cytokine gene knockout mice indicates that bone loss is age dependent and late in onset. ..
- Liu X, Leerberg J, MacDonald K, Leggatt G, Frazer I. IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. J Immunol. 2009;183:51-8 pubmed publisher..Systemic inhibition of both IL-10 and IFN-gamma at the time of immunization may therefore facilitate induction of effective immunotherapeutic responses against tumor specific and viral Ags. ..
- Perry C, Burke M, Stenzel D, McManus D, Ramm G, Gobert G. Differential expression of chemokine and matrix re-modelling genes is associated with contrasting schistosome-induced hepatopathology in murine models. PLoS Negl Trop Dis. 2011;5:e1178 pubmed publisher..This improved understanding of the immunopathogenesis in the murine model schistosomiasis provides the basis for a better appreciation of the complexities associated with chronic human schistosomiasis...
- Wykes M. Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity?. Trends Parasitol. 2012;28:182-6 pubmed publisher..in the spleen. This opinion article explores how the occupation of pDCs by the parasite may corrupt immunity against malaria. ..
- Handoko H, Rodero M, Boyle G, Ferguson B, Engwerda C, Hill G, et al. UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages. J Invest Dermatol. 2013;133:1803-12 pubmed publisher..By helping induce this effect, the infiltration of specific macrophage subpopulations after sunburn may be a factor in increasing the risk of subsequent neoplastic transformation of melanocytes. ..
- Major L, Partridge T, Gardner J, Kent S, De Rose R, Suhrbier A, et al. Induction of SerpinB2 and Th1/Th2 modulation by SerpinB2 during lentiviral infections in vivo. PLoS ONE. 2013;8:e57343 pubmed publisher..These data illustrate that SerpinB2 can be induced by lentiviral infection in vivo and support the emerging notion that a physiological role of SerpinB2 is modulation of Th1/Th2 responses...
- Williams M, Clouston A, Forbes S. Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology. 2014;146:349-56 pubmed publisher..Understanding the interactions between progenitor cells and matrix is critical for the development of novel regenerative and antifibrotic therapies. ..
- Yue X, Favot P, Dunn T, Cassady A, Hume D. Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Mol Cell Biol. 1993;13:3191-201 pubmed..The results suggest that expression of the c-fms gene in macrophages is controlled by sequences in intron 2 that act by regulating transcription elongation. ..
- Noakes P, Chin D, Kim S, Liang S, Phillips W. Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation. J Comp Neurol. 1999;410:531-40 pubmed..The delayed appearance of dynamin at the synapse, thus, heralds the neonatal development of robust synaptic transmission at the neuromuscular junction. ..
- Kennedy D, French J, Guitard E, Ru K, Tocque B, Mattick J. Characterization of G3BPs: tissue specific expression, chromosomal localisation and rasGAP(120) binding studies. J Cell Biochem. 2001;84:173-87 pubmed..Furthermore, we have characterized the protein expression of both G3BP-1 and G3BP-2a/b in adult mouse tissues, and show them to be both tissue and isoform specific. ..
- Hamilton B, Hurbungs M, Vernoux J, Jones A, Lewis R. Isolation and characterisation of Indian Ocean ciguatoxin. Toxicon. 2002;40:685-93 pubmed..Taken together, these results indicate that I-CTX is a new ciguatoxin (CTX) responsible for ciguatera caused by reef fish in the Indian Ocean. ..
- Smyth D, McManus D, Smout M, Laha T, Zhang W, Loukas A. Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method. Infect Immun. 2003;71:2548-54 pubmed..mansoni cDNAs. This is the first report describing the use of SST as a tool for identifying secreted proteins from any pathogenic organism. ..
- Batzloff M, Hayman W, Davies M, Zeng M, Pruksakorn S, Brandt E, et al. Protection against group A streptococcus by immunization with J8-diphtheria toxoid: contribution of J8- and diphtheria toxoid-specific antibodies to protection. J Infect Dis. 2003;187:1598-608 pubmed..DT may be an ideal carrier protein for J8 and other GAS peptides for GAS vaccines. ..
- Crowe M, Wang X, Rothnagel J. Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides. BMC Genomics. 2006;7:16 pubmed