Experts and Doctors on dendritic cells in South Brisbane, Queensland, Australia

Summary

Locale: South Brisbane, Queensland, Australia
Topic: dendritic cells

Top Publications

  1. Wilson J, Cullup H, Lourie R, Sheng Y, Palkova A, Radford K, et al. Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. J Exp Med. 2009;206:387-98 pubmed publisher
    ..Antibodies that target activated DC are a promising new therapeutic approach to the control of GVHD. ..
  2. Radford K, Turtle C, Kassianos A, Hart D. CD11c+ blood dendritic cells induce antigen-specific cytotoxic T lymphocytes with similar efficiency compared to monocyte-derived dendritic cells despite higher levels of MHC class I expression. J Immunother. 2006;29:596-605 pubmed
    ..The ability of BDCs to induce efficient CTL responses, combined with their migratory capacity, makes them an appealing alternative to be investigated in clinical immunotherapy research protocols. ..
  3. Kassianos A, Jongbloed S, Hart D, Radford K. Isolation of human blood DC subtypes. Methods Mol Biol. 2010;595:45-54 pubmed publisher
    ..Subsequent flow cytometry-based cell sorting allows the isolation of highly pure individual DC subsets that can then be used for functional studies. ..
  4. Wykes M, MacDonald K, Tran M, Quin R, Xing P, Gendler S, et al. MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. J Leukoc Biol. 2002;72:692-701 pubmed
    ..The function of CD227 on DC and T cells requires further elucidation. ..
  5. Hardy M, Kassianos A, Vulink A, Wilkinson R, Jongbloed S, Hart D, et al. NK cells enhance the induction of CTL responses by IL-15 monocyte-derived dendritic cells. Immunol Cell Biol. 2009;87:606-14 pubmed publisher
    ..These data implicate a role for small percentages of NK cells in the enhanced capacity of IL-15 MoDC to induce tumour-specific CTL independent of IL-12p70. ..
  6. Ju X, Clark G, Hart D. Review of human DC subtypes. Methods Mol Biol. 2010;595:3-20 pubmed publisher
    ..We also hope to clarify the differences in nomenclature between the human and mouse models that have arisen by way of the different experimental models. ..
  7. Jongbloed S, Kassianos A, McDonald K, Clark G, Ju X, Angel C, et al. Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med. 2010;207:1247-60 pubmed publisher
    ..The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens...
  8. Kassianos A, Hardy M, Ju X, Vijayan D, Ding Y, Vulink A, et al. Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli. Eur J Immunol. 2012;42:1512-22 pubmed publisher
    ..coli-derived Ag and failed to secrete cytokines in response to E. coli. These data demonstrate substantial differences in the nature of the response of human blood DC subsets to E. coli...
  9. Hart D, Hill G. Dendritic cell immunotherapy for cancer: application to low-grade lymphoma and multiple myeloma. Immunol Cell Biol. 1999;77:451-9 pubmed
    ..Data from animal models and clinical studies suggest that DC-based immunotherapy strategies, applied when the patient has minimal residual disease, may improve the long-term prognosis in these diseases. ..

More Information

Publications14

  1. Clark G, Jamriska L, Rao M, Hart D. Monocytes immunoselected via the novel monocyte specific molecule, CD300e, differentiate into active migratory dendritic cells. J Immunother. 2007;30:303-11 pubmed
    ..These data identify the CD300e antigen as another monocyte-specific marker that can be used to purify monocytes for differentiation into functionally active MoDC. ..
  2. Kato M, Khan S, d Aniello E, McDonald K, Hart D. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. J Immunol. 2007;179:6052-63 pubmed
    ..These data suggest that hDCL-1 is an unconventional lectin receptor that plays roles not only in endocytosis/phagocytosis but also in cell adhesion and migration and thus may become a target for therapeutic manipulation. ..
  3. Clark G, Ju X, Azlan M, Tate C, Ding Y, Hart D. The CD300 molecules regulate monocyte and dendritic cell functions. Immunobiology. 2009;214:730-6 pubmed publisher
  4. Ding Y, Ju X, Azlan M, Hart D, Clark G. Screening of the HLDA9 panel on peripheral blood dendritic cell populations. Immunol Lett. 2011;134:161-6 pubmed publisher
    ..Some of the mAb expected to bind to DC populations failed in this analysis. Overall, this screening highlighted similarities between the CD11c(+) DC subsets and the relatively immature state of peripheral blood DC. ..
  5. Eri R, Adams R, Tran T, Tong H, Das I, Roche D, et al. An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol. 2011;4:354-64 pubmed publisher
    ..Thus, the Winnie primary epithelial defect results in complex multicytokine-mediated colitis involving both innate and adaptive immune components with a prominent IL-23/T(H)17 response, similar to that of human ulcerative colitis. ..